메뉴 건너뛰기




Volumn 123, Issue 1, 2011, Pages 53-65

Focus on incretin-based therapies: Targeting the core defects of type 2 diabetes

Author keywords

Diabetes mellitus; DPP 4 inhibitors; GLP 1 receptor agonists; Incretins; Pathophysiology

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AMYLIN; CATECHOLAMINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GROWTH HORMONE; HYDROCORTISONE; INCRETIN; INSULIN; INSULIN GLARGINE; LIPID; LIRAGLUTIDE; METFORMIN; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN; ADAMANTANE; ANTIDIABETIC AGENT; DIPEPTIDE; DRUG DERIVATIVE; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; PEPTIDE; PYRAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; VENOM;

EID: 79952813680     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.3810/pgm.2011.01.2245     Document Type: Article
Times cited : (15)

References (98)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-1053.
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 2
    • 33644880189 scopus 로고    scopus 로고
    • National Diabetes Information Clearinghouse, Updated June 2008. Accessed September 23, 2009
    • National Diabetes Information Clearinghouse. National diabetes statistics, 2007. http://diabetes.niddk.nih.gov/dm/pubs/statistics/. Updated June 2008. Accessed September 23, 2009.
    • (2007) National Diabetes Statistics
  • 3
    • 57249103368 scopus 로고    scopus 로고
    • Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: An observational study in 13,087 patients
    • Eeg-Olofsson K, Cederholm J, Nilsson PM, et al. Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in 13,087 patients. Diabetologia. 2009;52(1):65-73.
    • (2009) Diabetologia , vol.52 , Issue.1 , pp. 65-73
    • Eeg-Olofsson, K.1    Cederholm, J.2    Nilsson, P.M.3
  • 4
    • 67651097482 scopus 로고    scopus 로고
    • Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study
    • Preis SR, Pencina MJ, Hwang SJ, et al. Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study. Circulation. 2009;120(3):212-220.
    • (2009) Circulation , vol.120 , Issue.3 , pp. 212-220
    • Preis, S.R.1    Pencina, M.J.2    Hwang, S.J.3
  • 6
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773-795.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 773-795
    • Defronzo, R.A.1
  • 7
    • 34249682591 scopus 로고    scopus 로고
    • β-Cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg BL. β-Cell failure in diabetes and preservation by clinical treatment. Endocr Rev. 2007;28(2):187-218.
    • (2007) Endocr Rev , vol.28 , Issue.2 , pp. 187-218
    • Wajchenberg, B.L.1
  • 8
    • 37349119004 scopus 로고    scopus 로고
    • Metabolic consequences of hyperglycemia and insulin resistance
    • Jellinger PS. Metabolic consequences of hyperglycemia and insulin resistance. Clin Cornerstone. 2007;8(suppl 7):S30-S42.
    • (2007) Clin Cornerstone , vol.8 , Issue.SUPPL. 7
    • Jellinger, P.S.1
  • 9
    • 57649234120 scopus 로고    scopus 로고
    • The incretin system and its role in type 2 diabetes mellitus
    • Holst JJ, Vilsbøll T, Deacon CF. The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol. 2009;297(1-2): 127-136.
    • (2009) Mol Cell Endocrinol , vol.297 , Issue.1-2 , pp. 127-136
    • Holst, J.J.1    Vilsbøll, T.2    Deacon, C.F.3
  • 10
    • 40949090627 scopus 로고    scopus 로고
    • Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
    • Vollmer K, Holst JJ, Baller B, et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes. 2008;57(3):678-687.
    • (2008) Diabetes , vol.57 , Issue.3 , pp. 678-687
    • Vollmer, K.1    Holst, J.J.2    Baller, B.3
  • 11
    • 1842855423 scopus 로고    scopus 로고
    • Incretins, insulin secretion and type 2 diabetes mellitus
    • Vilsbøll T, Holst JJ. Incretins, insulin secretion and type 2 diabetes mellitus. Diabetologia. 2004;47(3):357-366.
    • (2004) Diabetologia , vol.47 , Issue.3 , pp. 357-366
    • Vilsbøll, T.1    Holst, J.J.2
  • 12
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H, Stimmler L, Hlad CJ Jr, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab. 1964;24:1076-1082.
    • (1964) J Clin Endocrinol Metab , vol.24 , pp. 1076-1082
    • Elrick, H.1    Stimmler, L.2    Hlad Jr., C.J.3    Arai, Y.4
  • 13
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S, et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab. 2001;86(8):3717-3723.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.8 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 14
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care. 2003;26(10):2929-2940.
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2929-2940
    • Drucker, D.J.1
  • 15
    • 58149090676 scopus 로고    scopus 로고
    • The role of incretins in glucose homeostasis and diabetes treatment
    • Kim W, Egan JM. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60(4):470-512.
    • (2008) Pharmacol Rev , vol.60 , Issue.4 , pp. 470-512
    • Kim, W.1    Egan, J.M.2
  • 16
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab. 2006;3(3):153-165.
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 153-165
    • Drucker, D.J.1
  • 17
    • 0037373183 scopus 로고    scopus 로고
    • International union of pharmacology. XXXV. The glucagon receptor family
    • Mayo K, Miller L, Bataille D, et al. International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev. 2003;55:167-194.
    • (2003) Pharmacol Rev , vol.55 , pp. 167-194
    • Mayo, K.1    Miller, L.2    Bataille, D.3
  • 18
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagonlike peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M. Cardioprotective and vasodilatory actions of glucagonlike peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation. 2008;117(18):2340-2350.
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 19
    • 67849084815 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation
    • Dozier KC, Cureton EL, Kwan RO, et al. Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation. Peptides. 2009;30:1735-1741.
    • (2009) Peptides , vol.30 , pp. 1735-1741
    • Dozier, K.C.1    Cureton, E.L.2    Kwan, R.O.3
  • 20
    • 60849139443 scopus 로고    scopus 로고
    • GLP-1 agonist-based therapies: An emerging new class of antidiabetic drug with potential cardioprotective effects
    • Sulistio M, Carothers C, Mangat M, Lujan M, Oliveros R, Chilton R. GLP-1 agonist-based therapies: an emerging new class of antidiabetic drug with potential cardioprotective effects. Curr Atheroscler Rep. 2009;11(2):93-99.
    • (2009) Curr Atheroscler Rep , vol.11 , Issue.2 , pp. 93-99
    • Sulistio, M.1    Carothers, C.2    Mangat, M.3    Lujan, M.4    Oliveros, R.5    Chilton, R.6
  • 21
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagons-like peptide I are rapidly degraded from NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, et al. Both subcutaneously and intravenously administered glucagons-like peptide I are rapidly degraded from NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes. 1995;44(9):1126-1131.
    • (1995) Diabetes , vol.44 , Issue.9 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3
  • 22
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368(9548):1696-1705.
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 23
    • 0031908130 scopus 로고    scopus 로고
    • The structure and function of CD26 in the T-cell immune response
    • Morimoto C, Schlossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev. 1998;161:55-70.
    • (1998) Immunol Rev , vol.161 , pp. 55-70
    • Morimoto, C.1    Schlossman, S.F.2
  • 24
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA. 2007;298(2):194-206.
    • (2007) JAMA , vol.298 , Issue.2 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 25
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes. 1999;48(5):1026-1034.
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6    Denaro, M.7
  • 26
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. J Biol Chem. 1992;267(11):7402-7405.
    • (1992) J Biol Chem , vol.267 , Issue.11 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 27
    • 79952840650 scopus 로고    scopus 로고
    • Byetta (exenatide) [package insert]. San Diego, CA: Amylin Pharmaceuticals, Inc
    • Byetta (exenatide) [package insert]. San Diego, CA: Amylin Pharmaceuticals, Inc; 2010.
    • (2010)
  • 28
    • 15444367142 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus
    • Kolterman OG, Kim DD, Shen L, et al. Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus. Am J Health Syst Pharm. 2005;62(2): 173-181.
    • (2005) Am J Health Syst Pharm , vol.62 , Issue.2 , pp. 173-181
    • Kolterman, O.G.1    Kim, D.D.2    Shen, L.3
  • 29
    • 0036312680 scopus 로고    scopus 로고
    • Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
    • Tourrel C, Bailbe D, Lacorne M, et al. Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes. 2002;51(5):1443-1452.
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1443-1452
    • Tourrel, C.1    Bailbe, D.2    Lacorne, M.3
  • 30
    • 65949122087 scopus 로고    scopus 로고
    • One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: A randomized, controlled trial
    • Bunck MC, Diamant M, Cornér A, et al. One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care. 2009;32(5):762-768.
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 762-768
    • Bunck, M.C.1    Diamant, M.2    Cornér, A.3
  • 31
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • Turner RC, Cull CA, Frighi V, et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA. 1999;281:2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3
  • 32
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5 ́-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
    • Hui H, Nourparvar A, Zhao X, Perfetti R. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5 ́-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology. 2003;144(4):1444-1455.
    • (2003) Endocrinology , vol.144 , Issue.4 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3    Perfetti, R.4
  • 33
    • 7444228521 scopus 로고    scopus 로고
    • Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD; Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27(11):2628-2635.
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 34
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28(5):1092-1100.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1092-1100
    • Defronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 35
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care. 2005;28(5):1083-1091.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 36
    • 77249090274 scopus 로고    scopus 로고
    • Exenatide versus glibenclamide is patients with diabetes
    • Derosa G, Maffioli P, Salvadeo SA, et al. Exenatide versus glibenclamide is patients with diabetes. Diabetes Technol Ther. 2010;12(3):233-240.
    • (2010) Diabetes Technol Ther , vol.12 , Issue.3 , pp. 233-240
    • Derosa, G.1    Maffioli, P.2    Salvadeo, S.A.3
  • 37
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagons secretion, gastric emptying, and caloric intake: A randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcome JH, MacConell. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagons secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin. 2008;24(10):2943-2952.
    • (2008) Curr Med Res Opin , vol.24 , Issue.10 , pp. 2943-2952
    • Defronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcome, J.H.5    MacConell6
  • 38
    • 77954897689 scopus 로고    scopus 로고
    • Effects of exenatide plus rosiglitazone on beta cell function and insulin sensitivity in subjects with type 2 diabetes on metformin
    • DeFronzo RA, Triplitt C, Qu Y, Lewis MS, Maggs D, Glass LC. Effects of exenatide plus rosiglitazone on beta cell function and insulin sensitivity in subjects with type 2 diabetes on metformin. Diabetes Care. 2010;33(5):951-957.
    • (2010) Diabetes Care , vol.33 , Issue.5 , pp. 951-957
    • Defronzo, R.A.1    Triplitt, C.2    Qu, Y.3    Lewis, M.S.4    Maggs, D.5    Glass, L.C.6
  • 39
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin. 2008;24(1):275-286.
    • (2008) Curr Med Res Opin , vol.24 , Issue.1 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 40
    • 76749161358 scopus 로고    scopus 로고
    • Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
    • Okerson T, Yan P, Stonehouse A, Brodows R. Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. Am J Hypertension. 2010;23(3):334-339.
    • (2010) Am J Hypertension , vol.23 , Issue.3 , pp. 334-339
    • Okerson, T.1    Yan, P.2    Stonehouse, A.3    Brodows, R.4
  • 41
    • 57449094967 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, tolerability, and safety of exenatide in Japanese patients with type 2 diabetes mellitus
    • Kothare PA, Linnebjerg H, Isaka Y, et al. Pharmacokinetics, pharmacodynamics, tolerability, and safety of exenatide in Japanese patients with type 2 diabetes mellitus. J Clin Pharmacol. 2008;48(12): 1389-1399.
    • (2008) J Clin Pharmacol , vol.48 , Issue.12 , pp. 1389-1399
    • Kothare, P.A.1    Linnebjerg, H.2    Isaka, Y.3
  • 42
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study
    • Noel RA, Braun DK, Patterson RE, Bloomgren G. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32(5): 834-838.
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.4
  • 43
    • 33646486410 scopus 로고    scopus 로고
    • Acute pancreatitis
    • Kingsnorth A, O'Reilly D. Acute pancreatitis. BMJ. 2006;332 (7549):1072-1076.
    • (2006) BMJ , vol.332 , Issue.7549 , pp. 1072-1076
    • Kingsnorth, A.1    O'Reilly, D.2
  • 44
    • 4444228888 scopus 로고    scopus 로고
    • World Health Organization, Accessed December 7, 2009
    • World Health Organization. Obesity and overweight. 2009. www.who.int/dietphysicalactivity/publications/facts/obesity/en. Accessed December 7, 2009.
    • (2009) Obesity and Overweight
  • 45
    • 74349099732 scopus 로고    scopus 로고
    • FDA reviews incidences of acute pancreatitis in patients taking Byetta
    • Idris I. FDA reviews incidences of acute pancreatitis in patients taking Byetta. Diabetes Obes Metab. 2008;10:96-98.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 96-98
    • Idris, I.1
  • 46
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold Chan K. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin. 2009;25(4):1019-1027.
    • (2009) Curr Med Res Opin , vol.25 , Issue.4 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold, C.K.3
  • 47
    • 77953804197 scopus 로고    scopus 로고
    • Incidence of acute pancreatitis in exenatide initiators compared to other antidiabetic drug initiators: A retrospective, cohort study (abstract no. 158-OR)
    • Bloomgren G, Dore D, Patterson R, et al. Incidence of acute pancreatitis in exenatide initiators compared to other antidiabetic drug initiators: a retrospective, cohort study (abstract no. 158-OR). Diabetes. 2009;58(suppl 1):A41.
    • (2009) Diabetes , vol.58 , Issue.SUPPL. 1
    • Bloomgren, G.1    Dore, D.2    Patterson, R.3
  • 48
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • Kim D, MacConell L, Zhuang D, et al. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care. 2007;30(6):1487-1493.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1487-1493
    • Kim, D.1    Macconell, L.2    Zhuang, D.3
  • 49
    • 53249142132 scopus 로고    scopus 로고
    • Duration-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, et al; DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet. 2008;372(9645):1240-1250.
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 50
    • 77953828230 scopus 로고    scopus 로고
    • Duration-1 Study Group. DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • Buse JB, Drucker DJ, Taylor KL, et al; DURATION-1 Study Group. DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care. 2010;33(6):1255-1261.
    • (2010) Diabetes Care , vol.33 , Issue.6 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3
  • 51
    • 74249123519 scopus 로고    scopus 로고
    • Exenatide once weekly elicited improvements in blood pressure and lipid profile over 52 weeks in patients with type 2 diabetes (abstract no. 1239)
    • Bergenstal RM, Kim T, Trautmann ME, et al. Exenatide once weekly elicited improvements in blood pressure and lipid profile over 52 weeks in patients with type 2 diabetes (abstract no. 1239). Circulation. 2008;118(suppl 1):S1086.
    • (2008) Circulation , vol.118 , Issue.SUPPL. 1
    • Bergenstal, R.M.1    Kim, T.2    Trautmann, M.E.3
  • 52
    • 77955573674 scopus 로고    scopus 로고
    • Duration-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
    • Bergenstal RM, Wysham C, Macconell L, et al; DURATION-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet. 2010;376(9739):431-439.
    • (2010) Lancet , vol.376 , Issue.9739 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3
  • 53
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): An open-label randomised trial
    • Diamant M, Van Gaal L, Stranks S, et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet. 2010;375(9733):2234-2243.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2234-2243
    • Diamant, M.1    van Gaal, L.2    Stranks, S.3
  • 54
    • 62449169287 scopus 로고    scopus 로고
    • Lead-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al; LEAD-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care. 2009;32(1):84-90.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 55
    • 79952851040 scopus 로고    scopus 로고
    • Victoza (liraglutide) [package insert]. Princeton, NJ: Novo Nordisk, Inc
    • Victoza (liraglutide) [package insert]. Princeton, NJ: Novo Nordisk, Inc; 2010.
    • (2010)
  • 56
    • 67649189310 scopus 로고    scopus 로고
    • Liraglutide effect and action in diabetes (LEAD) trial
    • Madsbad S. Liraglutide effect and action in diabetes (LEAD) trial. Expert Rev Endocrinol Metab. 2009;4(2):119-129.
    • (2009) Expert Rev Endocrinol Metab , vol.4 , Issue.2 , pp. 119-129
    • Madsbad, S.1
  • 57
    • 59449101432 scopus 로고    scopus 로고
    • Lead-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al; LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373(9662):473-481.
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 58
    • 62449129181 scopus 로고    scopus 로고
    • Lead-1 SU study group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brändle M, et al; LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26(3):268-278.
    • (2009) Diabet Med , vol.26 , Issue.3 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 59
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care. 2009;32(7):1224-1230.
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 60
    • 67649666737 scopus 로고    scopus 로고
    • The Lead-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al, for the LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374(9683):39-47.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    et al4
  • 61
    • 77952309372 scopus 로고    scopus 로고
    • The 1860-LIRA-DPP-4 Study Group. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycemic control with metformin: A 26-week, randomized, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, et al, for the 1860-LIRA-DPP-4 Study Group. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycemic control with metformin: a 26-week, randomized, parallel-group, open-label trial. Lancet. 2010;375(9724):1447-1456.
    • (2010) Lancet , vol.375 , Issue.9724 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3    et al4
  • 62
    • 0029833629 scopus 로고    scopus 로고
    • Effects of glucagons and glucagon-like-peptide-1 (7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line
    • Crespel A, DeBoisvilliers F, Gros L, Kervran A. Effects of glucagons and glucagon-like-peptide-1 (7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line. Endocrinology. 1996;137(9):3674-3680.
    • (1996) Endocrinology , vol.137 , Issue.9 , pp. 3674-3680
    • Crespel, A.1    Deboisvilliers, F.2    Gros, L.3    Kervran, A.4
  • 64
    • 79952860507 scopus 로고    scopus 로고
    • US Food and Drug Administration. Briefing materials. Dated April 2, Accessed November 3, 2009
    • US Food and Drug Administration. Briefing materials. Dated April 2, 2009. http://www.fda.gov/ohrms/dockets/ac/09/briefing/2009-4422b2-01-FDA.pdf. Accessed November 3, 2009.
    • (2009)
  • 65
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Knudsen LB, Madsen LW, Andersen S, et al. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology. 2010;151(4):1473-1486.
    • (2010) Endocrinology , vol.151 , Issue.4 , pp. 1473-1486
    • Knudsen, L.B.1    Madsen, L.W.2    Andersen, S.3
  • 66
    • 0029118049 scopus 로고
    • Degradation of glucosedependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucosedependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology. 1995;136(8):3585-3596.
    • (1995) Endocrinology , vol.136 , Issue.8 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 68
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman GA, Stevens C, Van Dyck K, et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005;78(6):675-688.
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.6 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    van Dyck, K.3
  • 69
    • 41949084607 scopus 로고    scopus 로고
    • The changing landscape of type 2 diabetes: The role of incretin-based therapies in managed care outcomes
    • Triplitt CL, McGill JB, Porte D Jr, Conner CS. The changing landscape of type 2 diabetes: the role of incretin-based therapies in managed care outcomes. J Manag Care Pharm. 2007;13(9 suppl C):S2-S16.
    • (2007) J Manag Care Pharm , vol.13 , Issue.9 SUPPL. C
    • Triplitt, C.L.1    McGill, J.B.2    Porte Jr., D.3    Conner, C.S.4
  • 70
    • 79952851252 scopus 로고    scopus 로고
    • Januvia [package insert]. Whitehouse Station, NJ: Merck and Co
    • Januvia [package insert]. Whitehouse Station, NJ: Merck and Co; 2007.
    • (2007)
  • 71
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49(11):2564-2571.
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 72
    • 33845472504 scopus 로고    scopus 로고
    • Effect of dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK, et al. Effect of dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006; 29(12):2632-2637.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 73
    • 33751557143 scopus 로고    scopus 로고
    • The Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P, for the Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006;28(10):1556-1568.
    • (2006) Clin Ther , vol.28 , Issue.10 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 74
    • 33845476757 scopus 로고    scopus 로고
    • Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29(12):2638-2643.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 75
    • 70349333861 scopus 로고    scopus 로고
    • CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes
    • Rosenstock J, Aguilar-Salinas C, Klein E, Nepal S, List J, Chen R; CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes. Curr Med Res Opin. 2009;25(10):2401-2411.
    • (2009) Curr Med Res Opin , vol.25 , Issue.10 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3    Nepal, S.4    List, J.5    Chen, R.6
  • 76
    • 69749105421 scopus 로고    scopus 로고
    • FDA approves saxagliptin for type 2 diabetes
    • Traynor K. FDA approves saxagliptin for type 2 diabetes. Am J Health Syst Pharm. 2009;66(17):1513.
    • (2009) Am J Health Syst Pharm , vol.66 , Issue.17 , pp. 1513
    • Traynor, K.1
  • 77
    • 68949212458 scopus 로고    scopus 로고
    • CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomised controlled trial
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R; CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial. Int J Clin Pract. 2009;63(9):1395-1406.
    • (2009) Int J Clin Pract , vol.63 , Issue.9 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 78
    • 69549135336 scopus 로고    scopus 로고
    • Saxagliptin 014 Study Group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • DeFronzo RA, Hissa MN, Garber AJ, et al; Saxagliptin 014 Study Group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care. 2009;32(9):1649-1655.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1649-1655
    • Defronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3
  • 80
    • 77951758117 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus
    • Neumiller JJ, Wood L, Campbell RK. Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Pharmacotherapy. 2010;30(5):463-484.
    • (2010) Pharmacotherapy , vol.30 , Issue.5 , pp. 463-484
    • Neumiller, J.J.1    Wood, L.2    Campbell, R.K.3
  • 81
    • 77950880269 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in type 2 diabetes: A meta-analysis of randomized clinical trials
    • Monami M, Iacomelli I, Marchionni N, Mannucci E. Dipeptidyl peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis. 2010;20(4):224-235.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , Issue.4 , pp. 224-235
    • Monami, M.1    Iacomelli, I.2    Marchionni, N.3    Mannucci, E.4
  • 82
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu J, Woods J, Zhou Y-P, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes. 2006;55(6):1695-1704.
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.-P.3
  • 83
    • 43449096512 scopus 로고    scopus 로고
    • Sitagliptin Study 801 Group. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Scott R, Loeys T, Davies MJ, Engel SS; Sitagliptin Study 801 Group. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2008;10(10):959-969.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3    Engel, S.S.4
  • 84
    • 39749184723 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes
    • Raz I, Chen Y, Wu M, et al. Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin. 2008;24(2):537-550.
    • (2008) Curr Med Res Opin , vol.24 , Issue.2 , pp. 537-550
    • Raz, I.1    Chen, Y.2    Wu, M.3
  • 85
    • 41849099939 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
    • Mistry GC, Maes AL, Lasseter KC, Davies MJ, Gottesdiener KM, Wagner JA, Herman GA. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension. J Clin Pharmacol. 2008;48(5):592-598.
    • (2008) J Clin Pharmacol , vol.48 , Issue.5 , pp. 592-598
    • Mistry, G.C.1    Maes, A.L.2    Lasseter, K.C.3    Davies, M.J.4    Gottesdiener, K.M.5    Wagner, J.A.6    Herman, G.A.7
  • 86
    • 70349386312 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 (CD26). Knowing the function before inhibiting the enzyme
    • Matteucci E, Giampietro O. Dipeptidyl peptidase-4 (CD26). Knowing the function before inhibiting the enzyme. Curr Med Chem. 2009;16:2943-2951.
    • (2009) Curr Med Chem , vol.16 , pp. 2943-2951
    • Matteucci, E.1    Giampietro, O.2
  • 87
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardio-cerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large phase III type 2 diabetes population
    • Schweizer A, Dejager S, Foley JE, Couturier A, Ligueros-Saylan M, Kothny W. Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large phase III type 2 diabetes population. Diabetes Obes Metab. 2010;12(6):485-494.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.6 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Couturier, A.4    Ligueros-Saylan, M.5    Kothny, W.6
  • 88
    • 77953108350 scopus 로고    scopus 로고
    • A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes
    • Frederich R, Alexander JH, Fiedorek FT, et al. A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes. Postgrad Med. 2010;122(3):16-27.
    • (2010) Postgrad Med , vol.122 , Issue.3 , pp. 16-27
    • Frederich, R.1    Alexander, J.H.2    Fiedorek, F.T.3
  • 89
    • 77951069227 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in clinical studies: A pooled analysis of data from 10,246 patients with type 2 diabetes
    • Williams-Herman D, Engel SS, Round E, et al. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes. BMC Endocr Disord. 2010;10:7.
    • (2010) BMC Endocr Disord , vol.10 , pp. 7
    • Williams-Herman, D.1    Engel, S.S.2    Round, E.3
  • 90
    • 67649111182 scopus 로고    scopus 로고
    • Trajectories of glycemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: An analysis from the Whitehall II study
    • Tabak AG, Jokela M, Akbaraly T, Brunner EJ, Kivimäki M, Witte DR. Trajectories of glycemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet. 2009;373(9682):2215-2221.
    • (2009) Lancet , vol.373 , Issue.9682 , pp. 2215-2221
    • Tabak, A.G.1    Jokela, M.2    Akbaraly, T.3    Brunner, E.J.4    Kivimäki, M.5    Witte, D.R.6
  • 91
    • 0031972156 scopus 로고    scopus 로고
    • Ukpds 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
    • Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC. UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. Diabetic Med. 1998;15(4):297-303.
    • (1998) Diabetic Med , vol.15 , Issue.4 , pp. 297-303
    • Matthews, D.R.1    Cull, C.A.2    Stratton, I.M.3    Holman, R.R.4    Turner, R.C.5
  • 93
    • 67049155251 scopus 로고    scopus 로고
    • Unraveling the science of incretin biology
    • Nauck MA. Unraveling the science of incretin biology. Am J Med. 2009;122(6 suppl):S3-S10.
    • (2009) Am J Med , vol.122 , Issue.6 SUPPL.
    • Nauck, M.A.1
  • 94
    • 60849139443 scopus 로고    scopus 로고
    • GLP-1 agonist-based therapies: An emerging new class of antidiabetic drug with potential cardioprotective effects
    • Sulistio M, Carothers C, Mangat M, Lujan M, Oliveros R, Chilton R. GLP-1 agonist-based therapies: an emerging new class of antidiabetic drug with potential cardioprotective effects. Curr Atheroscler Rep. 2009;11(2):93-99.
    • (2009) Curr Atheroscler Rep , vol.11 , Issue.2 , pp. 93-99
    • Sulistio, M.1    Carothers, C.2    Mangat, M.3    Lujan, M.4    Oliveros, R.5    Chilton, R.6
  • 95
    • 9944251347 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    • Nyström T, Gonon AT, Sjöholm A, Pernow J. Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regul Pept. 2005;125(1-3):173-177.
    • (2005) Regul Pept , vol.125 , Issue.1-3 , pp. 173-177
    • Nyström, T.1    Gonon, A.T.2    Sjöholm, A.3    Pernow, J.4
  • 96
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagonlike peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagonlike peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation. 2004;109(8):962-965.
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 97
    • 33845293219 scopus 로고    scopus 로고
    • Glucagonlike peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP. Glucagonlike peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail. 2006;12(9):694-699.
    • (2006) J Card Fail , vol.12 , Issue.9 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 98
    • 34547930879 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting
    • Sokos GG, Bolukoglu H, German J, et al. Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting. Am J Cardiol. 2007;100(5):824-829.
    • (2007) Am J Cardiol , vol.100 , Issue.5 , pp. 824-829
    • Sokos, G.G.1    Bolukoglu, H.2    German, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.