메뉴 건너뛰기




Volumn 7, Issue 2, 2012, Pages 151-162

Novel medication targets for the treatment of alcoholism: Preclinical studies

Author keywords

Alcohol intake; ALDH2 inhibitor; Carisbamate; CVT 10216; GS 455534; Inbred alcohol preferring rats; Inbred fawn hooded rats; JNJ 5234801; JNJ 39220675; RWJ 333369; Sazetidine A

Indexed keywords

1 [2,5 DIMETHOXY 4 IODOPHENYL] 2 AMINOPROPANE; ACAMPROSATE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ANXIOLYTIC AGENT; BUSPIRONE; CARISBAMATE; DAIDZIN; DISULFIRAM; DRUGS USED IN THE TREATMENT OF ADDICTION; GS 455534; HISTAMINE H3 RECEPTOR ANTAGONIST; JNJ 39220675; JNJ 5234801; LAMOTRIGINE; N PHENYL 2 [1 [3 (2 PYRIDINYLETHYNYL)BENZOYL] 4 PIPERIDINE]ACETAMIDE; NALOXONE; NALTREXONE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2; OPIATE RECEPTOR; OXIDOREDUCTASE INHIBITOR; SAZETIDINE A; SEROTONIN 2A ANTAGONIST; SODIUM CHANNEL; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID; ZONISAMIDE;

EID: 84861747662     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488912800673182     Document Type: Review
Times cited : (15)

References (136)
  • 1
    • 72049083719 scopus 로고    scopus 로고
    • New horizons for therapeutics in drug and alcohol abuse
    • Jupp B, Lawrence AJ. New horizons for therapeutics in drug and alcohol abuse. Pharmacol Ther 2010; 125: 38-168.
    • (2010) Pharmacol Ther , vol.125 , pp. 38-168
    • Jupp, B.1    Lawrence, A.J.2
  • 2
    • 60249101338 scopus 로고    scopus 로고
    • The state of pharmacotherapy for the treatment of alcohol dependence
    • Garbutt JC. The state of pharmacotherapy for the treatment of alcohol dependence. J Subst Abuse Treat 2009; 36:15-23.
    • (2009) J Subst Abuse Treat , vol.36 , pp. 15-23
    • Garbutt, J.C.1
  • 3
    • 0033212713 scopus 로고    scopus 로고
    • The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption
    • Cowen MS, Lawrence AJ. The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption. Prog Neuropsychopharmacol Biol Psych 1999; 23: 171-212.
    • (1999) Prog Neuropsychopharmacol Biol Psych , vol.23 , pp. 171-212
    • Cowen, M.S.1    Lawrence, A.J.2
  • 4
    • 0033054979 scopus 로고    scopus 로고
    • Ethanol consumption by Fawn-Hooded rats following abstinence: Effects of naltrexone and changes in opioid receptors density
    • Cowen MS, Rezvani AH, Jarrott B, Lawrence AJ. Ethanol consumption by Fawn-Hooded rats following abstinence: Effects of naltrexone and changes in opioid receptors density. Alcohol Clin Exp Res 1999; 23: 1008-14.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 1008-1014
    • Cowen, M.S.1    Rezvani, A.H.2    Jarrott, B.3    Lawrence, A.J.4
  • 5
    • 0034821702 scopus 로고    scopus 로고
    • Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta-analysis
    • Kranzler JH, Van Kirk J. Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res 2001; 25:1335-41.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 1335-1341
    • Kranzler, J.H.1    van Kirk, J.2
  • 7
    • 33845198403 scopus 로고    scopus 로고
    • The alcohol-preferring P rat and animal models of excessive alcohol drinking
    • Bell RL, Rodd ZA, Lumeng L, Murphy JM, McBride WJ. The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol 2006; 11:270-88.
    • (2006) Addict Biol , vol.11 , pp. 270-288
    • Bell, R.L.1    Rodd, Z.A.2    Lumeng, L.3    Murphy, J.M.4    McBride, W.J.5
  • 8
    • 0027324698 scopus 로고
    • Selective breeding for alcohol preference and associated response
    • Li TK, Lumeng L, Doolittle DP. Selective breeding for alcohol preference and associated response. Behav Genet 1993; 23:163-70.
    • (1993) Behav Genet , vol.23 , pp. 163-170
    • Li, T.K.1    Lumeng, L.2    Doolittle, D.P.3
  • 9
    • 0025675459 scopus 로고
    • Genetic serotonin deficiency and alcohol preference in the Fawn-Hooded rats
    • Rezvani AH, Overstreet DH, Janowsky DS. Genetic serotonin deficiency and alcohol preference in the Fawn-Hooded rats. Alcohol Alcohol 1990; 25: 573-5.
    • (1990) Alcohol Alcohol , vol.25 , pp. 573-575
    • Rezvani, A.H.1    Overstreet, D.H.2    Janowsky, D.S.3
  • 10
    • 34247877587 scopus 로고    scopus 로고
    • Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: Implications for treatment
    • Overstreet DH, Rezvani AH, Cowen M, Cheng F, Lawrence AJ. Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment. Addict Biol 2006; 11: 356-73.
    • (2006) Addict Biol , vol.11 , pp. 356-373
    • Overstreet, D.H.1    Rezvani, A.H.2    Cowen, M.3    Cheng, F.4    Lawrence, A.J.5
  • 11
    • 34247100582 scopus 로고    scopus 로고
    • Further genetic characterization of the Fawn-Hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism
    • Rezvani AH, Overstreet DH, Cleves M, Parsian A. Further genetic characterization of the Fawn-Hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism. Psychiatr Genet 2007; 17: 77-83.
    • (2007) Psychiatr Genet , vol.17 , pp. 77-83
    • Rezvani, A.H.1    Overstreet, D.H.2    Cleves, M.3    Parsian, A.4
  • 12
    • 0033950679 scopus 로고    scopus 로고
    • Combination pharmacotherapy: A mixture of small doses of naltrexone, fluoxetine, and a TRH analog reduces alcohol intake in three strains of alcohol preferring rats
    • Rezvani AH, Overstreet DH, Mason GA, Janowsky DS, Hamedi M, Clark J., et al. Combination pharmacotherapy: A mixture of small doses of naltrexone, fluoxetine, and a TRH analog reduces alcohol intake in three strains of alcohol preferring rats. Alcohol & Alcoholism 2000; 35:76-83.
    • (2000) Alcohol & Alcoholism , vol.35 , pp. 76-83
    • Rezvani, A.H.1    Overstreet, D.H.2    Mason, G.A.3    Janowsky, D.S.4    Hamedi, M.5    Clark, J.6
  • 13
    • 77955473936 scopus 로고    scopus 로고
    • Effects of sazetidine-A, a selective EE4442 nicotinic acetylcholine receptor desensitizing agent on both alcohol and nicotine self-Administration in selectively-bred alcohol preferring rats
    • Rezvani AH, Slade S, Wells C, Petro A, Lumeng L, Li TK, et al. Effects of sazetidine-A, a selective EE4442 nicotinic acetylcholine receptor desensitizing agent on both alcohol and nicotine self-Administration in selectively-bred alcohol preferring rats. Psychopharmacol 2010; 211:161-74.
    • (2010) Psychopharmacol , vol.211 , pp. 161-174
    • Rezvani, A.H.1    Slade, S.2    Wells, C.3    Petro, A.4    Lumeng, L.5    Li, T.K.6
  • 14
    • 68149128403 scopus 로고    scopus 로고
    • Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol preferring rats
    • Rezvani AH, Overstreet DH, Vaidya AH, Zhao B, Levin ED. Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol preferring rats. Alcohol Clin Exp Res 2009; 33-1366-73.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1366-1373
    • Rezvani, A.H.1    Overstreet, D.H.2    Vaidya, A.H.3    Zhao, B.4    Levin, E.D.5
  • 15
    • 3042779902 scopus 로고    scopus 로고
    • Dopamine in drug abuse and addiction: Results from imaging studies and treatment implications
    • Volkow ND, Fowler JS, Wang GJ, Swanson JM. Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Mol Psychiatry 2004; 9:557-69.
    • (2004) Mol Psychiatry , vol.9 , pp. 557-569
    • Volkow, N.D.1    Fowler, J.S.2    Wang, G.J.3    Swanson, J.M.4
  • 16
    • 27644454004 scopus 로고    scopus 로고
    • Is there a common molecular pathway for addiction?
    • Nestler EJ. Is there a common molecular pathway for addiction? Nat Neurosci 2005; 8:1445-9.
    • (2005) Nat Neurosci , vol.8 , pp. 1445-1449
    • Nestler, E.J.1
  • 18
    • 0029416936 scopus 로고
    • [3H] epibatidine labels nicotinic receptors in rat brain: An autoradiographic study
    • Perry DC, Kellar KJ. [3H] epibatidine labels nicotinic receptors in rat brain: an autoradiographic study. J Pharmacol Exper Ther 1995; 275:1030-4.
    • (1995) J Pharmacol Exper Ther , vol.275 , pp. 1030-1034
    • Perry, D.C.1    Kellar, K.J.2
  • 19
    • 0035282788 scopus 로고    scopus 로고
    • Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei
    • Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux JP. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 2001; 21:1452-63.
    • (2001) J Neurosci , vol.21 , pp. 1452-1463
    • Klink, R.1    de Kerchove d'Exaerde, A.2    Zoli, M.3    Changeux, J.P.4
  • 20
    • 27644581385 scopus 로고    scopus 로고
    • Nicotine addiction and comorbidity with alcohol abuse and mental illness
    • Dani JA, Harris RA. Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nature Neurosci 2005; 8:1465-70.
    • (2005) Nature Neurosci , vol.8 , pp. 1465-1470
    • Dani, J.A.1    Harris, R.A.2
  • 21
    • 0038163466 scopus 로고    scopus 로고
    • Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats
    • Lou AD, Wang A, Harding S, Juzytsch W, Shaham Y. Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats. Psychopharmacol 2003; 168: 216-21.
    • (2003) Psychopharmacol , vol.168 , pp. 216-221
    • Lou, A.D.1    Wang, A.2    Harding, S.3    Juzytsch, W.4    Shaham, Y.5
  • 22
    • 0343517073 scopus 로고    scopus 로고
    • Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol
    • Söderpalm B, Ericson M, Olausson P, Blomqvist O, Engel JA. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. Behav Brain Res 2000; 113: 85-96.
    • (2000) Behav Brain Res , vol.113 , pp. 85-96
    • Söderpalm, B.1    Ericson, M.2    Olausson, P.3    Blomqvist, O.4    Engel, J.A.5
  • 23
    • 0027438502 scopus 로고
    • The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine
    • Blomqvist O, Engel JA, Nissbrandt H, Soderpalm B. The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine. Eur J Pharmacol 1993; 249: 207-13.
    • (1993) Eur J Pharmacol , vol.249 , pp. 207-213
    • Blomqvist, O.1    Engel, J.A.2    Nissbrandt, H.3    Soderpalm, B.4
  • 24
    • 0030608347 scopus 로고    scopus 로고
    • Voluntary ethanol intake in the rat: Effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment
    • Blomqvist O, Erickson M, Johnson DH, Engel JA, Soderpalm B. Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment. Eur J Pharmacol 1996; 314: 257-67.
    • (1996) Eur J Pharmacol , vol.314 , pp. 257-267
    • Blomqvist, O.1    Erickson, M.2    Johnson, D.H.3    Engel, J.A.4    Soderpalm, B.5
  • 25
    • 66049160668 scopus 로고    scopus 로고
    • Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice
    • Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice. Pharmacol 2009; 83: 379-84.
    • (2009) Pharmacol , vol.83 , pp. 379-384
    • Farook, J.M.1    Lewis, B.2    Gaddis, J.G.3    Littleton, J.M.4    Barron, S.5
  • 27
    • 0032500881 scopus 로고    scopus 로고
    • Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine
    • Ericson M, Blomqvist O, Engel JA, Söderpalm B. Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine. Eur J Pharmacol 1998; 358:189-96.
    • (1998) Eur J Pharmacol , vol.358 , pp. 189-196
    • Ericson, M.1    Blomqvist, O.2    Engel, J.A.3    Söderpalm, B.4
  • 28
    • 0031666575 scopus 로고    scopus 로고
    • Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration
    • Nadal R, Chappell AM, Samson H. Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration. Alcohol Clin Exp Res 1998; 22: 1190-8.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1190-1198
    • Nadal, R.1    Chappell, A.M.2    Samson, H.3
  • 29
    • 24044510845 scopus 로고    scopus 로고
    • Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat
    • Larsson A, Edström L, Svensson L, Söderpalm B, Engel JA. Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat. Alcohol Alcohol 2005; 40: 349-58.
    • (2005) Alcohol Alcohol , vol.40 , pp. 349-358
    • Larsson, A.1    Edström, L.2    Svensson, L.3    Söderpalm, B.4    Engel, J.A.5
  • 30
    • 0036121690 scopus 로고    scopus 로고
    • Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens
    • Tizabi Y, Copeland RL jr., Louis VA, Taylor RE. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res 2002; 26:394-9.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 394-399
    • Tizabi, Y.1    Copeland Jr., R.L.2    Louis, V.A.3    Taylor, R.E.4
  • 31
    • 35348934400 scopus 로고    scopus 로고
    • Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell
    • Tizabi Y, Bai L, Copeland RL Jr., Taylor RE. Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell. Alcohol Alcohol 2007; 42: 413-6.
    • (2007) Alcohol Alcohol , vol.42 , pp. 413-416
    • Tizabi, Y.1    Bai, L.2    Copeland Jr., R.L.3    Taylor, R.E.4
  • 32
    • 34547630911 scopus 로고    scopus 로고
    • Varenicline, an 4-2 nicotinic acetylcholine receptors partial agonist, selectively decreases ethanol consumption and seeking
    • Steensland P, Simms JA, Holgate J, Jemma K, Richards, Barlett SE. Varenicline, an 4-2 nicotinic acetylcholine receptors partial agonist, selectively decreases ethanol consumption and seeking. PNAS 2007; 104:12518-23.
    • (2007) PNAS , vol.104 , pp. 12518-12523
    • Steensland, P.1    Simms, J.A.2    Holgate, J.3    Jemma, K.4    Richards Barlett, S.E.5
  • 33
    • 77955403546 scopus 로고    scopus 로고
    • Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption
    • Hendrickson LM, Zhao-Shea R, Pang X, Gardner PD, Tapper AR. Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption. J of Neurosci 2010; 30:10169-76.
    • (2010) J of Neurosci , vol.30 , pp. 10169-10176
    • Hendrickson, L.M.1    Zhao-Shea, R.2    Pang, X.3    Gardner, P.D.4    Tapper, A.R.5
  • 34
    • 63849314202 scopus 로고    scopus 로고
    • The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system
    • Ericson M, Löf E, Stomberg R, Söderpalm B. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. J Pharmacol Exp Ther 2009; 329: 225-30.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 225-230
    • Ericson, M.1    Löf, E.2    Stomberg, R.3    Söderpalm, B.4
  • 36
    • 68349128648 scopus 로고    scopus 로고
    • Preclinical pharmacology of the alph4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
    • Rollema H, Hajos M, Seymore PA, Kozak R, Majchrzak MJ, Guanowsky V, et al. Preclinical pharmacology of the alph4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition. Biochem Pharmacol 2009; 78: 813-24.
    • (2009) Biochem Pharmacol , vol.78 , pp. 813-824
    • Rollema, H.1    Hajos, M.2    Seymore, P.A.3    Kozak, R.4    Majchrzak, M.J.5    Guanowsky, V.6
  • 37
    • 33845925227 scopus 로고    scopus 로고
    • Ethanol consumption produces changes in behavior and hippocampal alpha7 and alpha4beta2 nicotinic receptors
    • Robles N, Sabria J. Ethanol consumption produces changes in behavior and hippocampal alpha7 and alpha4beta2 nicotinic receptors. J Mol Neurosci 2006; 30: 119-20.
    • (2006) J Mol Neurosci , vol.30 , pp. 119-120
    • Robles, N.1    Sabria, J.2
  • 38
    • 33748927988 scopus 로고    scopus 로고
    • Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them
    • Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, et al. Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them. Mol Pharmacol 2006; 70:1454-60.
    • (2006) Mol Pharmacol , vol.70 , pp. 1454-1460
    • Xiao, Y.1    Fan, H.2    Musachio, J.L.3    Wei, Z.L.4    Chellappan, S.K.5    Kozikowski, A.P.6
  • 40
    • 77249132728 scopus 로고    scopus 로고
    • Sazetidine-A, a selective SS4442 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats
    • Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, et al. Sazetidine-A, a selective SS4442 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. J Pharmacol Exp Ther 2010; 332: 933-9.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 933-939
    • Levin, E.D.1    Rezvani, A.H.2    Xiao, Y.3    Slade, S.4    Cauley, M.5    Wells, C.6
  • 41
    • 0032742936 scopus 로고    scopus 로고
    • Suppression of alcohol intake by chronic naloxone treatment in P rats: Tolerance development and elevation of opiate receptor binding
    • Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Braun C, Bartus RB, Crews F. Suppression of alcohol intake by chronic naloxone treatment in P rats: Tolerance development and elevation of opiate receptor binding. Alcohol Clin Exp Res 1999; 23: 1761-71.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 1761-1771
    • Overstreet, D.H.1    Kampov-Polevoy, A.B.2    Rezvani, A.H.3    Braun, C.4    Bartus, R.B.5    Crews, F.6
  • 42
    • 33845875457 scopus 로고    scopus 로고
    • The Effects of atypical anxiolytic N-Phenyl-2-[1-[3-(2-pyridinylethynyl) benzoyl]-4-piperidine] acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats: Comparison with naltrexone
    • Rezvani AH, Overstreet DH, Levin ED, Rosenthal DI, Kordik CP, Reitz AB, et al. The Effects of atypical anxiolytic N-Phenyl-2-[1-[3-(2-pyridinylethynyl) benzoyl]-4-piperidine] acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats: Comparison with naltrexone. Alcohol Clin Exp Res 2007; 31:57-63.
    • (2007) Alcohol Clin Exp Res , vol.31 , pp. 57-63
    • Rezvani, A.H.1    Overstreet, D.H.2    Levin, E.D.3    Rosenthal, D.I.4    Kordik, C.P.5    Reitz, A.B.6
  • 43
    • 60549110829 scopus 로고    scopus 로고
    • Effects of subunit selective nACh receptors on operant ethanol self-administration and relapselike ethanol-drinking behavior
    • Kuzmin A, Jerlhag E, Liljequist EJ. Effects of subunit selective nACh receptors on operant ethanol self-administration and relapselike ethanol-drinking behavior. Psychopharmacology 2009; 203: 99-108.
    • (2009) Psychopharmacology , vol.203 , pp. 99-108
    • Kuzmin, A.1    Jerlhag, E.2    Liljequist, E.J.3
  • 44
    • 33644614050 scopus 로고    scopus 로고
    • Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes
    • Greenbaum L, Kanyas K, Karni O, Merbl Y, Olender T, Horowitz A, et al. Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. Mol Psychiatry 2006; 11: 312-22.
    • (2006) Mol Psychiatry , vol.11 , pp. 312-322
    • Greenbaum, L.1    Kanyas, K.2    Karni, O.3    Merbl, Y.4    Olender, T.5    Horowitz, A.6
  • 45
    • 38849084034 scopus 로고    scopus 로고
    • A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine-or methamphetamine-induced stimulation
    • Kamens HM, Phillips TJ. A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine-or methamphetamine-induced stimulation. Psychopharmacol 2008; 196: 377-87.
    • (2008) Psychopharmacol , vol.196 , pp. 377-387
    • Kamens, H.M.1    Phillips, T.J.2
  • 46
    • 40349116471 scopus 로고    scopus 로고
    • Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function
    • Rigbi A, Kanyas K, Yakir A, Greenbaum L, Pollak Y, Ben-Asher E, et al. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. Genes Brain Behav 2008; 7:164-72.
    • (2008) Genes Brain Behav , vol.7 , pp. 164-172
    • Rigbi, A.1    Kanyas, K.2    Yakir, A.3    Greenbaum, L.4    Pollak, Y.5    Ben-Asher, E.6
  • 47
    • 43049176325 scopus 로고    scopus 로고
    • The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults
    • Schlaepfer IR, Hoft NR, Collins AC, Corley RP, Hewitt JK, Hopfer CJ, et al. The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biol Psychiatry 2008; 63:1039-46.
    • (2008) Biol Psychiatry , vol.63 , pp. 1039-1046
    • Schlaepfer, I.R.1    Hoft, N.R.2    Collins, A.C.3    Corley, R.P.4    Hewitt, J.K.5    Hopfer, C.J.6
  • 48
    • 36348949690 scopus 로고    scopus 로고
    • Nicotine acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues
    • Löf E, Olausson P, deBejczy A, Stomberg R, McIntosh JM, Taylor JR, et al. Nicotine acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues. Psychopharmacol 2007; 195:333-43.
    • (2007) Psychopharmacol , vol.195 , pp. 333-343
    • Löf, E.1    Olausson, P.2    deBejczy, A.3    Stomberg, R.4    McIntosh, J.M.5    Taylor, J.R.6
  • 49
    • 72049132358 scopus 로고    scopus 로고
    • Effect of topiramate treatment on ethanol consumption in rats
    • Breslin FJ, Johnson BA, Lynch WJ. Effect of topiramate treatment on ethanol consumption in rats. Psychopharmacol 2010; 207-520-35.
    • (2010) Psychopharmacol , vol.207 , pp. 520-535
    • Breslin, F.J.1    Johnson, B.A.2    Lynch, W.J.3
  • 50
    • 0022495155 scopus 로고
    • Carbamazepine and ethanol elicited response in rodents
    • Messiha FS, Butler D, Adams MK. Carbamazepine and ethanol elicited response in rodents. Alcohol 1986; 3:131-3.
    • (1986) Alcohol , vol.3 , pp. 131-133
    • Messiha, F.S.1    Butler, D.2    Adams, M.K.3
  • 54
    • 33846260829 scopus 로고    scopus 로고
    • Topiramate reduces ethanol consumption by C57BL/6 mice
    • Nguyen SA, Malcolm R, Middugh LD. Topiramate reduces ethanol consumption by C57BL/6 mice. Synapse 2007; 61:150-6.
    • (2007) Synapse , vol.61 , pp. 150-156
    • Nguyen, S.A.1    Malcolm, R.2    Middugh, L.D.3
  • 55
    • 33646192507 scopus 로고    scopus 로고
    • The acute effects of gabapentin in combination with alcohol in heavy drinkers
    • Bisaga A, Evans SM. The acute effects of gabapentin in combination with alcohol in heavy drinkers. Drug Alcohol Depend 2006; 83: 25-32.
    • (2006) Drug Alcohol Depend , vol.83 , pp. 25-32
    • Bisaga, A.1    Evans, S.M.2
  • 56
    • 33646587064 scopus 로고    scopus 로고
    • Effects of lamotrigine in patients with bipolar disorder and alcohol dependence
    • Rubio G, Lupez-Munoz F, Alamo C. Effects of lamotrigine in patients with bipolar disorder and alcohol dependence. Bipolar Disorder 2006; 8:289-93.
    • (2006) Bipolar Disorder , vol.8 , pp. 289-293
    • Rubio, G.1    Lupez-Munoz, F.2    Alamo, C.3
  • 57
    • 33947230296 scopus 로고    scopus 로고
    • Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal
    • Knapp DJ, Overstreet DH, Breese GR. Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. Alcohol Clin Exp Res 2007; 31:582-95.
    • (2007) Alcohol Clin Exp Res , vol.31 , pp. 582-595
    • Knapp, D.J.1    Overstreet, D.H.2    Breese, G.R.3
  • 58
    • 33750900787 scopus 로고    scopus 로고
    • Pharmacokinetics of the new antiepileptic and CNS drug RWJ-333369 following single and multiple dosing to humans
    • Yao C, Doose DR, Novak G, Bialer M. Pharmacokinetics of the new antiepileptic and CNS drug RWJ-333369 following single and multiple dosing to humans. Epilepsis 2006; 47:1822-9.
    • (2006) Epilepsis , vol.47 , pp. 1822-1829
    • Yao, C.1    Doose, D.R.2    Novak, G.3    Bialer, M.4
  • 59
    • 33747049831 scopus 로고    scopus 로고
    • Diverse mechanisms of antiepileptic drugs in the development pipeline
    • Rogawski MA. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res 2006; 69:273-94.
    • (2006) Epilepsy Res , vol.69 , pp. 273-294
    • Rogawski, M.A.1
  • 60
    • 39749108897 scopus 로고    scopus 로고
    • Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS
    • François J, Boehrer A, Nehlig A. Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS. Epilepsia 2008; 49: 393-9.
    • (2008) Epilepsia , vol.49 , pp. 393-399
    • François, J.1    Boehrer, A.2    Nehlig, A.3
  • 61
    • 51449116680 scopus 로고    scopus 로고
    • A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy
    • Grabenstatter HL, Dudek FE. A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy. Epilepsia 2008; 49:1787-94.
    • (2008) Epilepsia , vol.49 , pp. 1787-1794
    • Grabenstatter, H.L.1    Dudek, F.E.2
  • 62
    • 36549086809 scopus 로고    scopus 로고
    • Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: Randomised, double-blind controlled study
    • Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 2007; 370:1915-22.
    • (2007) Lancet , vol.370 , pp. 1915-1922
    • Addolorato, G.1    Leggio, L.2    Ferrulli, A.3    Cardone, S.4    Vonghia, L.5    Mirijello, A.6
  • 64
    • 33750019252 scopus 로고    scopus 로고
    • Baclofeninduced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations
    • Colombo G, Serra S, Vacca G, Carai MA, Gessa GL. Baclofeninduced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations. Eur J Pharmacol 2006; 550:123-6.
    • (2006) Eur J Pharmacol , vol.550 , pp. 123-126
    • Colombo, G.1    Serra, S.2    Vacca, G.3    Carai, M.A.4    Gessa, G.L.5
  • 65
    • 70350765125 scopus 로고    scopus 로고
    • Role of the GABA(B) receptor in alcohol-seeking and drinking behavior
    • Maccioni P, Colombo G. Role of the GABA(B) receptor in alcohol-seeking and drinking behavior. Alcohol 2009; 43:555-68.
    • (2009) Alcohol , vol.43 , pp. 555-568
    • Maccioni, P.1    Colombo, G.2
  • 69
    • 0024526467 scopus 로고
    • Benzodiazepines in the treatment of alcoholism
    • Nutt D, Adinoff B, Linnoila M. Benzodiazepines in the treatment of alcoholism. Rec Devel Alcohol 1989; 7: 283-313.
    • (1989) Rec Devel Alcohol , vol.7 , pp. 283-313
    • Nutt, D.1    Adinoff, B.2    Linnoila, M.3
  • 70
    • 0033746413 scopus 로고    scopus 로고
    • Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats
    • Parkes H, Sinclair JD. Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats. Alcohol 2000; 21:215-21.
    • (2000) Alcohol , vol.21 , pp. 215-221
    • Parkes, H.1    Sinclair, J.D.2
  • 71
    • 0035891883 scopus 로고    scopus 로고
    • Paradoxical trafficking and regulation of 5-HT (2A receptors by agonists and antagonists
    • Gray JA, Roth BL. Paradoxical trafficking and regulation of 5-HT (2A receptors by agonists and antagonists. Brain Res Bull 2001; 56:441-51.
    • (2001) Brain Res Bull , vol.56 , pp. 441-451
    • Gray, J.A.1    Roth, B.L.2
  • 74
    • 0031837244 scopus 로고    scopus 로고
    • Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats
    • Silvestre JS, Palacios JM, Fernandez AG, O'Neill MF. Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats. J Psychopharmacol 1998; 12:168-76.
    • (1998) J Psychopharmacol , vol.12 , pp. 168-176
    • Silvestre, J.S.1    Palacios, J.M.2    Fernandez, A.G.3    O'Neill, M.F.4
  • 75
    • 70350494437 scopus 로고
    • Mechanism of the action of tetraethlthiuram disulfide in alcoholism: Iron as an antidote for the TETD-alcohol reaction
    • Christensen JC. Mechanism of the action of tetraethlthiuram disulfide in alcoholism: iron as an antidote for the TETD-alcohol reaction. Q J Stud Alcohol 1951; 12: 30-9.
    • (1951) Q J Stud Alcohol , vol.12 , pp. 30-39
    • Christensen, J.C.1
  • 76
    • 0027371881 scopus 로고
    • Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters
    • Keung WM, Vallee BL. Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters. Proc Natl Acad Sci USA 1993; 90:10008-12.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10008-10012
    • Keung, W.M.1    Vallee, B.L.2
  • 77
    • 0027466340 scopus 로고
    • Daidzin: A potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase
    • Keung WM, Vallee BL. Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Natl Acad Sci USA 1993; 90:1247-51.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1247-1251
    • Keung, W.M.1    Vallee, B.L.2
  • 78
    • 0029074733 scopus 로고
    • Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism
    • Keung WM, Lazo O, Kunze L, Vallee BL. Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism. Proc Natl Acad Sci USA 1995; 92: 8990-3.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8990-8993
    • Keung, W.M.1    Lazo, O.2    Kunze, L.3    Vallee, B.L.4
  • 79
    • 0042949939 scopus 로고    scopus 로고
    • Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters
    • Keung WM, Klyosov AA, Vallee BL. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci USA1997; 94:16755:5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 16755
    • Keung, W.M.1    Klyosov, A.A.2    Vallee, B.L.3
  • 81
    • 33645236729 scopus 로고    scopus 로고
    • The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcoholpreferring rats
    • Liang JH, Chen F, Krstew E, Cowen MS, Carroll FY, Crawford D, et al. The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcoholpreferring rats. Neuropharmacol 2006; 50: 632-9.
    • (2006) Neuropharmacol , vol.50 , pp. 632-639
    • Liang, J.H.1    Chen, F.2    Krstew, E.3    Cowen, M.S.4    Carroll, F.Y.5    Crawford, D.6
  • 83
    • 77956450412 scopus 로고    scopus 로고
    • Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis
    • Yao L, Fan P, Arolfo M, Jiang Z, Olive MF, Zablocki J, et al. Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. Nat Med 2010; 16: 1024-8.
    • (2010) Nat Med , vol.16 , pp. 1024-1028
    • Yao, L.1    Fan, P.2    Arolfo, M.3    Jiang, Z.4    Olive, M.F.5    Zablocki, J.6
  • 84
    • 0035319477 scopus 로고    scopus 로고
    • Increased brain histamine in an alcohol-preferring rat line, and modulation of ethanol consumption by H3 receptor mechanisms
    • Lintunen M, Hyytiä P, Sallmen T, Karlstedt K, Tuomisto L, Leurs R, et al. Increased brain histamine in an alcohol-preferring rat line, and modulation of ethanol consumption by H3 receptor mechanisms. FASEB J 2001; 15: 1074-6.
    • (2001) FASEB J , vol.15 , pp. 1074-1076
    • Lintunen, M.1    Hyytiä, P.2    Sallmen, T.3    Karlstedt, K.4    Tuomisto, L.5    Leurs, R.6
  • 86
    • 72649104589 scopus 로고    scopus 로고
    • Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice
    • Nuutinen S, Karlstedt K, Aitta-Aho T, Korpi ER, Panula P. Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice. Psychopharmacol 2009; 208: 75-86.
    • (2009) Psychopharmacol , vol.208 , pp. 75-86
    • Nuutinen, S.1    Karlstedt, K.2    Aitta-Aho, T.3    Korpi, E.R.4    Panula, P.5
  • 88
    • 0034879048 scopus 로고    scopus 로고
    • Distribution and modulation of histamine H3 receptors in basal ganglia and frontal cortex of healthy controls and patients with parkinson's disease
    • Anichtchik OV, Peitsaro N, Rinne JO, Kalimo H, Panula P. Distribution and modulation of histamine H3 receptors in basal ganglia and frontal cortex of healthy controls and patients with parkinson's disease. Neurobiol Dis 2001; 8: 707-16.
    • (2001) Neurobiol Dis , vol.8 , pp. 707-716
    • Anichtchik, O.V.1    Peitsaro, N.2    Rinne, J.O.3    Kalimo, H.4    Panula, P.5
  • 89
  • 90
    • 0027454927 scopus 로고
    • A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas
    • Pollard H, Moreau J, Arrang JM, Schwartz JC. A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas. Neurosci 1993; 52: 169-89.
    • (1993) Neurosci , vol.52 , pp. 169-189
    • Pollard, H.1    Moreau, J.2    Arrang, J.M.3    Schwartz, J.C.4
  • 91
    • 77953871163 scopus 로고    scopus 로고
    • Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development
    • Letavic MA, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, et al. Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development. Bioorg Medic Chem Lett 2010; 20: 4210-4.
    • (2010) Bioorg Medic Chem Lett , vol.20 , pp. 4210-4214
    • Letavic, M.A.1    Aluisio, L.2    Atack, J.R.3    Bonaventure, P.4    Carruthers, N.I.5    Dugovic, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.