Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells

Molecular Pharmacology

Volumn 62, Issue 4, 2002, Pages 927-935

  Zaragoza, Carlos ^a   Soria, Estrella ^a   López, Esther ^a   Browning, Darren ^c   Balbín, Milagros ^b   López Otín, Carlos ^b   Lamas, Santiago ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (N,N DIETHYLAMINO)DIAZENOLATE 2 OXIDE; 8 BROMO CYCLIC AMP; COLLAGENASE 3; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE 1 ALPHA; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DERIVATIVE; GUANYLATE CYCLASE INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE DONOR; PHENYL 1,N2 ETHENO 8 BROMOGUANOSINE 3',5' CYCLIC PHOSPHOROTHIOATE; RAF PROTEIN; RAF1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; CATTLE; CELL STRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; GENE OVEREXPRESSION; GENETIC TRANSFECTION; INFLAMMATION; ISOMER; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM;

EID: 0036784336     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.4.927     Document Type: Article

References (40)

1. Balbin M, Pendas AM, Uria JA, Jimenez MG, Freije JP, and Lopez-Otin C (1999) Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors. APMIS 107:45-53.
2. Boerth NJ and Lincoln TM (1994) Expression of the catalytic domain of cyclic GMP-dependent protein kinase in a baculovirus system. FEBS Lett 342:255-260.
3. Browning DD, McShane M, Marty C, and Ye RD (2001) Functional analysis of type 1alpha cGMP-dependent protein kinase using green fluorescent fusion proteins. J Biol Chem 276:13039-13048.
4. Browning DD, McShane MP, Marty C, and Ye RD (2000) Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase. J Biol Chem 275:2811-2816.
5. Damjanovski S, Puzianowska-Kuznicka M, Ishuzuya-Oka A, and Shi YB (2000) Differential regulation of three thyroid hormone-responsive matrix metalloproteinase genes implicates distinct functions during frog embryogenesis. FASEB J 14:503-510.
6. El-Dahr SS, Dipp S, and Baricos WH (1998) Bradykinin stimulates the ERK->Elk-1->Fos/AP-1 pathway in mesangial cells. Am J Physiol 275:F343-F352.
7. Genersch E, Hayess K, Neuenfeld Y, and Haller H (2000) Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways. J Cell Sci 113:4319-4330.
8. Gu M, Lynch J, and Brecher P (2000) Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k). J Biol Chem 275:11389-11396.
9. Hernandez-Perera O, Perez-Sala D, Soria E, and Lamas S (2000) Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res 87:616-622.
10. Hojo Y, Ikeda U, Takahashi M, Sakata Y, Takizawa T, Okada K, Saito T, and Shimada K (2000) Matrix metalloproteinase-1 expression by interaction between monocytes and vascular endothelial cells. J Mol Cell Cardiol 32:1459-1468.
11. Hood J and Granger HJ (1998) Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells. J Biol Chem 273:23504-23508.
12. Huang Y, Mironova M, and Lopes-Virella MF (1999) Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 19:2640-2647.
13. Huang Y, Song L, Wu S, Fan F, and Lopes-Virella MF (2001) Oxidized LDL differentially regulates MMP-1 and TIMP-1 expression in vascular endothelial cells. Atherosclerosis 156:119-125.
14. Jaffrey SR and Snyder SH (1995) Nitric oxide: a neural messenger. Annu Rev Cell Dev Biol 11:417-440.
15. Jeng AY, Chou M, Sawyer WK, Caplan SL, Von Linden-Reed J, Jeune M, and Prescott MF (1999) Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis. Ann N Y Acad Sci 878:555-558.
16. Johansson N, Ala-aho R, Uitto V, Grenman R, Fusenig NE, Lopez-Otin C, and Kahari VM (2000) Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase. J Cell Sci 113:227-235.
17. Johansson N, Westermarck J, Leppa S, Hakkinen L, Koivisto L, Lopez-Otin C, Peltonen J, Heino J, and Kahari VM (1997) Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta. Cell Growth Differ 8:243-250.
18. Johnson LL, Dyer R, and Hupe DJ (1998) Matrix metalloproteinases. Curr Opin Chem Biol 2:466-471.
19. Komalavilas P, Shah PK, Jo H, and Lincoln TM (1999) Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. J Biol Chem 274:34301-34309.
20. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, and Brinckerhoff CE (2000) Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase and nuclear factor kappa B: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 43:801-811.
21. Moncada S, Radomski MW, and Palmer RM (1988) Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol 37:2495-2501.
22. Nagase H and Woessner JF Jr (1999) Matrix metalloproteinases. J Biol Chem 274:21491-21494.
23. Nathan C and Xie QW (1994) Nitric oxide synthases: roles, tolls and controls. Cell 78:915-918.
24. Pendas AM, Balbin M, Llano E, Jimenez MG, and Lopez-Otin C (1997) Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13). Genomics 40:222-233.
25. Pendas AM, Uria JA, Jimenez MG, Balbin M, Freije JP, and Lopez-Otin C (2000) An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies. Clin Chim Acta 291:137-155.
26. Pfeilschifter J, Eberhardt W, and Huwiler A (2001) Nitric oxide and mechanisms of redox signalling: matrix and matrix-metabolizing enzymes as prime nitric oxide targets. Eur J Pharmacol 429:279-286.
27. Pilz RB, Suhasini M, Idriss S, Meinkoth JL, and Boss GR (1995) Nitric oxide and cGMP analogs activate transcription from AP-1- responsive promoters in mammalian cells. FASEB J 9:552-558.
28. Quinn CO, Bizek GM, and Agapova OA (2000) Induction of rat interstitial collagenase (MMP-13) mRNA in a development-dependent manner by parathyroid hormone in osteoblastic cells. Endocrine 12:227-236.
29. Ravanti L, Heino J, Lopez-Otin C, and Kahari VM (1999) Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen- activated protein kinase. J Biol Chem 274:2446-2455.
30. Saura M, Zaragoza C, Bao C, McMillan A, and Lowenstein CJ (1999) Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription. J Mol Biol 289:459-471.
31. Seandel M, Noack-Kunnmann K, Zhu D, Aimes RT, and Quigley JP (2001) Growth factor-induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen. Blood 97:2323-2332.
32. Silletti S, Kessler T, Goldberg J, Boger DL, and Cheresh DA (2001) Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci USA 98:119-124.
33. Siwik DA, Chang DL, and Colucci WS (2000) Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circ Res 86:1259-1265.
34. Stamler JS, Lamas S, and Fang FC (2001) Nitrosylation, the prototypic redox-based signaling mechanism. Cell 106:675-683.
35. Sukhova GK, Schonbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, and Libby P (1999) Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation 99:2503-2509.
36. Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, Lincoln TM, and Mendelsohn ME (1999) Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. Science (Wash DC) 286:1583-1587.
37. Tronc F, Mallat Z, Lehoux S, Wassef M, Esposito B, and Tedgui A (2000) Role of matrix metalloproteinases in blood flow-induced arterial enlargement: interaction with NO. Arterioscler Thromb Vasc Biol 20:E120-E126.
38. Yuasa K, Omori K, and Yanaka N (2000) Binding and phosphorylation of a novel male germ cell-specific cGMP- dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. J Biol Chem 275:4897-4905.
39. Zaragoza C, Balbin M, Lopez-Otin C, and Lamas S (2002) Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium. Kidney Int 61:804-808.
40. Zaragoza C, Ocampo C, Saura M, Leppo M, Wei XQ, Quick R, Moncada S, Liew FY, and Lowenstein CJ (1998) The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proc Natl Acad Sci USA 95:2469-2474.