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Volumn 91, Issue 6, 2012, Pages 859-869

Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation

Author keywords

aCD40ab administration; CD4; CD40 CD40L pathway; Effector functions; Immune responses

Indexed keywords

CD4 ANTIGEN; CD40 ANTIBODY; CD40 ANTIGEN; CD40 LIGAND; IMMUNOMODULATING AGENT; UNCLASSIFIED DRUG;

EID: 84861946462     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0611292     Document Type: Article
Times cited : (12)

References (58)
  • 1
    • 75749134098 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation
    • Obar, J. J., Lefrançois, L. (2010) Memory CD8+ T cell differentiation. Ann. N. Y Acad. Sci. 1183, 251-266.
    • (2010) Ann. N. Y Acad. Sci. , vol.1183 , pp. 251-266
    • Obar, J.J.1    Lefrançois, L.2
  • 2
    • 33745097728 scopus 로고    scopus 로고
    • The Tower of Babel of CD8+ T-cell memory: Known facts, deserted roads, muddy waters, and possible dead ends
    • Rocha, B., Tanchot, C. (2006) The Tower of Babel of CD8+ T-cell memory: known facts, deserted roads, muddy waters, and possible dead ends. Immunol. Rev. 211, 182-196.
    • (2006) Immunol. Rev. , vol.211 , pp. 182-196
    • Rocha, B.1    Tanchot, C.2
  • 3
    • 77951684508 scopus 로고    scopus 로고
    • Shaping successful and unsuccessful CD8 T cell responses following infection
    • Cox, M. A., Zajac, A. J. (2010) Shaping successful and unsuccessful CD8 T cell responses following infection. J. Biomed. Biotechnol. 2010, 159152.
    • (2010) J. Biomed. Biotechnol. , vol.2010 , pp. 159152
    • Cox, M.A.1    Zajac, A.J.2
  • 5
    • 0037144612 scopus 로고    scopus 로고
    • A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    • Bourgeois, C., Rocha, B., Tanchot, C. (2002) A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297, 2060-2063.
    • (2002) Science , vol.297 , pp. 2060-2063
    • Bourgeois, C.1    Rocha, B.2    Tanchot, C.3
  • 7
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CD8 T cell memory
    • Shedlock, D. J., Shen, H. (2003) Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337-339.
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.J.1    Shen, H.2
  • 8
    • 0037432776 scopus 로고    scopus 로고
    • Defective CD8 T cell memory following acute infection without CD4 T cell help
    • Sun, J. C., Bevan, M. J. (2003) Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339-342.
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 9
    • 0347382468 scopus 로고    scopus 로고
    • Mini-review CD4 T cells are required for CD8 T cell memory generation
    • Bourgeois, C., Tanchot, C. (2003) Mini-review CD4 T cells are required for CD8 T cell memory generation. Eur. J. Immunol. 33, 3225-3231.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 3225-3231
    • Bourgeois, C.1    Tanchot, C.2
  • 10
    • 3543099130 scopus 로고    scopus 로고
    • Helping the CD8(+) T-cell response
    • Bevan, M. J. (2004) Helping the CD8(+) T-cell response. Nat. Rev. Immunol. 4, 595-602.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 595-602
    • Bevan, M.J.1
  • 11
    • 33646174117 scopus 로고    scopus 로고
    • Cooperation between CD4+ and CD8+ T cells: When, where, and how
    • Castellino, F., Germain, R. N. (2006) Cooperation between CD4+ and CD8+ T cells: when, where, and how. Annu. Rev. Immunol. 24, 519-540.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 519-540
    • Castellino, F.1    Germain, R.N.2
  • 12
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal, I. S., Flavell, R. A. (1998) CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16, 111-35.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 13
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge, J. P., Di Rosa, F., Matzinger, P. (1998) A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474-478.
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    di Rosa, F.2    Matzinger, P.3
  • 15
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R., Melief, C. J. (1998) T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    van der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 16
    • 0343938858 scopus 로고    scopus 로고
    • Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells
    • Lefrançois, L., Altman, J. D., Williams, K., Olson, S. (2000) Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells. J. Immunol. 164, 725-732.
    • (2000) J. Immunol. , vol.164 , pp. 725-732
    • Lefrançois, L.1    Altman, J.D.2    Williams, K.3    Olson, S.4
  • 17
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
    • Diehl, L., den Boer, A. T., Schoenberger, S. P., van der Voort, E. I., Schumacher, T. N., Melief, C. J., Offringa, R., Toes, R. E. (1999) CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat. Med. 5, 774-779.
    • (1999) Nat. Med. , vol.5 , pp. 774-779
    • Diehl, L.1    den Boer, A.T.2    Schoenberger, S.P.3    van der Voort, E.I.4    Schumacher, T.N.5    Melief, C.J.6    Offringa, R.7    Toes, R.E.8
  • 18
    • 38449121160 scopus 로고    scopus 로고
    • Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigeninduced pancreatic tumors
    • Otahal, P., Knowles, B. B., Tevethia, S. S., Schell, T. D. (2007) Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigeninduced pancreatic tumors. J. Immunol. 179, 6686-6695.
    • (2007) J. Immunol. , vol.179 , pp. 6686-6695
    • Otahal, P.1    Knowles, B.B.2    Tevethia, S.S.3    Schell, T.D.4
  • 19
    • 0035933155 scopus 로고    scopus 로고
    • Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus
    • Sarawar, S. R., Lee, B. J., Reiter, S. K., Schoenberger, S. P. (2001) Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus. Proc. Natl. Acad. Sci. USA 98, 6325-6329.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6325-6329
    • Sarawar, S.R.1    Lee, B.J.2    Reiter, S.K.3    Schoenberger, S.P.4
  • 20
    • 0035845543 scopus 로고    scopus 로고
    • CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination
    • Kedl, R. M., Jordan, M., Potter, T., Kappler, J., Marrack, P., Dow, S. (2001) CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination. Proc. Natl. Acad. Sci. USA 98, 10811-10816.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10811-10816
    • Kedl, R.M.1    Jordan, M.2    Potter, T.3    Kappler, J.4    Marrack, P.5    Dow, S.6
  • 21
    • 36148940267 scopus 로고    scopus 로고
    • CD40-induced countercurrent conduits for tumor escape or elimination?
    • Murugaiyan, G., Martin, S., Saha, B. (2007) CD40-induced countercurrent conduits for tumor escape or elimination? Trends Immunol. 28, 467-473.
    • (2007) Trends Immunol. , vol.28 , pp. 467-473
    • Murugaiyan, G.1    Martin, S.2    Saha, B.3
  • 22
    • 33750533981 scopus 로고    scopus 로고
    • Giving blood: A new role for CD40 in tumorigenesis
    • Bergmann, S., Pandolfi, P. P. (2006) Giving blood: a new role for CD40 in tumorigenesis. J. Exp. Med. 203, 2409-2412.
    • (2006) J. Exp. Med. , vol.203 , pp. 2409-2412
    • Bergmann, S.1    Pandolfi, P.P.2
  • 25
    • 33846498110 scopus 로고    scopus 로고
    • Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus
    • Bartholdy, C., Kauffmann, S. Ø., Christensen, J. P., Thomsen, A. R. (2007) Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus. J. Immunol. 178, 1662-1670.
    • (2007) J. Immunol. , vol.178 , pp. 1662-1670
    • Bartholdy, C.1    Kauffmann, S.O.2    Christensen, J.P.3    Thomsen, A.R.4
  • 26
    • 0037025944 scopus 로고    scopus 로고
    • Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens
    • Hernández, J., Aung, S., Marquardt, K., Sherman, L. A. (2002) Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens. J. Exp. Med. 196, 323-333.
    • (2002) J. Exp. Med. , vol.196 , pp. 323-333
    • Hernández, J.1    Aung, S.2    Marquardt, K.3    Sherman, L.A.4
  • 27
    • 0036721808 scopus 로고    scopus 로고
    • Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease
    • Ichikawa, H. T., Williams, L. P., Segal, B. M. (2002) Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease. J. Immunol. 169, 2781-2787.
    • (2002) J. Immunol. , vol.169 , pp. 2781-2787
    • Ichikawa, H.T.1    Williams, L.P.2    Segal, B.M.3
  • 28
    • 0037093862 scopus 로고    scopus 로고
    • CD40 ligation in the presence of self-reactive CD8 T cells leads to severe immunopathology
    • Roth, E., Schwartzkopff, J., Pircher, H. (2002) CD40 ligation in the presence of self-reactive CD8 T cells leads to severe immunopathology. J. Immunol. 168, 5124-5129.
    • (2002) J. Immunol. , vol.168 , pp. 5124-5129
    • Roth, E.1    Schwartzkopff, J.2    Pircher, H.3
  • 29
    • 47949124522 scopus 로고    scopus 로고
    • CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements
    • Rapetti, L., Meunier, S., Pontoux, C., Tanchot, C. (2008) CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements. J. Immunol. 181, 299-308.
    • (2008) J. Immunol. , vol.181 , pp. 299-308
    • Rapetti, L.1    Meunier, S.2    Pontoux, C.3    Tanchot, C.4
  • 30
    • 65349149089 scopus 로고    scopus 로고
    • Molecular mechanism and function of CD40/CD40L engagement in the immune system
    • Elgueta, R., Benson, M. J., de Vries, V. C., Wasiuk, A., Guo, Y., Noelle, R. J. (2009) Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol. Rev. 229, 152-172.
    • (2009) Immunol. Rev. , vol.229 , pp. 152-172
    • Elgueta, R.1    Benson, M.J.2    de Vries, V.C.3    Wasiuk, A.4    Guo, Y.5    Noelle, R.J.6
  • 31
    • 0034232490 scopus 로고    scopus 로고
    • γ Chain required for naïve CD4+ T cell survival but not for antigen proliferation
    • Lantz, O., Grandjean, I., Matzinger, P., Di Santo, J. P. (2000) γ Chain required for naïve CD4+ T cell survival but not for antigen proliferation. Nat. Immunol. 1, 54-58.
    • (2000) Nat. Immunol. , vol.1 , pp. 54-58
    • Lantz, O.1    Grandjean, I.2    Matzinger, P.3    di Santo, J.P.4
  • 32
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naïve or memory T cells
    • Tanchot, C., Lemonnier, F. A., Pérarnau, B., Freitas, A. A., Rocha, B. (1997) Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science 276, 2057-2062.
    • (1997) Science , vol.276 , pp. 2057-2062
    • Tanchot, C.1    Lemonnier, F.A.2    Pérarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 33
    • 0346103729 scopus 로고    scopus 로고
    • A role for TCR affinity in regulating naive T cell homeostasis
    • Kieper, W. C., Burghardt, J. T., Surh, C. D. (2004) A role for TCR affinity in regulating naive T cell homeostasis. J. Immunol. 172, 40-44.
    • (2004) J. Immunol. , vol.172 , pp. 40-44
    • Kieper, W.C.1    Burghardt, J.T.2    Surh, C.D.3
  • 34
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto, F., Lenig, D., Förster, R., Lipp, M., Lanzavecchia, A. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Förster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 35
    • 0037100277 scopus 로고    scopus 로고
    • Cutting edge: CCR7+ and CCR7+ memory T cells do not differ in immediate effector cell function
    • Unsoeld, H., Krautwald, S., Voehringer, D., Kunzendorf, U., Pircher, H. (2002) Cutting edge: CCR7+ and CCR7+ memory T cells do not differ in immediate effector cell function. J. Immunol. 169, 638-641.
    • (2002) J. Immunol. , vol.169 , pp. 638-641
    • Unsoeld, H.1    Krautwald, S.2    Voehringer, D.3    Kunzendorf, U.4    Pircher, H.5
  • 36
    • 2542476167 scopus 로고    scopus 로고
    • CD40/ CD154 interactions at the interface of tolerance and immunity
    • Quezada, S. A., Jarvinen, L. Z., Lind, E. F., Noelle, R. J. (2004) CD40/ CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 22, 307-328.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 307-328
    • Quezada, S.A.1    Jarvinen, L.Z.2    Lind, E.F.3    Noelle, R.J.4
  • 37
    • 34248153303 scopus 로고    scopus 로고
    • Expression of CD40 and CD40L on tumor cells: The role of their interaction and new approach to immunotherapy
    • Bereznaya, N. M., Chekhun, V. F. (2007) Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy. Exp. Oncol. 29, 2-12.
    • (2007) Exp. Oncol. , vol.29 , pp. 2-12
    • Bereznaya, N.M.1    Chekhun, V.F.2
  • 38
    • 33947223664 scopus 로고    scopus 로고
    • Prospect of targeting the CD40 pathway for cancer therapy
    • Vonderheide, R. H. (2007) Prospect of targeting the CD40 pathway for cancer therapy. Clin. Cancer Res. 13, 1083-1088.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1083-1088
    • Vonderheide, R.H.1
  • 39
    • 0034614891 scopus 로고    scopus 로고
    • CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes
    • Lu, Z., Yuan, L., Zhou, X., Sotomayor, E., Levitsky, H. I., Pardoll, D. M. (2000) CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes. J. Exp. Med. 191, 541-550.
    • (2000) J. Exp. Med. , vol.191 , pp. 541-550
    • Lu, Z.1    Yuan, L.2    Zhou, X.3    Sotomayor, E.4    Levitsky, H.I.5    Pardoll, D.M.6
  • 40
    • 11844265969 scopus 로고    scopus 로고
    • Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells
    • Bullock, T. N. J., Yagita, H. (2005) Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells. J. Immunol. 174, 710-717.
    • (2005) J. Immunol. , vol.174 , pp. 710-717
    • Bullock, T.N.J.1    Yagita, H.2
  • 41
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Lee, S-J., Myers, L., Muralimohan, G., Dai, J., Qiao, Y., Li, Z., Mittler, R. S., Vella, A. T. (2004) 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J. Immunol. 173, 3002-3012.
    • (2004) J. Immunol. , vol.173 , pp. 3002-3012
    • Lee, S.-J.1    Myers, L.2    Muralimohan, G.3    Dai, J.4    Qiao, Y.5    Li, Z.6    Mittler, R.S.7    Vella, A.T.8
  • 42
    • 22544437564 scopus 로고    scopus 로고
    • During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion
    • Hendriks, J., Xiao, Y., Rossen, J. W. A., van der Sluijs, K. F., Sugamura, K., Ishii, N., Borst, J. (2005) During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J. Immunol. 175, 1665-1676.
    • (2005) J. Immunol. , vol.175 , pp. 1665-1676
    • Hendriks, J.1    Xiao, Y.2    Rossen, J.W.A.3    van der Sluijs, K.F.4    Sugamura, K.5    Ishii, N.6    Borst, J.7
  • 43
    • 8444234229 scopus 로고    scopus 로고
    • 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses
    • Dawicki, W., Bertram, E. M., Sharpe, A. H., Watts, T. H. (2004) 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. J. Immunol. 173, 5944-5951.
    • (2004) J. Immunol. , vol.173 , pp. 5944-5951
    • Dawicki, W.1    Bertram, E.M.2    Sharpe, A.H.3    Watts, T.H.4
  • 45
    • 33646474850 scopus 로고    scopus 로고
    • OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity
    • Soroosh, P., Ine, S., Sugamura, K., Ishii, N. (2006) OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. J. Immunol. 176, 5975-5987.
    • (2006) J. Immunol. , vol.176 , pp. 5975-5987
    • Soroosh, P.1    Ine, S.2    Sugamura, K.3    Ishii, N.4
  • 46
  • 47
    • 0029890580 scopus 로고    scopus 로고
    • CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response
    • Borrow, P., Tishon, A., Lee, S., Xu, J., Grewal, I. S., Oldstone, M. B., Flavell, R. A. (1996) CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J. Exp. Med. 183, 2129-2142.
    • (1996) J. Exp. Med. , vol.183 , pp. 2129-2142
    • Borrow, P.1    Tishon, A.2    Lee, S.3    Xu, J.4    Grewal, I.S.5    Oldstone, M.B.6    Flavell, R.A.7
  • 48
    • 3643064537 scopus 로고    scopus 로고
    • CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus
    • Thomsen, A. R., Nansen, A., Christensen, J. P., Andreasen, S. O., Marker, O. (1998) CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J. Immunol. 161, 4583-4590.
    • (1998) J. Immunol. , vol.161 , pp. 4583-4590
    • Thomsen, A.R.1    Nansen, A.2    Christensen, J.P.3    Andreasen, S.O.4    Marker, O.5
  • 49
    • 1842681952 scopus 로고    scopus 로고
    • Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    • Huster, K. M., Busch, V., Schiemann, M., Linkemann, K., Kerksiek, K. M., Wagner, H., Busch, D. H. (2004) Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. USA 101, 5610-5615.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5610-5615
    • Huster, K.M.1    Busch, V.2    Schiemann, M.3    Linkemann, K.4    Kerksiek, K.M.5    Wagner, H.6    Busch, D.H.7
  • 51
    • 4644297692 scopus 로고    scopus 로고
    • The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40
    • Montfort, M. J., Bouwer, H. G. A., Wagner, C. R., Hinrichs, D. J. (2004) The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40. J. Immunol. 173, 4084-4090.
    • (2004) J. Immunol. , vol.173 , pp. 4084-4090
    • Montfort, M.J.1    Bouwer, H.G.A.2    Wagner, C.R.3    Hinrichs, D.J.4
  • 52
    • 1542724501 scopus 로고    scopus 로고
    • Cutting edge: Long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells
    • Sun, J. C., Bevan, M. J. (2004) Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells. J. Immunol. 172, 3385-3389.
    • (2004) J. Immunol. , vol.172 , pp. 3385-3389
    • Sun, J.C.1    Bevan, M.J.2
  • 53
    • 0344305402 scopus 로고    scopus 로고
    • CD40-deficient, influenzaspecific CD8 memory T cells develop and function normally in a CD40-sufficient environment
    • Lee, B. O., Hartson, L., Randall, T. D. (2003) CD40-deficient, influenzaspecific CD8 memory T cells develop and function normally in a CD40-sufficient environment. J. Exp. Med. 198, 1759-1764.
    • (2003) J. Exp. Med. , vol.198 , pp. 1759-1764
    • Lee, B.O.1    Hartson, L.2    Randall, T.D.3
  • 55
    • 77954718056 scopus 로고    scopus 로고
    • CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions
    • Martin, S., Pahari, S., Sudan, R., Saha, B. (2010) CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions. J. Immunol. 184, 5510-5518.
    • (2010) J. Immunol. , vol.184 , pp. 5510-5518
    • Martin, S.1    Pahari, S.2    Sudan, R.3    Saha, B.4
  • 56
    • 69949083414 scopus 로고    scopus 로고
    • Modulation of adaptive immunity with Toll-like receptors
    • Manicassamy, S., Pulendran, B. (2009) Modulation of adaptive immunity with Toll-like receptors. Semin. Immunol. 21, 185-193.
    • (2009) Semin. Immunol. , vol.21 , pp. 185-193
    • Manicassamy, S.1    Pulendran, B.2
  • 57
    • 77951692771 scopus 로고    scopus 로고
    • Plasticity in programming of effector and memory CD8 T-cell formation
    • Arens, R., Schoenberger, S. P. (2010) Plasticity in programming of effector and memory CD8 T-cell formation. Immunol. Rev. 235, 190-205.
    • (2010) Immunol. Rev. , vol.235 , pp. 190-205
    • Arens, R.1    Schoenberger, S.P.2
  • 58
    • 61449121028 scopus 로고    scopus 로고
    • TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal
    • Mercier, B. C., Cottalorda, A., Coupet, C-A., Marvel, J., Bonnefoy-Bérard, N. (2009) TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal. J. Immunol. 182, 1860-1867.
    • (2009) J. Immunol. , vol.182 , pp. 1860-1867
    • Mercier, B.C.1    Cottalorda, A.2    Coupet, C.-A.3    Marvel, J.4    Bonnefoy-Bérard, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.