Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Alquezar, Carolina ^a,e   Esteras, Noemí ^a   Alzualde, Ainhoa ^b   Moreno, Fermín ^c   Ayuso, Matilde S ^a,e   de Munain, Adolfo López ^b,c,d   Martín Requero, Ángeles ^a,e  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

^c HOSPITAL DONOSTIA   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^e CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ADENINE; BUTYRIC ACID; CASPASE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 6; CYTOCHROME C; GUANINE; PROGRANULIN; RETINOBLASTOMA PROTEIN; CDK6 PROTEIN, HUMAN; GRANULIN PRECURSOR PROTEIN; SIGNAL PEPTIDE;

ADULT; AGED; AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CELL LINE; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOBLAST; LYMPHOBLASTOID CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOGENESIS; PROTEIN EXPRESSION; ANALYSIS OF VARIANCE; BLOOD; COMPARATIVE STUDY; FLUORESCENCE; GENE EXPRESSION REGULATION; GENETICS; HAPLOINSUFFICIENCY; IMMUNOBLOTTING; LYMPHOCYTE; MIDDLE AGED; PHYSIOLOGY; POINT MUTATION; SERUM;

ADULT; AGED; ANALYSIS OF VARIANCE; APOPTOSIS; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 6; FEMALE; FLUORESCENCE; FRONTOTEMPORAL LOBAR DEGENERATION; GENE EXPRESSION REGULATION; HAPLOINSUFFICIENCY; HUMANS; IMMUNOBLOTTING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; POINT MUTATION; SERUM;

EID: 84862058365     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037057     Document Type: Article

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