Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures

Brain Research

Volumn 1366, Issue , 2010, Pages 1-8

  Guo, Aobo ^a   Tapia, Lucia ^b   Bamji, Shernaz X ^a,b   Cynader, Max S ^a   Jia, William ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Apoptosis; Cortical neuron; FTLD U; Progranulin; RNA interference; TDP 43

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; LENTIVIRUS VECTOR; N METHYL DEXTRO ASPARTIC ACID; PROGRANULIN; SMALL INTERFERING RNA; TAR DNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL DEATH; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; FEMALE; FETUS; FRONTOTEMPORAL DEMENTIA; HUMAN; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ANIMALS; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; EXCITATORY AMINO ACID AGONISTS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; INDOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; N-METHYLASPARTATE; NEURONS; OXIDANTS; PREGNANCY; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION;

EID: 79251648286     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.09.099     Document Type: Article

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