2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells

Molecular Nutrition and Food Research

Volumn 56, Issue 5, 2012, Pages 761-774

  Shin, Soon Young ^a   Kim, Ji Ho ^a   Lee, Jung Ho ^a   Lim, Yoongho ^a   Lee, Young Han ^a  

^a Konkuk University   (South Korea)

Author keywords

Apoptosis; Colon cancer; Egr 1; Hydroxyflavanone; NAG 1

Indexed keywords

2' HYDROXYFLAVANONE; 2'-HYDROXYFLAVANONE; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CELL SURFACE RECEPTOR; EARLY GROWTH RESPONSE FACTOR 1; EPR1 PROTEIN, HUMAN; FLAVANONE DERIVATIVE; GDF15 PROTEIN, HUMAN; GROWTH DIFFERENTIATION FACTOR 15; PROTEIN BAX; PROTEIN P53; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

APOPTOSIS; ARTICLE; BINDING SITE; CELL STRAIN HCT116; COLON TUMOR; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PROMOTER REGION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BINDING SITES; COLONIC NEOPLASMS; DIETARY SUPPLEMENTS; DRUG SCREENING ASSAYS, ANTITUMOR; EARLY GROWTH RESPONSE PROTEIN 1; FLAVANONES; GROWTH DIFFERENTIATION FACTOR 15; HCT116 CELLS; HUMANS; PROMOTER REGIONS, GENETIC; RECEPTORS, CELL SURFACE; RHO GTP-BINDING PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861706678     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100651     Document Type: Article

References (36)

1. Sandler, R. S., Lyles, C. M., Peipins, L. A., McAuliffe, C. A. et al., Diet and risk of colorectal adenomas: macronutrients, cholesterol, and fiber. J. Natl. Cancer Inst. 1993, 85, 884-891.
2. Chao, A., Thun, M. J., Connell, C. J., McCullough, M. L. et al., Meat consumption and risk of colorectal cancer. JAMA 2005, 293, 172-182.
3. Araujo, J. R., Goncalves, P., Martel, F., Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr. Res. 2011, 31, 77-87.
4. Pietta, P. G., Flavonoids as antioxidants. J. Nat. Prod. 2000, 63, 1035-1042.
5. Yao, L. H., Jiang, Y. M., Shi, J., Tomas-Barberan, F. A. et al., Flavonoids in food and their health benefits. Plant Foods Hum. Nutr. 2004, 59, 113-122.
6. Knekt, P., Jarvinen, R., Seppanen, R., Hellovaara, M. et al., Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am. J. Epidemiol. 1997, 146, 223-230.
7. Prasad, S., Phromnoi, K., Yadav, V. R., Chaturvedi, M. M. et al., Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Med. 2010, 76, 1044-1063.
8. Kawaii, S., Tomono, Y., Katase, E., Ogawa, K. et al., HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices. J. Agric. Food Chem. 1999, 47, 128-135.
9. Jin, C. Y., Park, C., Hwang, H. J., Kim, G. Y. et al., Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells. Mol. Nutr. Food Res. 2011, 55, 300-309.
10. Ko, C. H., Shen, S. C., Chen, Y. C., Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species. Free Radic. Biol. Med. 2004, 36, 897-910.
11. Kanno, S., Tomizawa, A., Ohtake, T., Koiwai, K. et al., Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells. Toxicol. Lett. 2006, 166, 131-139.
12. Yang, M., Tanaka, T., Hirose, Y., Deguchi, T. et al., Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice. Int. J. Cancer 1997, 73, 719-724.
13. Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y. et al., Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharmacol. 1999, 58, 759-765.
14. Gibellini, L., Pinti, M., Nasi, M., Montagna, J. P. et al., Quercetin and cancer chemoprevention. Evid. Based Complement Alternat. Med. 2011, 591356, 1-15.
15. Garg, A. K., Buchholz, T. A., Aggarwal, B. B., Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid. Redox Signal. 2005, 7, 1630-1647.
16. Ko, C. H., Shen, S. C., Lin, H. Y., Hou, W. C. et al., Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process. J. Cell Physiol. 2002, 193, 93-102.
17. Shen, S. C., Ko, C. H., Tseng, S. W., Tsai, S. H. et al., Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. Toxicol. Appl. Pharmacol. 2004, 197, 84-95.
18. Shin, S. Y., Hyun, J., Yu, J. R., Lim, Y. et al., 5-Methoxy-flavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells. Toxicol. Appl. Pharmacol. 2011, 254, 288-298.
19. Shin, S. Y., Kim, C. G., Kim, S. H., Kim, Y. S. et al., Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells. Exp. Mol. Med. 2010, 42, 395-405.
20. Choi, B. H., Kim, C. G., Bae, Y. S., Lim, Y. et al., p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res. 2008, 68, 1369-1377.
21. Yang, S. H., Sharrocks, A. D., PIASx acts as an Elk-1 coactivator by facilitating derepression. EMBO J. 2005, 24, 2161-2171.
22. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. et al., Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371, 346-347.
23. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T. et al., Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282, 1497-1501.
24. Baek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C. et al., Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol. Pharmacol. 2001, 59, 901-908.
25. Li, P. X., Wong, J., Ayed, A., Ngo, D. et al., Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J. Biol. Chem. 2000, 275, 20127-20135.
26. Tan, M., Wang, Y., Guan, K., Sun, Y., PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 2000, 97, 109-114.
27. Liu, T., Bauskin, A. R., Zaunders, J., Brown, D. A. et al., Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res. 2003, 63, 5034-5040.
28. Shim, M., Eling, T. E., Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. J. Biol. Chem. 2005, 280, 18636-18642.
29. Lim, J. H., Park, J. W., Min, D. S., Chang, J. S. et al., NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells. Apoptosis 2007, 12, 411-421.
30. Lee, S., Woo, Y., Shin, S. Y., Lee, Y. H. et al., Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression. Bioorg. Med. Chem. Lett. 2009, 19, 2116-2120.
31. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. et al., The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75, 805-816.
32. Charrier-Savournin, F. B., Chateau, M. T., Gire, V., Sedivy, J. et al., p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Mol. Biol. Cell 2004, 15, 3965-3976.
33. Baek, S. J., Kim, J. S., Nixon, J. B., DiAugustine, R. P. et al., Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J. Biol. Chem. 2004, 279, 6883-6892.
34. Thiel, G., Cibelli, G., Regulation of life and death by the zinc finger transcription factor Egr-1. J. Cell Physiol. 2002, 193, 287-292.
35. Zagurovskaya, M., Shareef, M. M., Das, A., Reeves, A. et al., EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Oncogene 2009, 28, 1121-1131.
36. Shin, S. Y., Kim, C. G., Lim, Y., Lee, Y. H., The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21Waf1/Cip1 and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells. J. Biol. Chem. 2011, 286, 26860-26872.