Deletion of Gαz protein protects against diet-induced glucose intolerance via expansion of β-cell mass

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20344-20355

  Kimple, Michelle E ^a   Moss, Jennifer B ^b   Brar, Harpreet K ^a   Rosa, Taylor C ^b   Truchan, Nathan A ^a   Pasker, Renee L ^a   Newgard, Christopher B ^b   Casey, Patrick J ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CELL FUNCTIONS; CELL MASS; G PROTEIN; GLUCOSE INTOLERANCE; GLUCOSE-STIMULATED INSULIN SECRETIONS; GUANINE NUCLEOTIDE-BINDING PROTEINS; INSULIN SECRETION; ISOFORMS; PANCREATIC ISLET; PLASMA INSULIN LEVELS; PROSTAGLANDINE; SIGNALING PATHWAYS; TYPE-2 DIABETES;

CELL PROLIFERATION; CELLS; GLUCOSE; INSULIN; MAMMALS; NUTRITION; PHYSIOLOGY; PIGMENTS; PROTEINS;

CYTOLOGY;

GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA Z SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CELL PROLIFERATION; CELL PROTECTION; CELL SIZE; CONTROLLED STUDY; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RELEASE; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; UPREGULATION;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ANIMALS; CELL PROLIFERATION; CELL SIZE; CYCLIC AMP; DIETARY FATS; GENE DELETION; GLUCOSE INTOLERANCE; GTP-BINDING PROTEIN ALPHA SUBUNITS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, MUTANT STRAINS; SIGNAL TRANSDUCTION;

MUS;

EID: 84862006012     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.359745     Document Type: Article

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