Chlorpromazine activates p2iWaf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells

Experimental and Molecular Medicine

Volumn 42, Issue 5, 2010, Pages 395-405

  Shin, Soon Young ^a   Kim, Chang Gun ^a   Kim, Se Hyun ^b   Kim, Yong Sik ^b   Lim, Yoongho ^a   Lee, Young Han ^a  

^a Konkuk University   (South Korea)

^b Seoul National University Biomedical Research Institute   (South Korea)

Author keywords

C Jun N terminal kinase; Chlorpromazine; Cyclin dependent kinase inhibitor p21; Early growth re sponse 1; Extracellular signal regulated kinase; Tumor suppressor protein p53

Indexed keywords

CHLORPROMAZINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; EARLY GROWTH RESPONSE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EGR1 PROTEIN, HUMAN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; GENE INDUCTION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; GLIOMA CELL; NONHUMAN; POINT MUTATION; PROMOTER REGION; PROTEIN BINDING; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GLIOMA; METABOLISM; TUMOR CELL LINE;

RATTUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHLORPROMAZINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EARLY GROWTH RESPONSE PROTEIN 1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953567243     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.5.041     Document Type: Article

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