In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor.

Drug metabolism and pharmacokinetics

Volumn 22, Issue 5, 2007, Pages 336-349

  Obach, R Scott ^a   Margolis, Jeannine M ^a   Logman, Michael J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 TRIFLUOROMETHOXYSALICYLIC ACID; 5-TRIFLUOROMETHOXYSALICYLIC ACID; AMINE OXIDASE (FLAVIN CONTAINING); CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; ENZYME INHIBITOR; HYDROQUINONE DERIVATIVE; NEUROKININ 1 RECEPTOR; PIPERIDINE DERIVATIVE; RECOMBINANT PROTEIN; SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DEALKYLATION; DOG; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; IN VITRO STUDY; KINETICS; LIVER MICROSOME; MACACA; METABOLISM; RAT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; DOGS; ENZYME INHIBITORS; HUMANS; HYDROQUINONES; KINETICS; MACACA FASCICULARIS; MICROSOMES, LIVER; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; SALICYLIC ACIDS; SPECIES SPECIFICITY;

EID: 38449085299     PISSN: 13474367     EISSN: None     Source Type: Journal    
DOI: 10.2133/dmpk.22.336     Document Type: Article

References (0)