Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: Implications for substance P in NK1-R immune cell trafficking into the CNS

American Journal of Pathology

Volumn 177, Issue 3, 2010, Pages 1286-1297

  Vinet Oliphant, Heather ^a,b   Alvarez, Xavier ^a   Buza, Elizabeth ^c   Borda, Juan T ^a   Mohan, Mahesh ^a   Aye, Pyone P ^a   Tuluc, Florin ^d   Douglas, Steven D ^d   Lackner, Andrew A ^a  

^a TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^b TULANE UNIVERSITY   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; NEUROKININ 1 RECEPTOR; RANTES; SUBSTANCE P;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHEMOTAXIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; INFLAMMATION; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS CELL INTERACTION; VIRUS ENCEPHALITIS;

EID: 77956545772     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.091109     Document Type: Article

References (32)

1. Ho W-Z, Douglas SD: Substance P and neurokinin-1 receptor modulation of HIV. J Neuroimmunol 2004, 157:48-55
2. Leserman J: HIV disease progression: depression, stress, and possible mechanisms. Biol Psychiatry 2003, 54:295-306 (Pubitemid 37267859)
3. Williams KC, Hickey WF: Central Nervous System Damage, Monocytes and Macrophages, and Neurological Disorders in AIDS, Annu Rev Neurosci 2002, 25:537-562
4. Gonzalez-Scarano F, Martin-Garcia J: The neuropathogenesis of AIDS. Nat Rev Immunol 2005, 5:69-81
5. Navia B, Cho E, Petito C, Price R: The AIDS dementia complex: II Neuropathology. Ann Neurol 1986, 19:517-524
6. Navia B, Cho E, Petito C, Price R: The AIDS dementia complex: I Clinical Features. Ann Neurol 1986, 19:525-535 (Pubitemid 16085186)
7. Price R, Brew B, Sidtis J, Rosenblum M, Scheck A, Cleary P: The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988, 239:586-592 (Pubitemid 18066218)
8. Tuluc F, Lai JP, Kilpatrick LE, Evans DL, Douglas SD: Neurokinin 1 receptor isoforms and the control of innate immunity. Trends Immunol 2009, 30:271-276
9. Douglas SD, Lai J-P, Tuluc F, Schwartz L, Kilpatrick LE: Neurokinin-1 receptor expression and function in human macrophages and brain. Ann NY Acad Sci 2008, 1144:90-96
10. Masliah E, Ge N, Morey M, DeTeresa R, Terry R, Wiley C: Cortical dendritic pathology in human immunodeficiency virus encephalitis. Lab Invest 1992, 66:285-291
11. Crews L, Lentz MR, González RG, Fox HS, Masliah E: Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. J Neurovirol 2008, 14:327-339
12. Annunziata P, Cioni C, Toneatto S, Paccagnini E: HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P. AIDS 1998, 12:2377-2385 (Pubitemid 28558595)
13. Li Y, Douglas SD, Song L, Sun S, Ho W-Z: Substance P enhances HIV-1 replication in latently infected human immune cells. J Neuroimmunol 2001, 121:67-75 (Pubitemid 34008452)
14. Annunziata P: Blood-brain barrier changes during invasion of the central nervous system by HIV-1. J Neurol 2003, 250:901-906
15. Lai J-P, Ho W-Z, Zhan G-X, Yi Y, Collman RG, Douglas SD: Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes. Proc Natl Acad Sci USA 2001, 98:3970-3975
16. Ho W-Z, Lai J-P, Li Y, Douglas SD: HIV enhances substance P expression in human immune cells. FASEB J 2002, 16:616-618
17. Ho W, Cnaan A, Li Y, Zhao H, Lee H, Song L, Douglas S: Substance P modulates human immunodeficency virus replication in human peripheral blood monocyte-derived macrophages. AIDS Res Hum Retroviruses 1996, 12:195-198 (Pubitemid 26054163)
18. Annunziata P, Cioni C, Santonini R, Paccagnini E: Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium. J Neuroimmunol 2002, 131:41-49
19. O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP, Shanahan F: The role of substance P in inflammatory disease. J Cell Physiol 2004, 201:167-180
20. Derocq J-M, Ségui M, Blazy C, Emonds-Alt X, Le Fur G, Brelière J-C, Casellas P: Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists. FEBS Lett 1996, 399:321-325
21. Lai J-P, Ho W-Z, Yang J-H, Wang X, Song L, Douglas SD: A nonpeptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes. J Neuroimmunol 2002, 128:101-108 (Pubitemid 34722370)
22. Wang X, Douglas S, Lai J-P, Tuluc F, Tebas P, Ho W-Z: Neurokinin-1 Receptor Antagonist (Aprepitant) Inhibits Drug-Resistant HIV-1 Infection of Macrophages in vitro. J Neuroimmune Pharmacol 2007, 2:42-48
23. Wang X, Douglas S, Song L, Wang Y-J, Ho W-Z: Neurokinin-1 receptor antagonist (aprepitant) suppresses HIV-1 infection of microglia/macrophages. J Neuroimmune Pharmacol 2008, 3:257-264
24. Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM: Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998, 281:1640-1645
25. Borda JT, Alvarez X, Mohan M, Hasegawa A, Bernardino A, Jean S, Aye P, Lackner AA: CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier. Am J Pathol 2008, 172:725-737 (Pubitemid 351354545)
26. Chernova I, Lai J-P, Li H, Schwartz L, Tuluc F, Korchak HM, Douglas SD, Kilpatrick LE: Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). J Leukoc Biol 2009, 85:154-164
27. Pernow B: Substance P. Pharmacol Rev 1983, 35:85-141
28. Nakanishi S: Substance P precursor and kininogen: their structures, gene organizations, and regulation. Physiol Rev 1987, 67:1117-1142
29. Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD: Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Proc Natl Acad Sci U S A 2006, 103:7771-7776 (Pubitemid 43752856)
30. Fong TM, Anderson SA, Yu H, Huang RR, Strader CD: Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. Mol Pharmacol 1992, 41:24-30
31. Schmidlin F, Roosterman D, Bunnett NW: The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with {beta}-arrestins. Am J Physiol Cell Physiol 2003, 285: C945-C958 (Pubitemid 37158819)
32. Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW: Endosomal endothelin-converting enzyme-1. J Biol Chem 2009, 284:22411-22425