Qa-1/HLA-E-restricted regulatory CD8+ T cells and self-nonself discrimination: An essay on peripheral T-cell regulation

Human Immunology

Volumn 69, Issue 11, 2008, Pages 721-727

  Jiang, Hong ^a   Chess, Leonard ^a  

^a Columbia University ^*  (United States)

Author keywords

Avidity of T cell activation; Immunologically relevant clinical problems; Peripheral T cell regulation; Qa 1 HLA E restricted CD8+ T cells; Self nonself discrimination

Indexed keywords

HLA E ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADAPTIVE IMMUNITY; ALLERGY; ARTICLE; AUTOIMMUNE DISEASE; CD8+ T LYMPHOCYTE; CELL SELECTION; CONCEPTUAL FRAMEWORK; CORRELATION ANALYSIS; DOWN REGULATION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOPATHOLOGY; IMMUNOREGULATION; INFECTION; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THYMUS; TRANSPLANTATION TOLERANCE; TUMOR;

CD8-POSITIVE T-LYMPHOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 57649083400     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.08.279     Document Type: Article

References (53)

1. Cohn M. Whither T-suppressors: If they didn't exist would we have to invent them?. Cell Immunol 227 (2004) 81-92
2. Jiang H., and Chess L. Regulation of immune responses by T cells. N Engl J Med 354 (2006) 1166-1176
3. Jiang H., and Chess L. The specific regulation of immune responses by CD8+ T cells restricted by the MHC class IB molecule, QA-1. Annu Rev Immunol 18 (2000) 185-216
4. Jiang H., Wu Y., Liang B., Zheng Z., Tang G., Kanellopoulos J., et al. An affinity/avidity model of peripheral T cell regulation. J Clin Invest 115 (2005) 302-312
5. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22 (2004) 531-562
6. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6 (2005) 345-352
7. Fontenot J.D., and Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 6 (2005) 331-337
8. Jaeckel E., Kretschmer K., Apostolou I., and von Boehmer H. Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity. Semin Immunol 18 (2006) 89-92
9. Khattri R., Cox T., Yasayko S.A., and Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4 (2003) 337-342
10. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
11. Kretschmer K., Apostolou I., Hawiger D., Khazaie K., Nussenzweig M.C., and von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 6 (2005) 1219-1227
12. Zuo T., Wang L., Morrison C., Chang X., Zhang H., and Li W. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129 (2007) 1275-1286
13. Hansen S., and Leslie R.G. TGN1412: Scrutinizing preclinical trials of antibody-based medicines. Nature 441 (2006) 282
14. TGN1412. Drugs tests on trial. Nature 440 (2006) 970
15. Suntharalingam G., Perry M.R., Ward S., Brett S.J., Castello-Cortes A., Brunner M.D., and Panoskaltsis N. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355 (2006) 1018-1028
16. Burnet M, Fenner F. Production of Antibodies. McMillan, Melbourne, Australia 1949.
17. Billingham R.E., Brent L., and Medawar P.B. Actively acquired tolerance of foreign cells. Nature 172 (1953) 603-606
18. Bevan M.J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269 (1977) 417-418
19. Waldmann H. The influence of the major histocompatibility complex on the function of T-helper cells in antibody formation. Immunol Rev 42 (1978) 202-223
20. Zinkernagel R.M. Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control. Immunol Rev 42 (1978) 224-270
21. von Boehmer H., and Kisielow P. Self-nonself discrimination by T cells. Science 248 (1990) 1369-1373
22. Kappler J.W., Roehm N., and Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 49 (1987) 273-280
23. Hengartner H., Odermatt B., Schneider R., Schreyer M., Walle G., MacDonald H.R., and Zinkernagel R.M. Deletion of self-reactive T cells before entry into the thymus medulla. Nature 336 (1988) 388-390
24. Pircher H., Rohrer U.H., Moskophidis D., Zinkernagel R.M., and Hengartner H. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351 (1991) 482-485
25. Bouneaud C., Kourilsky P., and Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion. Immunity 13 (2000) 829-840
26. Sandberg J.K., Franksson L., Sundback J., Michaelsson J., Petersson M., Achour A., et al. T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity. J Immunol 165 (2000) 25-33
27. Jiang H., Curran S., Ruiz-Vazquez E., Liang B., Winchester R., and Chess L. Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 100 (2003) 8378-8383
28. Anderton S.M., Radu C.G., Lowrey P.A., Ward E.S., and Wraith D.C. Negative selection during the peripheral immune response to antigen. J Exp Med 193 (2001) 1-11
29. Han B., Serra P., Yamanouchi J., Amrani A., Elliott J.F., Dickie P., Dilorenzo T.P., and Santamaria P. Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes. J Clin Invest 115 (2005) 1879-1887
30. Zehn D., and Bevan M.J. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25 (2006) 261-270
31. Jiang H., Zhang S.I., and Pernis B. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 256 (1992) 1213-1215
32. Koh D.-R., Fung-Leung W.-P., Ho A., Gray D., Acha-Orbea H., and Mak T.-W. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science 256 (1992) 1210-1213
33. Jiang H., Ware R., Stall A., Flaherty L., Chess L., and Pernis B. Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing V beta 8 TCR: A role of the Qa-1 molecule. Immunity 2 (1995) 185-194
34. Jiang H., Kashleva H., Xu L.X., Forman J., Flaherty L., Pernis B., et al. T cell vaccination induces T cell receptor, Vbeta-specific Qa-1-frestricted regulatory CD8(+) T cells. Proc Natl Acad Sci U S A 95 (1998) 4533-4537
35. Jiang H., Braunstein N.S., Yu B., Winchester R., and Chess L. CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Natl Acad Sci U S A 98 (2001) 6301-6306
36. Hu D., Ikizawa K., Lu L., Sanchirico M.E., Shinohara M.L., and Cantor H. Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol 5 (2004) 516-523
37. Chen W., Zhang L., Liang B., Saenger Y., Li J., Ches L., and Jiang H. Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation. Proc Natl Acad Sci U S A 104 (2007) 20472-20477
38. Ware R., Jiang H., Braunstein N., Kent J., Wiener E., Pernis B., and Chess L. Human CD8+ T lymphocyte clones specific for T cell receptor V beta families expressed on autologous CD4+ T cells. Immunity 2 (1995) 177-184
39. Li J., Goldstein I., Glickman-Nir E., Jiang H., and Chess L. Induction of TCR Vbeta- specific CD8+ CTLs by TCR Vbeta-derived peptides bound to HLA-E. J Immunol 167 (2001) 3800-3808
40. Bach J.F. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347 (2002) 911-920
41. Tao X., Constant S., Jorritsma P., and Bottomly K. Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol 159 (1997) 5956-5963
42. Leitenberg D., and Bottomly K. Regulation of naive T cell differentiation by varying the potency of TCR signal transduction. Semin Immunol 11 (1999) 283-292
43. Brogdon J.L., Leitenberg D., and Bottomly K. The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol 168 (2002) 3825-3832
44. Miller A.T., Wilcox H.M., Lai Z., and Berg L.J. Signaling through ltk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 21 (2004) 67-80
45. Martins T.C., and Aguas A.P. A role for CD45RBlow CD38+ T cells and costimulatory pathways of T-cell activation in protection of non-obese diabetic (NOD) mice from diabetes. Immunology 96 (1999) 600-605
46. Lehmann D., and Ben-Nun A. Bacterial agents protect against autoimmune disease. I. Mice pre-exposed to Bordetella pertussis or Mycobacterium tuberculosis are highly refractory to induction of experimental autoimmune encephalomyelitis. J Autoimmun 5 (1992) 675-690
47. Hempel K., Freitag A., Freitag B., Endres B., Mai B., and Liebaldt G. Unresponsiveness to experimental allergic encephalomyelitis in Lewis rats pretreated with complete Freund's adjuvant. Int Arch Allergy Appl Immunol 76 (1985) 193-199
48. Greenwood B.M., Herrick E.M., and Voller A. Suppression of autoimmune disease in NZB and (NZB × NZW) F1 hybrid mice by infection with malaria. Nature 226 (1970) 266-267
49. Oldstone M.B., and Dixon F.J. Inhibition of antibodies to nuclear antigen and to DNA in New Zealand mice infected with lactate dehydrogenase virus. Science 175 (1972) 784-786
50. Hansen G., Yeung V.P., Berry G., Umetsu D.T., and DeKruyff R.H. Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced, airway hyperreactivity and inflammation: Role of CD8+ T cells and IL-18. J Immunol 164 (2000) 223-230
51. Zuany-Amorim C., Manlius C., Trifilieff A., Brunet L.R., Rook G., Bowen G., Pay G., and Walker C. Long-term protective and antigen-specific effect of heat-killed Mycobacterium vaccae in a murine model of allergic pulmonary inflammation. J Immunol 169 (2002) 1492-1499
52. Zuany-Amorim C., Sawicka E., Manlius C., Le Moine A., Brunet L.R., Kemeny D.M., et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med 8 (2002) 625-629
53. Pardoll D. Does the immune system see tumors as foreign or self?. Annu Rev Immunol 21 (2003) 807-839