Polyamine-mediated regulation of protein acetylation in murine skin and tumors

Molecular Carcinogenesis

Volumn 46, Issue 8, 2007, Pages 611-617

  Wei, Gang ^a   Hobbs, Cheryl A ^a,b   DeFeo, Karen ^a   Hayes, Candace S ^a   Gilmour, Susan K ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

Histone acetyltransferases (HAT); Ornithine decarboxylase (ODC); Transcriptional activation; Transgenic mice; Tumor suppressor protein p53

Indexed keywords

HISTONE; HISTONE ACETYLASE TIP60; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; MULTIPROTEIN COMPLEX; ORNITHINE DECARBOXYLASE; POLYAMINE; PROTEIN P53; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; HAIR FOLLICLE; MOUSE; NONHUMAN; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN TUMOR; TRANSCRIPTION INITIATION;

ACETYLATION; ANIMALS; HISTONE ACETYLTRANSFERASES; HISTONES; ORNITHINE DECARBOXYLASE; POLYAMINES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SKIN; SKIN NEOPLASMS;

EQUETUS ACUMINATUS; MURINAE; MUS MUSCULUS;

EID: 34547899201     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20350     Document Type: Conference Paper

References (29)

1. Dod B, Kervabon A, Parello J. Effect of cations on the acetylation of chromatin in vitro. Eur J Biochem 1982;121:401-405.
2. Estepa I, Pestana A. Activation by polyamines of the acetylation of endogenous histones in isolated chromatin and nuclei from Artemia. Eur J Biochem 1981;119:431-436.
3. Libby PR, Bertram JS. Biphasic effect of polyamines on chromatin-bound histone deacetylase. Arch Biochem Biophys 1980;201:359-361.
4. Vu QA, Zhang DE, Chroneos ZC, Nelson DA. Polyamines inhibit the yeast histone deacetylase. FEBS Lett 1987;220:79-83.
5. Megosh L, Gilmour SK, Rosson D, et al. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Cancer Res 1995;55:4205-4209.
6. Smith MK, Trempus CS, Gilmour SK. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin. Carcinogenesis 1998;19:1409-1415.
7. Hoobs CA, Gilmour SK. High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. J Cell Biochem 2000;77:345-360.
8. Cho KS, Elizondo LI, Boerkoel CF. Advances in chromatin remodeling and human disease. Curr Opin Genet Dev 2004;14:308-315.
9. Yang XJ. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res 2004;32:959-976.
10. Hobbs CA, Paul BA, Gilmour SK. Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors. Cancer Res 2002;62:67-74.
11. Kalkhoven E. CBP and p300: HATs for different occasions. Biochem Pharmacol 2004;68:1145-1155.
12. Turner BM. Acetylation and deacetylation of histone H4 continue through metaphase with depletion of more-acetylated isoforms and altered site usage. Exp Cell Res 1989;182:206-214.
13. Kelly TJ, Qin S, Gottschling DE, Parthun MR. Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 2000;20:7051-7058.
14. Hobbs CA, Wei G, Defeo K, Paul B, Hayes CS, Gilmour SK. Tip60 protein isoforms and altered function in skin and tumors that overexpress ornithine decarboxylase. Cancer Res 2006;66:8116-8122.
15. Frank SR, Parisi T, Taubert S, et al. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep 2003;4:575-580.
16. Patel JH, Du Y, Ard PG, et al. The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol 2004;24:10826-10834.
17. Gaughan L, Brady ME, Cook S, Neal DE, Robson CN. Tip60 is a co-activator specific for class I nuclear hormone receptors. J Biol Chem 2001;276:46841- 46848.
18. Sykes SM, Mellert HS, Holbert MA, et al. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 2006;24:841-851.
19. Tang Y, Luo J, Zhang W, Gu W. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 2006;24:827-839.
20. Halkidou K, Logan IR, Cook S, Neal DE, Robson CN. Putative involvement of the histone acetyltransferase Tip60 in ribosomal gene transcription. Nucleic Acids Res 2004;32:1654-1665.
21. Pegg AE, Feith DJ, Fong LY, et al. Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth. Biochem Soc Trans 2003;31:356-360.
22. Liu L, Scolnick DM, Trievel RC, et al. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 1999;19:1202-1209.
23. Ou YH, Chung PH, Sun TP, Shieh SY. p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation. Mol Biol Cell 2005;19:19.
24. Gilmour SK, Birchler M, Smith MK, Rayca K, Mostochuk J. Effect of elevated levels of ornithine decarboxylase on cell cycle progression in skin. Cell Growth Differ 1999;10:739-748.
25. Shore LJ, Soler AP, Gilmour SK. Ornithine decarboxylase expression leads to translocation and activation of protein kinase CK2 in vivo. J Biol Chem 1997;272:12536-12543.
26. Wang X, Taplick J, Geva N, Oren M. Inhibition of p53 degradation by Mdm2 acetylation. FEBS Lett 2004;561:195-201.
27. Luo J, Li M, Tang Y, Laszkowska M, Roeder RG, Gu W. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci USA 2004;101:2259-2264.
28. Libby PR. Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities. J Biol Chem 1978;253:233-237.
29. Turner BM. Histone acetylation and an epigenetic code. Bioessays 2000;22:836-845.