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Volumn 32, Issue SUPPL. 3, 2002, Pages 46-53

Redefining the clinical management of type 2 diabetes: Matching therapy to pathophysiology

Author keywords

cell dysfunction; Insulin resistance; Pathogenesis; Thiazolidinediones

Indexed keywords

B LYMPHOCYTE; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; DIET; DISEASE COURSE; GLUCOSE BLOOD LEVEL; METABOLISM; PANCREAS ISLET; PHYSIOLOGY; STATISTICS;

EID: 18744408481     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1046/j.1365-2362.32.s3.6.x     Document Type: Review
Times cited : (28)

References (75)
  • 1
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 1998;19:491-503.
    • (1998) Endocr Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 2
    • 0026969347 scopus 로고
    • Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM)
    • Hamman RF. Genetic and environmental determinants of non-insulin- dependent diabetes mellitus (NIDDM). Diabetes Metab Rev 1992;8:287-338.
    • (1992) Diabetes Metab Rev , vol.8 , pp. 287-338
    • Hamman, R.F.1
  • 3
    • 1842334456 scopus 로고    scopus 로고
    • Report of the Expert Committee on the diagnosis and classification of diabetes mellitus
    • American Diabetes Association. Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;20:1183-96.
    • (1997) Diabetes Care , vol.20 , pp. 1183-1196
  • 4
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini E. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 1998;19:477-90.
    • (1998) Endocr Rev , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 5
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. J Am Med Assoc 1999;281:2005-12.
    • (1999) J Am Med Assoc , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 6
    • 0031972156 scopus 로고    scopus 로고
    • UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
    • UK Prospective Diabetes Study (UKPDS) Group
    • Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC. UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med 1998;15:297-303.
    • (1998) Diabet Med , vol.15 , pp. 297-303
    • Matthews, D.R.1    Cull, C.A.2    Stratton, I.M.3    Holman, R.R.4    Turner, R.C.5
  • 7
    • 0026554640 scopus 로고
    • Molecular physiology and genetics of NIDDM. Importance of metabolic staging
    • Granner DK, O'Brien RM. Molecular physiology and genetics of NIDDM. Importance of metabolic staging. Diabetes Care 1992;15:369-95.
    • (1992) Diabetes Care , vol.15 , pp. 369-395
    • Granner, D.K.1    O'Brien, R.M.2
  • 9
    • 0033842027 scopus 로고    scopus 로고
    • Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
    • Cavaghan MK, Ehrmann DA, Polonsky KS. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest 2000;106:329-33.
    • (2000) J Clin Invest , vol.106 , pp. 329-333
    • Cavaghan, M.K.1    Ehrmann, D.A.2    Polonsky, K.S.3
  • 10
    • 0030762562 scopus 로고    scopus 로고
    • Treatment with the oral antidiabetic agent troglitazone improves β cell responses to glucose in subjects with impaired glucose tolerance
    • Cavaghan MK, Ehrmann DA, Byrne MM, Polonsky KS. Treatment with the oral antidiabetic agent troglitazone improves β cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest 1997;100:530-7.
    • (1997) J Clin Invest , vol.100 , pp. 530-537
    • Cavaghan, M.K.1    Ehrmann, D.A.2    Byrne, M.M.3    Polonsky, K.S.4
  • 11
    • 0031029345 scopus 로고    scopus 로고
    • Pathogenetic mechanisms of impaired glucose tolerance and type II diabetes in African-Americans. The significance of insulin secretion, insulin sensitivity, and glucose effectiveness
    • Osei K, Gaillard T, Schuster DP. Pathogenetic mechanisms of impaired glucose tolerance and type II diabetes in African-Americans. The significance of insulin secretion, insulin sensitivity, and glucose effectiveness. Diabetes Care 1997;20:396-404.
    • (1997) Diabetes Care , vol.20 , pp. 396-404
    • Osei, K.1    Gaillard, T.2    Schuster, D.P.3
  • 12
    • 0034128587 scopus 로고    scopus 로고
    • Insulin secretion and insulin sensitivity in relation to glucose tolerance: Lessons from the Botnia Study
    • Tripathy D, Carlsson M, Almgren P, Isomaa B, Taskinen MR, Tuomi T et al. Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes 2000;49:975-80.
    • (2000) Diabetes , vol.49 , pp. 975-980
    • Tripathy, D.1    Carlsson, M.2    Almgren, P.3    Isomaa, B.4    Taskinen, M.R.5    Tuomi, T.6
  • 13
    • 0031421292 scopus 로고    scopus 로고
    • Metabolic abnormalities in impaired glucose tolerance
    • Gerich JE. Metabolic abnormalities in impaired glucose tolerance. Metabolism 1997;46:40-3.
    • (1997) Metabolism , vol.46 , pp. 40-43
    • Gerich, J.E.1
  • 15
    • 0024026298 scopus 로고
    • Lilly lecture 1987. the triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA. Lilly lecture 1987. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988;37:667-87.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • Defronzo, R.A.1
  • 16
    • 0029022819 scopus 로고
    • Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
    • Pimenta W, Korytkowski M, Mitrakou A, Jenssen T, Yki-Jarvinen H, Evron W et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. J Am Med Assoc 1995;273:1855-61.
    • (1995) J Am Med Assoc , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3    Jenssen, T.4    Yki-Jarvinen, H.5    Evron, W.6
  • 17
    • 0029851834 scopus 로고    scopus 로고
    • Pathogenesis and treatment of type 2 (noninsulin-dependent) diabetes mellitus (NIDDM)
    • Gerich JE. Pathogenesis and treatment of type 2 (noninsulin-dependent) diabetes mellitus (NIDDM). Horm Metab Res 1996;28:404-12.
    • (1996) Horm Metab Res , vol.28 , pp. 404-412
    • Gerich, J.E.1
  • 18
    • 0029056128 scopus 로고
    • Insulin deficiency and insulin resistance in the pathogenesis of NIDDM. Is a divorce possible?
    • Cerasi E. Insulin deficiency and insulin resistance in the pathogenesis of NIDDM. Is a divorce possible? Diabetologia 1995;38:992-7.
    • (1995) Diabetologia , vol.38 , pp. 992-997
    • Cerasi, E.1
  • 19
    • 0014093149 scopus 로고
    • Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic control of insulin response?
    • Cerasi E, Luft R. Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic control of insulin response? Acta Endocrinol (Copenh) 1967;55:330-45.
    • (1967) Acta Endocrinol (Copenh) , vol.55 , pp. 330-345
    • Cerasi, E.1    Luft, R.2
  • 20
    • 0014195410 scopus 로고
    • Glucose tolerance and serum insulin in unaffected identical twins of diabetics
    • Pyke DA, Taylor KW. Glucose tolerance and serum insulin in unaffected identical twins of diabetics. Br Med J 1967;4:21-2.
    • (1967) Br Med J , vol.4 , pp. 21-22
    • Pyke, D.A.1    Taylor, K.W.2
  • 22
    • 0028837903 scopus 로고
    • Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Madsbad S, Holm N, Beck-Nielsen H. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:690-8.
    • (1995) J Clin Invest , vol.95 , pp. 690-698
    • Vaag, A.1    Henriksen, J.E.2    Madsbad, S.3    Holm, N.4    Beck-Nielsen, H.5
  • 24
    • 0033656405 scopus 로고    scopus 로고
    • From obesity to diabetes: Why, when and who?
    • Scheen AJ. From obesity to diabetes: why, when and who? Acta Clin Belg 2000;55:9-15.
    • (2000) Acta Clin Belg , vol.55 , pp. 9-15
    • Scheen, A.J.1
  • 25
    • 0033960006 scopus 로고    scopus 로고
    • Reduced β-cell compensation to the insulin resistance associated with obesity in members of Caucasian familial type 2 diabetic kindreds
    • Elbein SC, Wegner K, Kahn SE. Reduced β-cell compensation to the insulin resistance associated with obesity in members of Caucasian familial type 2 diabetic kindreds. Diabetes Care 2000;23:221-7.
    • (2000) Diabetes Care , vol.23 , pp. 221-227
    • Elbein, S.C.1    Wegner, K.2    Kahn, S.E.3
  • 26
    • 0028874605 scopus 로고
    • The pharmacological treatment of hyperglycemia in NIDDM
    • American Diabetes Association. The pharmacological treatment of hyperglycemia in NIDDM. Diabetes Care 1995;18:1510-18.
    • (1995) Diabetes Care , vol.18 , pp. 1510-1518
  • 27
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 28
    • 0028817815 scopus 로고
    • UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: A progressive disease
    • UK Prospective Diabetes Study (UKPDS) Group. UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995;44:1249-58.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 29
    • 0031961242 scopus 로고    scopus 로고
    • Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: The 10-year follow-up of the Belfast Diet Study
    • Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med 1998;15:290-6.
    • (1998) Diabet Med , vol.15 , pp. 290-296
    • Levy, J.1    Atkinson, A.B.2    Bell, P.M.3    McCance, D.R.4    Hadden, D.R.5
  • 30
    • 0031847401 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats
    • Buckingham RE, Al-Barazanji KA, Toseland CD, Slaughter M, Connor SC, West A et al. Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Diabetes 1998;47:1326-34.
    • (1998) Diabetes , vol.47 , pp. 1326-1334
    • Buckingham, R.E.1    Al-Barazanji, K.A.2    Toseland, C.D.3    Slaughter, M.4    Connor, S.C.5    West, A.6
  • 31
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats
    • Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unger RH. Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci USA 1999;96:11513-18.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11513-11518
    • Higa, M.1    Zhou, Y.T.2    Ravazzola, M.3    Baetens, D.4    Orci, L.5    Unger, R.H.6
  • 32
    • 0033536224 scopus 로고    scopus 로고
    • Epidemiology of insulin resistance and its relation to coronary artery disease
    • Haffner SM. Epidemiology of insulin resistance and its relation to coronary artery disease. Am J Cardiol 1999;84:11J-14J.
    • (1999) Am J Cardiol , vol.84
    • Haffner, S.M.1
  • 33
    • 0026651566 scopus 로고
    • In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: Effects of diet treatment
    • Bak JF, Moller N, Schmitz O, Saaek A, Pedersen O. In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. Diabetologia 1992;35:777-84.
    • (1992) Diabetologia , vol.35 , pp. 777-784
    • Bak, J.F.1    Moller, N.2    Schmitz, O.3    Saaek, A.4    Pedersen, O.5
  • 34
    • 0023798487 scopus 로고
    • Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss
    • Freidenberg GR, Reichart D, Olefsky JM, Henry RR. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest 1988;82:1398-406.
    • (1988) J Clin Invest , vol.82 , pp. 1398-1406
    • Freidenberg, G.R.1    Reichart, D.2    Olefsky, J.M.3    Henry, R.R.4
  • 35
    • 0018833234 scopus 로고
    • Effects of dietary changes on cellular insulin binding and in vivo insulin sensitivity
    • Beck-Nielsen H, Pedersen O, Sorensen NS. Effects of dietary changes on cellular insulin binding and in vivo insulin sensitivity. Metabolism 1980;29:482-7.
    • (1980) Metabolism , vol.29 , pp. 482-487
    • Beck-Nielsen, H.1    Pedersen, O.2    Sorensen, N.S.3
  • 36
    • 0018373044 scopus 로고
    • Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year
    • Beck-Nielsen H, Pedersen O, Lindskov HO. Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year. Acta Endocrinol (Copenh) 1979;90:103-12.
    • (1979) Acta Endocrinol (Copenh) , vol.90 , pp. 103-112
    • Beck-Nielsen, H.1    Pedersen, O.2    Lindskov, H.O.3
  • 37
    • 0030935652 scopus 로고    scopus 로고
    • Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT Diabetes Study
    • Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT Diabetes Study. Diabetes Care 1997;20:537-44.
    • (1997) Diabetes Care , vol.20 , pp. 537-544
    • Pan, X.R.1    Li, G.W.2    Hu, Y.H.3    Wang, J.X.4    Yang, W.Y.5    An, Z.X.6
  • 38
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-50.
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.G.3    Valle, T.T.4    Hamalainen, H.5    Ilanne-Parikka, P.6
  • 39
    • 0034127645 scopus 로고    scopus 로고
    • Can dietary intervention produce long-term reduction in insulin resistance?
    • Mann JI. Can dietary intervention produce long-term reduction in insulin resistance? Br J Nutr 2000;83 (Suppl. 1):S169-S172.
    • (2000) Br J Nutr , vol.83 , Issue.SUPPL. 1
    • Mann, J.I.1
  • 40
    • 0030837469 scopus 로고    scopus 로고
    • Glucose: A continuous risk factor for cardiovascular disease
    • Gerstein HC. Glucose: a continuous risk factor for cardiovascular disease. Diabet Med 1997;14:S25-S31.
    • (1997) Diabet Med , vol.14
    • Gerstein, H.C.1
  • 41
    • 0035814611 scopus 로고    scopus 로고
    • Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk)
    • Khaw KT, Wareham N, Luben R, Bingham S, Oakes S, Welch A et al. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk). Br Med J 2001;322:15-18.
    • (2001) Br Med J , vol.322 , pp. 15-18
    • Khaw, K.T.1    Wareham, N.2    Luben, R.3    Bingham, S.4    Oakes, S.5    Welch, A.6
  • 42
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saltiel AR, Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 1996;45:1661-9.
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 44
    • 0027934465 scopus 로고
    • Effects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes
    • Mimura K, Umeda F, Hiramatsu S, Taniguchi S, Ono Y, Nakashima N et al. Effects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes. Diabet Med 1994;11:685-91.
    • (1994) Diabet Med , vol.11 , pp. 685-691
    • Mimura, K.1    Umeda, F.2    Hiramatsu, S.3    Taniguchi, S.4    Ono, Y.5    Nakashima, N.6
  • 45
    • 0343415083 scopus 로고    scopus 로고
    • 2 and troglitazone: Evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression
    • 2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes 2000;49:346-55.
    • (2000) Diabetes , vol.49 , pp. 346-355
    • Maggi, L.B.J.1    Sadeghi, H.2    Weigand, C.3    Scarim, A.L.4    Heitmeier, M.R.5    Corbett, J.A.6
  • 46
    • 0034665083 scopus 로고    scopus 로고
    • Troglitazone inhibits the expression of inducible nitric oxide synthase in adipocytes in vitro and in vivo study in 3T3-L1 cells and Otsuka Long-Evans Tokushima Fatty rats
    • Dobashi K, Asayama K, Nakane T, Kodera K, Hayashibe H, Nakazawa S. Troglitazone inhibits the expression of inducible nitric oxide synthase in adipocytes in vitro and in vivo study in 3T3-L1 cells and Otsuka Long-Evans Tokushima Fatty rats. Life Sci 2000;67:2093-101.
    • (2000) Life Sci , vol.67 , pp. 2093-2101
    • Dobashi, K.1    Asayama, K.2    Nakane, T.3    Kodera, K.4    Hayashibe, H.5    Nakazawa, S.6
  • 47
    • 0028076266 scopus 로고
    • A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
    • Oakes ND, Kennedy CJ, Jenkins AB, Laybutt DR, Chisholm DJ, Kraegen EW. A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 1994;43:1203-10.
    • (1994) Diabetes , vol.43 , pp. 1203-1210
    • Oakes, N.D.1    Kennedy, C.J.2    Jenkins, A.B.3    Laybutt, D.R.4    Chisholm, D.J.5    Kraegen, E.W.6
  • 48
    • 0033032470 scopus 로고    scopus 로고
    • Effects of troglitazone on substrate storage and utilization in insulin-resistant rats
    • Sreenan S, Keck S, Fuller T, Cockburn B, Burant CF. Effects of troglitazone on substrate storage and utilization in insulin-resistant rats. Am J Physiol 1999;276:E1119-E1129.
    • (1999) Am J Physiol , vol.276
    • Sreenan, S.1    Keck, S.2    Fuller, T.3    Cockburn, B.4    Burant, C.F.5
  • 49
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction
    • Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction. Eur J Clin Invest 2002;32 (Suppl. 3):14-23.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 3 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 50
    • 0036616582 scopus 로고    scopus 로고
    • Identifying the links between insulin resistance and β-cell function: The role of cytokines
    • Greenberg AS, McDaniel ML. Identifying the links between insulin resistance and β-cell function: the role of cytokines;. Eur J Clin Invest 2002;32 (Suppl. 3):24-34.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 3 , pp. 24-34
    • Greenberg, A.S.1    McDaniel, M.L.2
  • 51
    • 0001677801 scopus 로고    scopus 로고
    • Rosiglitazone (BRL49653) monotherapy has significant glucose lowering effect in type 2 diabetic patients
    • Patel J, Miller E, Patwardhan R. Rosiglitazone (BRL49653) monotherapy has significant glucose lowering effect in type 2 diabetic patients. Diabetes 1998;47 (Suppl. 1):A17.
    • (1998) Diabetes , vol.47 , Issue.SUPPL. 1
    • Patel, J.1    Miller, E.2    Patwardhan, R.3
  • 52
    • 28244497373 scopus 로고    scopus 로고
    • Rosiglitazone improves insulin sensitivity and decreases hepatic fat in patients with type 2 diabetes
    • Sydney, Australia. 29th October - 2nd November, Poster P0645A
    • Carey DG, Cowin GJ, Galloway GJ, Dodrell D, Matfin G. Rosiglitazone improves insulin sensitivity and decreases hepatic fat in patients with type 2 diabetes. 11 th International Congress of Endocrinology. Sydney, Australia. 29th October - 2nd November, Poster P0645A, 2000.
    • (2000) 11 Th International Congress of Endocrinology
    • Carey, D.G.1    Cowin, G.J.2    Galloway, G.J.3    Dodrell, D.4    Matfin, G.5
  • 53
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • McGarry JD, Dobbins RL. Fatty acids, lipotoxicity and insulin secretion. Diabetologia 1999;42:128-38.
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 54
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995;44:863-70.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 56
    • 0032488968 scopus 로고    scopus 로고
    • Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
    • Shimabukuro M, Zhou YT, Lee Y, Unger RH. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 1998;273:3547-50.
    • (1998) J Biol Chem , vol.273 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.T.2    Lee, Y.3    Unger, R.H.4
  • 57
    • 0033811933 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells
    • Dubois M, Pattou F, Kerr-Conte J, Gmyr V, Vandewalle B, Desreumaux P et al. Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells. Diabetologia 2000;43:1165-9.
    • (2000) Diabetologia , vol.43 , pp. 1165-1169
    • Dubois, M.1    Pattou, F.2    Kerr-Conte, J.3    Gmyr, V.4    Vandewalle, B.5    Desreumaux, P.6
  • 59
    • 0029911503 scopus 로고    scopus 로고
    • Effect of troglitazone on insulin sensitivity and pancreatic β-cell function in women at high risk for NIDDM
    • Berkowitz K, Peters R, Kjos SL, Goico J, Marroquin A, Dunn ME et al. Effect of troglitazone on insulin sensitivity and pancreatic β-cell function in women at high risk for NIDDM. Diabetes 1996;45:1572-9.
    • (1996) Diabetes , vol.45 , pp. 1572-1579
    • Berkowitz, K.1    Peters, R.2    Kjos, S.L.3    Goico, J.4    Marroquin, A.5    Dunn, M.E.6
  • 60
    • 0027983920 scopus 로고
    • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky JM. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994;331:1188-93.
    • (1994) N Engl J Med , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3    Joyce, M.4    Olefsky, J.M.5
  • 61
    • 0033975057 scopus 로고    scopus 로고
    • Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients
    • Wolffenbuttel BH, Gomis R, Squatrito S, Jones NP, Patwardhan RN. Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients. Diabet Med 2000;17:40-7.
    • (2000) Diabet Med , vol.17 , pp. 40-47
    • Wolffenbuttel, B.H.1    Gomis, R.2    Squatrito, S.3    Jones, N.P.4    Patwardhan, R.N.5
  • 62
    • 0034607438 scopus 로고    scopus 로고
    • Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: A randomized controlled trial
    • Fonseca V, Rosenstock J, Patwardhan R, Salzman A. Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial. J Am Med Assoc 2000;283:1695-702.
    • (2000) J Am Med Assoc , vol.283 , pp. 1695-1702
    • Fonseca, V.1    Rosenstock, J.2    Patwardhan, R.3    Salzman, A.4
  • 63
    • 0000543683 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone as monotherapy or in combination with metformin
    • Jones NP, Mather R, Owen S, Porter LE, Patwardhan R. Long-term efficacy of rosiglitazone as monotherapy or in combination with metformin. Diabetologia 2000;43:A192.
    • (2000) Diabetologia , vol.43
    • Jones, N.P.1    Mather, R.2    Owen, S.3    Porter, L.E.4    Patwardhan, R.5
  • 64
    • 0001917059 scopus 로고    scopus 로고
    • Rosiglitazone therapy is not associated with hepatotoxicity
    • Salzman A, Patel J. Rosiglitazone therapy is not associated with hepatotoxicity. Diabetes 1999;48 (Suppl. 1):A95.
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1
    • Salzman, A.1    Patel, J.2
  • 65
    • 0034531195 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: A randomized, placebo-controlled study
    • The Pioglitazone 027 Study Group
    • Einhorn D, Rendell M, Rosenzweig J, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study Group. Clin Ther 2000;22:1395-409.
    • (2000) Clin Ther , vol.22 , pp. 1395-1409
    • Einhorn, D.1    Rendell, M.2    Rosenzweig, J.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 66
    • 0035458604 scopus 로고    scopus 로고
    • Congestive heart failure in type 2 diabetes: Prevalence, incidence, and risk factors
    • Nichols GA, Hillier TA, Erbey JR, Brown JB. Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care 2001;24:1614-19.
    • (2001) Diabetes Care , vol.24 , pp. 1614-1619
    • Nichols, G.A.1    Hillier, T.A.2    Erbey, J.R.3    Brown, J.B.4
  • 67
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 68
    • 0000454838 scopus 로고    scopus 로고
    • Insulin resistance: The fundamental trigger of type 2 diabetes
    • Groop LC. Insulin resistance: The fundamental trigger of type 2 diabetes. Diabetes Obes Metab 1999;1 (Suppl. 1):S1-S7.
    • (1999) Diabetes Obes Metab , vol.1 , Issue.SUPPL. 1
    • Groop, L.C.1
  • 69
    • 0034031561 scopus 로고    scopus 로고
    • Globalization, coca-colonization and the chronic disease epidemic: Can the Doomsday scenario be averted?
    • Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted? J Intern Med 2000;247:301-10.
    • (2000) J Intern Med , vol.247 , pp. 301-310
    • Zimmet, P.1
  • 71
    • 0030821976 scopus 로고    scopus 로고
    • Is leptin the link between obesity and insulin resistance?
    • Girard J. Is leptin the link between obesity and insulin resistance? Diabetes Metab 1997;23:16-24.
    • (1997) Diabetes Metab , vol.23 , pp. 16-24
    • Girard, J.1
  • 74
    • 0030983816 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes
    • Nauck MA, Holst JJ, Willms B, Schmiegel W. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Exp Clin Endocrinol Diabetes 1997;105:187-95.
    • (1997) Exp Clin Endocrinol Diabetes , vol.105 , pp. 187-195
    • Nauck, M.A.1    Holst, J.J.2    Willms, B.3    Schmiegel, W.4


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