Pressure effects on enzyme-catalyzed quantum tunneling events arise from protein-specific structural and dynamic changes

Journal of the American Chemical Society

Volumn 134, Issue 23, 2012, Pages 9749-9754

  Hay, Sam ^a   Johannissen, Linus O ^a,b   Hothi, Parvinder ^a   Sutcliffe, Michael J ^a,b   Scrutton, Nigel S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINES; CONSTANT PRESSURES; DONOR-ACCEPTORS; DYNAMIC CHANGES; ENZYME-CATALYZED REACTIONS; KINETIC ISOTOPE EFFECTS; MOLECULAR DYNAMICS SIMULATIONS; PHENYLETHYLAMINES; PRESSURE AND TEMPERATURE; QUANTUM MECHANICAL; QUANTUM TUNNELING; REACTION COORDINATES; TUNNELING MODELS;

CATALYSIS; ISOTOPES; MOLECULAR DYNAMICS; PRESSURE EFFECTS; QUANTUM THEORY; REACTION KINETICS; TEMPERATURE DISTRIBUTION;

ENZYMES;

ENZYME; PHENETHYLAMINE;

ANISOTROPY; ARTICLE; CALCULATION; CATALYSIS; CHEMICAL REACTION; ENVIRONMENTAL FACTOR; KINETIC ISOTOPE EFFECT; KINETICS; MOLECULAR DYNAMICS; PRESSURE; PROTEIN STRUCTURE; PROTON TRANSPORT; QUANTUM CHEMISTRY; SIMULATION; TEMPERATURE DEPENDENCE; VIBRATION;

ALCALIGENES FAECALIS; KINETICS; MODELS, MOLECULAR; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PHENETHYLAMINES; PRESSURE; PROTEIN CONFORMATION; PROTONS; THERMODYNAMICS;

EID: 84862239089     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3024115     Document Type: Article

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