Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor

Alcoholism: Clinical and Experimental Research

Volumn 33, Issue 11, 2009, Pages 1935-1944

  Arolfo, Maria P ^a   Overstreet, David H ^b   Yao, Lina ^a   Fan, Peidong ^a   Lawrence, Andrew J ^c   Tao, Guoxin ^d   Keung, Wing Ming ^d   Vallee, Bert L ^d   Olive, M Foster ^e   Gass, Justin T ^e   Rubin, Emanuel ^f   Anni, Helen ^f   Hodge, Clyde W ^b   Besheer, Joyce ^b   Zablocki, Jeff ^a   Leung, Kwan ^a   Blackburn, Brent K ^a   Lange, Louis G ^a   Diamond, Ivan ^a  

^a CV THERAPEUTICS INC   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Endowment for Research in Human Biology Inc   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Acetaldehyde; Alcohol; ALDH 2 Inhibitor; Dopamine; Rat

Indexed keywords

3 [[3 (4(METHYLSULFONAMIDO)PHENYL) 4 OXO 4H CHROMEN 7 YLOXY]METHYL]BENZOIC ACID; ACETALDEHYDE; ALDEHYDE DEHYDROGENASE INHIBITOR; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CVT 10216; DAIDZIN; DOPAMINE; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOPAMINE RELEASE; DRINKING BEHAVIOR; DRUG EFFICACY; LONG EVANS RAT; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; THERAPY EFFECT;

ACETALDEHYDE; ALCOHOL DETERRENTS; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ANIMALS; CHOICE BEHAVIOR; CONDITIONING, OPERANT; CUES; DOPAMINE; ENZYME INHIBITORS; EXTINCTION, PSYCHOLOGICAL; ISOFLAVONES; MALE; MICRODIALYSIS; MITOCHONDRIAL PROTEINS; NUCLEUS ACCUMBENS; PUERARIA; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; RECURRENCE; SELF ADMINISTRATION;

PUERARIA MONTANA VAR. LOBATA; RATTUS; RODENTIA;

EID: 70350513815     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.01031.x     Document Type: Article

References (43)

1. Arolfo MP, Yao L, Gordon AS, Diamond I, Janak PH (2004) Ethanol operant self-administration in rats is regulated by adenosine A2 receptors. Alcohol Clin Exp Res 28 : 1308 1316.
2. Berridge KC (2007) The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl) 191 : 391 431.
3. Besheer J, Faccidomo S, Grondin JJ, Hodge CW (2008) Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats. Alcohol 42 : 13 20.
4. Brady JF, Xiao F, Wang MH, Li Y, Ning SM, Gapac JM, Yang CS (1991) Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats. Toxicol Appl Pharmacol 108 : 366 373.
5. Christensen JA (1951) Mechanism of the action of tetraethylthiuram disulfide in alcoholism; iron as antidote for the TETD-alcohol reaction. Q J Stud Alcohol 12 : 30 39.
6. Cichelli MJ, Lewis MJ (2002) Naloxone nonselective suppression of drinking of ethanol, sucrose, saccharin, and water by rats. Pharmacol Biochem Behav 72 : 699 706.
7. Cowen MS, Djouma E, Lawrence AJ (2005) The mGlu5 antagonist MTEP reduces ethanol self- administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp Ther 315 : 590 600.
8. Di Chiara G, Bassareo V (2007) Reward system and addiction: what dopamine does and doesn't do [erratum appears in Curr Opin Pharmacol 7(2):233]. Curr Opin Pharmacol 7 : 69 76.
9. Eisenhofer G, Kopin IJ, Goldstein DS (2004) Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev 56 : 331 349.
10. Eneanya DI, Bianchine JR, Duran DO, Andresen BD (1981) The actions of metabolic fate of disulfiram. Annu Rev Pharmacol Toxicol 21 : 575 596.
11. Eriksson CJ (2001) The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 25 (5 Suppl. ISBRA 15S 32S.
12. Foddai M, Dosia G, Spiga S, Diana M (2004) Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 29 : 530 536.
13. Garver E, Ross AD, Tu GC, Cao QN, Zhou F, Israel Y (2000) Paradigm to test a drug-induced aversion to ethanol. Alcohol Alcohol 35 : 435 438.
14. Gastfriend DR, Garbutt JC, Pettinati HM, Forman RF (2007) Reduction in heavy drinking as a treatment outcome in alcohol dependence. J Subst Abuse Treat 33 : 71 80.
15. Goldstein M, Anagnoste B, Lauber E, McKeregham MR (1964) Inhibition of dopamine-beta-hydroxylase by disulfiram. Life Sci 3 : 763 767.
16. Gonzales RA, Weiss F (1998) Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci 18 : 10663 10671.
17. Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Nakayama K, Kawamoto T (2002) Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12 : 621 626.
18. Johnson BA (2008) Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem Pharmacol 75 : 34 56.
19. Keung WM, Klyosov AA, Vallee BL (1997) Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci U S A 94 : 1675 1679.
20. Keung WM, Lazo O, Kunze L, Vallee BL (1995) Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism. Proc Natl Acad Sci USA 92 : 8990 8993.
21. Keung WM, Vallee BL (1993a) Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters. Proc Natl Acad Sci USA 90 : 10008 10012.
22. Keung WM, Vallee BL (1993b) Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Natl Acad Sci U S A 90 : 1247 1251.
23. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B (2006) The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148 : 752 759.
24. Liang JH, Chen F, Krstew E, Cowen MS, Carroll FY, Crawford D, Beart PM, Lawrence AJ (2006) The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats. Neuropharmacology 50 : 632 639.
25. Mann K, Lehert P, Morgan MY (2004) The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res 28 : 51 63.
26. McBride WJ, Le AD, Noronha A (2002) Central nervous system mechanisms in alcohol relapse. Alcohol Clin Exp Res 26 : 280 286.
27. Melis M, Enrico P, Peana AT, Diana M (2007) Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system. Eur J Neurosci 26 : 2824 2833.
28. Morales L, Perez-Garcia C, Herradon G, Alguacil LF (2007) Place conditioning in a two- or three-conditioning compartment apparatus: a comparative study with morphine and U-50,488. Addict Biol 12 : 482 484.
29. O'Brien CP, Gardner EL (2005) Critical assessment of how to study addiction and its treatment: human and non-human animal models. Pharmacol Ther 108 : 18 58.
30. Olive MF, Mehmert KK, Hodge CW (2000) Modulation of extracellular neurotransmitter levels in the nucleus accumbens by a taurine uptake inhibitor. Eur J Pharmacol 409 : 291 294.
31. Overstreet DH, McArthur RA, Rezvani AH, Post C (1997) Selective inhibition of alcohol intake in diverse alcohol-preferring rat strains by the 5-HT2A antagonists amperozide and FG 5974. Alcohol Clin Exp Res 21 : 1448 1454.
32. Paxinos G, Watson C (2005) The Rat Brain in Stereotaxic Coordinates, 5th edn. Elsevier, Burlington, MA.
33. Quintanilla ME, Tampier L, Sapag A, Israel Y (2005) Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Pharmacogenet Genomics 15 : 427 431.
34. Redmond EM, Sitzmann JV, Cahill PA (2000) Potential mechanisms for cardiovascular protective effect of ethanol. Acta Pharmacologica Sinica 21 : 385 390.
35. Rezvani AH, Parsian A, Overstreet DH (2002) The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism. Psychiatr Genet 12 : 1 16.
36. Rodd ZA, Bell RL, Sable HJ, Murphy JM, McBride WJ (2004) Recent advances in animal models of alcohol craving and relapse. Pharmacol Biochem Behav 79 : 439 450.
37. Samson HH (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10 : 436 442.
38. Suh JJ, Pettinati HM, Kampman KM, O'Brien CP (2006) The status of disulfiram: a half of a century later [see comment]. J Clin Psychopharmacol 26 : 290 302.
39. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48 : 677 681.
40. Ward RJ, Colantuoni C, Dahchour A, Quertemont E, De Witte P (1997) Acetaldehyde-induced changes in monoamine and amino acid extracellular microdialysate content of the nucleus accumbens. Neuropharmacology 36 : 225 232.
41. Weiss F, Lorang MT, Bloom FE, Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267 : 250 258.
42. Whitworth AB, Fischer F, Lesch OM, Nimmerrichter A, Oberbauer H, Platz T, Potgieter A, Walter H, Fleischhacker WW (1996) Comparison of acamprosate and placebo in long-term treatment of alcohol dependence [see comment]. Lancet 347 : 1438 1442.
43. Wise RA (2002) Brain reward circuitry: insights from unsensed incentives. Neuron 36 : 229 240.