Enhanced proteasome-dependent degradation of the CDK inhibitor p27kip1 in immortalized lymphocytes from Alzheimer's dementia patients

Neurobiology of Aging

Volumn 29, Issue 10, 2008, Pages 1474-1484

  Muñoz, Úrsula ^a   Bartolomé, Fernando ^a   Bermejo, Félix ^b   Martín Requero, Ángeles ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

Alzheimer's disease; Calmodulin; Cell proliferation; Lymphocytes; p27; PI3K Akt; Proteasome activity

Indexed keywords

CALMODULIN INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEASOME; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CELL CYCLE; CELL DEGENERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; LYMPHOBLAST; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MITOSIS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BINDING SITES; CALCIUM SIGNALING; CALMODULIN; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; NERVE DEGENERATION; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THREONINE; UBIQUITINATION;

EID: 49149107832     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.03.013     Document Type: Article

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