Metabolic compartmentation of lactate in the glucose-perfused rat heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 1 39-1, 1996, Pages

  Chatham, John C ^a   Forder, John R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

glucose metabolism; nuclear magnetic resonance spectroscopy

Indexed keywords

ACETYL COENZYME A; ALANINE; GLUCOSE; LACTIC ACID;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; HEART MUSCLE METABOLISM; HEART PERFUSION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STEADY STATE;

EID: 0030058579     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.1.h224     Document Type: Article

References (24)

1. 13C NMR. FEES Lett. 123: 315-318, 1981.
2. Bünger, R. Compartmented pyruvate in perfused working heart. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H439-H229, 1985.
3. Bünger, R., S. Glanert, O. Sommer, and E. Gerlach. Inhibition by (aminooxy)acetate of the malate-aspartate cycle in the isolated working guinea pig heart. Hoppe-Seyler's Z. Physiol. Chem. 362: 907-914. 1980.
4. 13C NMR studies in perfused rat hearts J. Biol. Chem. 258: 13785-13794, 1983.
5. 13C NMR spectroscopy. J. Mol. Cell. Cardiol. 22: 1187-1197, 1990.
6. 13C-NMR study of glucose oxidation in the intact functioning rat heart following diabetesinduced cardiomyopathy. J. Mol. Cell. Cardiol. 25: 1203-1213, 1993.
7. Chatham, J. C., and J. D. Glickson. Altered glucose metabolism in adriamycin-induced heart failure. Biochim, Biophys. Acta 1138: 1-5, 1992.
8. From, A, H. L., S. D. Zimmer, S. P. Michurski, M. P. V. K. Ulstad, W. J. Thoma, and K. Ugurbil. Regulation of the oxidative phosphorylation rate in the intact cell. Biochemistry 29:3731-3743, 1990.
9. Hockings, P. D., M. R. Bendall, and P. J. Rogers. Selective mtracellular lactate invisibility in Enterococcus faccalis. Magn. Reaon. Med. 24: 253-261,1992.
10. Jones, J. G., A. D. Sherry, F. M. H. Jeffrey, C. J. Storey, and C. R. Malloy. Sources of acetyl CoA entering the tricarboxylic acid cycle as determined by analysis of succinate C-13 isotopomers. Biochemistry 32: 12240-12244, 1993.
11. Lewandowski, E. D. Metabolic heterogeneity of carbon substrate utilization in mammalian heart: NMR determination of mitochondrial versus cytosolic compartmentation. Biochemistry 31: 8916-8923, 1992.
12. Malloy, C. R., A. D. Sherry, and F. M. H. Jeffrey. Carbon flux through citric acid cycle pathways in perfused heart by I3C NMR spectroscopy. FEES Lett. 212: 58-62, 1987.
13. 13C isotope isomers. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H987-H995, 1990.
14. 13C NMR studies of heart metabolism. Proc. Natl. Acad. Sci. USA 80: 1603-1607, 1983.
15. Peuhkurinen, K. J., and I. E. Hassinen. Pyruvate carboxylation as an anaplerotic mechanism in the isolated perfused rat heart. Biochem J. 202: 67-76,1982.
16. Peuhkurinen, K. J., J. K. Hiltunen, and I. E. Hassinen. Metabolic compartmentation of pyruvate in isolated perfused rat heart. Biochem. J. 210: 193-198,1983.
17. Peuhkurinen, K. J., E. M. Nuutinen, E. P. Pietiläinen, J. K. Hiltunen, and I. E. Hassinen. Role of pyruvate carboxylation in the energy-linked regulation of pool sizes of TCA-cycle intermediates in the myocardium. Biochem. J. 208: 577-581, 1982.
18. Randle, P. J., and P. K. Tubbs. Carbohydrate and fatty acid metabolism. In: Handbook of Physiology. The Cardiovascular System. The Heart. Bethesda, MD: Am. Physiol. Soc.. 1979, sect. 2, vol. I, chapt. 23, p. 805-844.
19. 31P NMR assessment of altered metabolism during graded reductions in coronary flow in intact rat hearts. Proc. Natl. Acad. Sci. USA 86: 6426-6430, 1989.
20. Weiss, R. G., S. T. Gloth, R. Kalil-Filho, V. P. Chacko, M. D. Stern, and G. Gerstenblith. Indexing tricarboxylic acid cycle flux in intact hearts by carbon-13 nuclear magnetic resonance. Circ. Res. 70: 392-408, 1992.
21. 13C NMR metabolic enrichments in perfused rat hearts using FACSIMILE. In: Simulation and Imaging of the Cardiac System, edited by S. Sideman and R. Beyar. Boston, MA: Martinus Nijhoff, 1985, p. 391-410.
22. 1H NMR visibility of lactate and alanine in perfused rat hearts (Abstract). Proc. Soc. Magn. Reson. 3: 1242, 1994.
23. 13C]pyruvate. FEES Lett. 303: 247-250, 1992.
24. 1H NMR detection of lactate and alanine in perfused rat hearts during global and low pressure ischemia. Magn. Reson. Med. 33: 53-60, 1995.