Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice

Journal of Magnetic Resonance

Volumn 202, Issue 1, 2010, Pages 85-92

  Zierhut, Matthew L ^a,b   Yen, Yi Fen ^c   Chen, Albert P ^b   Bok, Robert ^b   Albers, Mark J ^a,b   Zhang, Vickie ^b   Tropp, Jim ^c   Park, Ilwoo ^a,b   Vigneron, Daniel B ^a,b   Kurhanewicz, John ^a,b   Hurd, Ralph E ^c   Nelson, Sarah J ^a,b  

^a UCSF/UCB Joint Graduate Group in Bioengineering   (United States)

^b UCSF Surbeck Laboratory of Advanced Imaging   (United States)

^c GE HEALTHCARE   (United States)

Author keywords

Dynamic spectroscopy; EPSI; Hyperpolarized 13C; Lactate; Metabolism; Modeling; Pyruvate; TRAMP

Indexed keywords

ANATOMICAL STRUCTURES; DISEASE PROGRESSION; DOSE RESPONSE; DYNAMIC DATA; ECHO-PLANAR SPECTROSCOPIC IMAGING; ENCODING TECHNIQUES; EXCHANGE RATES; EXPONENTIAL EQUATIONS; FITTING ERROR; HYPERPOLARIZED; HYPERPOLARIZED 13C; IN-VIVO; KINETIC MODELING; KINETIC MODELS; METABOLIC ACTIVITY; METABOLIC PARAMETERS; MICHAELIS-MENTEN KINETIC; MODEL ROBUSTNESS; MODEL SYSTEM; PARAMETER VALUES; PARAMETERS ESTIMATED; PRE-CLINICAL; PROSTATE TUMOR; PYRUVATE METABOLISM; PYRUVATES; RAT KIDNEYS; SPECTROSCOPIC DATA; SPECTROSCOPY DATA; TRANSGENICS; TUMOR PROGRESSIONS; WILD TYPES;

BIOCHEMISTRY; IGNEOUS ROCKS; METABOLISM; RATE CONSTANTS; RATS; SPIN POLARIZATION; TUMORS;

PARAMETER ESTIMATION;

ALANINE; CARBON; DIAGNOSTIC AGENT; LACTIC ACID; PYRUVIC ACID;

ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; KINETICS; MALE; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROSTATE TUMOR; TRANSGENIC MOUSE;

ALANINE; ALGORITHMS; ANIMALS; CARBON ISOTOPES; COMPUTER SIMULATION; KINETICS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PROSTATIC NEOPLASMS; PYRUVIC ACID;

MUS; RATTUS;

EID: 72149088738     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2009.10.003     Document Type: Article

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