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Volumn 7, Issue 6, 2012, Pages

Osteoclast activated FoxP3 + CD8 + T-cells suppress bone resorption in vitro

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; CYTOKINE; ENHANCED GREEN FLUORESCENT PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; MONOCLONAL ANTIBODY; OSTEOCLAST DIFFERENTIATION FACTOR; PRIMER DNA; TNFSF11 PROTEIN, MOUSE;

EID: 84862001747     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038199     Document Type: Article
Times cited : (64)

References (101)
  • 1
    • 67349277390 scopus 로고    scopus 로고
    • Local communication on and within bone controls bone remodeling
    • Henriksen K, Neutzsky-Wulff AV, Bonewald LF, Karsdal MA, (2009) Local communication on and within bone controls bone remodeling. Bone 44: 1026-1033.
    • (2009) Bone , vol.44 , pp. 1026-1033
    • Henriksen, K.1    Neutzsky-Wulff, A.V.2    Bonewald, L.F.3    Karsdal, M.A.4
  • 2
    • 0032854699 scopus 로고    scopus 로고
    • Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand
    • Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, et al. (1999) Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand. Bone 25: 517-523.
    • (1999) Bone , vol.25 , pp. 517-523
    • Udagawa, N.1    Takahashi, N.2    Jimi, E.3    Matsuzaki, K.4    Tsurukai, T.5
  • 3
    • 0032714454 scopus 로고    scopus 로고
    • Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production
    • Takami M, Woo JT, Nagai K, (1999) Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production. Cell Tissue Res 298: 327-334.
    • (1999) Cell Tissue Res , vol.298 , pp. 327-334
    • Takami, M.1    Woo, J.T.2    Nagai, K.3
  • 4
    • 0033304730 scopus 로고    scopus 로고
    • Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, et al. (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345-357.
    • (1999) Endocr Rev , vol.20 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3    Jimi, E.4    Gillespie, M.T.5
  • 5
    • 0033398996 scopus 로고    scopus 로고
    • Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors
    • Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, et al. (1999) Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med 190: 1741-1754.
    • (1999) J Exp Med , vol.190 , pp. 1741-1754
    • Arai, F.1    Miyamoto, T.2    Ohneda, O.3    Inada, T.4    Sudo, T.5
  • 6
    • 0034735792 scopus 로고    scopus 로고
    • Bone versus immune system
    • Arron JR, Choi Y, (2000) Bone versus immune system. Nature 408: 535-536.
    • (2000) Nature , vol.408 , pp. 535-536
    • Arron, J.R.1    Choi, Y.2
  • 7
    • 34548494841 scopus 로고    scopus 로고
    • Osteoimmunology: a view from the bone
    • David JP, (2007) Osteoimmunology: a view from the bone. Adv Immunol 95: 149-165.
    • (2007) Adv Immunol , vol.95 , pp. 149-165
    • David, J.P.1
  • 8
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, et al. (2006) Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 203: 2673-2682.
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3    Yamaguchi, A.4    Morishita, Y.5
  • 9
    • 24144480260 scopus 로고    scopus 로고
    • Osteoimmunological insight into bone damage in rheumatoid arthritis
    • Takayanagi H, (2005) Osteoimmunological insight into bone damage in rheumatoid arthritis. Mod Rheumatol 15: 225-231.
    • (2005) Mod Rheumatol , vol.15 , pp. 225-231
    • Takayanagi, H.1
  • 10
    • 28644452244 scopus 로고    scopus 로고
    • Immune response: the key to bone resorption in periodontal disease
    • Taubman MA, Valverde P, Han X, Kawai T, (2005) Immune response: the key to bone resorption in periodontal disease. J Periodontol 76: 2033-2041.
    • (2005) J Periodontol , vol.76 , pp. 2033-2041
    • Taubman, M.A.1    Valverde, P.2    Han, X.3    Kawai, T.4
  • 11
    • 33744782835 scopus 로고    scopus 로고
    • Protective and destructive immunity in the periodontium: Part 2-T-cell-mediated immunity in the periodontium
    • Teng YT, (2006) Protective and destructive immunity in the periodontium: Part 2-T-cell-mediated immunity in the periodontium. J Dent Res 85: 209-219.
    • (2006) J Dent Res , vol.85 , pp. 209-219
    • Teng, Y.T.1
  • 12
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • Theill LE, Boyle WJ, Penninger JM, (2002) RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 20: 795-823.
    • (2002) Annu Rev Immunol , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 13
    • 33645657715 scopus 로고    scopus 로고
    • Osteoimmunology: interplay between the immune system and bone metabolism
    • Walsh MC, Kim N, Kadono Y, Rho J, Lee SY, et al. (2006) Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol 24: 33-63.
    • (2006) Annu Rev Immunol , vol.24 , pp. 33-63
    • Walsh, M.C.1    Kim, N.2    Kadono, Y.3    Rho, J.4    Lee, S.Y.5
  • 14
    • 15544379426 scopus 로고    scopus 로고
    • Interleukin-6 and osteoprotegerin systems in Paget's disease of bone: relationship to risedronate treatment
    • Mossetti G, Rendina D, De Filippo G, Viceconti R, Di Domenico G, et al. (2005) Interleukin-6 and osteoprotegerin systems in Paget's disease of bone: relationship to risedronate treatment. Bone 36: 549-554.
    • (2005) Bone , vol.36 , pp. 549-554
    • Mossetti, G.1    Rendina, D.2    De Filippo, G.3    Viceconti, R.4    Di Domenico, G.5
  • 15
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan GA, Martin TJ, (2000) Therapeutic approaches to bone diseases. Science 289: 1508-1514.
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 17
    • 48149084609 scopus 로고    scopus 로고
    • Estrogen deficiency, T cells and bone loss
    • Pacifici R, (2008) Estrogen deficiency, T cells and bone loss. Cell Immunol 252: 68-80.
    • (2008) Cell Immunol , vol.252 , pp. 68-80
    • Pacifici, R.1
  • 18
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F, (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4: 337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 20
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF, (2001) Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem 276: 37672-37679.
    • (2001) J Biol Chem , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 21
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27: 68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5
  • 22
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY, (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 23
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S, (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 25
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10
    • Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA, (2004) Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 172: 5213-5221.
    • (2004) J Immunol , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 26
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, et al. (1998) Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10: 1969-1980.
    • (1998) Int Immunol , vol.10 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3    Sakaguchi, N.4    Itoh, M.5
  • 27
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S, (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6: 345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 28
    • 0038783387 scopus 로고    scopus 로고
    • Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10
    • Asseman C, Read S, Powrie F, (2003) Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol 171: 971-978.
    • (2003) J Immunol , vol.171 , pp. 971-978
    • Asseman, C.1    Read, S.2    Powrie, F.3
  • 29
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li MO, Sanjabi S, Flavell RA, (2006) Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and-independent mechanisms. Immunity 25: 455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 31
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, et al. (2007) The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450: 566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5
  • 32
    • 75649130405 scopus 로고    scopus 로고
    • Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells
    • Paterson AM, Sharpe AH, (2010) Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells. Nat Immunol 11: 109-111.
    • (2010) Nat Immunol , vol.11 , pp. 109-111
    • Paterson, A.M.1    Sharpe, A.H.2
  • 33
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ, (2007) CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 8: 1353-1362.
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 34
    • 33747143361 scopus 로고    scopus 로고
    • From vanilla to 28 flavors: multiple varieties of T regulatory cells
    • Shevach EM, (2006) From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 25: 195-201.
    • (2006) Immunity , vol.25 , pp. 195-201
    • Shevach, E.M.1
  • 35
    • 67650699325 scopus 로고    scopus 로고
    • Treating autoimmune disease by targeting CD8(+) T suppressor cells
    • Konya C, Goronzy JJ, Weyand CM, (2009) Treating autoimmune disease by targeting CD8(+) T suppressor cells. Expert Opin Biol Ther 9: 951-965.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 951-965
    • Konya, C.1    Goronzy, J.J.2    Weyand, C.M.3
  • 38
    • 51549118939 scopus 로고    scopus 로고
    • The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells
    • Sharabi A, Mozes E, (2008) The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells. J Immunol 181: 3243-3251.
    • (2008) J Immunol , vol.181 , pp. 3243-3251
    • Sharabi, A.1    Mozes, E.2
  • 39
    • 37249067503 scopus 로고    scopus 로고
    • CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer
    • Kiniwa Y, Miyahara Y, Wang HY, Peng W, Peng G, et al. (2007) CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res 13: 6947-6958.
    • (2007) Clin Cancer Res , vol.13 , pp. 6947-6958
    • Kiniwa, Y.1    Miyahara, Y.2    Wang, H.Y.3    Peng, W.4    Peng, G.5
  • 40
    • 34250222393 scopus 로고    scopus 로고
    • CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    • Singh RP, La Cava A, Wong M, Ebling F, Hahn BH, (2007) CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J Immunol 178: 7649-7657.
    • (2007) J Immunol , vol.178 , pp. 7649-7657
    • Singh, R.P.1    La Cava, A.2    Wong, M.3    Ebling, F.4    Hahn, B.H.5
  • 41
    • 77951882989 scopus 로고    scopus 로고
    • Reversal of autoimmunity by boosting memory-like autoregulatory T cells
    • Tsai S, Shameli A, Yamanouchi J, Clemente-Casares X, Wang J, et al. (2010) Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32: 568-580.
    • (2010) Immunity , vol.32 , pp. 568-580
    • Tsai, S.1    Shameli, A.2    Yamanouchi, J.3    Clemente-Casares, X.4    Wang, J.5
  • 42
    • 34548058081 scopus 로고    scopus 로고
    • Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions
    • Kiesel J, Miller C, Abu-Amer Y, Aurora R, (2007) Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions. Dev Dyn 236: 2181-2197.
    • (2007) Dev Dyn , vol.236 , pp. 2181-2197
    • Kiesel, J.1    Miller, C.2    Abu-Amer, Y.3    Aurora, R.4
  • 43
    • 77955475327 scopus 로고    scopus 로고
    • Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells
    • Li H, Hong S, Qian J, Zheng Y, Yang J, et al. (2010) Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood 116: 210-217.
    • (2010) Blood , vol.116 , pp. 210-217
    • Li, H.1    Hong, S.2    Qian, J.3    Zheng, Y.4    Yang, J.5
  • 44
    • 66949172165 scopus 로고    scopus 로고
    • Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells
    • Kiesel JR, Buchwald ZS, Aurora R, (2009) Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells. J Immunol 182: 5477-5487.
    • (2009) J Immunol , vol.182 , pp. 5477-5487
    • Kiesel, J.R.1    Buchwald, Z.S.2    Aurora, R.3
  • 45
    • 34247581650 scopus 로고    scopus 로고
    • Signaling crosstalk between RANKL and interferons in osteoclast differentiation
    • Takayanagi H, Kim S, Taniguchi T, (2002) Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res 4 (Suppl 3): S227-232.
    • (2002) Arthritis Res , vol.4 , Issue.SUPPL. 3
    • Takayanagi, H.1    Kim, S.2    Taniguchi, T.3
  • 46
    • 0034610060 scopus 로고    scopus 로고
    • Interferon-gamma directly inhibits TRANCE-induced osteoclastogenesis
    • Fox SW, Chambers TJ, (2000) Interferon-gamma directly inhibits TRANCE-induced osteoclastogenesis. Biochem Biophys Res Commun 276: 868-872.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 868-872
    • Fox, S.W.1    Chambers, T.J.2
  • 47
    • 1842370348 scopus 로고    scopus 로고
    • Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity
    • van't Hof RJ, Ralston SH, (1997) Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity. J Bone Miner Res 12: 1797-1804.
    • (1997) J Bone Miner Res , vol.12 , pp. 1797-1804
    • van't Hof, R.J.1    Ralston, S.H.2
  • 49
    • 37149026641 scopus 로고    scopus 로고
    • Treg cells suppress osteoclast formation: A new link between the immune system and bone
    • Zaiss MM, Axmann R, Zwerina J, Polzer K, Guckel E, et al. (2007) Treg cells suppress osteoclast formation: A new link between the immune system and bone. Arthritis Rheum 56: 4104-4112.
    • (2007) Arthritis Rheum , vol.56 , pp. 4104-4112
    • Zaiss, M.M.1    Axmann, R.2    Zwerina, J.3    Polzer, K.4    Guckel, E.5
  • 50
    • 8444225359 scopus 로고    scopus 로고
    • The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis
    • Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, et al. (2004) The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. Bone 35: 1059-1068.
    • (2004) Bone , vol.35 , pp. 1059-1068
    • Nagahama, K.1    Aoki, K.2    Nonaka, K.3    Saito, H.4    Takahashi, M.5
  • 51
    • 0038377650 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene
    • Cheung J, Mak YT, Papaioannou S, Evans BA, Fogelman I, et al. (2003) Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene. J Endocrinol 177: 423-433.
    • (2003) J Endocrinol , vol.177 , pp. 423-433
    • Cheung, J.1    Mak, Y.T.2    Papaioannou, S.3    Evans, B.A.4    Fogelman, I.5
  • 52
    • 33847370194 scopus 로고    scopus 로고
    • Regulatory T cells dynamically control the primary immune response to foreign antigen
    • Haribhai D, Lin W, Relland LM, Truong N, Williams CB, et al. (2007) Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol 178: 2961-2972.
    • (2007) J Immunol , vol.178 , pp. 2961-2972
    • Haribhai, D.1    Lin, W.2    Relland, L.M.3    Truong, N.4    Williams, C.B.5
  • 53
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • Lin W, Haribhai D, Relland LM, Truong N, Carlson MR, et al. (2007) Regulatory T cell development in the absence of functional Foxp3. Nat Immunol 8: 359-368.
    • (2007) Nat Immunol , vol.8 , pp. 359-368
    • Lin, W.1    Haribhai, D.2    Relland, L.M.3    Truong, N.4    Carlson, M.R.5
  • 54
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5
  • 55
    • 33947644716 scopus 로고    scopus 로고
    • Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson TS, DiPaolo RJ, Andersson J, Shevach EM, (2007) Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 178: 4022-4026.
    • (2007) J Immunol , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    DiPaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 56
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-5153.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5
  • 57
    • 0028324095 scopus 로고
    • Osteoclast synthesis and secretion and activation of latent transforming growth factor beta
    • Oursler MJ, (1994) Osteoclast synthesis and secretion and activation of latent transforming growth factor beta. J Bone Miner Res 9: 443-452.
    • (1994) J Bone Miner Res , vol.9 , pp. 443-452
    • Oursler, M.J.1
  • 58
    • 0031046958 scopus 로고    scopus 로고
    • Effects of retinol on activation of latent transforming growth factor-beta by isolated osteoclasts
    • Bonewald LF, Oreffo RO, Lee CH, Park-Snyder S, Twardzik D, et al. (1997) Effects of retinol on activation of latent transforming growth factor-beta by isolated osteoclasts. Endocrinology 138: 657-666.
    • (1997) Endocrinology , vol.138 , pp. 657-666
    • Bonewald, L.F.1    Oreffo, R.O.2    Lee, C.H.3    Park-Snyder, S.4    Twardzik, D.5
  • 59
  • 60
    • 0037077212 scopus 로고    scopus 로고
    • Proteolysis of latent transforming growth factor-beta (TGF-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix
    • Dallas SL, Rosser JL, Mundy GR, Bonewald LF, (2002) Proteolysis of latent transforming growth factor-beta (TGF-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix. J Biol Chem 277: 21352-21360.
    • (2002) J Biol Chem , vol.277 , pp. 21352-21360
    • Dallas, S.L.1    Rosser, J.L.2    Mundy, G.R.3    Bonewald, L.F.4
  • 61
    • 0033899812 scopus 로고    scopus 로고
    • A role for TGFbeta(1) in osteoclast differentiation and survival
    • Fuller K, Lean JM, Bayley KE, Wani MR, Chambers TJ, (2000) A role for TGFbeta(1) in osteoclast differentiation and survival. J Cell Sci 113 (Pt 13): 2445-2453.
    • (2000) J Cell Sci , vol.113 , Issue.Pt 13 , pp. 2445-2453
    • Fuller, K.1    Lean, J.M.2    Bayley, K.E.3    Wani, M.R.4    Chambers, T.J.5
  • 62
    • 1242318796 scopus 로고    scopus 로고
    • Fluorescence-based staining for tartrate-resistant acidic phosphatase (TRAP) in osteoclasts combined with other fluorescent dyes and protocols
    • Filgueira L, (2004) Fluorescence-based staining for tartrate-resistant acidic phosphatase (TRAP) in osteoclasts combined with other fluorescent dyes and protocols. J Histochem Cytochem 52: 411-414.
    • (2004) J Histochem Cytochem , vol.52 , pp. 411-414
    • Filgueira, L.1
  • 63
    • 79954423688 scopus 로고    scopus 로고
    • IFN-gamma directly inhibits TNF-alpha-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions
    • Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, et al. (2011) IFN-gamma directly inhibits TNF-alpha-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. Immunol Lett 137: 53-61.
    • (2011) Immunol Lett , vol.137 , pp. 53-61
    • Kohara, H.1    Kitaura, H.2    Fujimura, Y.3    Yoshimatsu, M.4    Morita, Y.5
  • 64
    • 79960472059 scopus 로고    scopus 로고
    • Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis
    • Huang X, Yokota T, Iwata J, Chai Y, (2011) Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis. J Dent Res 90: 981-987.
    • (2011) J Dent Res , vol.90 , pp. 981-987
    • Huang, X.1    Yokota, T.2    Iwata, J.3    Chai, Y.4
  • 65
    • 79960037004 scopus 로고    scopus 로고
    • IL-18 mediates proapoptotic signaling in renal tubular cells through a Fas ligand-dependent mechanism
    • Zhang H, Hile KL, Asanuma H, Vanderbrink B, Franke EI, et al. (2011) IL-18 mediates proapoptotic signaling in renal tubular cells through a Fas ligand-dependent mechanism. Am J Physiol Renal Physiol 301: F171-178.
    • (2011) Am J Physiol Renal Physiol , vol.301
    • Zhang, H.1    Hile, K.L.2    Asanuma, H.3    Vanderbrink, B.4    Franke, E.I.5
  • 66
    • 78650239453 scopus 로고    scopus 로고
    • Osteoclast motility: putting the brakes on bone resorption
    • Novack DV, Faccio R, (2011) Osteoclast motility: putting the brakes on bone resorption. Ageing Res Rev 10: 54-61.
    • (2011) Ageing Res Rev , vol.10 , pp. 54-61
    • Novack, D.V.1    Faccio, R.2
  • 67
    • 77649223348 scopus 로고    scopus 로고
    • Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae
    • Soysa NS, Alles N, Aoki K, Ohya K, (2009) Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae. J Med Dent Sci 56: 107-112.
    • (2009) J Med Dent Sci , vol.56 , pp. 107-112
    • Soysa, N.S.1    Alles, N.2    Aoki, K.3    Ohya, K.4
  • 68
    • 55249119822 scopus 로고    scopus 로고
    • The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly
    • Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, et al. (2007) The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS One 2: e179.
    • (2007) PLoS One , vol.2
    • Luxenburg, C.1    Geblinger, D.2    Klein, E.3    Anderson, K.4    Hanein, D.5
  • 69
    • 0034725639 scopus 로고    scopus 로고
    • Signaling by covalent heterodimers of interferon-gamma. Evidence for one-sided signaling in the active tetrameric receptor complex
    • Krause CD, Lunn CA, Izotova LS, Mirochnitchenko O, Kotenko SV, et al. (2000) Signaling by covalent heterodimers of interferon-gamma. Evidence for one-sided signaling in the active tetrameric receptor complex. J Biol Chem 275: 22995-23004.
    • (2000) J Biol Chem , vol.275 , pp. 22995-23004
    • Krause, C.D.1    Lunn, C.A.2    Izotova, L.S.3    Mirochnitchenko, O.4    Kotenko, S.V.5
  • 70
    • 58149459512 scopus 로고    scopus 로고
    • Osteoimmunology-the hidden immune regulation of bone
    • Caetano-Lopes J, Canhao H, Fonseca JE, (2009) Osteoimmunology-the hidden immune regulation of bone. Autoimmun Rev 8: 250-255.
    • (2009) Autoimmun Rev , vol.8 , pp. 250-255
    • Caetano-Lopes, J.1    Canhao, H.2    Fonseca, J.E.3
  • 71
  • 72
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi H, (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7: 292-304.
    • (2007) Nat Rev Immunol , vol.7 , pp. 292-304
    • Takayanagi, H.1
  • 73
    • 57649099846 scopus 로고    scopus 로고
    • CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
    • Aandahl EM, Torgersen KM, Tasken K, (2008) CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype? Hum Immunol 69: 696-699.
    • (2008) Hum Immunol , vol.69 , pp. 696-699
    • Aandahl, E.M.1    Torgersen, K.M.2    Tasken, K.3
  • 74
    • 57649095902 scopus 로고    scopus 로고
    • Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3gamma1 (Ala-Ala)
    • Ablamunits V, Herold KC, (2008) Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3gamma1 (Ala-Ala). Hum Immunol 69: 732-736.
    • (2008) Hum Immunol , vol.69 , pp. 732-736
    • Ablamunits, V.1    Herold, K.C.2
  • 75
    • 0036828289 scopus 로고    scopus 로고
    • Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
    • Allez M, Brimnes J, Dotan I, Mayer L, (2002) Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 123: 1516-1526.
    • (2002) Gastroenterology , vol.123 , pp. 1516-1526
    • Allez, M.1    Brimnes, J.2    Dotan, I.3    Mayer, L.4
  • 76
    • 33751231701 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells: Current controversies and future perspectives
    • Banham AH, Powrie FM, Suri-Payer E, (2006) FOXP3+ regulatory T cells: Current controversies and future perspectives. Eur J Immunol 36: 2832-2836.
    • (2006) Eur J Immunol , vol.36 , pp. 2832-2836
    • Banham, A.H.1    Powrie, F.M.2    Suri-Payer, E.3
  • 77
    • 17844363998 scopus 로고    scopus 로고
    • Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease
    • Brimnes J, Allez M, Dotan I, Shao L, Nakazawa A, et al. (2005) Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J Immunol 174: 5814-5822.
    • (2005) J Immunol , vol.174 , pp. 5814-5822
    • Brimnes, J.1    Allez, M.2    Dotan, I.3    Shao, L.4    Nakazawa, A.5
  • 78
    • 0037239885 scopus 로고    scopus 로고
    • Regulatory CD8+CD28- T cells in heart transplant recipients
    • Colovai AI, Mirza M, Vlad G, Wang S, Ho E, et al. (2003) Regulatory CD8+CD28- T cells in heart transplant recipients. Hum Immunol 64: 31-37.
    • (2003) Hum Immunol , vol.64 , pp. 31-37
    • Colovai, A.I.1    Mirza, M.2    Vlad, G.3    Wang, S.4    Ho, E.5
  • 79
    • 77951712594 scopus 로고    scopus 로고
    • Role of CD8+ CD25+ Foxp3+ regulatory T cells in multiple sclerosis
    • Correale J, Villa A, (2010) Role of CD8+ CD25+ Foxp3+ regulatory T cells in multiple sclerosis. Ann Neurol 67: 625-638.
    • (2010) Ann Neurol , vol.67 , pp. 625-638
    • Correale, J.1    Villa, A.2
  • 81
    • 57649083400 scopus 로고    scopus 로고
    • Qa-1/HLA-E-restricted regulatory CD8+ T cells and self-nonself discrimination: an essay on peripheral T-cell regulation
    • Jiang H, Chess L, (2008) Qa-1/HLA-E-restricted regulatory CD8+ T cells and self-nonself discrimination: an essay on peripheral T-cell regulation. Hum Immunol 69: 721-727.
    • (2008) Hum Immunol , vol.69 , pp. 721-727
    • Jiang, H.1    Chess, L.2
  • 82
    • 33846250032 scopus 로고    scopus 로고
    • Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
    • Kared H, Adle-Biassette H, Fois E, Masson A, Bach JF, et al. (2006) Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity 25: 823-834.
    • (2006) Immunity , vol.25 , pp. 823-834
    • Kared, H.1    Adle-Biassette, H.2    Fois, E.3    Masson, A.4    Bach, J.F.5
  • 83
    • 0034122206 scopus 로고    scopus 로고
    • In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation
    • Kezuka T, Streilein JW, (2000) In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 41: 1803-1811.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 1803-1811
    • Kezuka, T.1    Streilein, J.W.2
  • 84
    • 33646371011 scopus 로고    scopus 로고
    • Foxp3 expressing CD4+ CD25+ and CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma
    • Meloni F, Morosini M, Solari N, Passadore I, Nascimbene C, et al. (2006) Foxp3 expressing CD4+ CD25+ and CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma. Hum Immunol 67: 1-12.
    • (2006) Hum Immunol , vol.67 , pp. 1-12
    • Meloni, F.1    Morosini, M.2    Solari, N.3    Passadore, I.4    Nascimbene, C.5
  • 85
    • 45449108015 scopus 로고    scopus 로고
    • Emerging concepts in CD8(+) T regulatory cells
    • Niederkorn JY, (2008) Emerging concepts in CD8(+) T regulatory cells. Curr Opin Immunol 20: 327-331.
    • (2008) Curr Opin Immunol , vol.20 , pp. 327-331
    • Niederkorn, J.Y.1
  • 87
    • 34249806715 scopus 로고    scopus 로고
    • Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses
    • Stephens GL, Andersson J, Shevach EM, (2007) Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol 178: 6901-6911.
    • (2007) J Immunol , vol.178 , pp. 6901-6911
    • Stephens, G.L.1    Andersson, J.2    Shevach, E.M.3
  • 88
    • 79951804510 scopus 로고    scopus 로고
    • CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity
    • Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, et al. (2011) CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immunol 41: 716-725.
    • (2011) Eur J Immunol , vol.41 , pp. 716-725
    • Mayer, C.T.1    Floess, S.2    Baru, A.M.3    Lahl, K.4    Huehn, J.5
  • 89
    • 46049087498 scopus 로고    scopus 로고
    • Th17 cells and rheumatoid arthritis-from the standpoint of osteoclast differentiation
    • Sato K, (2008) Th17 cells and rheumatoid arthritis-from the standpoint of osteoclast differentiation. Allergol Int 57: 109-114.
    • (2008) Allergol Int , vol.57 , pp. 109-114
    • Sato, K.1
  • 90
    • 70049095101 scopus 로고    scopus 로고
    • How do regulatory T cells work?
    • Corthay A, (2009) How do regulatory T cells work? Scand J Immunol 70: 326-336.
    • (2009) Scand J Immunol , vol.70 , pp. 326-336
    • Corthay, A.1
  • 92
    • 56349142989 scopus 로고    scopus 로고
    • Bone remodelling: its local regulation and the emergence of bone fragility
    • Martin TJ, Seeman E, (2008) Bone remodelling: its local regulation and the emergence of bone fragility. Best Pract Res Clin Endocrinol Metab 22: 701-722.
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 701-722
    • Martin, T.J.1    Seeman, E.2
  • 93
    • 42749088910 scopus 로고    scopus 로고
    • Osteoclast-osteoblast communication
    • Matsuo K, Irie N, (2008) Osteoclast-osteoblast communication. Arch Biochem Biophys 473: 201-209.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 201-209
    • Matsuo, K.1    Irie, N.2
  • 94
    • 33645103515 scopus 로고    scopus 로고
    • The hematopoietic stem cell in its place
    • Adams GB, Scadden DT, (2006) The hematopoietic stem cell in its place. Nat Immunol 7: 333-337.
    • (2006) Nat Immunol , vol.7 , pp. 333-337
    • Adams, G.B.1    Scadden, D.T.2
  • 95
    • 33646448451 scopus 로고    scopus 로고
    • Regulation of hematopoiesis and its interaction with stem cell niches
    • Arai F, Hirao A, Suda T, (2005) Regulation of hematopoiesis and its interaction with stem cell niches. Int J Hematol 82: 371-376.
    • (2005) Int J Hematol , vol.82 , pp. 371-376
    • Arai, F.1    Hirao, A.2    Suda, T.3
  • 96
    • 34547194164 scopus 로고    scopus 로고
    • The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny
    • Badillo AT, Flake AW, (2006) The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny. Stem Cell Rev 2: 241-246.
    • (2006) Stem Cell Rev , vol.2 , pp. 241-246
    • Badillo, A.T.1    Flake, A.W.2
  • 97
    • 26444446918 scopus 로고    scopus 로고
    • Stem cell regulation by the hematopoietic stem cell niche
    • Haylock DN, Nilsson SK, (2005) Stem cell regulation by the hematopoietic stem cell niche. Cell Cycle 4: 1353-1355.
    • (2005) Cell Cycle , vol.4 , pp. 1353-1355
    • Haylock, D.N.1    Nilsson, S.K.2
  • 98
    • 34247889894 scopus 로고    scopus 로고
    • The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization
    • Kollet O, Dar A, Lapidot T, (2007) The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization. Annu Rev Immunol 25: 51-69.
    • (2007) Annu Rev Immunol , vol.25 , pp. 51-69
    • Kollet, O.1    Dar, A.2    Lapidot, T.3
  • 99
    • 33744983304 scopus 로고    scopus 로고
    • Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
    • Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, et al. (2006) Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med 12: 657-664.
    • (2006) Nat Med , vol.12 , pp. 657-664
    • Kollet, O.1    Dar, A.2    Shivtiel, S.3    Kalinkovich, A.4    Lapid, K.5
  • 100
    • 0024553650 scopus 로고
    • Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification
    • Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L, (1989) Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. J Immunol 142: 1536-1541.
    • (1989) J Immunol , vol.142 , pp. 1536-1541
    • Dasch, J.R.1    Pace, D.R.2    Waegell, W.3    Inenaga, D.4    Ellingsworth, L.5
  • 101
    • 70349116967 scopus 로고    scopus 로고
    • Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss
    • Tomimori Y, Mori K, Koide M, Nakamichi Y, Ninomiya T, et al. (2009) Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss. J Bone Miner Res 24: 1194-1205.
    • (2009) J Bone Miner Res , vol.24 , pp. 1194-1205
    • Tomimori, Y.1    Mori, K.2    Koide, M.3    Nakamichi, Y.4    Ninomiya, T.5


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