Proportion of 11778 mutant mitochondrial DNA and clinical expression in a Thai population with Leber hereditary optic neuropathy

Journal of Neuro-Ophthalmology

Volumn 25, Issue 3, 2005, Pages 173-175

  Chuenkongkaew, Wanicha L ^a   Suphavilai, Rungnapa ^a   Vaeusorn, Lookjan ^a   Phasukkijwatana, Nopasak ^a   Lertrit, Patcharee ^a   Suktitipat, Bhoom ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DENSITOMETRY; FEMALE; GENE EXPRESSION; GENE MUTATION; HETEROPLASMY; HOMOPLASY; HUMAN; LEBER HEREDITARY OPTIC NEUROPATHY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PEDIGREE ANALYSIS; POPULATION GENETICS; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; THAILAND; VISUAL IMPAIRMENT;

ADOLESCENT; ADULT; AGE OF ONSET; AGED, 80 AND OVER; CHILD; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; OPTIC ATROPHY, HEREDITARY, LEBER; PEDIGREE; POINT MUTATION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; THAILAND; VISUAL ACUITY;

EID: 24944517167     PISSN: 10708022     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wno.0000176631.87234.49     Document Type: Article

References (6)

1. Chinnery PF, Andrews RM, Turnbull DM, et al. Leber hereditary optic neuropathy: Does heteroplasmy influence the inheritance and expression of the G11778A mitochondrial DNA mutation? Am J Med Genet 2001;98:235-43.
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4. Hotta Y, Fujiki K, Hayawaka M, et al. Clinical features of Japanese Leber's hereditary optic neuropathy with 11778 mutation of mitochondrial DNA. Jpn J Ophthalmol 1995;39:96-108.
5. Sudoyo H, Suryadi H, Lertrit P, et al. Asian-specific mtDNA backgrounds associated with the primary G11778A mutation of Leber's hereditary optic neuropathy. J Hum Genet 2002;47:594-60,
6. Harding AE, Sweeney MG, Govan GG, et al. Pedigree analysis in Leber hereditary optic neuropathy families with a pathogenic mtDNA mutation. Am J Hum Genet 1995;57:77-86.