Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae

Journal of Medical and Dental Sciences

Volumn 56, Issue 3, 2009, Pages 107-112

  Soysa, Niroshani Surangika ^a   Alles, Neil ^a   Aoki, Kazuhiro ^a   Ohya, Keiichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

3 D measurement; Confocal microscope; Osteoclast

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; BIOLOGICAL MARKER; COLECALCIFEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOENZYME; NBD PEPTIDE, MOUSE; PEPTIDE; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANIMAL; ARTICLE; BONE MARROW CELL; CELL CULTURE; COCULTURE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; DENTIN; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MOUSE; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PATHOLOGY; THREE DIMENSIONAL IMAGING;

ACID PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; BONE RESORPTION; CELLS, CULTURED; CHOLECALCIFEROL; COCULTURE TECHNIQUES; DENTIN; DOSE-RESPONSE RELATIONSHIP, DRUG; IMAGING, THREE-DIMENSIONAL; ISOENZYMES; MICE; MICE, INBRED ICR; MICROSCOPY, CONFOCAL; NF-KAPPA B; OSTEOBLASTS; OSTEOCLASTS; PEPTIDES;

EID: 77649223348     PISSN: 13428810     EISSN: 13428810     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Jones SJ, Boyde A. Histomorphometry of Howship's lacunae formed in vivo and in vitro: depths and volumes measured by scanning electron and confocal microscopy. Bone 1993; 14:455-460.
2. Boyde A, Jones SJ. Pitfalls in pit measurement. Calcif Tissue Int 1991; 49:65-70.
3. Walsh CA, Beresford JN, Birch MA, et al. Application of reflected light microscopy to identify and quantitate resorption by isolated osteoclasts. J Bone Miner Res 1991; 6:661-671.
4. Jimi E, Aoki K, Saito H, et al. Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004; 10:617-624.
5. Soysa NS, Alles N, Shimokawa H, et al. Inhibition of the classical NF-kappaB pathway prevents osteoclast bone- resorbing activity. J Bone Miner Metab 2009; 27:131-139.
6. Yamada Y, Itoh A, Sakane M, et al. Laser microscopic measurement of osteoclastic resorption pits on biomaterials. Materials Science & Engineering C 2007; 27:762-766.
7. Varghese BJ, Aoki K, Shimokawa H, et al. Bovine deciduous dentine is more susceptible to osteoclastic resorption than permanent dentine: results of quantitative analyses. J Bone Miner Metab 2006; 24:248-254.
8. Taylor ML, Maconnachie E, Frank K, et al. The effect of fluoride on the resorption of dentine by osteoclasts in vitro. J Bone Miner Res 1990; 5 Suppl 1:S121-130.
9. Saito H, Soysa N, Alles N, et al. Three-Dimensional measurements of Bone Resorption Lacunae Reveal Inhibition of Osteoclast Activity by TNF-α Antagonists In vitro. Dentistry In Japan 2006; 42:35-37.
10. Sato K, Suematsu A, Nakashima T, et al. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 2006; 12:1410-1416.
11. Asagiri M, Hirai T, Kunigami T, et al. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science 2008; 319:624-627.
12. Gil-Henn H, Destaing O, Sims NA, et al. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2 (-/-) mice. J Cell Biol 2007; 178:1053-1064.
13. Aoki K, Saito H, Itzstein C, et al. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest 2006; 116:1525-1534.