A role for TGFβ1 in osteoclast differentiation and survival

Journal of Cell Science

Volumn 113, Issue 13, 2000, Pages 2445-2453

  Fuller, K ^a   Lean, J M ^a   Bayley, K E ^a   Wani, M R ^a   Chambers, T J ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bone matrix; Bone resorption; Osteoclast; RANKL; TGF

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOKINE; OSTEOCLAST DIFFERENTIATION FACTOR; RECOMBINANT RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW; BONE MATRIX; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; MONOCYTE; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL;

ANIMALIA;

EID: 0033899812     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
2. Modulation of macrophage function by transforming growth factor β, interleukin-4, and interleukin-10
3. Role of active and latent transforming growth factor β in bone formation
4. Role of transforming growth factor-beta in bone remodeling
5. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
6. Histochemical demonstration of acid phosphatases with naphthol AS-phosphate
7. Transforming growth factor-β gene family members and bone
8. Regulation of osteoclast development and function
9. Transforming growth factor β inhibits formation of osteoclast-like cells in long-term human marrow cultures
10. Single-step method of RNA isolation by acid guanidinium-thiocynate-phenol-chloroform extraction
11. Inhibiting and stimulating effects of TGF-β1 on osteoclastic bone resorption in fetal mouse bone organ cultures
12. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
13. Increased expression of TGF-β2 in osteoblasts results in an osteoporosis-like phenotype
14. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2 and PAF
15. Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts
16. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts
17. Other functions, other genes: Alternative activation of antigen-presenting cells
18. 1 on the regulation of osteoclastic development and function
19. Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose
20. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induved by osteoprotegerin ligand
21. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β
22. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function
23. Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur
24. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
25. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
26. Regulation of immune responses by TGF-β
27. In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice
28. The transforming growth factor-beta family
29. Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone
30. Activation-induced apoptosis in human macrophages: Developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon γ
31. Transforming growth factor-β1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells
32. Transforming growth factor-β primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism
33. In vivo stimulation of bone formation by transforming growth factor-β
34. Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines
35. Immunohistochemical localization of TGF-β1, TGF-β2, and TGF-β3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
36. Transforming growth factor beta inhibits resorption in fetal rat long bone cultures
37. Osteoblasts synthesize and respond to transforming growth factor-type β (TGF β) in vitro
38. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype
39. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
40. Enhanced expression of TGFβ and c-fos mRNA in the growth plates of developing human long bones
41. TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF
42. Cartilage-inducing factor-A: Apparent identity to transforming growth factor-β
43. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
44. Transorming growth factor-beta: Multiple actions and potential clinical applications
45. Modulation of osteoclast differentiation
46. Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells
47. α and β human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria
48. Deactivation of macrophages by transforming growth factor-β
49. The regulation of mononuclear phagocyte entry into S-phase by the colony stimulating factor CSF-1
50. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
51. Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes
52. 2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: Synergistic activation of differentiation, cell spreading, and fusion
53. Selective induction of Fc gamma RIII on human monocytes by transforming growth factor-beta
54. Macrophage phenotype regulation by colony-stimulating factors at bone marrow level
55. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
56. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
57. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and identical to TRANCE-RANKL