Treatment of cachexia with ghrelin in patients with COPD

Chest

Volumn 128, Issue 3, 2005, Pages 1187-1193

  Nagaya, Noritoshi ^a   Itoh, Takefumi ^a   Murakami, Shinsuke ^a   Oya, Hideo ^a   Uematsu, Masaaki ^b   Miyatake, Kunio ^a   Kangawa, Kenji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b KANSAI ROSAI HOSPITAL   (Japan)

Author keywords

Cachexia; Chronic obstructive; Exercise capacity; Ghrelin; Nutrition

Indexed keywords

GHRELIN; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; INSULIN; INTERLEUKIN 6; NORADRENALIN; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; BODY COMPOSITION; CACHEXIA; CHRONIC LUNG DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; EXERCISE TEST; FEMALE; FOOD INTAKE; FUNCTIONAL ASSESSMENT; GROWTH HORMONE BLOOD LEVEL; HUMAN; LEAN BODY WEIGHT; LUNG FUNCTION TEST; MALE; METABOLIC PARAMETERS; MUSCLE STRENGTH; NORADRENALIN BLOOD LEVEL; NUTRITION; OPEN STUDY; PILOT STUDY; PRIORITY JOURNAL; PROGNOSIS; SYMPATHETIC NERVE; TREATMENT OUTCOME;

EID: 24944473849     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.128.3.1187     Document Type: Article

References (29)

1. Schols AM. Pulmonary cachexia. Int J Cardiol 2002; 85:101-110
2. Wilson DO, Rogers RM, Wright EC, et al. Body weight in chronic obstructive pulmonary disease: the National Institutes of Health Intermittent Positive Breathing Trial. Am Rev Respir Dis 1989; 139:1435-1438
3. Landbo C, Prescott E, Lange P, et al. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160:1856-1861
4. Anker SD, Ponikowski P, Varney S, et al. Wasting as independent risk factor for mortality in chronic heart failure. Lancet 1997; 349:1050-1053
5. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402:656-660
6. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407:908-913
7. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409:194-198
8. Nagaya N, Kojima M, Uematsu M, et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol 2001; 280:R1483-R1487
9. Matsumura K, Tsuchihashi T, Fujii K, et al. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 2002; 40:694-699
10. Nagaya N, Uematsu M, Kojima M, et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001; 104:1430-1435
11. Yeh SS, DeGuzman B, Kramer T, et al. Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest 2002; 122:421-428
12. Burdet L, de Muralt B, Schutz Y, et al. Administration of growth hormone to underweight patients with chronic obstructive pulmonary disease: a prospective, randomized, controlled study. Am J Respir Crit Care Med 1997; 156:1800-1806
13. Berglund E, Birath G, Bjure J, et al. Spirometric studies in normal subjects. Acta Med Scand 1963; 173:185-191
14. Woo MA, Moser DK, Stevenson LW, et al. Six-minute walk test and heart rate variability: lack of association in advanced stages of heart failure. Am J Respir Crit Care Med 1997; 6:348-354
15. Nagaya N, Moriya J, Yasumura Y, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 2004; 110:3674-3679
16. Nagaya N, Uematsu M, Kojima M, et al. Elevated circulating levels of ghrelin in the cachexia associated with chronic heart failure. Circulation 2001; 104:2034-2038
17. Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res 2003; 9:774-778
18. Takaya K, Ariyasu H, Kanamoto N, et al. Ghrelin strongly stimulates growth hormone (GH) release in humans. J Clin Endocrinol Metab 2000; 85:4908-4911
19. Amato G, Carella C, Fazio S, et al. Body composition, bone metabolism, heart structure and function in growth hormone deficient adults before and after growth hormone replacement therapy at low doses. J Clin Endocrinol Metab 1993; 77:1671-1676
20. Bark TH, McNurlan MA, Lang CH, et al. Increased protein synthesis after acute IGF-I or insulin infusion is localized to muscle in mice. Am J Physiol 1998; 275:E118-E123
21. Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001; 50:227-232
22. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000; 141:4325-4328
23. Anker SD, Chua TP, Ponikowski P, et al. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia. Circulation 1997; 96:526-534
24. Anderson P, Saltin B. Maximal perfusion of skeletal muscle in man. J Appl Physiol 1985; 366:233-249
25. Nagaya N, Miyatake K, Uematsu M, et al. Hemodynamic, renal and hormonal effects of ghrelin infusion in patients with chronic heart failure. J Clin Endocrinol Metab 2001; 86: 5854-5859
26. Pape GS, Friedman M, Underwood LE, et al. The effect of growth hormone on weight gain and pulmonary function in patients with chronic obstructive lung disease. Chest 1991; 99:1495-1500
27. Papadakis MA, Grady DG, Black D, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996; 124:708-716
28. Pichard C, Kyle U, Chevrolet JC, et al. Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation: a prospective. Crit Care Med 1996; 24:403-413
29. Burdet L, de Muralt B, Schutz Y, et al. Administration of growth hormone to underweight patients with chronic obstructive pulmonary disease: a prospective, randomized, controlled study. Am J Respir Crit Care Med 1997; 156:1800-1806