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Volumn 33, Issue 6, 2012, Pages 331-340

At the heart of the matter: The endocannabinoid system in cardiovascular function and dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; AM 3506; ANANDAMIDE; CALCIUM CHANNEL; CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DOXORUBICIN; ENDOCANNABINOID; FATTY ACID AMIDASE INHIBITOR; N ARACHIDONOYLDOPAMINE; N PALMITOYL ETHENOLAMINE; PALMIDROL; POTASSIUM CHANNEL; RIMONABANT; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

EID: 84861916493     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.03.002     Document Type: Review
Times cited : (127)

References (91)
  • 1
    • 67449119913 scopus 로고    scopus 로고
    • The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
    • Di Marzo, V. (2009) The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol. Res. 60, 77-84
    • (2009) Pharmacol. Res. , vol.60 , pp. 77-84
    • Di Marzo, V.1
  • 2
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di Marzo, V. (2008) Targeting the endocannabinoid system: to enhance or reduce? Nat. Rev. Drug Discov. 7, 438-455
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 3
    • 0036838392 scopus 로고    scopus 로고
    • Cardiovascular system effects of marijuana
    • Jones, R.T. (2002) Cardiovascular system effects of marijuana. J. Clin. Pharmacol. 42, 58S-63S
    • (2002) J. Clin. Pharmacol. , vol.42
    • Jones, R.T.1
  • 5
    • 0031773354 scopus 로고    scopus 로고
    • Cardiovascular actions of cannabinoids and their generation during shock
    • Wagner, J.A. et al. (1998) Cardiovascular actions of cannabinoids and their generation during shock. J. Mol. Med. (Berl.) 76, 824-836 (Pubitemid 28518708)
    • (1998) Journal of Molecular Medicine , vol.76 , Issue.12 , pp. 824-836
    • Wagner, J.A.1    Varga, K.2    Kunos, G.3
  • 7
    • 0035210486 scopus 로고    scopus 로고
    • 1 receptor-mediated changes in heart rate and blood pressure in anaesthetized rats
    • DOI 10.1007/s00210-001-0498-6
    • Malinowska, B. et al. (2001) Anandamide and methanandamide induce both vanilloid VR1- and cannabinoid CB1 receptor-mediated changes in heart rate and blood pressure in anaesthetized rats. Naunyn Schmiedebergs Arch. Pharmacol. 364, 562-569 (Pubitemid 33145097)
    • (2001) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.364 , Issue.6 , pp. 562-569
    • Malinowska, B.1    Kwolek, G.2    Gothert, M.3
  • 9
    • 1642430679 scopus 로고    scopus 로고
    • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    • Jordt, S.E. et al. (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265
    • (2004) Nature , vol.427 , pp. 260-265
    • Jordt, S.E.1
  • 10
    • 1442315642 scopus 로고    scopus 로고
    • Cannabinoid pharmacology in the cardiovascular system: Potential protective mechanisms through lipid signalling
    • DOI 10.1017/S1464793103006201
    • Hiley, C.R. and Ford, W.R. (2004) Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling. Biol. Rev. Camb. Philos. Soc. 79, 187-205 (Pubitemid 38282051)
    • (2004) Biological Reviews of the Cambridge Philosophical Society , vol.79 , Issue.1 , pp. 187-205
    • Hiley, C.R.1    Ford, W.R.2
  • 11
    • 0035816432 scopus 로고    scopus 로고
    • 1 receptors
    • DOI 10.1016/S0014-2999(01)01112-8, PII S0014299901011128
    • Wagner, J.A. et al. (2001) Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB1 receptors. Eur. J. Pharmacol. 423, 203-210 (Pubitemid 32614159)
    • (2001) European Journal of Pharmacology , vol.423 , Issue.2-3 , pp. 203-210
    • Wagner, J.A.1    Jarai, Z.2    Batkai, S.3    Kunos, G.4
  • 12
    • 0038845604 scopus 로고    scopus 로고
    • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    • Járai, Z. et al. (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc. Natl. Acad. Sci. U.S.A. 96, 14136-14141
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 14136-14141
    • Járai, Z.1
  • 13
    • 34247218666 scopus 로고    scopus 로고
    • Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in wistar rats fed a high-salt diet
    • DOI 10.1124/jpet.106.112904
    • Wang, Y. et al. (2007) Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet. J. Pharmacol. Exp. Ther. 321, 763-769 (Pubitemid 46624495)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.2 , pp. 763-769
    • Wang, Y.1    Kaminski, N.E.2    Wang, D.H.3
  • 16
    • 0033555839 scopus 로고    scopus 로고
    • Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
    • Ledent, C. et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283, 401-404
    • (1999) Science , vol.283 , pp. 401-404
    • Ledent, C.1
  • 17
    • 34548608480 scopus 로고    scopus 로고
    • 2+-dependent potassium channels in in vitro anandamide-mediated mesenteric vasorelaxation in rats with biliary cirrhosis
    • 2+-dependent potassium channels in in vitro anandamide-mediated mesenteric vasorelaxation in rats with biliary cirrhosis. Liver Int. 27, 1045-1055
    • (2007) Liver Int. , vol.27 , pp. 1045-1055
    • Yang, Y.Y.1
  • 20
    • 1842611872 scopus 로고    scopus 로고
    • Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA)
    • DOI 10.1038/sj.bjp.0705643
    • O'Sullivan, S.E. et al. (2004) Characterisation of the vasorelaxant properties of the novel endocannabinoid N-arachidonoyl-dopamine (NADA). Br. J. Pharmacol. 141, 803-812 (Pubitemid 38446181)
    • (2004) British Journal of Pharmacology , vol.141 , Issue.5 , pp. 803-812
    • O'Sullivan, S.E.1    Kendall, D.A.2    Randall, M.D.3
  • 21
    • 27144465067 scopus 로고    scopus 로고
    • Cardiovascular pharmacology of cannabinoids
    • Pacher, P. et al. (2005) Cardiovascular pharmacology of cannabinoids. Handb. Exp. Pharmacol. 168, 599-625
    • (2005) Handb. Exp. Pharmacol. , vol.168 , pp. 599-625
    • Pacher, P.1
  • 22
    • 78649349136 scopus 로고    scopus 로고
    • Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects
    • Godlewski, G. et al. (2010) Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chem. Biol. 17, 1256-1266
    • (2010) Chem. Biol. , vol.17 , pp. 1256-1266
    • Godlewski, G.1
  • 24
    • 67651065226 scopus 로고    scopus 로고
    • The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways
    • Bradshaw, H.B. et al. (2009) The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. BMC Biochem. 10, 14
    • (2009) BMC Biochem. , vol.10 , pp. 14
    • Bradshaw, H.B.1
  • 25
    • 77952609532 scopus 로고    scopus 로고
    • N-Arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels
    • Parmar, N. and Ho, W.S. (2010) N-Arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels. Br. J. Pharmacol. 160, 594-603
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 594-603
    • Parmar, N.1    Ho, W.S.2
  • 26
    • 27644586203 scopus 로고    scopus 로고
    • Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed
    • DOI 10.1113/jphysiol.2005.094292
    • Poblete, I.M. et al. (2005) Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. J. Physiol. 568, 539-551 (Pubitemid 41555456)
    • (2005) Journal of Physiology , vol.568 , Issue.2 , pp. 539-551
    • Poblete, I.M.1    Orliac, M.L.2    Briones, R.3    Adler-Graschinsky, E.4    Huidobro-Toro, J.P.5
  • 27
    • 77952731052 scopus 로고    scopus 로고
    • N-Arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
    • McHugh, D. et al. (2010) N-Arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci. 11, 44
    • (2010) BMC Neurosci. , vol.11 , pp. 44
    • McHugh, D.1
  • 28
    • 57349088304 scopus 로고    scopus 로고
    • 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors
    • Ho, W.S. et al. (2008) 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br. J. Pharmacol. 155, 837-846
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 837-846
    • Ho, W.S.1
  • 29
    • 84855527414 scopus 로고    scopus 로고
    • Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries
    • Wheal, A.J. et al. (2012) Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries. Eur. J. Pharmacol. 674, 384-390
    • (2012) Eur. J. Pharmacol. , vol.674 , pp. 384-390
    • Wheal, A.J.1
  • 30
    • 35648944276 scopus 로고    scopus 로고
    • GPR55 and the vascular receptors for cannabinoids
    • DOI 10.1038/sj.bjp.0707421, PII 0707421
    • Hiley, C.R. and Kaup, S.S. (2007) GPR55 and the vascular receptors for cannabinoids. Br. J. Pharmacol. 152, 559-561 (Pubitemid 350034976)
    • (2007) British Journal of Pharmacology , vol.152 , Issue.5 , pp. 559-561
    • Hiley, C.R.1    Kaup, S.S.2
  • 32
    • 4344627156 scopus 로고    scopus 로고
    • 1 receptor knock-out mice
    • DOI 10.1113/jphysiol.2004.064824
    • Pacher, P. et al. (2004) Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. J. Physiol. 558, 647-657 (Pubitemid 39117608)
    • (2004) Journal of Physiology , vol.558 , Issue.2 , pp. 647-657
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 36
    • 11244328917 scopus 로고    scopus 로고
    • The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    • DOI 10.1124/mol.104.006353
    • Lo Verme, J. et al. (2005) The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol. Pharmacol. 67, 15-19 (Pubitemid 40069962)
    • (2005) Molecular Pharmacology , vol.67 , Issue.1 , pp. 15-19
    • Lo, V.J.1    Fu, J.2    Astarita, G.3    La, R.G.4    Russo, R.5    Calignano, A.6    Piomelli, D.7
  • 37
    • 0035881542 scopus 로고    scopus 로고
    • Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    • DOI 10.1042/0264-6021:3580249
    • Di Marzo, V. et al. (2001) Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem. J. 358, 249-255 (Pubitemid 32778120)
    • (2001) Biochemical Journal , vol.358 , Issue.1 , pp. 249-255
    • Di, M.V.1    Melck, D.2    Orlando, P.3    Bisogno, T.4    Zagoory, O.5    Bifulco, M.6    Vogel, Z.7    De Petrocellis, L.8
  • 38
    • 0035120753 scopus 로고    scopus 로고
    • Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide
    • Lagneux, C. and Lamontagne, D. (2001) Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide. Br. J. Pharmacol. 132, 793-796 (Pubitemid 32193634)
    • (2001) British Journal of Pharmacology , vol.132 , Issue.4 , pp. 793-796
    • Lagneux, C.1    Lamontagne, D.2
  • 39
    • 0036023638 scopus 로고    scopus 로고
    • Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts
    • DOI 10.1016/S0008-6363(02)00268-7, PII S0008636302002687
    • Joyeux, M. et al. (2002) Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts. Cardiovasc. Res. 55, 619-625 (Pubitemid 34874956)
    • (2002) Cardiovascular Research , vol.55 , Issue.3 , pp. 619-625
    • Joyeux, M.1    Arnaud, C.2    Godin-Ribuot, D.3    Demenge, P.4    Lamontagne, D.5    Ribuot, C.6
  • 40
    • 63349100859 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion
    • Montecucco, F. et al. (2009) CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion. J. Mol. Cell Cardiol. 46, 612-620
    • (2009) J. Mol. Cell Cardiol. , vol.46 , pp. 612-620
    • Montecucco, F.1
  • 41
    • 68549123561 scopus 로고    scopus 로고
    • The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy
    • Defer, N. et al. (2009) The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion- induced cardiomyopathy. FASEB J. 23, 2120-2130
    • (2009) FASEB J. , vol.23 , pp. 2120-2130
    • Defer, N.1
  • 43
    • 78649984380 scopus 로고    scopus 로고
    • Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
    • Rajesh, M. et al. (2010) Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J. Am. Coll. Cardiol. 56, 2115-2125
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 2115-2125
    • Rajesh, M.1
  • 46
    • 77953959767 scopus 로고    scopus 로고
    • Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice
    • Montecucco, F. et al. (2010) Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice. Arterioscler. Thromb. Vasc. Biol. 30, 1371-1377
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1371-1377
    • Montecucco, F.1
  • 47
    • 77953198702 scopus 로고    scopus 로고
    • Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
    • Walsh, S.K. et al. (2010) Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion. Br. J. Pharmacol. 160, 1234-1242
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 1234-1242
    • Walsh, S.K.1
  • 48
    • 73049097844 scopus 로고    scopus 로고
    • Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner
    • Amorós, I. et al. (2010) Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. J. Mol. Cell Cardiol. 48, 201-210
    • (2010) J. Mol. Cell Cardiol. , vol.48 , pp. 201-210
    • Amorós, I.1
  • 49
    • 38149136656 scopus 로고    scopus 로고
    • Atrial fibrillation and marijuana smoking
    • Korantzopoulos, P. et al. (2008) Atrial fibrillation and marijuana smoking. Int. J. Clin. Pract. 62, 308-313
    • (2008) Int. J. Clin. Pract. , vol.62 , pp. 308-313
    • Korantzopoulos, P.1
  • 50
    • 0032563825 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy
    • DOI 10.1056/NEJM199809243391307
    • Singal, P.K. and Iliskovic, N. (1998) Doxorubicin-induced cardiomyopathy. N. Engl. J. Med. 339, 900-905 (Pubitemid 28446849)
    • (1998) New England Journal of Medicine , vol.339 , Issue.13 , pp. 900-905
    • Singal, P.K.1    Iliskovic, N.2
  • 51
    • 70450260555 scopus 로고    scopus 로고
    • Cardiomyocyte death in doxorubicin-induced cardiotoxicity
    • Zhang, Y.W. et al. (2009) Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Arch. Immunol. Ther. Exp. (Warsz) 57, 435-445
    • (2009) Arch. Immunol. Ther. Exp. (Warsz) , vol.57 , pp. 435-445
    • Zhang, Y.W.1
  • 52
    • 61449164929 scopus 로고    scopus 로고
    • Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model
    • Hydock, D.S. et al. (2009) Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model. J. Cardiovasc. Pharmacol. Ther. 14, 59-67
    • (2009) J. Cardiovasc. Pharmacol. Ther. , vol.14 , pp. 59-67
    • Hydock, D.S.1
  • 53
    • 78650716667 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury
    • Mukhopadhyay, P. et al. (2011) Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury. Free Radic. Biol. Med. 50, 179-195
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 179-195
    • Mukhopadhyay, P.1
  • 54
    • 76749118468 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
    • Mukhopadhyay, P. et al. (2010) CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovasc. Res. 85, 773-784
    • (2010) Cardiovasc. Res. , vol.85 , pp. 773-784
    • Mukhopadhyay, P.1
  • 55
    • 84861454735 scopus 로고    scopus 로고
    • Cardiac dysfunction in cirrhosis - Does adrenal function play a role? A hypothesis
    • DOI: 10.1111/j.1478-3231.2011.02751.x
    • Theocharidou, E. et al. (2012) Cardiac dysfunction in cirrhosis - does adrenal function play a role? A hypothesis. Liver Int. DOI: 10.1111/j.1478-3231. 2011.02751.x
    • (2012) Liver Int.
    • Theocharidou, E.1
  • 56
    • 0034928628 scopus 로고    scopus 로고
    • Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis
    • Bá tkai, S. et al. (2001) Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat. Med. 7, 827-832
    • (2001) Nat. Med. , vol.7 , pp. 827-832
    • Bátkai, S.1
  • 57
    • 34548444632 scopus 로고    scopus 로고
    • Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats
    • Bá tkai, S. et al. (2007) Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. Am. J. Physiol. Heart Circ. Physiol. 293, H1689-H1695
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293
    • Bátkai, S.1
  • 58
    • 27144518128 scopus 로고    scopus 로고
    • Cirrhotic cardiomyopathy: An endocannabinoid connection?
    • DOI 10.1038/sj.bjp.0706332, PII 0706332
    • Pacher, P. et al. (2005) Cirrhotic cardiomyopathy: an endocannabinoid connection? Br. J. Pharmacol. 146, 313-314 (Pubitemid 41486672)
    • (2005) British Journal of Pharmacology , vol.146 , Issue.3 , pp. 313-314
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 59
    • 77955305508 scopus 로고    scopus 로고
    • Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNFalpha and endocannabinoids
    • Yang, Y.Y. et al. (2010) Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids. J. Hepatol. 53, 298-306
    • (2010) J. Hepatol. , vol.53 , pp. 298-306
    • Yang, Y.Y.1
  • 62
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients - RIO-North America: A randomized controlled trial
    • DOI 10.1001/jama.295.7.761
    • Pi-Sunyer, F.X. et al. (2006) Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. J. Am. Med. Assoc. 295, 761-775 (Pubitemid 43244304)
    • (2006) Journal of the American Medical Association , vol.295 , Issue.7 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3    Devin, J.4    Rosenstock, J.5
  • 63
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-Year experience from the RIO-Europe study
    • DOI 10.1016/S0140-6736(05)66374-X
    • Van Gaal, L.F. et al. (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365, 1389-1397 (Pubitemid 40523733)
    • (2005) Lancet , vol.365 , Issue.9468 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5
  • 65
    • 70350347327 scopus 로고    scopus 로고
    • CB1 antagonists for obesity - What lessons have we learned from rimonabant?
    • Di Marzo, V. and Després, J.P. (2009) CB1 antagonists for obesity - what lessons have we learned from rimonabant? Nat. Rev. Endocrinol. 5, 633-638
    • (2009) Nat. Rev. Endocrinol. , vol.5 , pp. 633-638
    • Di Marzo, V.1    Després, J.P.2
  • 66
    • 80052035103 scopus 로고    scopus 로고
    • Energy balance regulation by endocannabinoids at central and peripheral levels
    • Quarta, C. et al. (2011) Energy balance regulation by endocannabinoids at central and peripheral levels. Trends Mol. Med. 17, 518-526
    • (2011) Trends Mol. Med. , vol.17 , pp. 518-526
    • Quarta, C.1
  • 67
    • 79955632246 scopus 로고    scopus 로고
    • Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
    • Di Marzo, V. et al. (2011) Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. Handb. Exp. Pharmacol. 203, 75-104
    • (2011) Handb. Exp. Pharmacol. , vol.203 , pp. 75-104
    • Di Marzo, V.1
  • 68
    • 67449165616 scopus 로고    scopus 로고
    • Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis
    • Montecucco, F. et al. (2009) Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis. Atherosclerosis 205, 433-441
    • (2009) Atherosclerosis , vol.205 , pp. 433-441
    • Montecucco, F.1
  • 69
    • 58849099529 scopus 로고    scopus 로고
    • Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice
    • Dol-Gleizes, F. et al. (2009) Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 29, 12-18
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 12-18
    • Dol-Gleizes, F.1
  • 70
    • 77953099666 scopus 로고    scopus 로고
    • CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function
    • Tiyerili, V. et al. (2010) CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function. Basic Res. Cardiol. 105, 465-477
    • (2010) Basic Res. Cardiol. , vol.105 , pp. 465-477
    • Tiyerili, V.1
  • 71
    • 58149471799 scopus 로고    scopus 로고
    • Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: Associations with changes in metabolic risk factors
    • Di Marzo, V. et al. (2009) Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. Diabetologia 52, 213-217
    • (2009) Diabetologia , vol.52 , pp. 213-217
    • Di Marzo, V.1
  • 72
    • 79958109354 scopus 로고    scopus 로고
    • Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity
    • Quercioli, A. et al. (2011) Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. Eur. Heart J. 32, 1369-1378
    • (2011) Eur. Heart J. , vol.32 , pp. 1369-1378
    • Quercioli, A.1
  • 73
    • 59049102067 scopus 로고    scopus 로고
    • Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages
    • Sugamura, K. et al. (2009) Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages. Circulation 119, 28-36
    • (2009) Circulation , vol.119 , pp. 28-36
    • Sugamura, K.1
  • 75
    • 77952604846 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells
    • Rajesh, M. et al. (2010) Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. Br. J. Pharmacol. 160, 688-700
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 688-700
    • Rajesh, M.1
  • 76
    • 70849114191 scopus 로고    scopus 로고
    • CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages
    • Han, K.H. et al. (2009) CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages. Cardiovasc. Res. 84, 378-386
    • (2009) Cardiovasc. Res. , vol.84 , pp. 378-386
    • Han, K.H.1
  • 77
    • 56349095425 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation
    • Rajesh, M. et al. (2008) Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation. Biochem. Biophys. Res. Commun. 377, 1248-1252
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 1248-1252
    • Rajesh, M.1
  • 78
    • 79957784091 scopus 로고    scopus 로고
    • Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: Approach to therapy
    • Curcio, A. et al. (2011) Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy. Circ. J. 75, 1287-1296
    • (2011) Circ. J. , vol.75 , pp. 1287-1296
    • Curcio, A.1
  • 79
    • 80052547791 scopus 로고    scopus 로고
    • Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line
    • El-Remessy, A.B. et al. (2011) Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line. Diabetologia 54, 1567-1578
    • (2011) Diabetologia , vol.54 , pp. 1567-1578
    • El-Remessy, A.B.1
  • 80
    • 84863116202 scopus 로고    scopus 로고
    • Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy
    • Rajesh, M. et al. (2012) Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes 61, 716-727
    • (2012) Diabetes , vol.61 , pp. 716-727
    • Rajesh, M.1
  • 81
    • 84856010479 scopus 로고    scopus 로고
    • The endocannabinoid system and plantderived cannabinoids in diabetes and diabetic complications
    • Horvá th, B. et al. (2012) The endocannabinoid system and plantderived cannabinoids in diabetes and diabetic complications. Am. J. Pathol. 180, 432-442
    • (2012) Am. J. Pathol. , vol.180 , pp. 432-442
    • Horváth, B.1
  • 82
    • 67149122049 scopus 로고    scopus 로고
    • Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction
    • Maeda, N. et al. (2009) Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. Fundam. Clin. Pharmacol. 23, 351-357
    • (2009) Fundam. Clin. Pharmacol. , vol.23 , pp. 351-357
    • Maeda, N.1
  • 85
    • 80055107075 scopus 로고    scopus 로고
    • Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo
    • Hoyer, F.F. et al. (2011) Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J. Mol. Cell Cardiol. 51, 1007-1014
    • (2011) J. Mol. Cell Cardiol. , vol.51 , pp. 1007-1014
    • Hoyer, F.F.1
  • 87
    • 77958495412 scopus 로고    scopus 로고
    • Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice
    • Netherland, C.D. et al. (2010) Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice. Atherosclerosis 213, 102-108
    • (2010) Atherosclerosis , vol.213 , pp. 102-108
    • Netherland, C.D.1
  • 88
    • 80053487797 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 deficiency in haematopoietic cells aggravates early atherosclerosis in LDL receptor deficient mice
    • Delsing, D.J. et al. (2011) Cannabinoid receptor 2 deficiency in haematopoietic cells aggravates early atherosclerosis in LDL receptor deficient mice. Open Cardiovasc. Med. J. 5, 15-21
    • (2011) Open Cardiovasc. Med. J. , vol.5 , pp. 15-21
    • Delsing, D.J.1
  • 89
    • 38349113185 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration
    • Rajesh, M. et al. (2008) CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration. Br. J. Pharmacol. 153, 347-357
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 347-357
    • Rajesh, M.1
  • 90
    • 84857346670 scopus 로고    scopus 로고
    • The cannabinoid receptor CB2 protects against balloon-induced neointima formation
    • Molica, F. et al. (2012) The cannabinoid receptor CB2 protects against balloon-induced neointima formation. Am. J. Physiol. Heart Circ. Physiol. 312, H1064-H1074
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.312
    • Molica, F.1
  • 91
    • 84859496535 scopus 로고    scopus 로고
    • The activation of the cannabinoid receptor type 2 (CB2) reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques
    • DOI: 10.1093/eurheartj/ehr449
    • Montecucco, F. et al. (2011) The activation of the cannabinoid receptor type 2 (CB2) reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. Eur. Heart J. DOI: 10.1093/eurheartj/ehr449
    • (2011) Eur. Heart J.
    • Montecucco, F.1


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