How the signal-to-noise ratio influences hyperpolarized 13C dynamic MRS data fitting and parameter estimation

NMR in Biomedicine

Volumn 25, Issue 7, 2012, Pages 925-934

  Santarelli, Maria Filomena ^a,b   Positano, Vincenzo ^a,b   Giovannetti, Giulio ^a   Frijia, Francesca ^b   Menichetti, Luca ^a,b   Ardenkjaer Larsen, Jan Henrik ^c,d   De Marchi, Daniele ^b   Lionetti, Vincenzo ^e   Aquaro, Giovanni ^b   Lombardi, Massimo ^b   Landini, Luigi ^a,b,f  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b FONDAZIONE TOSCANA GABRIELE MONASTERIO   (Italy)

^c GE HEALTHCARE   (Denmark)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^e SCUOLA SUPERIORE SANT ANNA   (Italy)

^f UNIVERSITY OF PISA   (Italy)

Author keywords

Dynamic MRS; Hyperpolarized nuclei; in vivo cardiac metabolism; Kinetic model; MRS; Signal to noise ratio

Indexed keywords

BIOMEDICAL SIGNAL PROCESSING; KINETIC PARAMETERS; KINETIC THEORY; METABOLISM; METABOLITES; MONTE CARLO METHODS; PARAMETER ESTIMATION; SIGNAL ANALYSIS;

DYNAMIC MRS; EXPERIMENTAL PLANNING; HYPERPOLARIZED NUCLEUS; IN-VIVO; IN-VIVO EXPERIMENTS; KINETIC MODELING; LOW SIGNAL-TO-NOISE RATIO; SPATIAL RESOLUTION;

SIGNAL TO NOISE RATIO;

CARBON 13;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; HYPERPOLARIZATION; KINETICS; MONTE CARLO METHOD; NONHUMAN; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; SIGNAL NOISE RATIO;

ANIMALIA;

EID: 84862313772     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1813     Document Type: Article

References (43)

1. 13C NMR spectroscopy and metabolic modelling in the brain: a practical perspective. Magn. Res. Imaging, 2006; 24: 527-539.
2. Neurohr KJ, Barrett EJ, Shulman RG. In vivo carbon-13 nuclear magnetic resonance studies of heart metabolism. Proc. Natl. Acad. Sci. USA, 1983; 80: 1603-1607.
3. Chatham JC, Forder JR. Metabolic compartmentation of lactate in the glucose-perfused rat heart. Am. J. Physiol. 1996; 270: H224-H229.
4. 13C NMR spectroscopy. NMR Biomed. 1998; 11(8): 395-404.
5. 13C MRS in vivo. NMR Biomed. 2003; 16: 358-369.
6. Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K. Increase in signal-to-noise ratio of >10, 000 times in liquid-state NMR. Proc. Natl. Acad. Sci. USA, 2003; 100(18): 10 158-10 163.
7. 13C imaging. Magn. Reson. Med. 2006; 56: 932-937.
8. 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc. Natl. Acad. Sci. USA, 2007; 104: 19 773-19 777.
9. 13C magnetic resonance imaging and spectroscopy. Nat Med. 2007; 13: 1382-1387.
10. Tyler DJ, Schroeder MA, Cochlin LE, Clarke K, Radda GK. Application of hyperpolarized magnetic resonance in the study of cardiac metabolism. Appl. Magn. Reson. 2008; 34: 523-531.
11. 13C magnetic resonance metabolic imaging for cancer applications. Appl. Magn. Reson. 2008; 34: 533-544.
12. Schroeder MA, Cochlin LE, Heather LC, Clarke K, Radda GK, Tyler DJ. In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc. Natl. Acad. Sci. USA, 2008; 105: 12 051-12 056.
13. Golman K, in't Zandt R, Thaning M. Real-time metabolic imaging. Proc. Natl. Acad. Sci. USA, 2006; 103: 11 270-11 275.
14. 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res. 2006; 66: 10 855-10 860.
15. 13C-1-pyruvate. Magn. Reson. Med. 2007; 58: 65-69.
16. 13C]pyruvate. J. Cardiovasc. Magn. Reson. 2011; 13(Suppl. 1): M2.
17. 13C MRI. Magn. Reson. Med. 2008; 59: 1005-1013.
18. Gadian DG. NMR and its Applications to Living Systems. Oxford Science Publications: Oxford University Press; 1995.
19. 13C MRS surface coil: design and signal-to-noise ratio estimation. Med. Phys. 2010; 37(10): 5361-5369.
20. 13C-pyruvate. Magn. Reson. Med. 2009; 62: 1-10.
21. 13C MRS. J. Cardiovasc. Magn. Reson. 2011; 13(Suppl. 1): P343.
22. Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson SJ, Vigneron DB. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J. Magn. Res. 2008; 193: 139-146.
23. 13C pyruvate and bicarbonate in the heart. Magn. Reson. Med. 2010; 64(5): 1323-1331.
24. 1-pyruvate. Magn. Reson. Med. 2009; 62(3): 557-564.
25. 13C studies. Magn. Reson. Med. 2010; 65(3): 610-619.
26. 13C]pyruvate in the rat brain using a high-performance gradient insert. Magn. Res. Med. 2011; 65: 1228-1233.
27. 13C]pyruvate. J. Magn. Reson. 2011; 209: 332-336.
28. Vanhamme L, Sundin T, Van Hecke P, Van Huffel S. MR spectroscopy quantitation: a review of time-domain methods. NMR Biomed. 2001; 14: 233-246.
29. 31P NMR signals using the variable projection method and prior knowledge. Magn. Reson. Med. 1988; 6: 92-98.
30. Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J. Magn. Reson. 1997; 129: 35-43.
31. Van Hecke P, Van Huffel S. NMR spectroscopy quantitation. NMR Biomed. 2001; 14: 223.
32. Soderstrom T, Stoica P. System Identification. Prentice-Hall International: London; 1989.
33. 1-pyruvate transport and metabolism in living human breast cancer cells. Proc. Natl. Acad. Sci. USA, 2009; 106(43): 18 131-18 136.
34. 13C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism. Magn. Reson. Med. 2010; 63: 322-329.
35. 13C]pyruvate. J. Magn. Res. 2010; 206: 210-218.
36. 1-pyruvate metabolism in normal rats and TRAMP mice. J Magn. Res. 2010; 202: 85-92.
37. Atherton HJ, Schroeder MA, Dodd MS, Heather LC, Carter EE, Cochlin LE, Nagel S, Sibson NR, Radda GK, Clarke K, Tyler DJ. Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised (13)C MRS. NMR Biomed. 2011; 24(2): 201-208.
38. 13C]pyruvate. NMR Biomed. 2011; 24(8): 980-987.
39. 1H spectra: from finite impulse response filter design for solvent suppression to parameter estimation. J. Magn. Res. 1999; 139: 189-204.
40. Vanhamme L, Van Huffel S, Van Hecke P, van Ormondt D. Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals. J. Magn. Res. 1999; 140: 120-130.
41. Cavassila S, Deval S, Huegen C, van Ormondt D, Graveron-Demilly D. Cramer-Rao bound expressions for parametric estimation of overlapping peaks: influence of prior knowledge. J. Magn. Res. 2000; 143: 311-320.
42. 13C] pyruvate: a feasibility study in mini-pig with a large dose injection. J. Card. Magn. Res. 2010; 12(Suppl, 1): 323-324.
43. Van Ormondt D, De Beer R, Marien AJH, den Hollander JA, Luyten PR, Vermeulen JWAH. 2D approach to quantitation of inversion-recovery data. J. Magn. Res. 1990; 88: 652-659.