메뉴 건너뛰기




Volumn 12, Issue 7, 2012, Pages 593-599

NK-1 receptor antagonists: A new generation of anticancer drugs

Author keywords

Apoptosis; Metastasis; Neoangiogenesis; Substance P; Tumor cells

Indexed keywords

ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; ANXIOLYTIC AGENT; APREPITANT; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOSTATIC AGENT; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MORPHOLINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PACLITAXEL; PIPERIDINE DERIVATIVE; VINBLASTINE;

EID: 84861726798     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955712800626692     Document Type: Article
Times cited : (14)

References (94)
  • 1
    • 23244463917 scopus 로고    scopus 로고
    • Antitumoural action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines
    • Muñoz, M.; Rosso, M.; Pérez, A.; Coveñas, R.; Rosso, R.; Zamarriego, C.; Soult, J.A.; Montero, I. Antitumoural action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines. Invest. Ophthalmol. Vis. Sci., 2005, 46, 2567-70.
    • (2005) Invest. Ophthalmol. Vis. Sci , vol.46 , pp. 2567-2570
    • Muñoz, M.1    Rosso, M.2    Pérez, A.3    Coveñas, R.4    Rosso, R.5    Zamarriego, C.6    Soult, J.A.7    Montero, I.8
  • 2
    • 34347273792 scopus 로고    scopus 로고
    • Neurokinin-1 receptors located in human retinoblastoma cell lines: Antitumor action of its antagonist, L-732,138
    • Muñoz, M.; Rosso, M.; Coveñas, R.; Montero, I.; González-Moles, M.A.; Robles, M.J. Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138. Invest. Ophthalmol. Vis. Sci., 2007, 48, 2775-81.
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48 , pp. 2775-2781
    • Muñoz, M.1    Rosso, M.2    Coveñas, R.3    Montero, I.4    González-Moles, M.A.5    Robles, M.J.6
  • 3
    • 79952199924 scopus 로고    scopus 로고
    • Neurokinin-1 receptor: A new promising target in the treatment of cancer
    • Muñoz, M.; Coveñas, R. Neurokinin-1 receptor: a new promising target in the treatment of cancer. Discov. Med., 2010, 10, 305-13.
    • (2010) Discov. Med , vol.10 , pp. 305-313
    • Muñoz, M.1    Coveñas, R.2
  • 4
    • 2542435999 scopus 로고    scopus 로고
    • Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines
    • Muñoz, M.; Pérez, A.; Coveñas, R.; Rosso, M.; Castro, E. Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines. Arch. Ital. Biol., 2004, 142, 105-12.
    • (2004) Arch. Ital. Biol , vol.142 , pp. 105-112
    • Muñoz, M.1    Pérez, A.2    Coveñas, R.3    Rosso, M.4    Castro, E.5
  • 5
    • 3042799978 scopus 로고    scopus 로고
    • Antitumoural action of NK1 receptor antagonist L-733,060 on human melanoma cell lines
    • Muñoz, M.; Pérez, A.; Rosso, M.; Zamarriego, C.; Rosso, R. Antitumoural action of NK1 receptor antagonist L-733,060 on human melanoma cell lines. Melanoma Res., 2004, 14, 183-8.
    • (2004) Melanoma Res , vol.14 , pp. 183-188
    • Muñoz, M.1    Pérez, A.2    Rosso, M.3    Zamarriego, C.4    Rosso, R.5
  • 6
    • 23044450652 scopus 로고    scopus 로고
    • The NK1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines
    • Muñoz, M.; Rosso, M.; Pérez, A.; Coveñas, R.; Rosso, R.; Zamarriego, C.; Piruat, J.I. The NK1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines. Neuropeptides, 2005, 39, 427-32.
    • (2005) Neuropeptides , vol.39 , pp. 427-432
    • Muñoz, M.1    Rosso, M.2    Pérez, A.3    Coveñas, R.4    Rosso, R.5    Zamarriego, C.6    Piruat, J.I.7
  • 7
    • 77950639335 scopus 로고    scopus 로고
    • A new frontier in the treatment of cancer: NK-1 receptor antagonists
    • Muñoz, M.; Rosso, M.; Coveñas, R. A new frontier in the treatment of cancer: NK-1 receptor antagonists. Curr. Med. Chem., 2010, 17, 504-16.
    • (2010) Curr. Med. Chem , vol.17 , pp. 504-516
    • Muñoz, M.1    Rosso, M.2    Coveñas, R.3
  • 8
    • 77955653145 scopus 로고    scopus 로고
    • Paravertebral anesthesia: How substance P and the NK-1 receptor could be involved in regional block and breast cancer recurrence
    • Muñoz, M.; Rosso, M.; Casinello, F.; Coveñas, R. Paravertebral anesthesia: how substance P and the NK-1 receptor could be involved in regional block and breast cancer recurrence. Breast Cancer Res. Treat., 2010, 122, 601-3.
    • (2010) Breast Cancer Res. Treat , vol.122 , pp. 601-603
    • Muñoz, M.1    Rosso, M.2    Casinello, F.3    Coveñas, R.4
  • 9
    • 77955151651 scopus 로고    scopus 로고
    • The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines
    • Muñoz, M.; Rosso, M.; Robles-Frías, M.J.; Salinas-Martín, M.V.; Rosso, R.; Gonzalez-Ortega, A.; Coveñas, R. The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines. Lab. Invest., 2010, 90, 1259-69.
    • (2010) Lab. Invest , vol.90 , pp. 1259-1269
    • Muñoz, M.1    Rosso, M.2    Robles-Frías, M.J.3    Salinas-Martín, M.V.4    Rosso, R.5    Gonzalez-Ortega, A.6    Coveñas, R.7
  • 12
    • 58649098981 scopus 로고    scopus 로고
    • Expression of substance P and neurokinin-1-receptor in laryngeal cancer: Linking chronic inflammation to cancer promotion and progression
    • Esteban, F.; González-Moles, M.A.; Castro, D.; Martín-Jaén, M.M.; Redondo, M.; Ruiz-Avila, I.; Rosso, M.; Muñoz, M. Expression of substance P and neurokinin-1-receptor in laryngeal cancer: linking chronic inflammation to cancer promotion and progression. Histopathology, 2009, 54, 258-60.
    • (2009) Histopathology , vol.54 , pp. 258-260
    • Esteban, F.1    González-Moles, M.A.2    Castro, D.3    Martín-Jaén, M.M.4    Redondo, M.5    Ruiz-Avila, I.6    Rosso, M.7    Muñoz, M.8
  • 14
    • 0032920530 scopus 로고    scopus 로고
    • Substance P activates responses correlated with tumour growth in human glioma cells line bearing tachykinin NK1 receptors
    • Palma, C., Nardelli, F.; Manzini, S.; Maggi, C.A. Substance P activates responses correlated with tumour growth in human glioma cells line bearing tachykinin NK1 receptors. Br. J. Cancer, 1999, 79, 236-43.
    • (1999) Br. J. Cancer , vol.79 , pp. 236-243
    • Palma, C.1    Nardelli, F.2    Manzini, S.3    Maggi, C.A.4
  • 15
    • 33745590666 scopus 로고    scopus 로고
    • The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines
    • Muñoz, M.; Rosso, M.; Coveñas, R. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett. Drug Des. Discovery, 2006, 3, 323-9.
    • (2006) Lett. Drug Des. Discovery , vol.3 , pp. 323-329
    • Muñoz, M.1    Rosso, M.2    Coveñas, R.3
  • 16
    • 40549118238 scopus 로고    scopus 로고
    • NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2
    • Muñoz, M.; Rosso, M.; Aguilar, F.J.; González-Moles, M.A.; Redondo, M.; Esteban, F. NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2. Investig. New Drugs, 2008, 26, 111-8.
    • (2008) Investig. New Drugs , vol.26 , pp. 111-118
    • Muñoz, M.1    Rosso, M.2    Aguilar, F.J.3    González-Moles, M.A.4    Redondo, M.5    Esteban, F.6
  • 17
    • 51049102605 scopus 로고    scopus 로고
    • The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines
    • Rosso, M.; Robles-Frías, M.J.; Coveñas, R.; Salinas-Martín, M.V.; Muñoz, M. The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines. Tumor Biol., 2008, 29, 245-54.
    • (2008) Tumor Biol , vol.29 , pp. 245-254
    • Rosso, M.1    Robles-Frías, M.J.2    Coveñas, R.3    Salinas-Martín, M.V.4    Muñoz, M.5
  • 18
    • 0029961467 scopus 로고    scopus 로고
    • Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway
    • Luo, W.; Sharif, T.R.; Sharif, M. Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway. Cancer Res., 1996, 56, 4983-91.
    • (1996) Cancer Res , vol.56 , pp. 4983-4991
    • Luo, W.1    Sharif, T.R.2    Sharif, M.3
  • 19
    • 27644463170 scopus 로고    scopus 로고
    • Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231
    • Bigioni, M.; Benzo, A.; Irrisuto, C.; Maggi, CA.; Goso, C. Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231. Anticancer Drugs, 2005, 16, 1083-9.
    • (2005) Anticancer Drugs , vol.16 , pp. 1083-1089
    • Bigioni, M.1    Benzo, A.2    Irrisuto, C.3    Maggi, C.A.4    Goso, C.5
  • 20
    • 33646558897 scopus 로고    scopus 로고
    • A role for substance P in cancer promotion and progression: A mechanism to counteract intracellular death signals following oncogene activation or DNA damage
    • Esteban, F.; Muñoz, M.; González-Moles, M.A.; Rosso, M. A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metast. Rev., 2006, 25, 137-45.
    • (2006) Cancer Metast. Rev , vol.25 , pp. 137-145
    • Esteban, F.1    Muñoz, M.2    González-Moles, M.A.3    Rosso, M.4
  • 21
    • 79952267748 scopus 로고    scopus 로고
    • The NK-1 receptor antagonist L-732,13 8 induces apoptosis and counteracts substance P-related mitogenesis in human melanoma cell lines
    • Muñoz, M.; Rosso, M.; González-Ortega, A.; Coveñas, R. The NK-1 receptor antagonist L-732,13 8 induces apoptosis and counteracts substance P-related mitogenesis in human melanoma cell lines. Cancers, 2010, 2, 611-23.
    • (2010) Cancers , vol.2 , pp. 611-623
    • Muñoz, M.1    Rosso, M.2    González-Ortega, A.3    Coveñas, R.4
  • 22
    • 79953669021 scopus 로고    scopus 로고
    • The Nk-1 receptor: A new target in cancer therapy
    • Muñoz, M.; Rosso, M.; Coveñas, R. The Nk-1 receptor: a new target in cancer therapy. Curr. Drug Targets., 2011, 12, 909-21.
    • (2011) Curr. Drug Targets , vol.12 , pp. 909-921
    • Muñoz, M.1    Rosso, M.2    Coveñas, R.3
  • 23
    • 84861738830 scopus 로고    scopus 로고
    • The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines
    • DOI 10.1007/s10637-010-9594-0
    • Muñoz, M.; González-Ortega, A.; Coveñas, R. The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines. Invest. New Drugs, 2011, DOI 10.1007/s10637-010-9594-0.
    • (2011) Invest. New Drugs
    • Muñoz, M.1    González-Ortega, A.2    Coveñas, R.3
  • 24
    • 0042854927 scopus 로고    scopus 로고
    • Peptide receptors as molecular targets for cancer diagnosis and therapy
    • Reubi, J.C. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr. Rev., 2003, 24, 389-427.
    • (2003) Endocr. Rev , vol.24 , pp. 389-427
    • Reubi, J.C.1
  • 26
    • 0034602721 scopus 로고    scopus 로고
    • Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: Implications for bone marrow metastasis
    • Singh, D.; Joshi, D.D.; Hameed, M.; Qian, J.; Gascon, P.; Maloof, P.B.; Mosenthal, A.; Rameshwar P. Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis. Proc. Natl. Acad. Sci. USA., 2000, 97, 388-93.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 388-393
    • Singh, D.1    Joshi, D.D.2    Hameed, M.3    Qian, J.4    Gascon, P.5    Maloof, P.B.6    Mosenthal, A.7    Rameshwar, P.8
  • 27
    • 0029071971 scopus 로고
    • Substance-P receptors in human primary neoplasms: Tumoral and vascular localization
    • Hennig, I.M.; Laissue.; J.A.; Horisberger, U.; Reubi, J.C. Substance-P receptors in human primary neoplasms: tumoral and vascular localization. Int. J. Cancer, 1995, 61, 786-92.
    • (1995) Int. J. Cancer , vol.61 , pp. 786-792
    • Hennig, I.M.1    Laissue, J.A.2    Horisberger, U.3    Reubi, J.C.4
  • 28
    • 0028078691 scopus 로고
    • Substance P enhances forskolinstimulated cyclic AMP production in human UC11MG astrocytoma cells
    • Fowler, C.J.; Brannstrom, G. Substance P enhances forskolinstimulated cyclic AMP production in human UC11MG astrocytoma cells. Methods. Find. Exp. Clin. Pharmacol., 1994, 16, 21-8.
    • (1994) Methods. Find. Exp. Clin. Pharmacol , vol.16 , pp. 21-28
    • Fowler, C.J.1    Brannstrom, G.2
  • 29
    • 8744280019 scopus 로고    scopus 로고
    • The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies
    • Morgan, G.; Ward, R.; Barton, M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin. Oncol. (R. Coll. Radiol.), 2004, 16, 549-60.
    • (2004) Clin. Oncol. (R. Coll. Radiol.) , vol.16 , pp. 549-560
    • Morgan, G.1    Ward, R.2    Barton, M.3
  • 30
    • 0033976868 scopus 로고    scopus 로고
    • Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft
    • Palma, C.; Bigioni, M.; Irrissuto, C.; Nardelli, F.; Maggi, C.A.; Manzini, S. Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft. Br. J. Cancer, 2000, 82, 480-7.
    • (2000) Br. J. Cancer , vol.82 , pp. 480-487
    • Palma, C.1    Bigioni, M.2    Irrissuto, C.3    Nardelli, F.4    Maggi, C.A.5    Manzini, S.6
  • 32
    • 78649332115 scopus 로고    scopus 로고
    • Localization of NK-1 receptors and roles of substance P in subepithelial fibroblasts of rat intestinal villi
    • Furuya, S.; Furuya, K.; Shigemoto, R.; Sokabe, M. Localization of NK-1 receptors and roles of substance P in subepithelial fibroblasts of rat intestinal villi. Cell Tissue Res., 2010, 342, 243-59.
    • (2010) Cell Tissue Res , vol.342 , pp. 243-259
    • Furuya, S.1    Furuya, K.2    Shigemoto, R.3    Sokabe, M.4
  • 34
    • 0031283503 scopus 로고    scopus 로고
    • The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation
    • Quartara, L.; Maggi, C.A. The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation. Neuropeptides, 1997, 31, 537-63.
    • (1997) Neuropeptides , vol.31 , pp. 537-563
    • Quartara, L.1    Maggi, C.A.2
  • 35
    • 79251535010 scopus 로고    scopus 로고
    • Neurokinin-1 receptor: Functional significance in the immune system in reference to selected infections and inflammation
    • Douglas, S.D.; Leeman, S.E. Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann. NY Acad. Sci., 2011, 1217, 83-95.
    • (2011) Ann. NY Acad. Sci , vol.1217 , pp. 83-95
    • Douglas, S.D.1    Leeman, S.E.2
  • 36
    • 0035137002 scopus 로고    scopus 로고
    • Substance P: A pioneer amongst neuropeptides
    • Hökfelt, T.; Pernow, B.; Wahren, J. Substance P: a pioneer amongst neuropeptides. J. Intern. Med., 2001, 249, 27-40.
    • (2001) J. Intern. Med , vol.249 , pp. 27-40
    • Hökfelt, T.1    Pernow, B.2    Wahren, J.3
  • 38
    • 0031594899 scopus 로고    scopus 로고
    • The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles
    • Quartara, L.; Maggi, C.A. The tachykinin NK1 receptor. Part II: distribution and pathophysiological roles. Neuropeptides, 1998, 32, 1-49.
    • (1998) Neuropeptides , vol.32 , pp. 1-49
    • Quartara, L.1    Maggi, C.A.2
  • 39
    • 0037331104 scopus 로고    scopus 로고
    • The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test
    • Varty, G.B.; Cohen-Williams, M.E.; Hunter, J.C. The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test. Behav. Pharmacol., 2003, 14, 87-95.
    • (2003) Behav. Pharmacol , vol.14 , pp. 87-95
    • Varty, G.B.1    Cohen-Williams, M.E.2    Hunter, J.C.3
  • 40
    • 0037379926 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury
    • Bang, R.; Sass, G.; Kiemer, A.K.; Vollmar, A.M.; Neuhuber, W.L.; Tiegs, G. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J. Pharmacol. Exp. Ther., 2003, 305, 31-9.
    • (2003) J. Pharmacol. Exp. Ther , vol.305 , pp. 31-39
    • Bang, R.1    Sass, G.2    Kiemer, A.K.3    Vollmar, A.M.4    Neuhuber, W.L.5    Tiegs, G.6
  • 43
    • 77956545772 scopus 로고    scopus 로고
    • Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: Implications for substance P in NK1-R immune cell
    • Vinet-Oliphant, H.; Alvarez, X.; Buza, E.; Borda, J.T.; Mohan, M.; Aye, P.P.; Tuluc, F.; Douglas, S.D.; Lackner, A.A. Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: implications for substance P in NK1-R immune cell. Am. L. Pathol., 2010, 177, 1286-97.
    • (2010) Am. L. Pathol , vol.177 , pp. 1286-1297
    • Vinet-Oliphant, H.1    Alvarez, X.2    Buza, E.3    Borda, J.T.4    Mohan, M.5    Aye, P.P.6    Tuluc, F.7    Douglas, S.D.8    Lackner, A.A.9
  • 44
    • 77953356592 scopus 로고    scopus 로고
    • Modulation of the CRH system by substance P/NKA in an animal model of depression
    • Frisch, P.; Bilkei-Gorzó, A.; Rácz, I.; Zimmer, A. Modulation of the CRH system by substance P/NKA in an animal model of depression. Behav. Brain Res., 2010, 213, 103-8.
    • (2010) Behav. Brain Res , vol.213 , pp. 103-108
    • Frisch, P.1    Bilkei-Gorzó, A.2    Rácz, I.3    Zimmer, A.4
  • 45
    • 84858206016 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: Molecular insights
    • Hegde, A.; Koh, Y.H.; Moochhala, S.M.; Bhatia, M. Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insights. Int. J. Inflam., 2010, 2010, 601098.
    • (2010) Int. J. Inflam , vol.2010 , pp. 601098
    • Hegde, A.1    Koh, Y.H.2    Moochhala, S.M.3    Bhatia, M.4
  • 46
    • 0031964247 scopus 로고    scopus 로고
    • The neuropeptide/mast cell secretagogue substance P is expressed in cutaneus melanocytic lesions
    • Khare, V.K.; Albino, A.P.; Reed, J.A. The neuropeptide/mast cell secretagogue substance P is expressed in cutaneus melanocytic lesions. J. Cutan. Pathol., 1998, 25, 2-10.
    • (1998) J. Cutan. Pathol , vol.25 , pp. 2-10
    • Khare, V.K.1    Albino, A.P.2    Reed, J.A.3
  • 48
    • 0025092876 scopus 로고
    • Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells
    • Ziche, M.; Morbidelli, L.; Pacini, M.; Gepetti, P.; Alessandri, G.; Maggi, C.A. Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc. Res., 1990, 40, 264-78.
    • (1990) Microvasc. Res , vol.40 , pp. 264-278
    • Ziche, M.1    Morbidelli, L.2    Pacini, M.3    Gepetti, P.4    Alessandri, G.5    Maggi, C.A.6
  • 49
    • 80052335918 scopus 로고    scopus 로고
    • Substance P immunoreactive nerve fibers are related to gastric cancer differentiation status and could promote proliferation and migration of gastric cancer cells
    • DOI: 10.1042/CBI20100229
    • Feng, F.; Yang, J.; Tong, L.; Yuan, S.; Hong, L.; Wang, W.; Zhang, H. Substance P immunoreactive nerve fibers are related to gastric cancer differentiation status and could promote proliferation and migration of gastric cancer cells. Cell Biol. Int., 2011, DOI: 10.1042/CBI20100229.
    • (2011) Cell Biol. Int
    • Feng, F.1    Yang, J.2    Tong, L.3    Yuan, S.4    Hong, L.5    Wang, W.6    Zhang, H.7
  • 51
    • 0029071430 scopus 로고
    • Delineation of the endocytic pathway of substance P and its seven transmembrane domains NK1 receptor
    • Grady, E.F.; Garland, A.M.; Gamp, P.D.; Lovett, M.; Payan, D.G.; Bunnett, N.W. Delineation of the endocytic pathway of substance P and its seven transmembrane domains NK1 receptor. Mol. Biol. Cell., 1995, 6, 509-24.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 509-524
    • Grady, E.F.1    Garland, A.M.2    Gamp, P.D.3    Lovett, M.4    Payan, D.G.5    Bunnett, N.W.6
  • 53
    • 0020964719 scopus 로고
    • Specific stimulation of human T lymphocytes by substance P
    • Payan, D.G.; Brewster, D.R.; Goetzl, E.J. Specific stimulation of human T lymphocytes by substance P. J. Immunol., 1983, 131, 1613-5.
    • (1983) J. Immunol , vol.131 , pp. 1613-1615
    • Payan, D.G.1    Brewster, D.R.2    Goetzl, E.J.3
  • 54
    • 0025193496 scopus 로고
    • NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins
    • Ziche, M.; Morbidelli, L.; Pacini, M.; Dolara P.; Maggi, C.A. NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. Br. J. Pharmacol., 1990, 100, 11-4.
    • (1990) Br. J. Pharmacol , vol.100 , pp. 11-14
    • Ziche, M.1    Morbidelli, L.2    Pacini, M.3    Dolara, P.4    Maggi, C.A.5
  • 56
    • 66149137995 scopus 로고    scopus 로고
    • Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinasedependent mechanism
    • Meshki, J.; Douglas, S.D.; Lai, J.P.; Schwartz, L.; Kilpatrick, L.E.; Tuluc, F. Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinasedependent mechanism. J. Biol. Chem., 2009, 284, 9280-9.
    • (2009) J. Biol. Chem , vol.284 , pp. 9280-9289
    • Meshki, J.1    Douglas, S.D.2    Lai, J.P.3    Schwartz, L.4    Kilpatrick, L.E.5    Tuluc, F.6
  • 57
    • 45349096499 scopus 로고    scopus 로고
    • Cell motility through plasma membrane blebbing
    • Fackler, O.T.; Grosse, R. Cell motility through plasma membrane blebbing. J. Cell. Biol., 2008, 181, 879-84.
    • (2008) J. Cell. Biol , vol.181 , pp. 879-884
    • Fackler, O.T.1    Grosse, R.2
  • 58
    • 77954948706 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonists: A comprehensive patent survey
    • Huang, S.C.; Korlipara, V.L. Neurokinin-1 receptor antagonists: a comprehensive patent survey. Expert. Opin. Ther. Pat., 2010, 20, 1019-45.
    • (2010) Expert. Opin. Ther. Pat , vol.20 , pp. 1019-1045
    • Huang, S.C.1    Korlipara, V.L.2
  • 60
    • 33746814503 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonists: Between hope and disappointment
    • Rost, K.; Fleischer, F.; Nieber, K. Neurokinin-1 receptor antagonists: between hope and disappointment. Med. Monatsschr. Pharm., 2006, 29, 200-5.
    • (2006) Med. Monatsschr. Pharm , vol.29 , pp. 200-205
    • Rost, K.1    Fleischer, F.2    Nieber, K.3
  • 62
    • 38449085299 scopus 로고    scopus 로고
    • In vitro metabolism of CP-122,721(2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor
    • Obach, R.S.; Margolis, J.M.; Logman, M.J. In vitro metabolism of CP-122,721(2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab. Pharmacokinet., 2007, 22, 336-49.
    • (2007) Drug Metab. Pharmacokinet , vol.22 , pp. 336-349
    • Obach, R.S.1    Margolis, J.M.2    Logman, M.J.3
  • 63
    • 33745428781 scopus 로고    scopus 로고
    • The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: A randomized, controlled trial
    • Sindrup, S.H.; Graf, A.; Sfikas, N. The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomized, controlled trial. Eur. J. Pain, 2006, 10, 567-71.64.
    • (2006) Eur. J. Pain , vol.10 , pp. 567-571
    • Sindrup, S.H.1    Graf, A.2    Sfikas, N.3
  • 64
    • 6344256891 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonism by SR140,333: Enhanced in vivo ACh in the hippocampus and promnestic post-trial effects
    • Kart, E.; Jocham, G.; Müller, C.P.; Schlömer, C.; Brandão, M.L.; Huston, J.P.; de Souza Silva, M.A. Neurokinin-1 receptor antagonism by SR140,333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects. Peptides, 2004, 25, 1959-69.
    • (2004) Peptides , vol.25 , pp. 1959-1969
    • Kart, E.1    Jocham, G.2    Müller, C.P.3    Schlömer, C.4    Brandão, M.L.5    Huston, J.P.6    de Souza Silva, M.A.7
  • 65
    • 79955680163 scopus 로고    scopus 로고
    • NK-1 receptor antagonists: A new paradigm in pharmacological therapy
    • Muñoz, M.; Coveñas, R. NK-1 receptor antagonists: a new paradigm in pharmacological therapy. Curr. Med. Chem., 2011, 18, 1820-31.
    • (2011) Curr. Med. Chem , vol.18 , pp. 1820-1831
    • Muñoz, M.1    Coveñas, R.2
  • 67
    • 72749096071 scopus 로고    scopus 로고
    • Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis
    • Rudick, C.N.; Schaeffer, A.J.; Klumpp, D.J. Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. BMC Urol., 2009, 9, 16.
    • (2009) BMC Urol , vol.9 , pp. 16
    • Rudick, C.N.1    Schaeffer, A.J.2    Klumpp, D.J.3
  • 68
    • 69649089496 scopus 로고    scopus 로고
    • Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision
    • Sahbaie, P.; Shi, X.; Guo, T.Z.; Qiao, Y.; Yeomans, D.C.; Kingery, W.S.; Clark, J.D. Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision. Pain, 2009, 145, 341-9.
    • (2009) Pain , vol.145 , pp. 341-349
    • Sahbaie, P.1    Shi, X.2    Guo, T.Z.3    Qiao, Y.4    Yeomans, D.C.5    Kingery, W.S.6    Clark, J.D.7
  • 69
    • 0034057760 scopus 로고    scopus 로고
    • Pharmacological blockade or genetic deletion of substance P (NK(1) receptors attenuates neonatal vocalization in guinea-pigs and mice
    • Rupniak, N.M.; Carlson, E.C.; Harrison, T.; Oates, B.; Seward, E.; Owen, S.; de Felipe, C.; Hunt, S.; Wheeldon, A. Pharmacological blockade or genetic deletion of substance P (NK(1) receptors attenuates neonatal vocalization in guinea-pigs and mice. Neuropharmacology, 2000, 39, 1413-21.
    • (2000) Neuropharmacology , vol.39 , pp. 1413-1421
    • Rupniak, N.M.1    Carlson, E.C.2    Harrison, T.3    Oates, B.4    Seward, E.5    Owen, S.6    de Felipe, C.7    Hunt, S.8    Wheeldon, A.9
  • 70
    • 0036171973 scopus 로고    scopus 로고
    • Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    • Bolay, H.; Reuter, U.; Dunn, A.K.; Huang, Z.; Boas, D.A.; Moskowitz, M.A. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med., 2002, 8, 136-42.
    • (2002) Nat Med , vol.8 , pp. 136-142
    • Bolay, H.1    Reuter, U.2    Dunn, A.K.3    Huang, Z.4    Boas, D.A.5    Moskowitz, M.A.6
  • 71
    • 0032185613 scopus 로고    scopus 로고
    • A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity
    • Zachrisson, O.; Lindefors, N.; Brené, S. A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity. Brain Res. Mol. Brain Res., 1998, 60, 291-5.
    • (1998) Brain Res. Mol. Brain Res , vol.60 , pp. 291-295
    • Zachrisson, O.1    Lindefors, N.2    Brené, S.3
  • 72
    • 0036829194 scopus 로고    scopus 로고
    • Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain
    • Yu, J.; Cadet, J.L.; Angulo, J.A. Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J. Neurochem., 2002, 83, 613-22.
    • (2002) J. Neurochem , vol.83 , pp. 613-622
    • Yu, J.1    Cadet, J.L.2    Angulo, J.A.3
  • 73
    • 77958545469 scopus 로고    scopus 로고
    • Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer
    • Pagán, B.; Isidro, A.A.; Coppola, D.; Chen, Z.; Ren, Y.; Wu, J.; Appleyard, C.B. Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. Anticancer Res., 2010, 30, 3345-53.
    • (2010) Anticancer Res , vol.30 , pp. 3345-3353
    • Pagán, B.1    Isidro, A.A.2    Coppola, D.3    Chen, Z.4    Ren, Y.5    Wu, J.6    Appleyard, C.B.7
  • 74
    • 78650173721 scopus 로고    scopus 로고
    • NK-1-receptor-mediated lesion of spinal post-synaptic dorsal column neurons might improve intractable visceral pain of cancer origin
    • Wang, Y.; Mu, X.; Liu, Y.; Zhang, X.; Wu, A:, Yue, Y. NK-1-receptor-mediated lesion of spinal post-synaptic dorsal column neurons might improve intractable visceral pain of cancer origin. Med. Hypotheses, 2011, 76, 102-4.
    • (2011) Med. Hypotheses , vol.76 , pp. 102-104
    • Wang, Y.1    Mu, X.2    Liu, Y.3    Zhang, X.4    Wu, A.5    Yue, Y.6
  • 75
    • 79952860744 scopus 로고    scopus 로고
    • Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting
    • Hargreaves, R.; Ferreira, J.C.; Hughes, D.; Brands, J.; Hale, J.; Mattson, B.; Mills S. Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Ann. NY Acad. Sci., 2011, 1222, 40-8.
    • (2011) Ann. NY Acad. Sci , vol.1222 , pp. 40-48
    • Hargreaves, R.1    Ferreira, J.C.2    Hughes, D.3    Brands, J.4    Hale, J.5    Mattson, B.6    Mills, S.7
  • 76
    • 0033774032 scopus 로고    scopus 로고
    • Potential of substance P antagonists as antiemetics
    • Diemunsch, P.; Grelot, L. Potential of substance P antagonists as antiemetics. Drugs, 2000, 60, 533-46.
    • (2000) Drugs , vol.60 , pp. 533-546
    • Diemunsch, P.1    Grelot, L.2
  • 77
    • 77956193969 scopus 로고    scopus 로고
    • Targeting the neurokinin receptor 1 with aprepitant: A novel antipruritic strategy
    • Ständer, S.; Siepmann, D.; Herrgott, I.; Sunderkötter, C:, Luger, T.A. Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy. PLoS One, 2010, 5, e10968.
    • (2010) PLoS One , vol.5
    • Ständer, S.1    Siepmann, D.2    Herrgott, I.3    Sunderkötter, C.4    Luger, T.A.5
  • 78
    • 77952240278 scopus 로고    scopus 로고
    • The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug
    • Muñoz, M.; Rosso, M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest. New Drugs, 2010, 28, 187-93.
    • (2010) Invest. New Drugs , vol.28 , pp. 187-193
    • Muñoz, M.1    Rosso, M.2
  • 79
    • 0032413398 scopus 로고    scopus 로고
    • Induction of apoptosis by a short-chain neuropeptide analog in small cell lung cancer-stimulation of multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo
    • Rosati, R.; Adil, M.R.; Ali, M.A.; Eliason, J.; Orosz, A.; Sebestye, N.F.; Kalemkerian, G.P. Induction of apoptosis by a short-chain neuropeptide analog in small cell lung cancer-stimulation of multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo. Peptides, 1998, 19, 1519-23.
    • (1998) Peptides , vol.19 , pp. 1519-1523
    • Rosati, R.1    Adil, M.R.2    Ali, M.A.3    Eliason, J.4    Orosz, A.5    Sebestye, N.F.6    Kalemkerian, G.P.7
  • 80
    • 0024163078 scopus 로고
    • 11] Substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro
    • 11] Substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc. Natl. Acad. Sci. USA., 1988, 35, 1859-63.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.35 , pp. 1859-1863
    • Woll, P.J.1    Rozengurt, E.2
  • 81
    • 0028174947 scopus 로고
    • 11] Substance P induces apoptosis in lung cancer cell lines in vitro
    • 11] Substance P induces apoptosis in lung cancer cell lines in vitro. Biochem. Bioph. Res. Com., 1994, 199, 1313-9.
    • (1994) Biochem. Bioph. Res. Com , vol.199 , pp. 1313-1319
    • Reeve, J.G.1    Bleehen, N.M.2
  • 82
    • 2642523937 scopus 로고    scopus 로고
    • Direct effects of octreotide, galanin and serotonin on human colon cancer cells
    • El-Salhy, M.; Starefeldt, A. Direct effects of octreotide, galanin and serotonin on human colon cancer cells. Oncol. Rep., 2003, 10, 1723-8.
    • (2003) Oncol. Rep , vol.10 , pp. 1723-1728
    • El-Salhy, M.1    Starefeldt, A.2
  • 83
    • 65649138814 scopus 로고    scopus 로고
    • A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas
    • Akazawa, T.; Kwatra, S.G.; Goldsmith, L.E.; Richardson, M.D.; Cox, E.A.; Sampson, J.H.; Kwatra, M.M. A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J. Neurochem., 2009, 109, 1079-86.
    • (2009) J. Neurochem , vol.109 , pp. 1079-1086
    • Akazawa, T.1    Kwatra, S.G.2    Goldsmith, L.E.3    Richardson, M.D.4    Cox, E.A.5    Sampson, J.H.6    Kwatra, M.M.7
  • 84
    • 77952516646 scopus 로고    scopus 로고
    • SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D
    • Huang, W.Q.; Wang, J.G.; Chen, L.; Wei, H.J.; Chen, H. SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D. J. Exp. Clin. Cancer Res., 2010, 24, 29-55.
    • (2010) J. Exp. Clin. Cancer Res , vol.24 , pp. 29-55
    • Huang, W.Q.1    Wang, J.G.2    Chen, L.3    Wei, H.J.4    Chen, H.5
  • 85
    • 0034718604 scopus 로고    scopus 로고
    • The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestindependent scaffolding complex
    • DeFea, K.A.; Vaughn, Z.D.; O'Bryan, E.M.; Nishijima, D.; Dery, O.; Bunnett, N.W. The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestindependent scaffolding complex. Proc. Natl. Acad. Sci. USA., 2000, 97, 11086-91.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11086-11091
    • DeFea, K.A.1    Vaughn, Z.D.2    O'Bryan, E.M.3    Nishijima, D.4    Dery, O.5    Bunnett, N.W.6
  • 86
    • 0043195904 scopus 로고    scopus 로고
    • Antagonists at the neurokinin receptors-Recent patent literature
    • Giardina, G.A.M.; Gagliardi, S.; Martinelli, M. Antagonists at the neurokinin receptors-Recent patent literature. Drugs, 2003, 6, 758-72.
    • (2003) Drugs , vol.6 , pp. 758-772
    • Giardina, G.A.M.1    Gagliardi, S.2    Martinelli, M.3
  • 88
    • 4544321026 scopus 로고    scopus 로고
    • Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs
    • Lang, K.; Drell, T.L.; Lindecke, A.; Niggemann, B.; Kaltschmidt, C.; Zaenker, K.S.; Entschladen, F. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int. J. Cancer, 2004, 112, 231-8.
    • (2004) Int. J. Cancer , vol.112 , pp. 231-238
    • Lang, K.1    Drell, T.L.2    Lindecke, A.3    Niggemann, B.4    Kaltschmidt, C.5    Zaenker, K.S.6    Entschladen, F.7
  • 89
    • 16844365620 scopus 로고    scopus 로고
    • Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1, DTrp5,7,9, Leu11]SP: A dual inhibitor of growth and angiogenesis in pancreatic cancer
    • Guha, S.; Eibl, G.; Kisfalvi, K.; Fan.; R.S.; Burdick, M.; Reber, H.; Hines, O.J.; Strieter, R.; Rozengurt, E. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1, DTrp5,7,9, Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res., 2005, 65, 2738-45.
    • (2005) Cancer Res , vol.65 , pp. 2738-2745
    • Guha, S.1    Eibl, G.2    Kisfalvi, K.3    Fan, R.S.4    Burdick, M.5    Reber, H.6    Hines, O.J.7    Strieter, R.8    Rozengurt, E.9
  • 90
    • 33749165919 scopus 로고    scopus 로고
    • Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?
    • Exadaktylos, A.K.; Buggy, D.J.; Moriarty, D.C.; Mascha, E.; Sessler, D.I. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology, 2006, 105, 660-4.
    • (2006) Anesthesiology , vol.105 , pp. 660-664
    • Exadaktylos, A.K.1    Buggy, D.J.2    Moriarty, D.C.3    Mascha, E.4    Sessler, D.I.5
  • 91
    • 79955611266 scopus 로고    scopus 로고
    • Synergy between microtubule destabilizing agents and neurokinin 1 receptor antagonists identified by an siRNA synthetic lethal screen
    • Kitchens, C.A.; McDonald, P.R.; Pollack, I.F.; Wipf, P.; Lazo, J.S. Synergy between microtubule destabilizing agents and neurokinin 1 receptor antagonists identified by an siRNA synthetic lethal screen. FASEB. J., 2009, 23, 756.13.
    • (2009) FASEB. J , vol.23 , pp. 756
    • Kitchens, C.A.1    McDonald, P.R.2    Pollack, I.F.3    Wipf, P.4    Lazo, J.S.5
  • 92
    • 0033624773 scopus 로고    scopus 로고
    • Role of NK1 receptors on cisplatininduced nephrotoxicity in the rat
    • Alfieri, A.B.; Cubeddu, L.X. Role of NK1 receptors on cisplatininduced nephrotoxicity in the rat. Naunyn. Schmiebergs. Arch. Pharmacol., 2000, 361, 334-8.
    • (2000) Naunyn. Schmiebergs. Arch. Pharmacol , vol.361 , pp. 334-338
    • Alfieri, A.B.1    Cubeddu, L.X.2
  • 93
    • 79955621751 scopus 로고    scopus 로고
    • Efectos de los antagonistas de los receptores NK1 y de la dexametasona sobre la inflamación neurogénica inducida por ciclofosfamida y por radiación X, en la rata
    • Alfieri, A.B.; Cubeddu, L.X. Efectos de los antagonistas de los receptores NK1 y de la dexametasona sobre la inflamación neurogénica inducida por ciclofosfamida y por radiación X, en la rata. AVFT., 2004, 23, 61-6.
    • (2004) AVFT , vol.23 , pp. 61-66
    • Alfieri, A.B.1    Cubeddu, L.X.2
  • 94
    • 3042733290 scopus 로고    scopus 로고
    • Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent
    • Sendo, T.; Itoh, Y.; Goromaru, T.; Hirakawa, T.; Ishida, M.; Nakano, H.; Oishi, R. Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent. Peptides, 2004, 25, 1205-8.
    • (2004) Peptides , vol.25 , pp. 1205-1208
    • Sendo, T.1    Itoh, Y.2    Goromaru, T.3    Hirakawa, T.4    Ishida, M.5    Nakano, H.6    Oishi, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.