Association analysis of variation in/near FT0, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in pima indians

Diabetes

Volumn 58, Issue 2, 2009, Pages 478-488

  Rong, Rong ^a   Hanson, Robert L ^a   Ortiz, Daniel ^a   Wiedrich, Christopher ^a   Kobes, Sayuko ^a   Knowler, William C ^a   Bogardus, Clifton ^a   Baier, Leslie J ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; CATION TRANSPORT PROTEIN; CDKAL1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR 2B; EXOSTOSIN 2; EXOSTOSIN-2; FTO PROTEIN, HUMAN; HHEX PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; IMP 2 PROTEIN, HUMAN; IMP-2 PROTEIN, HUMAN; N ACETYLGLUCOSAMINYLTRANSFERASE; PROTEIN; RNA BINDING PROTEIN; SLC30A8 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; AMERICAN INDIAN; ARTICLE; BODY FAT; BODY MASS; CLINICAL ARTICLE; DIABETES MELLITUS; FEMALE; GENETIC RISK; GENOTYPE; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; METHODOLOGY; MIDDLE AGED; QUANTITATIVE TRAIT LOCUS;

ADOLESCENT; ADULT; CATION TRANSPORT PROTEINS; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; INDIANS, NORTH AMERICAN; MALE; MIDDLE AGED; N-ACETYLGLUCOSAMINYLTRANSFERASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; QUANTITATIVE TRAIT LOCI; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 63249107785     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0877     Document Type: Article

References (40)

1. Baier LJ, Hanson RL: Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle. Diabetes 53:1181-1186, 2004
2. Sladek R, Rocheleau G, Rung J, et al.: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885, 2007
3. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al.: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770-775, 2007
4. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes of BioMedical Research, et al.: Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336, 2007
5. Scott LJ, Mohlke KL, Bonnycastle LL, et al.: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345, 2007
6. Zeggini E, Weedon MN, Lindgren CM, et al.: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341, 2007
7. The Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common disease and 3,000 shared controls. Nature 447:661-678, 2007
8. Guo T, Hanson RL, Traurig M, et al.: TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals. Diabetes 56:3082-3088, 2007
9. Hanson RL, Bogardus C, Duggan D, et al.: A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes 56:3045-3052, 2007
10. Knowler WC, Bennett PH, Hamman RF, et al.: Diabetes incidence and prevalence in Pima Indians: a 19-fold greater incidence than in Rochester, Minnesota. Am J Epidemiol 108:497-505, 1978
11. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1985 (Tech. Rep. Ser., no. 727)
12. Lillioja S, Mott DM, Spraul M, et al.: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 329:1988-1992, 1993
13. Norman RA, Tataranni PA, Pratley R, et al.: Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet 62:659-668, 1998
14. Permana PA, Nair S, Lee YH, et al.: Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity. Am J Physiol Endocrinol Metab 286:E958-E962, 2004
15. Abecasis GR, Cardon LR, Cookson WOC: A general test of association for quantitative traits in nuclear families. Am, J Hum Genet 66:279-292, 2000
16. Petitti DB: Statistical methods in meta-analysis. In Meta-Analysis, Decision Analysis and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine. Petitti DB, Ed. Oxford, Oxford University Press, p. 94-118, 2000
17. Hedges LV, Pigott TD: The power of statistical tests in meta-analysis. Psychol Methods 6:203-217, 2001
18. Grarup N, Rose CS, Andersson EA, et al.: Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies Diabetes 56:3105-3111, 2007
19. Horikoshi M, Hara K, Ito C, et al.: Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50:2461-2466, 2007
20. Furukawa Y, Shimada T, Furuta H, et al.: Polymorphisms in the IDE-KIF11- HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 93:310-314, 2008
21. Ng MC, Park KS, Oh B, et al.: Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes 57:2226-2233, 2008
22. Omori S, Tanaka Y, Takahashi A, et al.: Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57:791-795, 2008
23. Lewis JP, Palmer ND, Hicks PJ, et al.: Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 57:2220 -2225, 2008
24. Pascoe L, Tura A, Patel SK, et al.: Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic β-cell function. Diabetes 56:3101-3104, 2007
25. Frayling TM, Timpson NJ, Weedon MN, et al.: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894, 2007
26. Dina C, Meyre D, Gallina S, et al.: Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougneres P, Kovacs P, Marre M, Balkau B, Cauchi S, Chevre JC, Froguel P: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39:724-726, 2007
27. Scuteri A, Sanna S, Chen WM, et al.: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3:e115, 2007
28. Hinney A, Nguyen TT, Scherag A, et al.: Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2:e1361, 2007
29. Chang YC, Liu PH, Lee WJ, et al.: Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes 57:2245-2252, 2008
30. Marvelle AF, Lange LA, Qin L, et al.: Association of FTO with obesityrelated traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes 57:1987-1991, 2008
31. Hotta K, Nakata Y, Matsuo T, et al.: Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum, Genet 53:546-553, 2008
32. Li H, Wu Y, Loos RJ, et al.: Variants in FTO gene are not associated with obesity in a Chinese Han population. Diabetes 57:264-268, 2008
33. Ohashi J, Naka I, Kimura R, et al.: FTO polymorphisms in oceanic populations. J Hum Genet 52:1031-1035, 2007
34. Bogardus C: Metabolic abnormalities in the development of non-insulin dependent diabetes mellitus. In Diabetes Mellitus: A Fundamental and Clinical Text. LeRoith D, Taylor SI, Olefsky JM, Eds. Philadelphia, Lippincott-Raven, p. 459-467, 1996
35. Stancáková A, Pihlajamaki J, Kuusisto J, et al.: Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93:1924-1930, 2008
36. Bort R, Martinez-Barbera JP, Beddington RS, et al.: Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 131:797-806, 2004
37. Gerken T, Girard CA, Tung YC, et al.: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318:1469-1472, 2007
38. Kloting N, Schleinitz D, Ruschke K, et al.: Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia 51:641-647, 2008
39. Wåhlen K, Sjölin E, Hoffstedt J: The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res 49:607-611, 2008
40. Zeggini E, Scott LJ, Saxena R, et al.: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645, 2008