Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl) benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats

Alcoholism: Clinical and Experimental Research

Volumn 31, Issue 1, 2007, Pages 57-63

  Rezvani, Amir H ^a   Overstreet, David H ^b   Levin, Edward D ^a   Rosenthal, Daniel I ^c   Kordik, Cheryl P ^c   Reitz, Allen B ^c   Vaidya, Anil H ^c  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Alcoholism; Alcoholism Treatment; Medication Developments; Naltrexone

Indexed keywords

ALCOHOL; ANXIOLYTIC AGENT; DRINKING WATER; JNJ 5234801; N PHENYL 2 [1 [3 (2 PYRIDINYLETHYNYL)BENZOYL] 4 PIPERIDINE]ACETAMIDE; NALTREXONE; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL TOLERANCE; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; FLUID INTAKE; FOOD; FOOD INTAKE; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ACUTE DISEASE; ALCOHOL DRINKING; ANIMALS; ANTI-ANXIETY AGENTS; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG TOLERANCE; INJECTIONS, INTRAPERITONEAL; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; PIPERIDINES; PYRIDINES; RATS;

ANIMALIA;

EID: 33845875457     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00264.x     Document Type: Article

References (36)

1. Anton RF, Moak DH, Ward LR, Latham PK, Malcolm RJ, Dias JK (1999) Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial. Am J Psychiatry 156:1658-1764.
2. Anton RF, Swift RM (2003) Current pharmacotherapies on alcoholism: a U.S. perspective. Am J Addict 12:53-S68.
3. Bymaster F, Perry KW, Nelson DL, Wong DT, Rasmussen K, Moore NA, Calligaro DO (1999) Olanzapine: a basic science update. Br J Psychiatry 37 (suppl): 36-40.
4. Cowen MS, Rezvani AH, Jarrott B, Lawrence AJ (1999) Ethanol consumption by Fawn-Hooded rats following abstinence: effect of naltrexone and changes in mu-opioid receptor density. Alcohol Clin Exp Res 23:1008-1014.
5. Gray JA, Roth BL (2001) Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Res Bull 56:441-451.
6. Hutchison KE, Ray L, Sandman E, Rutter MC, Peters A, Davidson D, Swift R (2006) The effect of olanzapine on craving and alcohol consumption. Neuropsychopharmacology 31:1310-1317.
7. Ingman K, Korpi ER (2006) Alcohol drinking of alcohol-preferring AA rats is differentially affected by clozapine and olanzapine. Eur J Pharmacol 534:133-140.
8. Johnson BA (2003) The role of serotonergic agents as treatments for alcoholism. Drugs Today (Barc) 39:665-672.
9. Kampov-Polevoy AB, Matthews DB, Gause L, Morrow AL, Overstreet DH (2000) P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking. Alcohol Clin Exp Res 24:278-284.
10. Kordik CP, Luo C, Gutherman M, Vaidya AH, Rosentharl D, Crooke JJ, McKenney SL, Plata-Salaman CR, Reitz AB (2006) Diarylacetylene piperidinyl amides as novel anxiolytics. Bioorg Med Chem Lett 16:3065-3067.
11. Kranzler HR, Burleson JA, Del Boca FK, Babor TF, Korner P, Brown J, Bohn MJ (1994) Buspirone treatment of anxious alcoholics. A placebo-controlled trial. Arch Gen Psychiatry 51:720-731.
12. Litten RZ, Allen JP, Fertig J (1996) Pharmacotherapies for alcohol problems: a review of research with focus on developments since 1991. Alcohol Clin Exp Res 20:859-876.
13. Litten RZ, Allen JP (1991) Pharmacotherapies for alcoholism: promising agents and clinical issues. Alcohol Clin Exp Res 15:620-633.
14. Litten RZ, Allen JP (1998) Advances in development of medications for alcoholism treatment. Psychopharmacology 139:20-33.
15. Myers RD, Lankford M, Bjork A (1993) Irreversible suppression of alcohol drinking in cyanamide-treated rats after sustained delivery of the 5-HT-2 antagonist amperozide. Alcohol 10:117-125.
16. Myrick H, Brady KT, Malcolm R (2001) New developments in the pharmacotherapy of alcohol dependence. Am J Addict 10 (suppl): 3-15.
17. Nutt D, Adinoff B, Linnoila M (1989) Benzodiazepines in the treatment of alcoholism. Rec Dev Alcohol 7:283-313.
18. O'Malley SS, Jaffe A, Chang G, Wite G, Schottenfeld RS, Rounsaville BJ (1992a) Naltrexone in the treatment of alcohol dependence: preliminary findings, in Novel Pharmacological Interventions for Alcoholism (Naranjo C ed), pp 148-157. Springer Verlag, New York.
19. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B (1992b) Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry 49:881-887.
20. 2A antagonists amperozide and FG 5974. Alcohol Clin Exp Res 21:1448-1454.
21. Overstreet DH, Lee Y-W, Rezvani AH, Chen TC (1998) The Chinese herbal medicine NPI-028 suppresses alcohol intake in alcohol-preferring rats and monkeys without inducing taste aversion. Perfusion 11:381-390.
22. Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Braun C, Bartus RB, Crews FT (1999) Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding. Alcohol Clin Exp Res 23:1761-1771.
23. Parkes H, Sinclair JD (2000) Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats. Alcohol 21:215-221.
24. Pettinati HM (2004) Antidepressant treatment of co-occurring depression and alcohol dependence. Biol Psychiatry 56:785-792.
25. Rezvani AH, Grady D (1994) Suppression of alcohol consumption by fenfluramine in Fawn-Hooded rats with serotonin dysfunction. Pharmacol Biochem Behav 48:105-110.
26. Rezvani AH, Mason GA, Garbutt JC, Janowsky DS, Overstreet DH (1993) Reductions of tolerance to anti-craving drugs for alcohol. Alcohol Clin Exp Res 17:515.
27. Rezvani AH, Overstreet DH, Lee YW (1995) Attenuation of alcohol intake by ibogaine in three strains of alcohol preferring rats. Pharmacol Biochem Behav 52:615-620.
28. Rezvani AH, Overstreet DH, Yang Y, Maisonneuve IM, Bandarage UK, Kuehne MD, Glick SD (1997) Attenuation of alcohol consumption by a novel non-toxic ibogaine analog (18-methoxyccoronaridine) in alcohol-preferring rats. Pharmacol Biochem Behav 58:615-619.
29. Rezvani AH, Overstreet DH, Yang Y, Clark E Jr (1999) Attenuation of alcohol intake by the extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats. Alcohol Alcohol 34:699-705.
30. Rezvani AH, Overstreet DH, Mason GA, Janowsky DS, Hamedi M, Clark E Jr, Yang Y (2000) Combination pharmacotherapy: a mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats. Alcohol Alcohol 35:76-83.
31. Rodd ZA, Bell RL, Zhang Y, Murphy JM, Goldstein A, Zaffaroni A, Li TK, McBride WJ (2005) Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin. Neuropsychopharmacology 30:330-338.
32. Silvestre JS, Palacios JM, Fernandez AG, O'Neill MF (1998) Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats. J Psychopharmacol 12:168-176.
33. Tomkins DM, Joharchi N, Tampakeras M, Martin JR, Wichman J, Higgins GA (2002) An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration Behaviour. Pharmacol Biochem Behav 71:735-744.
34. Vaidya AH, Rosenthal D, Crooke JJ, Milewski M, Dubinsky B, Kordik CP, Plata-Salaman CR, Reitz AB (2003) In-vivo characterization of JNJ-5234801: a typical anxiolytic. Presented at Society for Neuroscience meeting, November 12, 2003.
35. Volpicelli JR, Rhines KC, Rhines JS, Volpicelli LA, Alterman AI, O'Brien CP (1997) Naltrexone and alcohol dependence. Role of subject compliance. Arch Gen Psychiatry 54:737-742.
36. Volpicelli JR, Alterman AIf, Hayashida M, O'Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880.