Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis

Nature Medicine

Volumn 16, Issue 9, 2010, Pages 1024-1028

  Yao, Lina ^a   Fan, Peidong ^a   Arolfo, Maria ^a   Jiang, Zhan ^a   Olive, M Foster ^b   Zablocki, Jeff ^a   Sun, Hai Ling ^a   Chu, Nancy ^a   Lee, Jeongrim ^c   Kim, Hee Yong ^c   Leung, Kwan ^a   Shryock, John ^a   Blackburn, Brent ^a   Diamond, Ivan ^a  

^a Gilead Sciences   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2 INHIBITOR; COCAINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE; DOPAMINE 2 RECEPTOR; OXIDOREDUCTASE INHIBITOR; PROTEIN KINASE C; TETRAHYDROPAPAVEROLINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; 2,3,10,11-TETRAHYDROXYTETRAHYDROPROTOBERBERINE; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, RAT; BERBERINE DERIVATIVE; DOPAMINE RECEPTOR BLOCKING AGENT; MITOCHONDRIAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO CULTURE; MOLECULAR MECHANICS; NEGATIVE FEEDBACK; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VENTRAL TEGMENTUM; ANIMAL; ANTAGONISTS AND INHIBITORS; ASSOCIATION; BIOSYNTHESIS; COCAINE-RELATED DISORDERS; DISEASE MODEL; ENZYME ACTIVATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM;

ALDEHYDE DEHYDROGENASE; ANIMALS; BERBERINE ALKALOIDS; COCAINE; COCAINE-RELATED DISORDERS; CUES; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE ANTAGONISTS; ENZYME ACTIVATION; INFUSIONS, INTRAVENOUS; MITOCHONDRIAL PROTEINS; RATS; TYROSINE 3-MONOOXYGENASE;

RATTUS;

EID: 77956450412     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2200     Document Type: Article

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