Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci

Radiotherapy and Oncology

Volumn 101, Issue 1, 2011, Pages 35-38

  Martin, Nathan T ^a,b   Nahas, Shareef A ^a   Tunuguntla, Rashmi ^a   Fike, Francesca ^a   Gatti, Richard A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BRCA1; Foci; H2AX; Kinetics; Radiosensitivity

Indexed keywords

BRCA1 PROTEIN;

ANALYTIC METHOD; ARTICLE; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; GAMMA HISTONE H2AX IRRADIATION INDUCED FOCI KINETICS; GOLD STANDARD; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; KINETICS; PRIORITY JOURNAL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

CHROMOSOME BREAKAGE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; GAMMA RAYS; GENETIC MARKERS; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; RADIATION DOSAGE; RADIATION TOLERANCE; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASES;

EID: 80655127832     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.065     Document Type: Article

References (31)

1. R. Gatti, E. Boder, and R. Good Immunodeficiency, radiosensitivity, and the XCIND syndrome Immunol Res 38 2007 87 101 (Pubitemid 47574934)
2. K.K. Khanna, and S.P. Jackson DNA double-strand breaks: signaling, repair and the cancer connection Nat Genet 27 2001 247 254 (Pubitemid 32201842)
3. J. Kobayashi, A. Antoccia, H. Tauchi, S. Matsuura, and K. Komatsu NBS1 and its functional role in the DNA damage response DNA Repair 3 2004 855 861 (Pubitemid 38997927)
4. B.L. Mahaney, K. Meek, and S.P. Lees-miller Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining Biochem J 417 2009 639 650
5. Devgan, SS, Sanal, O, Doil, C, et al. Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Differ 2011; Epub ahead of print.
6. G.S. Stewart, S. Panier, and K. Townsend The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage Cell 136 2009 420 434
7. C. Doil, N. Mailand, and S. Bekker-Jensen RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins Cell 136 2009 435 446
8. M. Weinfeld, R.S. Mani, I. Abdou, R.D. Aceytuno, and J.N.M. Glover Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair Trends in Biochemical Sciences 36 2011 262 271
9. J. Shen, E.C. Gilmore, and C.A. Marshall Mutations in PNKP cause microcephaly, seizures and defects in DNA repair Nat Genet 42 2010 245 249
10. X. Sun, S.G. Becker-Catania, and H.H. Chun Early diagnosis of ataxia-telangiectasia using radiosensitivity testing J Pediatr 140 2002 724 731 (Pubitemid 34666692)
11. M. Lobrich, Beucher.A. SA, A. Fisher, M. Ensminger, A.A. Goodarzi, and O. Barton GammaH2AX Foci Analysis for Monitoring DNA double-strand Break Repair: Strengths, Limitations and Optimization Cell Cycle 9 2010 662 669
12. S.A. Nahas, and R.A. Gatti DNA double strand break repair defects, primary immunodeficiency disorders and radiosensitivity Curr Opin Allergy Clin Immunol 9 2009 510 516
13. B. Xu, S.-t. Kim, and M.B. Kastan Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation Mol Cell Biol 21 2001 3445 3450 (Pubitemid 32381780)
14. T.E. Schmid, G. Dollinger, and W. Beisker Differences in the kinetics of -H2AX fluorescence decay after exposure to low and high LET radiation Int. J Radiat Biol 86 2010 682 691
15. Beels, L, Werbrouck, J, Thierens, H. Dose response and repair kinetics of -H2AX foci induced by in vitro irradiation of whole blood and T-lymphocytes with X- and -radiation. Int J Radiat Biol 2010; 86:760-768.
16. T.F. Coleman, and Y. Li An Interior Trust Region Approach for Nonlinear Minimization Subject to Bounds SIAM J Optimization 6 1996 418 445
17. B. Wang, S. Matsuoka, and B.A. Ballif Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response Science 316 2007 1194 1198 (Pubitemid 46877482)
18. K. Koch, A. Wrona, E. Dikomey, and K. Borgmann Impact of homologous recombination on individual cellular radiosensitivity Radiother Oncol 90 2009 265 272
19. H. Kim, J. Chen, and X. Yu Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response Science 316 2007 1202 1205 (Pubitemid 46877484)
20. Andreassen, CN. Searching for genetic determinants of normal tissue radiosensitivity - Are we on the right track? Radiother Oncol 2010;97:1-8.
21. Zschenker, O, Raabe, A, Boeckelmann, IK, et al. Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol 2010;97:26-32.
22. N. Taneja, M. Davis, and J.S. Choy Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy J Biol Chem 279 2004 2273 2280 (Pubitemid 38084500)
23. J.P. Banath, S.H. MacPhail, and P.L. Olive Radiation Sensitivity, H2AX Phosphorylation, and Kinetics of Repair of DNA Strand Breaks in Irradiated Cervical Cancer Cell Lines Cancer Res 64 2004 7144 7149 (Pubitemid 39331029)
24. P.L. Olive, J.P. Banáth, and M. Keyes Residual [gamma]H2AX after irradiation of human lymphocytes and monocytes in vitro and its relation to late effects after prostate brachytherapy Radiother Oncol 86 2008 336 346 (Pubitemid 351335443)
25. H. Farmer, N. McCabe, and C.J. Lord Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921 (Pubitemid 40559006)
26. B.J. Moeller, W. Arap, and R. Pasqualini Targeting Synthetic Lethality in DNA Damage Repair Pathways as an Anti-Cancer Strategy Curr Drug Targets 11 2010 1336 1340
27. H.P. Rodemann Molecular radiation biology: Perspectives for radiation oncology Radiother Oncol 92 2009 293 298
28. A.J. Nakamura, V.A. Rao, Y. Pommier, and W.M. Bonner The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks Cell Cycle 9 2010 389 397
29. Y. Hu, R. Scully, B. Sobhian, A. Xie, E. Shestakova, and D.M. Livingston RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci Genes Dev 25 2011 685 700
30. M.S.Y. Huen, R. Grant, and I. Manke RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly Cell 131 2007 901 914 (Pubitemid 350138083)
31. O. Fernandez-Capetillo, H.-T. Chen, and A. Celeste DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 Nat Cell Biol 4 2002 993 997 (Pubitemid 35469431)