Lebers hereditary optic neuropathy: New quinone therapies change the paradigm

Expert Review of Ophthalmology

Volumn 7, Issue 3, 2012, Pages 251-259

  Sadun, Alfredo A ^a   La Morgia, Chiara ^b   Carelli, Valerio ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

gene therapy; idebenone; Lebers hereditary optic neuropathy; mitochondria; mitochondrial DNA; optic nerve; quinone; therapy

Indexed keywords

ALPHA TOCOTRIENOL QUINONE; BRIMONIDINE; CURCUMIN; CYANOCOBALAMIN; DECYLUBIQUINONE; FOLIC ACID; GENE THERAPY AGENT; GLUTATHIONE; IDEBENONE; MITOCHONDRIAL DNA; ND4; NDI1; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TROLOX C; UBIDECARENONE; UBIQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

EVOKED VISUAL RESPONSE; GENE DOSAGE; GENE MUTATION; GENE THERAPY; HETEROPLASMY; HISTOPATHOLOGY; HUMAN; LEBER HEREDITARY OPTIC NEUROPATHY; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; PREVALENCE; PUPIL REFLEX; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA GANGLION CELL; RETINA NERVE CELL; REVIEW; RISK FACTOR; SEX DIFFERENCE; VISUAL ACUITY; VISUAL FIELD; VISUAL IMPAIRMENT; VITAMIN SUPPLEMENTATION;

EID: 84861760081     PISSN: 17469899     EISSN: 17469902     Source Type: Journal    
DOI: 10.1586/eop.12.27     Document Type: Review

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