Three-dimensional imaging reveals the spatial separation of γh2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci

Radiotherapy and Oncology

Volumn 103, Issue 3, 2012, Pages 415-420

  Mok, Myth T S ^a   Henderson, Beric R ^a  

^a WESTMEAD HOSPITAL   (Australia)

Author keywords

H2AX; 53BP1; Abraxas (CCDC98); BRCA1; BRCC36; DNA damage; Ionizing radiation; MDC1; Merit40 (NBA1); Nuclear foci; RAP80; RNF168; RNF8

Indexed keywords

53BP1 PROTEIN; ABRAXAS PROTEIN; BRCA1 PROTEIN; BRCC36 PROTEIN; HISTONE H2AX; MDC1 PROTEIN; MERIT40 PROTEIN; NUCLEAR PROTEIN; RAP80 PROTEIN; RNF168 PROTEIN; RNF8 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN MCF 7; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SINGLE CELL ANALYSIS; THREE DIMENSIONAL IMAGING;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; DNA DAMAGE; DNA END-JOINING REPAIR; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; HUMANS; IMAGING, THREE-DIMENSIONAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROSCOPY, CONFOCAL; MULTIPROTEIN COMPLEXES; NEOPLASM PROTEINS; NUCLEAR PROTEINS; RADIATION, IONIZING; RECOMBINATIONAL DNA REPAIR; TRANS-ACTIVATORS; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84861800872     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.04.009     Document Type: Article

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