Chemokines and adult bone marrow stem cells

Immunology Letters

Volumn 145, Issue 1-2, 2012, Pages 47-54

  Rankin, Sara M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bone marrow; Chemokines; Mobilization; Stem cells

Indexed keywords

ATI 2341; CHEMOKINE; CHEMOKINE RECEPTOR AGONIST; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CHEMOKINE RECEPTOR CXCR7; CTCE 0021; CXCL11 CHEMOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PLACEBO; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A;

ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL FUNCTION; CELL MIGRATION; CELL POPULATION; CELL SUBPOPULATION; CYTOKINE PRODUCTION; DOSE RESPONSE; DOWN REGULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENTIATION; DRUG TOLERABILITY; ENDOTHELIAL PROGENITOR CELL; FIBROCYTE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LEUKOCYTOSIS; MACROPHAGE ACTIVATION; MESENCHYMAL STEM CELL; MOLECULAR DYNAMICS; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL MOBILIZATION; STEM CELL NICHE; STROMA CELL; STRUCTURE ACTIVITY RELATION; TISSUE REGENERATION;

EID: 84862194058     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.04.009     Document Type: Review

References (103)

1. Kiel M.J., Morrison S.J. Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 2008, 8:290-301.
2. Mendez-Ferrer S., Michurina T.V., Ferraro F., Mazloom A.R., Macarthur B.D., Lira S.A., et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010, 466:829-834.
3. Chow A., Lucas D., Hidalgo A., Mendez-Ferrer S., Hashimoto D., Scheiermann C., et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 2011, 208:261-271.
4. Christopher M.J., Rao M., Liu F., Woloszynek J.R., Link D.C. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med 2011, 208:251-260.
5. Tashiro K., Tada H., Heilker R., Shirozu M., Nakano T., Honjo T. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science 1993, 261:600-603.
6. Nagasawa T., Kikutani H., Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci U S A 1994, 91:2305-2309.
7. Sugiyama T., Kohara H., Noda M., Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006, 25:977-988.
8. Mendez-Ferrer S., Lucas D., Battista M., Frenette P.S. Haematopoietic stem cell release is regulated by circadian oscillations. Nature 2008, 452:442-447.
9. Mendez-Ferrer S., Battista M., Frenette P.S. Cooperation of beta(2)- and beta(3)-adrenergic receptors in hematopoietic progenitor cell mobilization. Ann N Y Acad Sci 2010, 1192:139-144.
10. Loetscher M., Geiser T., O'Reilly T., Zwahlen R., Baggiolini M., Moser B. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 1994, 269:232-237.
11. Balabanian K., Lagane B., Infantino S., Chow K.Y., Harriague J., Moepps B., et al. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 2005, 280:35760-35766.
12. Burns J.M., Summers B.C., Wang Y., Melikian A., Berahovich R., Miao Z., et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 2006, 203:2201-2213.
13. Rajagopal S., Kim J., Ahn S., Craig S., Lam C.M., Gerard N.P., et al. Beta-arrestin- but not G protein-mediated signaling by the decoy receptor CXCR7. Proc Natl Acad Sci U S A 2010, 107:628-632.
14. Naumann U., Cameroni E., Pruenster M., Mahabaleshwar H., Raz E., Zerwes H.G., et al. CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS One 2010, 5:e9175.
15. Berahovich R.D., Zabel B.A., Penfold M.E., Lewen S., Wang Y., Miao Z., et al. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol 2010, 185:5130-5139.
16. Zabel B.A., Wang Y., Lewen S., Berahovich R.D., Penfold M.E., Zhang P., et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol 2009, 183:3204-3211.
17. Sierro F., Biben C., Martinez-Munoz L., Mellado M., Ransohoff R.M., Li M., et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A 2007, 104:14759-14764.
18. Boldajipour B., Mahabaleshwar H., Kardash E., Reichman-Fried M., Blaser H., Minina S., et al. Control of chemokine-guided cell migration by ligand sequestration. Cell 2008, 132:463-473.
19. Mazzinghi B., Ronconi E., Lazzeri E., Sagrinati C., Ballerini L., Angelotti M.L., et al. Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J Exp Med 2008, 205:479-490.
20. Cruz-Orengo L., Holman D.W., Dorsey D., Zhou L., Zhang P., Wright M., et al. CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med 2011, 208:327-339.
21. Aiuti A., Webb I.J., Bleul C., Springer T., Gutierrez-Ramos J.C. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997, 185:111-120.
22. Broxmeyer H.E., Kohli L., Kim C.H., Lee Y., Mantel C., Cooper S., et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol 2003, 73:630-638.
23. Lee Y., Gotoh A., Kwon H.J., You M., Kohli L., Mantel C., et al. Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines. Blood 2002, 99:4307-4317.
24. Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996, 382:635-638.
25. Ma Q., Jones D., Springer T.A. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 1999, 10:463-471.
26. Peled A., Petit I., Kollet O., Magid M., Ponomaryov T., Byk T., et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999, 283:845-848.
27. Basu S., Ray N.T., Atkinson S.J., Broxmeyer H.E. Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells. J Immunol 2007, 179:3075-3085.
28. Petit I., Goichberg P., Spiegel A., Peled A., Brodie C., Seger R., et al. Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest 2005, 115:168-176.
29. Glodek A.M., Le Y., Dykxhoorn D.M., Park S.Y., Mostoslavsky G., Mulligan R., et al. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia 2007, 21:1723-1732.
30. Wang J.F., Park I.W., Groopman J.E. Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood 2000, 95:2505-2513.
31. Tan W., Martin D., Gutkind J.S. The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. J Biol Chem 2006, 281:39542-39549.
32. Kumar A., Kremer K.N., Dominguez D., Tadi M., Hedin K.E. Galpha13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation. J Immunol 2011, 186:951-958.
33. Cashman J., Clark-Lewis I., Eaves A., Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood 2002, 99:792-799.
34. Tzeng Y.S., Li H., Kang Y.L., Chen W.C., Cheng W.C., Lai D.M. Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood 2011, 117:429-439.
35. Christopher M.J., Liu F., Hilton M.J., Long F., Link D.C. Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood 2009, 114:1331-1339.
36. Broxmeyer H.E. Regulation of hematopoiesis by chemokine family members. Int J Hematol 2001, 74:9-17.
37. Greenbaum A.M., Link D.C. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization. Leukemia 2011, 25:211-217.
38. Liu F., Poursine-Laurent J., Link D.C. Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF. Blood 2000, 95:3025-3031.
39. Levesque J.P., Takamatsu Y., Nilsson S.K., Haylock D.N., Simmons P.J. Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood 2001, 98:1289-1297.
40. Levesque J.P., Liu F., Simmons P.J., Betsuyaku T., Senior R.M., Pham C., et al. Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood 2004, 104:65-72.
41. Levesque J.P., Hendy J., Takamatsu Y., Simmons P.J., Bendall L.J. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 2003, 111:187-196.
42. Semerad C.L., Christopher M.J., Liu F., Short B., Simmons P.J., Winkler I., et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 2005, 106:3020-3027.
43. Petit I., Szyper-Kravitz M., Nagler A., Lahav M., Peled A., Habler L., et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002, 3:687-694.
44. Christopherson K.W., Cooper S., Broxmeyer H.E. Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells. Blood 2003, 101:4680-4686.
45. Christopherson K.W., Cooper S., Hangoc G., Broxmeyer H.E. CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice. Exp Hematol 2003, 31:1126-1134.
46. Marquez-Curtis L., Jalili A., Deiteren K., Shirvaikar N., Lambeir A.M., Janowska-Wieczorek A., et al. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization. Stem Cells 2008, 26:1211-1220.
47. Winkler I.G., Sims N.A., Pettit A.R., Barbier V., Nowlan B., Helwani F., et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood 2010, 116:4815-4828.
48. Reiffers J., Faberes C., Boiron J.M., Marit G., Foures C., Ferrer A.M., et al. Peripheral blood progenitor cell transplantation in 118 patients with hematological malignancies: analysis of factors affecting the rate of engraftment. J Hematother 1994, 3:185-191.
49. Bensinger W., Appelbaum F., Rowley S., Storb R., Sanders J., Lilleby K., et al. Factors that influence collection and engraftment of autologous peripheral-blood stem cells. J Clin Oncol 1995, 13:2547-2555.
50. Weaver C.H., Hazelton B., Birch R., Palmer P., Allen C., Schwartzberg L., et al. An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood 1995, 86:3961-3969.
51. Gertz M.A., Wolf R.C., Micallef I.N., Gastineau D.A. Clinical impact and resource utilization after stem cell mobilization failure in patients with multiple myeloma and lymphoma. Bone Marrow Transplant 2010, 45:1396-1403.
52. Haas R., Mohle R., Fruhauf S., Goldschmidt H., Witt B., Flentje M., et al. Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma. Blood 1994, 83:3787-3794.
53. Sugrue M.W., Williams K., Pollock B.H., Khan S., Peracha S., Wingard J.R., et al. Characterization and outcome of " hard to mobilize" lymphoma patients undergoing autologous stem cell transplantation. Leuk Lymphoma 2000, 39:509-519.
54. Liles W.C., Broxmeyer H.E., Rodger E., Wood B., Hubel K., Cooper S., et al. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 2003, 102:2728-2730.
55. Devine S.M., Flomenberg N., Vesole D.H., Liesveld J., Weisdorf D., Badel K., et al. Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J Clin Oncol 2004, 22:1095-1102.
56. Broxmeyer H.E., Orschell C.M., Clapp D.W., Hangoc G., Cooper S., Plett P.A., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 2005, 201:1307-1318.
57. Martin C., Bridger G.J., Rankin S.M. Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro. Br J Haematol 2006, 134:326-329.
58. DiPersio J.F., Micallef I.N., Stiff P.J., Bolwell B.J., Maziarz R.T., Jacobsen E., et al. Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantation for patients with non-Hodgkin's lymphoma. J Clin Oncol 2009, 27:4767-4773.
59. DiPersio J.F., Stadtmauer E.A., Nademanee A., Micallef I.N., Stiff P.J., Kaufman J.L., et al. Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma. Blood 2009, 113:5720-5726.
60. Pusic I., DiPersio J.F. Update on clinical experience with AMD3100, an SDF-1/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells. Curr Opin Hematol 2010, 17:319-326.
61. Abraham M., Biyder K., Begin M., Wald H., Weiss I.D., Galun E., et al. Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003. Stem Cells 2007, 25:2158-2166.
62. Hattori K., Heissig B., Tashiro K., Honjo T., Tateno M., Shieh J.H., et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 2001, 97:3354-3360.
63. Pelus L.M., Bian H., Fukuda S., Wong D., Merzouk A., Salari H. The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor. Exp Hematol 2005, 33:295-307.
64. Tchernychev B., Ren Y., Sachdev P., Janz J.M., Haggis L., O'Shea A., et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A 2010, 107:22255-22259.
65. Barreiro O., Martin P., Gonzalez-Amaro R., Sanchez-Madrid F. Molecular cues guiding inflammatory responses. Cardiovasc Res 2010, 86:174-182.
66. Wengner A.M., Pitchford S.C., Furze R.C., Rankin S.M. The coordinated action of G-CSF and ELR+ CXC chemokines in neutrophil mobilization during acute inflammation. Blood 2008, 111:42-49.
67. Palframan R.T., Collins P.D., Williams T.J., Rankin S.M. Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood 1998, 91:2240-2248.
68. Lord B.I., Woolford L.B., Wood L.M., Czaplewski L.G., McCourt M., Hunter M.G., et al. Mobilization of early hematopoietic progenitor cells with BB-10010: a genetically engineered variant of human macrophage inflammatory protein-1 alpha. Blood 1995, 85:3412-3415.
69. Broxmeyer H.E., Orazi A., Hague N.L., Sledge G.W., Rasmussen H., Gordon M.S. Myeloid progenitor cell proliferation and mobilization effects of BB10010, a genetically engineered variant of human macrophage inflammatory protein-1alpha, in a phase I clinical trial in patients with relapsed/refractory breast cancer. Blood Cells Mol Dis 1998, 24:14-30.
70. Laterveer L., Lindley I.J., Hamilton M.S., Willemze R., Fibbe W.E. Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability. Blood 1995, 85:2269-2275.
71. Laterveer L., Lindley I.J., Heemskerk D.P., Camps J.A., Pauwels E.K., Willemze R., et al. Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8. Blood 1996, 87:781-788.
72. King A.G., Horowitz D., Dillon S.B., Levin R., Farese A.M., MacVittie T.J., et al. Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GRObeta. Blood 2001, 97:1534-1542.
73. King S.M. Escape-related behaviours in an unstable, elevated and exposed environment. II. Long-term sensitization after repetitive electrical stimulation of the rodent midbrain defence system. Behav Brain Res 1999, 98:127-142.
74. Liu F., Poursine-Laurent J., Link D.C. The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand. Blood 1997, 90:2522-2528.
75. Pruijt J.F., Fibbe W.E., Laterveer L., Pieters R.A., Lindley I.J., Paemen L., et al. Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9). Proc Natl Acad Sci U S A 1999, 96:10863-10868.
76. Fibbe W.E., Pruijt J.F., Velders G.A., Opdenakker G., van Kooyk Y., Figdor C.G., et al. Biology of IL-8-induced stem cell mobilization. Ann N Y Acad Sci 1999, 872:71-82.
77. Asahara T., Murohara T., Sullivan A., Silver M., van der Zee R., Li T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967.
78. Yoder M.C., Ingram D.A. Endothelial progenitor cell: ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system. Curr Opin Hematol 2009, 16:269-273.
79. Asosingh K., Hanson J.D., Cheng G., Aronica M.A., Erzurum S.C. Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia. J Allergy Clin Immunol 2010, 125:918-925.
80. Critser P.J., Yoder M.C. Endothelial colony-forming cell role in neoangiogenesis and tissue repair. Curr Opin Organ Transplant 2010, 15:68-72.
81. Li Calzi S., Neu M.B., Shaw L.C., Kielczewski J.L., Moldovan N.I., Grant M.B. EPCs and pathological angiogenesis: when good cells go bad. Microvasc Res 2010, 79:207-216.
82. Capoccia B.J., Shepherd R.M., Link D.C. G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood 2006, 108:2438-2445.
83. Shepherd R.M., Capoccia B.J., Devine S.M., Dipersio J., Trinkaus K.M., Ingram D., et al. Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood 2006, 108:3662-3667.
84. Pitchford S.C., Furze R.C., Jones C.P., Wengner A.M., Rankin S.M. Differential mobilization of subsets of progenitor cells from the bone marrow. Cell Stem Cell 2009, 4:62-72.
85. Hristov M., Zernecke A., Liehn E.A., Weber C. Regulation of endothelial progenitor cell homing after arterial injury. Thromb Haemost 2007, 98:274-277.
86. Jones C.P., Pitchford S.C., Lloyd C.M., Rankin S.M. CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodeling. Stem Cells 2009, 27:3074-3081.
87. Strieter R.M., Burdick M.D., Gomperts B.N., Belperio J.A., Keane M.P. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev 2005, 16:593-609.
88. Bernardo M.E., Locatelli F., Fibbe W.E. Mesenchymal stromal cells. Ann N Y Acad Sci 2009, 1176:101-117.
89. Fox J.M., Chamberlain G., Ashton B.A., Middleton J. Recent advances into the understanding of mesenchymal stem cell trafficking. Br J Haematol 2007, 137:491-502.
90. Dwyer R.M., Potter-Beirne S.M., Harrington K.A., Lowery A.J., Hennessy E., Murphy J.M., et al. Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res 2007, 13:5020-5027.
91. Belema-Bedada F., Uchida S., Martire A., Kostin S., Braun T. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell 2008, 2:566-575.
92. Abbott J.D., Huang Y., Liu D., Hickey R., Krause D.S., Giordano F.J. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004, 110:3300-3305.
93. Mansilla E., Marin G.H., Drago H., Sturla F., Salas E., Gardiner C., et al. Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine. Transplant Proc 2006, 38:967-969.
94. Lazarus H.M., Haynesworth S.E., Gerson S.L., Caplan A.I. Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections. J Hematother 1997, 6:447-455.
95. Brouard N., Driessen R., Short B., Simmons P.J. G-CSF increases mesenchymal precursor cell numbers in the bone marrow via an indirect mechanism involving osteoclast-mediated bone resorption. Stem Cell Res 2010, 5:65-75.
96. Liu L., Yu Q., Lin J., Lai X., Cao W., Du K., et al. Hypoxia-inducible factor-1alpha is essential for hypoxia-induced mesenchymal stem cell mobilization into the peripheral blood. Stem Cells Dev 2011, 11:1961-1971.
97. Hartlapp I., Abe R., Saeed R.W., Peng T., Voelter W., Bucala R., et al. Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. FASEB J 2001, 15:2215-2224.
98. Andersson-Sjoland A., de Alba C.G., Nihlberg K., Becerril C., Ramirez R., Pardo A., et al. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 2008, 40:2129-2140.
99. Hong K.M., Belperio J.A., Keane M.P., Burdick M.D., Strieter R.M. Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma. J Biol Chem 2007, 282:22910-22920.
100. Phillips R.J., Burdick M.D., Hong K., Lutz M.A., Murray L.A., Xue Y.Y., et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004, 114:438-446.
101. Quan T.E., Cowper S.E., Bucala R. The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep 2006, 8:145-150.
102. Moore B.B., Kolodsick J.E., Thannickal V.J., Cooke K., Moore T.A., Hogaboam C., et al. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 2005, 166:675-684.
103. Mehrad B., Burdick M.D., Strieter R.M. Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol 2009, 41:1708-1718.