메뉴 건너뛰기




Volumn 16, Issue 4, 2010, Pages 381-391

Nitric oxide and cancer therapy: The emperor has NO clothes

Author keywords

Cancer; Chemotherapy; Metastasis; Nitric oxide; Nitric oxide synthase

Indexed keywords

ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; CELECOXIB; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GT 049; GT 094; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 2; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; SC 51; UNCLASSIFIED DRUG; NITRIC OXIDE DONOR;

EID: 77949464599     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210790232149     Document Type: Review
Times cited : (126)

References (97)
  • 2
    • 0035296203 scopus 로고    scopus 로고
    • Role of nitric oxide in carcinogenesis and tumour progression
    • Lala PK, Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol 2001; 2: 149-56.
    • (2001) Lancet Oncol , vol.2 , pp. 149-156
    • Lala, P.K.1    Chakraborty, C.2
  • 3
    • 34247613216 scopus 로고    scopus 로고
    • Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities
    • Mocellin S, Bronte V, Nitti D. Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities. Med Res Rev 2007; 27: 317-52.
    • (2007) Med Res Rev , vol.27 , pp. 317-352
    • Mocellin, S.1    Bronte, V.2    Nitti, D.3
  • 4
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0030613746 scopus 로고    scopus 로고
    • NG-nitro-L-arginine methyl ester inhibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model
    • Iwasaki T, Higashiyama M, Kuriyama K, Sasaki A, Mukai M, Shinkai K, et al. NG-nitro-L-arginine methyl ester inhibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model. Jpn J Cancer Res 1997; 88: 861-6.
    • (1997) Jpn J Cancer Res , vol.88 , pp. 861-866
    • Iwasaki, T.1    Higashiyama, M.2    Kuriyama, K.3    Sasaki, A.4    Mukai, M.5    Shinkai, K.6
  • 8
    • 57549092526 scopus 로고    scopus 로고
    • The tumour microenvironment: A novel target for cancer therapy
    • Hanna E, Quick J, Libutti SK. The tumour microenvironment: a novel target for cancer therapy. Oral Dis 2009; 15: 8-17.
    • (2009) Oral Dis , vol.15 , pp. 8-17
    • Hanna, E.1    Quick, J.2    Libutti, S.K.3
  • 9
    • 33645057441 scopus 로고    scopus 로고
    • Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis
    • Blavier L, Lazaryev A, Dorey F, Shackleford GM, DeClerck YA. Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis. Cancer Res 2006; 66: 2691-9.
    • (2006) Cancer Res , vol.66 , pp. 2691-2699
    • Blavier, L.1    Lazaryev, A.2    Dorey, F.3    Shackleford, G.M.4    DeClerck, Y.A.5
  • 10
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001; 29: 117-29.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 11
    • 0035866363 scopus 로고    scopus 로고
    • Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: Implications for tumor development and progression
    • Shekhar MP, Werdell J, Santner SJ, Pauley RJ, Tait L. Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res 2001; 61: 1320-6.
    • (2001) Cancer Res , vol.61 , pp. 1320-1326
    • Shekhar, M.P.1    Werdell, J.2    Santner, S.J.3    Pauley, R.J.4    Tait, L.5
  • 12
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • Christofori G. New signals from the invasive front. Nature 2006; 441: 444-50.
    • (2006) Nature , vol.441 , pp. 444-450
    • Christofori, G.1
  • 13
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006; 127: 679-95.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 14
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895-904.
    • (2006) Nat Med , vol.12 , pp. 895-904
    • Steeg, P.S.1
  • 15
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3: 453-8.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 16
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9: 274-84.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 17
    • 6344250414 scopus 로고    scopus 로고
    • Modulation of prostate cancer growth in bone microenvironments
    • Edlund M, Sung SY, Chung LW. Modulation of prostate cancer growth in bone microenvironments. J Cell Biochem 2004; 91: 686-705.
    • (2004) J Cell Biochem , vol.91 , pp. 686-705
    • Edlund, M.1    Sung, S.Y.2    Chung, L.W.3
  • 19
    • 0023777633 scopus 로고
    • Breast cancer: Metastatic patterns and their prognosis
    • Patanaphan V, Salazar OM, Risco R. Breast cancer: metastatic patterns and their prognosis. South Med J 1988; 81: 1109-12.
    • (1988) South Med J , vol.81 , pp. 1109-1112
    • Patanaphan, V.1    Salazar, O.M.2    Risco, R.3
  • 22
    • 0021674404 scopus 로고
    • Sites of recurrence in resected stage I non-small-cell lung cancer: A guide for future studies
    • Feld R, Rubinstein LV, Weisenberger TH. Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. J Clin Oncol 1984; 2: 1352-8.
    • (1984) J Clin Oncol , vol.2 , pp. 1352-1358
    • Feld, R.1    Rubinstein, L.V.2    Weisenberger, T.H.3
  • 25
    • 0034485823 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival
    • Ekmekcioglu S, Ellerhorst J, Smid CM, Prieto VG, Munsell M, Buzaid AC, et al. Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. Clin Cancer Res 2000; 6: 4768-75.
    • (2000) Clin Cancer Res , vol.6 , pp. 4768-4775
    • Ekmekcioglu, S.1    Ellerhorst, J.2    Smid, C.M.3    Prieto, V.G.4    Munsell, M.5    Buzaid, A.C.6
  • 26
    • 19944434036 scopus 로고    scopus 로고
    • The role of early expression of inducible nitric oxide synthase in human breast cancer
    • Loibl S, Buck A, Strank C, von Minckwitz G, Roller M, Sinn HP, et al. The role of early expression of inducible nitric oxide synthase in human breast cancer. Eur J Cancer 2005; 41: 265-71.
    • (2005) Eur J Cancer , vol.41 , pp. 265-271
    • Loibl, S.1    Buck, A.2    Strank, C.3    von Minckwitz, G.4    Roller, M.5    Sinn, H.P.6
  • 27
    • 1342300679 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: Correlation with clinical outcome
    • Raspollini MR, Amunni G, Villanucci A, Boddi V, Baroni G, Taddei A, et al. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. Gynecol Oncol 2004; 92: 806-12.
    • (2004) Gynecol Oncol , vol.92 , pp. 806-812
    • Raspollini, M.R.1    Amunni, G.2    Villanucci, A.3    Boddi, V.4    Baroni, G.5    Taddei, A.6
  • 28
    • 14644432481 scopus 로고    scopus 로고
    • Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma
    • Connelly ST, Macabeo-Ong M, Dekker N, Jordan RC, Schmidt BL. Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma. Oral Oncol 2005; 41: 261-7.
    • (2005) Oral Oncol , vol.41 , pp. 261-267
    • Connelly, S.T.1    Macabeo-Ong, M.2    Dekker, N.3    Jordan, R.C.4    Schmidt, B.L.5
  • 29
    • 39149132505 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase: Correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma
    • Brennan PA, Dennis S, Poller D, Quintero M, Puxeddu R, Thomas GJ. Inducible nitric oxide synthase: correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma. Head Neck 2008; 30: 208-14.
    • (2008) Head Neck , vol.30 , pp. 208-214
    • Brennan, P.A.1    Dennis, S.2    Poller, D.3    Quintero, M.4    Puxeddu, R.5    Thomas, G.J.6
  • 31
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992; 256: 668-70.
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3    Preisinger, A.C.4    Moser, A.R.5    Luongo, C.6
  • 32
    • 0035577764 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production
    • Ahn B, Ohshima H. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 2001; 61: 8357-60.
    • (2001) Cancer Res , vol.61 , pp. 8357-8360
    • Ahn, B.1    Ohshima, H.2
  • 33
    • 0034793607 scopus 로고    scopus 로고
    • Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse
    • Scott DJ, Hull MA, Cartwright EJ, Lam WK, Tisbury A, Poulsom R, et al. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 2001; 121: 889-99.
    • (2001) Gastroenterology , vol.121 , pp. 889-899
    • Scott, D.J.1    Hull, M.A.2    Cartwright, E.J.3    Lam, W.K.4    Tisbury, A.5    Poulsom, R.6
  • 34
    • 0036144387 scopus 로고    scopus 로고
    • Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor
    • Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res 2002; 62: 165-70.
    • (2002) Cancer Res , vol.62 , pp. 165-170
    • Rao, C.V.1    Indranie, C.2    Simi, B.3    Manning, P.T.4    Connor, J.R.5    Reddy, B.S.6
  • 35
    • 0033988477 scopus 로고    scopus 로고
    • Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor
    • Kawamori T, Takahashi M, Watanabe K, Ohta T, Nakatsugi S, Sugimura T, et al. Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor. Cancer Lett 2000; 148: 33-7.
    • (2000) Cancer Lett , vol.148 , pp. 33-37
    • Kawamori, T.1    Takahashi, M.2    Watanabe, K.3    Ohta, T.4    Nakatsugi, S.5    Sugimura, T.6
  • 36
    • 4444384291 scopus 로고    scopus 로고
    • Overexpression of iNOS gene suppresses the tumorigenicity and metastasis of oral cancer cells
    • Harada K, Supriatno, Kawaguchi S, Tomitaro O, Yoshida H, Sato M. Overexpression of iNOS gene suppresses the tumorigenicity and metastasis of oral cancer cells. In Vivo 2004; 18: 449-55.
    • (2004) In Vivo , vol.18 , pp. 449-455
    • Harada, K.1    Supriatno2    Kawaguchi, S.3    Tomitaro, O.4    Yoshida, H.5    Sato, M.6
  • 37
    • 0028929559 scopus 로고
    • Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells
    • Xie K, Huang S, Dong Z, Juang SH, Gutman M, Xie QW, et al. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med 1995; 181: 1333-43.
    • (1995) J Exp Med , vol.181 , pp. 1333-1343
    • Xie, K.1    Huang, S.2    Dong, Z.3    Juang, S.H.4    Gutman, M.5    Xie, Q.W.6
  • 40
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nat Genet 2003; 33: 49-54.
    • (2003) Nat Genet , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 41
    • 0034625260 scopus 로고    scopus 로고
    • Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
    • Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, et al. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 2000; 101: 671-84.
    • (2000) Cell , vol.101 , pp. 671-684
    • Schmucker, D.1    Clemens, J.C.2    Shu, H.3    Worby, C.A.4    Xiao, J.5    Muda, M.6
  • 42
    • 53149135036 scopus 로고    scopus 로고
    • Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver
    • Decker NK, Abdelmoneim SS, Yaqoob U, Hendrickson H, Hormes J, Bentley M, et al. Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver. Am J Pathol 2008; 173: 1002-12.
    • (2008) Am J Pathol , vol.173 , pp. 1002-1012
    • Decker, N.K.1    Abdelmoneim, S.S.2    Yaqoob, U.3    Hendrickson, H.4    Hormes, J.5    Bentley, M.6
  • 43
    • 0011031944 scopus 로고    scopus 로고
    • Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis
    • Jadeski LC, Hum KO, Chakraborty C, Lala PK. Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis. Int J Cancer 2000; 86: 30-9.
    • (2000) Int J Cancer , vol.86 , pp. 30-39
    • Jadeski, L.C.1    Hum, K.O.2    Chakraborty, C.3    Lala, P.K.4
  • 44
    • 0032850637 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors
    • Jadeski LC, Lala PK. Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors. Am J Pathol 1999; 155: 1381-90.
    • (1999) Am J Pathol , vol.155 , pp. 1381-1390
    • Jadeski, L.C.1    Lala, P.K.2
  • 45
    • 5644299014 scopus 로고    scopus 로고
    • HIF-1α and p53 as targets of NO in affecting cell proliferation, death and adaptation
    • Zhou J, Schmid T, Brune B. HIF-1α and p53 as targets of NO in affecting cell proliferation, death and adaptation. Curr Mol Med 2004; 4: 741-51.
    • (2004) Curr Mol Med , vol.4 , pp. 741-751
    • Zhou, J.1    Schmid, T.2    Brune, B.3
  • 46
    • 2642597076 scopus 로고    scopus 로고
    • Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
    • Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997; 100: 3131-9.
    • (1997) J Clin Invest , vol.100 , pp. 3131-3139
    • Papapetropoulos, A.1    Garcia-Cardena, G.2    Madri, J.A.3    Sessa, W.C.4
  • 47
    • 57349173966 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase expression in glial tumors: Correlation with malignancy and tumor proliferation
    • Tanriover N, Ulu MO, Isler C, Durak H, Oz B, Uzan M, et al. Neuronal nitric oxide synthase expression in glial tumors: correlation with malignancy and tumor proliferation. Neurol Res 2008; 30: 940-4.
    • (2008) Neurol Res , vol.30 , pp. 940-944
    • Tanriover, N.1    Ulu, M.O.2    Isler, C.3    Durak, H.4    Oz, B.5    Uzan, M.6
  • 50
    • 0026733806 scopus 로고
    • Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity
    • van Ravenswaay Claasen HH, Kluin PM, Fleuren GJ. Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity. Lab Invest 1992; 67: 166-74.
    • (1992) Lab Invest , vol.67 , pp. 166-174
    • van Ravenswaay Claasen, H.H.1    Kluin, P.M.2    Fleuren, G.J.3
  • 51
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • Bingle L, Brown NJ, Lewis CE. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002; 196: 254-65.
    • (2002) J Pathol , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 55
    • 4544229787 scopus 로고    scopus 로고
    • Tumour-derived and host-derived nitric oxide differentially regulate breast carcinoma metastasis to the lungs
    • Gauthier N, Lohm S, Touzery C, Chantome A, Perette B, Reveneau S, et al. Tumour-derived and host-derived nitric oxide differentially regulate breast carcinoma metastasis to the lungs. Carcinogenesis 2004; 25: 1559-65.
    • (2004) Carcinogenesis , vol.25 , pp. 1559-1565
    • Gauthier, N.1    Lohm, S.2    Touzery, C.3    Chantome, A.4    Perette, B.5    Reveneau, S.6
  • 56
    • 66849109065 scopus 로고    scopus 로고
    • Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N)
    • Epub ahead of print
    • Mehibel M, Singh S, Chinje EC, Cowen RL, Stratford IJ. Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N). Mol Cancer Ther 2009; [Epub ahead of print].
    • (2009) Mol Cancer Ther
    • Mehibel, M.1    Singh, S.2    Chinje, E.C.3    Cowen, R.L.4    Stratford, I.J.5
  • 57
    • 4344566972 scopus 로고    scopus 로고
    • Update on mechanism and catalytic regulation in the NO synthases
    • Stuehr DJ, Santolini J, Wang ZQ, Wei CC, Adak S. Update on mechanism and catalytic regulation in the NO synthases. J Biol Chem 2004; 279: 36167-70.
    • (2004) J Biol Chem , vol.279 , pp. 36167-36170
    • Stuehr, D.J.1    Santolini, J.2    Wang, Z.Q.3    Wei, C.C.4    Adak, S.5
  • 58
    • 0035793178 scopus 로고    scopus 로고
    • The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2
    • Thomas DD, Liu X, Kantrow SP, Lancaster JR, Jr. The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci USA 2001; 98: 355-60.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 355-360
    • Thomas, D.D.1    Liu, X.2    Kantrow, S.P.3    Lancaster Jr., J.R.4
  • 59
    • 0037039449 scopus 로고    scopus 로고
    • On the activation of soluble guanylyl cyclase by nitric oxide
    • Bellamy TC, Wood J, Garthwaite J. On the activation of soluble guanylyl cyclase by nitric oxide. Proc Natl Acad Sci USA 2002; 99: 507-10.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 507-510
    • Bellamy, T.C.1    Wood, J.2    Garthwaite, J.3
  • 60
    • 2942665472 scopus 로고    scopus 로고
    • Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
    • Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, et al. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci USA 2004; 101: 8894-9.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8894-8899
    • Thomas, D.D.1    Espey, M.G.2    Ridnour, L.A.3    Hofseth, L.J.4    Mancardi, D.5    Harris, C.C.6
  • 62
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-4.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 63
    • 0041508234 scopus 로고    scopus 로고
    • Hydroxyl radical formation by O-O bond homolysis in peroxynitrous acid
    • Lymar SV, Khairutdinov RF, Hurst JK. Hydroxyl radical formation by O-O bond homolysis in peroxynitrous acid. Inorg Chem 2003; 42: 5259-66.
    • (2003) Inorg Chem , vol.42 , pp. 5259-5266
    • Lymar, S.V.1    Khairutdinov, R.F.2    Hurst, J.K.3
  • 65
    • 21644479899 scopus 로고    scopus 로고
    • Tumour invasion and metastasis: Challenges facing drug discovery
    • Elvin P, Garner AP. Tumour invasion and metastasis: challenges facing drug discovery. Curr Opin Pharmacol 2005; 5: 374-81.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 374-381
    • Elvin, P.1    Garner, A.P.2
  • 66
    • 2042458747 scopus 로고    scopus 로고
    • Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
    • Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti JM, Schepartz S, et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 2001; 84: 1424-31.
    • (2001) Br J Cancer , vol.84 , pp. 1424-1431
    • Johnson, J.I.1    Decker, S.2    Zaharevitz, D.3    Rubinstein, L.V.4    Venditti, J.M.5    Schepartz, S.6
  • 67
    • 0032410157 scopus 로고    scopus 로고
    • Orthotopic models are necessary to predict therapy of transplantable tumors in mice
    • Killion JJ, Radinsky R, Fidler IJ. Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev 1998; 17: 279-84.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 279-284
    • Killion, J.J.1    Radinsky, R.2    Fidler, I.J.3
  • 68
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 2003; 5: 711-9.
    • (2003) Nat Cell Biol , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 69
    • 0037455576 scopus 로고    scopus 로고
    • Compensation mechanism in tumor cell migration: Mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    • Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, et al. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 2003; 160: 267-77.
    • (2003) J Cell Biol , vol.160 , pp. 267-277
    • Wolf, K.1    Mazo, I.2    Leung, H.3    Engelke, K.4    von Andrian, U.H.5    Deryugina, E.I.6
  • 73
    • 0034656848 scopus 로고    scopus 로고
    • Biological chemistry and clinical potential of S-nitrosothiols
    • Hogg N. Biological chemistry and clinical potential of S-nitrosothiols. Free Radic Biol Med 2000; 28: 1478-86.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1478-1486
    • Hogg, N.1
  • 74
    • 23844458342 scopus 로고    scopus 로고
    • .)- and nitroxyl (HNO)-generating diazeniumdiolates (NONOates): Emerging commercial opportunities
    • .)- and nitroxyl (HNO)-generating diazeniumdiolates (NONOates): emerging commercial opportunities. Curr Top Med Chem 2005; 5: 625-36.
    • (2005) Curr Top Med Chem , vol.5 , pp. 625-636
    • Keefer, L.K.1
  • 75
    • 27744464047 scopus 로고    scopus 로고
    • Synthesis of peroxynitrite from nitrite and hydrogen peroxide
    • Robinson KM, Beckman JS. Synthesis of peroxynitrite from nitrite and hydrogen peroxide. Methods Enzymol 2005; 396: 207-14.
    • (2005) Methods Enzymol , vol.396 , pp. 207-214
    • Robinson, K.M.1    Beckman, J.S.2
  • 76
    • 0024796728 scopus 로고
    • On the mechanism of NO release from sydnonimines
    • Feelisch M, Ostrowski J, Noack E. On the mechanism of NO release from sydnonimines. J Cardiovasc Pharmacol 1989; 14 (Suppl 11): S13-22.
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.SUPPL. 11
    • Feelisch, M.1    Ostrowski, J.2    Noack, E.3
  • 77
    • 19944434346 scopus 로고    scopus 로고
    • Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH
    • Miranda KM, Dutton AS, Ridnour LA, Foreman CA, Ford E, Paolocci N, et al. Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH. J Am Chem Soc 2005; 127: 722-31.
    • (2005) J Am Chem Soc , vol.127 , pp. 722-731
    • Miranda, K.M.1    Dutton, A.S.2    Ridnour, L.A.3    Foreman, C.A.4    Ford, E.5    Paolocci, N.6
  • 78
    • 0034638623 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
    • Sandau KB, Faus HG, Brune B. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem Biophys Res Commun 2000; 278: 263-7.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 263-267
    • Sandau, K.B.1    Faus, H.G.2    Brune, B.3
  • 79
    • 0035864361 scopus 로고    scopus 로고
    • Accumulation of HIF-1α under the influence of nitric oxide
    • Sandau KB, Fandrey J, Brune B. Accumulation of HIF-1α under the influence of nitric oxide. Blood 2001; 97: 1009-15.
    • (2001) Blood , vol.97 , pp. 1009-1015
    • Sandau, K.B.1    Fandrey, J.2    Brune, B.3
  • 81
    • 18044393604 scopus 로고    scopus 로고
    • Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells
    • Turpaev K, Bouton C, Diet A, Glatigny A, Drapier JC. Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells. Free Radic Biol Med 2005; 38: 1392-400.
    • (2005) Free Radic Biol Med , vol.38 , pp. 1392-1400
    • Turpaev, K.1    Bouton, C.2    Diet, A.3    Glatigny, A.4    Drapier, J.C.5
  • 82
    • 0026460303 scopus 로고
    • Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature
    • Andrade SP, Hart IR, Piper PJ. Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature. Br J Pharmacol 1992; 107: 1092-5.
    • (1992) Br J Pharmacol , vol.107 , pp. 1092-1095
    • Andrade, S.P.1    Hart, I.R.2    Piper, P.J.3
  • 84
    • 0030032392 scopus 로고    scopus 로고
    • Effects of N(g)-methyl-L-arginine, an inhibitor of nitric oxide synthesis, on interleukin-2-induced capillary leakage and antitumor responses in healthy and tumor-bearing mice
    • Orucevic A, Lala PK. Effects of N(g)-methyl-L-arginine, an inhibitor of nitric oxide synthesis, on interleukin-2-induced capillary leakage and antitumor responses in healthy and tumor-bearing mice. Cancer Immunol Immunother 1996; 42: 38-46.
    • (1996) Cancer Immunol Immunother , vol.42 , pp. 38-46
    • Orucevic, A.1    Lala, P.K.2
  • 85
    • 21244493555 scopus 로고    scopus 로고
    • Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats
    • Inano H, Onoda M. Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats. Nitric Oxide 2005; 12: 15-20.
    • (2005) Nitric Oxide , vol.12 , pp. 15-20
    • Inano, H.1    Onoda, M.2
  • 86
    • 68349128259 scopus 로고    scopus 로고
    • Hypoxia and radiation therapy: Past history, ongoing research, and future promise
    • Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. Curr Mol Med 2009; 9: 442-58.
    • (2009) Curr Mol Med , vol.9 , pp. 442-458
    • Rockwell, S.1    Dobrucki, I.T.2    Kim, E.Y.3    Marrison, S.T.4    Vu, V.T.5
  • 87
    • 47149085610 scopus 로고    scopus 로고
    • Solid tumor physiology and hypoxia-induced chemo/radio- resistance: Novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer
    • Yasuda H. Solid tumor physiology and hypoxia-induced chemo/radio- resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer. Nitric Oxide 2008; 19: 205-16.
    • (2008) Nitric Oxide , vol.19 , pp. 205-216
    • Yasuda, H.1
  • 88
    • 40749161463 scopus 로고    scopus 로고
    • Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound
    • Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE. Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound. Bioorg Med Chem 2008; 16: 2657-64.
    • (2008) Bioorg Med Chem , vol.16 , pp. 2657-2664
    • Chakrapani, H.1    Wilde, T.C.2    Citro, M.L.3    Goodblatt, M.M.4    Keefer, L.K.5    Saavedra, J.E.6
  • 89
    • 34547138439 scopus 로고    scopus 로고
    • JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
    • Kiziltepe T, Hideshima T, Ishitsuka K, Ocio EM, Raje N, Catley L, et al. JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells. Blood 2007; 110: 709-18.
    • (2007) Blood , vol.110 , pp. 709-718
    • Kiziltepe, T.1    Hideshima, T.2    Ishitsuka, K.3    Ocio, E.M.4    Raje, N.5    Catley, L.6
  • 91
    • 28044436484 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress
    • Gao J, Liu X, Rigas B. Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. Proc Natl Acad Sci USA 2005; 102: 17207-12.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17207-17212
    • Gao, J.1    Liu, X.2    Rigas, B.3
  • 92
    • 34249008406 scopus 로고    scopus 로고
    • Chemical insights in the concept of hybrid drugs: The antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin
    • Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, et al. Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem 2007; 50: 2424-31.
    • (2007) J Med Chem , vol.50 , pp. 2424-2431
    • Hulsman, N.1    Medema, J.P.2    Bos, C.3    Jongejan, A.4    Leurs, R.5    Smit, M.J.6
  • 93
    • 38149120931 scopus 로고    scopus 로고
    • Quinone formation as a chemoprevention strategy for hybrid drugs: Balancing cytotoxicity and cytoprotection
    • Dunlap T, Chandrasena RE, Wang Z, Sinha V, Thatcher GR. Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chem Res Toxicol 2007; 20: 1903-12.
    • (2007) Chem Res Toxicol , vol.20 , pp. 1903-1912
    • Dunlap, T.1    Chandrasena, R.E.2    Wang, Z.3    Sinha, V.4    Thatcher, G.R.5
  • 97
    • 45549089561 scopus 로고    scopus 로고
    • Chemosensitization of cancer by nitric oxide
    • Sullivan R, Graham CH. Chemosensitization of cancer by nitric oxide. Curr Pharm Des 2008; 14(11): 1113-23.
    • (2008) Curr Pharm Des , vol.14 , Issue.11 , pp. 1113-1123
    • Sullivan, R.1    Graham, C.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.