APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 23, 2012, Pages 8919-8924

  Cheng, Kenneth K Y ^a   Lam, Karen S L ^a   Wu, Donghai ^b   Wang, Yu ^a   Sweeney, Gary ^c   Hoo, Ruby L C ^a   Zhang, Jialiang ^a   Xu, Aimin ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^c YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APPL1 PROTEIN; INSULIN; LIPID; PROTEIN; PROTEIN KINASE B; SNARE PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; EXOCYTOSIS; GENE INACTIVATION; GLUCOSE INTOLERANCE; INSULIN RELEASE; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SNARE PROTEINS;

ADENOVIRIDAE; MUS; RATTUS;

EID: 84861853310     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202435109     Document Type: Article

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