Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells

Journal of Leukocyte Biology

Volumn 73, Issue 5, 2003, Pages 630-638

  Broxmeyer, Hal E ^a,b   Kohli, Lisa ^a,b   Kim, Chang H ^c   Lee, Younghee ^a,b   Mantel, Charlie ^a,b   Cooper, Scott ^a,b   Hangoc, Giao ^a,b   Shaheen, Montaser ^a,b   Li, Xiaxin ^a   Clapp, D Wade ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Apoptosis; Chemokines; Cytokines; Hematopoietic progenitor and stem cells

Indexed keywords

ALPHA CHEMOKINE; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 6; STEEL FACTOR; STROMAL CELL DERIVED FACTOR 1; CYTOKINE; GNAI2 PROTEIN, HUMAN; GNAI2 PROTEIN, MOUSE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ONCOPROTEIN; PERTUSSIS TOXIN; RECOMBINANT PROTEIN; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1BETA;

APOPTOSIS; ARTICLE; BONE MARROW; CELL CULTURE; CELL POPULATION; CELL SURVIVAL; COLONY FORMATION; COLONY FORMING UNIT; CONTROLLED STUDY; ERYTHROID CELL; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MACROPHAGE; MEGAKARYOCYTE; MYELOID PROGENITOR CELL; PRIORITY JOURNAL; STEM CELL; UMBILICAL CORD BLOOD; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CLONOGENIC ASSAY; CONGENIC STRAIN; CYTOLOGY; DRUG EFFECT; FEMALE; FETUS BLOOD; MOUSE; NEWBORN; PHYSIOLOGY; RADIATION CHIMERA;

ANIMALS; ANIMALS, CONGENIC; APOPTOSIS; BONE MARROW CELLS; CELLS, CULTURED; CHEMOKINES, CXC; COLONY-FORMING UNITS ASSAY; CYTOKINES; FEMALE; FETAL BLOOD; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; INFANT, NEWBORN; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MYELOID CELLS; PERTUSSIS TOXIN; PROTO-ONCOGENE PROTEINS; RADIATION CHIMERA; RECEPTORS, CXCR4; RECOMBINANT PROTEINS; STEM CELL FACTOR;

EID: 0038500953     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1002495     Document Type: Article

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