The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug

Investigational New Drugs

Volumn 28, Issue 2, 2010, Pages 187-193

  Muñoz, Miguel ^a   Rosso, Marisa ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Antitumor; Apoptosis; Aprepitant; Drug; NK 1 receptor antagonist

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ANTINEOPLASTIC AGENT; APREPITANT; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST;

APOPTOSIS; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; COLON CARCINOMA; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; COULTER COUNTER; GLIOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LARYNX CARCINOMA; NEUROBLASTOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; RETINOBLASTOMA; REVIEW; STOMACH CARCINOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MITOGENS; MORPHOLINES; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 77952240278     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9218-8     Document Type: Review

References (33)

1. Muñoz M, Rosso M, Soult JA, Coveñas R (2006b) Antitumoural action of neurokinin-1 receptor antagonists on human brain cancer cell lines. In: Yang AV (ed) Brain cancer: therapy and surgical intervention. Nova Science, New York, pp 45-75
2. T Hökfelt B Pernow J Wahren 2001 Substance P: a pioneer amongst neuropeptides J Intern Med 249 27 40 10.1046/j.0954-6820.2000.00773.x 11168782 (Pubitemid 32147090)
3. S Harrison P Geppetti 2001 Substance P Int J Biochem Cell Biol 33 555 576 10.1016/S1357-2725(01)00031-0 1:CAS:528:DC%2BD3MXjvV2nt78%3D 11378438 (Pubitemid 32510811)
4. W Luo TR Sharif M Sharif 1996 Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway Cancer Res 56 4983 4991 1:CAS:528:DyaK28XmsFygt7w%3D 8895754
5. M Muñoz A Pérez M Rosso C Zamarriego R Rosso 2004 Antitumoural action of NK1 receptor antagonist L-733,060 on human melanoma cell lines Melanoma Res 14 183 188 10.1097/01.cmr.0000129376.22141.a3 15179186 (Pubitemid 38879579)
6. M Muñoz M Rosso A Pérez R Coveñas R Rosso C Zamarriego JI Piruat 2005 The NK1 receptor is involved in the antitumoural action of L-733,060 and the mitogenic action of substance P on neuroblastoma and glioma cell lines Neuropeptides 39 427 432 10.1016/j.npep.2005.03.004 15939468 (Pubitemid 41073623)
7. M Muñoz M Rosso A Pérez R Coveñas R Rosso C Zamarriego JA Soult I Montero 2005 Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines Invest Ophthalmol Vis Sci 46 2567 2570 10.1167/iovs.04-1530 15980249 (Pubitemid 43119507)
8. M Muñoz M Rosso R Coveñas 2006 The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines Lett Drug Des Discov 3 323 329 10.2174/157018006777574168 (Pubitemid 43988115)
9. Muñoz M, Rosso M, Coveñas R (2007a) NK-1 receptor antagonists as new anti-tumoural agents: action on human neuroblastoma cell lines. In: Fernandes JA (ed) Focus on Neuroblastoma Research. Nova Science, New York, pp 31-56
10. M Muñoz M Rosso FJ Aguilar MA González-Moles M Redondo F Esteban 2008 NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2 Invest New Drugs 26 111 118 10.1007/s10637-007-9087-y 17906845
11. M Rosso MJ Robles-Frías R Coveñas MV Salinas-Martín M Muñoz 2008 The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines Tumour Biol 29 245 254 10.1159/000152942 1:CAS:528:DC%2BD1cXhtFKhur7F 18781096
12. M Ziche L Morbidelli M Pacini P Gepetti G Alessandri CA Maggi 1990 Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells Microvasc Res 40 264 278 10.1016/0026-2862(90)90024-L 1:CAS:528:DyaK3MXhslyksbY%3D 1701206 (Pubitemid 20327679)
13. K Lang TL Drell A Lindecke B Niggemann C Kaltschmidt KS Zaenker F Entschladen 2004 Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs Int J Cancer 112 231 238 10.1002/ijc.20410 1:CAS:528:DC%2BD2cXnvVejsL8%3D 15352035 (Pubitemid 39244363)
14. GAM Giardina S Gagliardi M Martinelli 2003 Antagonists at the neurokinin receptors-Recent patent literature IDrugs 6 758 772 1:CAS:528: DC%2BD3sXnvVGkurc%3D 12917772
15. NM Rupniak E Carlson S Boyce JK Webb RG Hill 1996 Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils Pain 67 189 195 10.1016/0304-3959(96)03109-0 1:CAS:528:DyaK28XmsFCgurg%3D 8895247 (Pubitemid 26319652)
16. MS Kramer N Cutler J Feighner R Shrivastava J Carman JJ Sramek SA Reines G Liu D Snavely E Wyatt-knowles JJ Halle SG Mills M MacCoss CJ Swain T Harrison RG Hill F Hefti EM Scolnick MA Cascieri GG Chicchi S Sadowski AR Williams L Hewson D Smith EJ Carlsson RJ Hargreaves NM Rupniak 1998 Distinct mechanism for antidepressant activity by blockade of central substance P receptors Science 281 1640 1645 10.1126/science.281.5383.1640 1:CAS:528:DyaK1cXmtVSqtb0%3D 9733503 (Pubitemid 28435572)
17. GB Varty ME Cohen-Williams CA Morgan U Pylak RA Duffy JE Lachowicz GJ Carey VL Coffin 2002 The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists Neuropsychopharmacology 27 371 379 10.1016/S0893-133X(02)00313-5 1:CAS:528:DC%2BD38XmvVWqsrw%3D 12225694 (Pubitemid 35253785)
18. R Bang G Sass AK Kiemer AM Vollmar WL Neuhuber G Tiegs 2003 Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury J Pharmacol Exp Ther 305 31 39 10.1124/jpet.102.043539 1:CAS:528:DC%2BD3sXis1antLg%3D 12649350 (Pubitemid 36373833)
19. 11] Substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells Cancer Res 57 51 54 1:CAS:528:DyaK2sXjvFGiug%3D%3D 8988040
20. C Palma M Bigioni C Irrissuto F Nardelli CA Maggi S Manzini 2000 (200)Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft Br J Cancer 82 480 487 10.1054/bjoc.1999.0946 1:CAS:528:DC%2BD3cXpt12htQ%3D%3D 10646908
21. M Muñoz A Pérez R Coveñas M Rosso E Castro 2004 Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines Arch Ital Biol 142 105 112 15248566
22. M Muñoz M Rosso R Coveñas I Montero MA González-Moles 2007 Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonists, L-732,138 Invest Ophthalmol Vis Sci 20 48 2775 2781 10.1167/iovs.05-1591 (Pubitemid 351261233)
23. FD Tattersall W Rycroft M Cumberbatch G Mason S Tye DJ Williamson JJ Hale SG Mills PE Finke M MacCoss S Sadowski E Ber M Cascieri RG Hill DE MacIntyre RJ Hargreaves 2000 The novel NK-1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets Neuropharmacology 39 652 663 10.1016/S0028-3908(99)00172-0 1:CAS:528:DC%2BD3cXhtFWqs7w%3D 10728886 (Pubitemid 30089315)
24. M Bigioni A Benzo C Irrissuto CA Maggi C Goso 2005 Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231 Anticancer Drugs 16 1083 1089 10.1097/00001813-200511000-00007 1:CAS:528:DC%2BD2MXhtV2ktrbM 16222150 (Pubitemid 41565774)
25. IM Hennig JA Laissue U Horisberger JC Reubi 1995 Substance-P receptors in human primary neoplasms: tumoral and vascular localization Int J Cancer 61 786 792 10.1002/ijc.2910610608 1:STN:280:DyaK2MzhtVSmtw%3D%3D 7790112
26. H Friess Z Zhu V Liard X Shi SV Shrikhande L Wang K Lieb M Korc C Palma A Zimmermann JC Reubi MW Buchler 2003 Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer Lab Invest 83 731 742 1:CAS:528:DC%2BD3sXjtlKjs7o%3D 12746482
27. D Singh DD Joshi M Hameed J Qian P Gascón PB Maloof A Mosenthal P Rameshwar 2000 Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: Implications for bone marrow metastasis Proc Natl Acad Sci USA 97 388 393 10.1073/pnas.97.1.388 1:CAS:528: DC%2BD3cXjvVGhtQ%3D%3D 10618428 (Pubitemid 30055841)
28. Esteban F, González-Moles MA, Castro D, Martín-Jaén MM, Redondo M, Ruiz-Avila I, Muñoz M (2009) Expression of substance P and Neurokinin-1-receptor in laryngeal cancer: linking chronic inflammation to cancer promotion and progression. Histopath doi: 10.1111/j.1365-2559.2008.03193. x
29. 11] Substance P induces apoptosis in lung cancer cell lines in vitro Biochem Biophys Res Commun 199 1313 1319 10.1006/bbrc.1994.1374 1:CAS:528:DyaK2cXitlKrtrw%3D 7511895
30. F Esteban M Muñoz MA González-Moles M Rosso 2006 A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage Cancer Metastasis Rev 25 137 145 10.1007/s10555-006-8161-9 1:CAS:528: DC%2BD28Xktlaksrg%3D 16680578 (Pubitemid 43723988)
31. S Guha G Eibl K Kisfalvi RS Fan M Burdick H Reber OJ Hines R Strieter E Rozengurt 2005 Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1, DTrp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer Cancer Res 65 2738 2745 10.1158/0008-5472.CAN-04-3197 1:CAS:528:DC%2BD2MXjtVeqsbo%3D 15805273 (Pubitemid 40490075)
32. GB Varty ME Cohen-Williams JC Hunter 2003 The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test Behav Pharmacol 14 87 95 1:CAS:528:DC%2BD3sXht1Cmsb8%3D 12576885
33. J Yu JL Cadet JA Angulo 2002 Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain J Neurochem 83 613 622 10.1046/j.1471-4159.2002.01155.x 1:CAS:528:DC%2BD38Xos1Sjtbc%3D 12390523 (Pubitemid 35231815)