Giving blood: A new role for CD40 in tumorigenesis

Journal of Experimental Medicine

Volumn 203, Issue 11, 2006, Pages 2409-2412

  Bergmann, Stephan ^a   Pandolfi, Pier Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; CD36 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CLOPIDOGREL; FAS LIGAND; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; THROMBOSPONDIN 1; VASCULOTROPIN;

ANGIOGENESIS; ANTIGEN EXPRESSION; B LYMPHOCYTE; CARCINOGENESIS; CD4+ T LYMPHOCYTE; DRUG MECHANISM; DRUG TARGETING; ENDOTHELIUM CELL; IMMUNE RESPONSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR GROWTH; TUMOR VASCULARIZATION;

ANIMALS; ANTIGENS, CD40; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC;

EID: 33750533981     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20061754     Document Type: Review

References (31)

1. Hanahan, D., and R.A. Weinberg. 2000. The hallmarks of cancer. Cell. 100:57-70.
2. Chiodoni, C., M. Iezzi, C. Guiducci, S. Sangaletti, I. Alessandrini, C. Ratti, F. Tiboni, P. Musiani, D.N. Granger, and M.P. Colombo. 2006. Triggering CD40 on endothelial cells contributes to tumor growth. J. Exp. Med. 203:2441-2450.
3. van Kooten, C., and J. Banchereau. 2000. 1998. CD40-CD40 ligand. J. Leukoc. Biol. 67:2-17.
4. Grewal, I.S., and R.A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111-135.
5. Melter, M., M.E. Reinders, M. Sho, S. Pal, C. Geehan, M.D. Denton, D. Mukhopadhyay, and D.M. Briscoe. 2000. Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo. Blood. 96:3801-3808.
6. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1:167-178.
7. Castigli, E., F.W. Alt, L. Davidson, A. Bottaro, E. Mizoguchi, A.K. Bhan, and R.S. Geha. 1994. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl. Acad. Sci. USA. 91:12135-12139.
8. Reinders, M.E., M. Sho, S.W. Robertson, C.S. Geehan, and D.M. Briscoe. 2003. Proangiogenic function of CD40 ligand-CD40 interactions. J. Immunol. 171:1534-1541.
9. Flaxenburg, J.A., M. Melter, P.H. Lapchak, D.M. Briscoe, and S. Pal. 2004. The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. J. Immunol. 172:7503-7509.
10. Kluth, B., S. Hess, H. Engelmann, S. Schafnitzel, G. Riethmuller, and H.E. Feucht. 1997. Endothelial expression of CD40 in renal cell carcinoma. Cancer Res. 57:891-899.
11. Pammer, J., A. Plettenberg, W. Weninger, B. Diller, M. Mildner, A. Uthman, W. Issing, M. Sturzl, and E. Tschachler. 1996. CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma. Am. J. Pathol. 148:1387-1396.
12. Grewal, I.S., and R.A. Flavell. 1996. A central role of CD40 ligand in the regulation of CD4+ T-cell responses. Immunol. Today. 17:410-414.
13. Grewal, I.S., H.G. Foellmer, K.D. Grewal, J. Xu, F. Hardardottir, J.L. Baron, C.A. Janeway Jr., and R.A. Flavell. 1996. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 273:1864-1867.
14. Henn, V., J.R. Slupsky, M. Grafe, I. Anagnostopoulos, R. Forster, G. Muller-Berghaus, and R.A. Kroczek. 1998. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 391:591-594.
15. Buchner, K., V. Henn, M. Grafe, O.J. de Boer, A.E. Becker, and R.A. Kroczek. 2003. CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signaling in atherosclerosis. J. Pathol. 201:288-295.
16. Schafer, A.I. 1996. Antiplatelet therapy. Am. J. Med. 101:199-209.
17. Hermann, A., B.H. Rauch, M. Braun, K. Schror, and A.A. Weber. 2001. Platelet CD40 ligand (CD40L)-subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets. 12:74-82.
18. Condeelis, J., and J.W. Pollard. 2006. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 124:263-266.
19. Yuan, A., J.J. Chen, P.L. Yao, and P.C. Yang. 2005. The role of interleukin-8 in cancer cells and microenvironment interaction. Front. Biosci. 10:853-865.
20. Kaplan, R.N., R.D. Riba, S. Zacharoulis, A.H. Bramley, L. Vincent, C. Costa, D.D. MacDonald, D.K. Jin, K. Shido, S.A. Kerns, et al. 2005. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 438:820-827.
21. Veikkola, T., and K. Alitalo. 1999. VEGFs, receptors and angiogenesis. Semin. Cancer Biol. 9:211-220.
22. Roy, H., S. Bhardwaj, and S. Yla-Herttuala. 2006. Biology of vascular endothelial growth factors. FEBS Lett. 580:2879-2887.
23. Ge, Y., and M.T. Elghetany. 2005. CD36: a multiligand molecule. Lab. Hematol. 11:31-37.
24. Bergers, G., and L.E. Benjamin. 2003. Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer. 3:401-410.
25. De Raeve, H.R., and K. Vanderkerken. 2005. The role of the bone marrow microenvironment in multiple myeloma. Histol. Histopathol. 20:1227-1250.
26. Cruz-Munoz, W., I. Kim, and R. Khokha. 2006. TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis. Oncogene. 25:650-655.
27. Bergers, G., K. Javaherian, K.M. Lo, J. Folkman, and D. Hanahan. 1999. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 284:808-812.
28. Ben-Baruch, A. 2003. Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor-microenvironment interactions. Breast Cancer Res. 5:31-36.
29. Mach, F., U. Schonbeck, G.K. Sukhova, T. Bourcier, J.Y. Bonnefoy, J.S. Pober, and P. Libby. 1997. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc. Natl. Acad. Sci. USA. 94:1931-1936.
30. Carmeliet, P. 2005. Angiogenesis in life, disease and medicine. Nature. 438:932-936.
31. Hill, S.C., S.J. Youde, S. Man, G.R. Teale, A.J. Baxendale, A. Hislop, C.C. Davies, D.M. Luesley, A.M. Blom, A.B. Rickinson, et al. 2005. Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis. J. Immunol. 174:41-50.