Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via inos-mediated MMP-2 production

Toxicological Sciences

Volumn 106, Issue 2, 2008, Pages 364-375

  Chen, Jing Hsien ^a   Lin, Hui Hsuan ^b   Chiang, Tai An ^a   Hsu, Jeng Dong ^c   Ho, Hsieh Hsun ^b   Lee, Yi Chieh ^a   Wang, Chau Jong ^b  

^a CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Gaseous nitrogen oxide; Human lung cancer A549 cells; Inducible nitric oxide synthases; Malignant progression; Matrix metalloproteinase; NG nitro L arginine methyl ester; Tissue inhibitors of metalloprotease 2

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MATRIX METALLOPROTEINASE; NITROGEN OXIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CELL MIGRATION; CELL STRAIN; CELL STRAIN A549; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME RELEASE; ENZYME REPRESSION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CARCINOGENESIS; LUNG METASTASIS; MALIGNANT TRANSFORMATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

BASE SEQUENCE; CELL LINE, TUMOR; CELL MOVEMENT; CULTURE MEDIA; DNA PRIMERS; GASES; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITROGEN OXIDES; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 56649085337     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn195     Document Type: Article

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