Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKGERK signaling pathways

Clinical and Experimental Metastasis

Volumn 29, Issue 5, 2012, Pages 471-492

  Babykutty, Suboj ^a   Suboj, Priya ^a   Srinivas, Priya ^b   Nair, Asha S ^b   Chandramohan, K ^c   Gopala, Srinivas ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

^b RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^c REGIONAL CANCER CENTRE   (India)

Author keywords

Colon cancer; ERK 1 2; Migration; MMP 2 9; Nitric oxide

Indexed keywords

BETA CATENIN; CASPASE 3; CASPASE 8; CASPASE 9; COLLAGENASE 3; CYCLIC GMP; GELATINASE A; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE 15; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUTROPHIL COLLAGENASE; NITRIC OXIDE; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; STROMELYSIN; STROMELYSIN 2; STROMELYSIN 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR FRA 2; VASCULOTROPIN A; CYCLIC GMP DEPENDENT PROTEIN KINASE; MESSENGER RNA;

APOPTOSIS; ARTICLE; CANCER INVASION; CELL PROLIFERATION; CELL VIABILITY; COLON ADENOCARCINOMA; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; IN VITRO STUDY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ADENOCARCINOMA; CELL ADHESION; CELL MOTION; COLON TUMOR; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ADENOCARCINOMA; BLOTTING, WESTERN; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NITRIC OXIDE; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84862336710     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-012-9464-6     Document Type: Article

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