Diarylacetylene piperidinyl amides as novel anxiolytics

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 3065-3067

  Kordik, Cheryl P ^a   Luo, Chi ^a   Gutherman, Maryann ^a   Vaidya, Anil H ^a   Rosenthal, Daniel I ^a   Crooke, Jeffrey J ^a   McKenney, Sandra L ^a   Plata Salaman, Carlos R ^a   Reitz, Allen B ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Anxiolytics; Diarylacetylenes; Elevated plus maze; Neurokinin; Piperidines; Sonogashira coupling

Indexed keywords

ACETAMIDE DERIVATIVE; ANXIOLYTIC AGENT; N PHENYL 2 [1 [3 (2 PYRIDINYLETHYNYL)BENZOYL] 4 PIPERIDINE]ACETAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; ACETYLENE; AMIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; MAZE TEST; MOUSE; NONHUMAN; RAT; TRANQUILIZING ACTIVITY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; HAMSTER; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALIA;

ACETYLENE; AMIDES; ANIMALS; ANTI-ANXIETY AGENTS; CHO CELLS; CRICETINAE; HUMANS; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746649567     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.027     Document Type: Article

References (15)

1. Hood S.D., Argyropoulos S.V., and Nutt D.J. Exp. Opin. Ther. Pat. 13 (2003) 401
2. Gordon J.A., and Hen R. Annu. Rev. Neurosci. 27 (2004) 193
3. Airaksinen E., Larsson M., and Forsell Y. J. Psychiatr. Res. 39 (2005) 207
4. Bignan G.C., Connolly P.J., and Middleton S.A. Exp. Opin. Ther. Patents 15 (2005) 357
5. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders; 4th ed.; Text Revision, American Psychiatric Association: Washington, DC, 2000.
6. McLean S. Curr. Pharm. Des. 11 (2005) 1529
7. Holmes A., Heilig M., Rupniak N.M.J., Steckler T., and Griebel G. Trends Pharmacol. Sci. 24 (2003) 580
8. Rupniak N.M.J., and Kramer M.S. Trends Pharm. Sci. 20 (1999) 485
9. Patel L., and Lindley C. Exp. Opin. Pharmacother. 4 (2003) 2279
10. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G., Snavely D., Wyatt-Knowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., and Rupniak N.M.J. Science 281 (1998) 1640
11. Ofner S., Hauser K., Schilling W., Vassout A., and Veenstra S.J. Bioorg. Med. Chem. Lett. 6 (1996) 1623
12. Negishi E.-I., and Anastasia L. Chem. Rev. 103 (2003) 1979
13. Sibille E., Sarnyai Z., Benjamin D., Gal J., Baker H., and Toth M. Mol. Pharmacol. 52 (1997) 1056
14. Willins D.L., and Meltzer H.Y. J. Pharmacol. Exp. Ther. 282 (1997) 699
15. Dubinsky B., Vaidya A.H., Rosenthal D.I., Hochman C., Crooke J.J., Deluca S., Devine A., Cheo-Isaacs C.T., Carter A.R., Jordan A.D., Reitz A.B., and Shank R.P. J. Pharmacol. Exp. Ther. 303 (2002) 777