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Volumn 318, Issue 11, 2012, Pages 1221-1228

Neurotrophins and cell death

Author keywords

Apoptosis; Cell death; Dependence receptors; Kinase; Neurotrophins; Trk

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN TYROSINE KINASE A;

EID: 84861677996     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.03.006     Document Type: Review
Times cited : (94)

References (80)
  • 1
    • 33746647820 scopus 로고    scopus 로고
    • Neurotrophin signaling: many exciting surprises!
    • Arevalo J.C., Wu S.H. Neurotrophin signaling: many exciting surprises!. Cell Mol Life Sci 2006, 63:1523-1537.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1523-1537
    • Arevalo, J.C.1    Wu, S.H.2
  • 2
    • 0041488911 scopus 로고    scopus 로고
    • Trk receptors: roles in neuronal signal transduction
    • Huang E.J., Reichardt L.F. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 2003, 72:609-642.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichardt, L.F.2
  • 4
    • 78651025304 scopus 로고
    • Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions
    • Hamburger V., Levi-Montalcini R. Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. J. Exp. Zool. 1949, 111:457-501.
    • (1949) J. Exp. Zool. , vol.111 , pp. 457-501
    • Hamburger, V.1    Levi-Montalcini, R.2
  • 5
    • 76549232764 scopus 로고
    • The development to the acoustico-vestibular centers in the chick embryo in the absence of the afferent root fibers and of descending fiber tracts
    • illust, incl 203 pl
    • Levi-Montalcini R. The development to the acoustico-vestibular centers in the chick embryo in the absence of the afferent root fibers and of descending fiber tracts. J. Comp. Neurol. 1949, 91:209-241. illust, incl 203 pl.
    • (1949) J. Comp. Neurol. , vol.91 , pp. 209-241
    • Levi-Montalcini, R.1
  • 7
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim R.W. Cell death during development of the nervous system. Annu. Rev. Neurosci. 1991, 14:453-501.
    • (1991) Annu. Rev. Neurosci. , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 8
  • 9
    • 0030947095 scopus 로고    scopus 로고
    • Programmed cell death in animal development
    • Jacobson M.D., Weil M., Raff M.C. Programmed cell death in animal development. Cell 1997, 88:347-354.
    • (1997) Cell , vol.88 , pp. 347-354
    • Jacobson, M.D.1    Weil, M.2    Raff, M.C.3
  • 10
    • 50549180370 scopus 로고
    • Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro
    • Levi-Montalcini R., Angeletti P.U. Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro. Dev. Biol. 1963, 7:653-659.
    • (1963) Dev. Biol. , vol.7 , pp. 653-659
    • Levi-Montalcini, R.1    Angeletti, P.U.2
  • 11
    • 0023851503 scopus 로고
    • Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
    • Martin D.P., Schmidt R.E., DiStefano P.S., Lowry O.H., Carter J.G., Johnson E.M. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 1988, 106:829-844.
    • (1988) J. Cell Biol. , vol.106 , pp. 829-844
    • Martin, D.P.1    Schmidt, R.E.2    DiStefano, P.S.3    Lowry, O.H.4    Carter, J.G.5    Johnson, E.M.6
  • 12
    • 0026454763 scopus 로고
    • Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene
    • Garcia I., Martinou I., Tsujimoto Y., Martinou J.C. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 1992, 258:302-304.
    • (1992) Science , vol.258 , pp. 302-304
    • Garcia, I.1    Martinou, I.2    Tsujimoto, Y.3    Martinou, J.C.4
  • 15
    • 0033198217 scopus 로고    scopus 로고
    • BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases
    • Putcha G.V., Deshmukh M., Johnson E.M. BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases. J. Neurosci. 1999, 19:7476-7485.
    • (1999) J. Neurosci. , vol.19 , pp. 7476-7485
    • Putcha, G.V.1    Deshmukh, M.2    Johnson, E.M.3
  • 16
    • 0032555934 scopus 로고    scopus 로고
    • Blocking cytochrome c activity within intact neurons inhibits apoptosis
    • Neame S.J., Rubin L.L., Philpott K.L. Blocking cytochrome c activity within intact neurons inhibits apoptosis. J. Cell Biol. 1998, 142:1583-1593.
    • (1998) J. Cell Biol. , vol.142 , pp. 1583-1593
    • Neame, S.J.1    Rubin, L.L.2    Philpott, K.L.3
  • 20
    • 33847026754 scopus 로고    scopus 로고
    • Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons
    • Wright K.M., Vaughn A.E., Deshmukh M. Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons. Cell Death Differ. 2007, 14:625-633.
    • (2007) Cell Death Differ. , vol.14 , pp. 625-633
    • Wright, K.M.1    Vaughn, A.E.2    Deshmukh, M.3
  • 21
    • 0029925683 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by neurotrophic factors
    • Segal R.A., Greenberg M.E. Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 1996, 19:463-489.
    • (1996) Annu. Rev. Neurosci. , vol.19 , pp. 463-489
    • Segal, R.A.1    Greenberg, M.E.2
  • 22
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 23
    • 0035802115 scopus 로고    scopus 로고
    • Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons
    • Orike N., Middleton G., Borthwick E., Buchman V., Cowen T., Davies A.M. Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons. J. Cell Biol. 2001, 154:995-1005.
    • (2001) J. Cell Biol. , vol.154 , pp. 995-1005
    • Orike, N.1    Middleton, G.2    Borthwick, E.3    Buchman, V.4    Cowen, T.5    Davies, A.M.6
  • 25
    • 33645100728 scopus 로고    scopus 로고
    • The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons
    • Wyttenbach A., Tolkovsky A.M. The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J. Neurochem. 2006, 96:1213-1226.
    • (2006) J. Neurochem. , vol.96 , pp. 1213-1226
    • Wyttenbach, A.1    Tolkovsky, A.M.2
  • 26
  • 27
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • Gilley J., Coffer P.J., Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 2003, 162:613-622.
    • (2003) J. Cell Biol. , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 28
    • 0035049449 scopus 로고    scopus 로고
    • Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
    • Whitfield J., Neame S.J., Paquet L., Bernard O., Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 2001, 29:629-643.
    • (2001) Neuron , vol.29 , pp. 629-643
    • Whitfield, J.1    Neame, S.J.2    Paquet, L.3    Bernard, O.4    Ham, J.5
  • 29
    • 0032484019 scopus 로고    scopus 로고
    • CREB is a regulatory target for the protein kinase Akt/PKB
    • Du K., Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 1998, 273:32377-32379.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32377-32379
    • Du, K.1    Montminy, M.2
  • 30
    • 0033579301 scopus 로고    scopus 로고
    • Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
    • Riccio A., Ahn S., Davenport C.M., Blendy J.A., Ginty D.D. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 1999, 286:2358-2361.
    • (1999) Science , vol.286 , pp. 2358-2361
    • Riccio, A.1    Ahn, S.2    Davenport, C.M.3    Blendy, J.A.4    Ginty, D.D.5
  • 32
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
    • Estus S., Zaks W.J., Freeman R.S., Gruda M., Bravo R., Johnson E.M. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 1994, 127:1717-1727.
    • (1994) J. Cell Biol. , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson, E.M.6
  • 33
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 34
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J., Babij C., Whitfield J., Pfarr C.M., Lallemand D., Yaniv M., Rubin L.L. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995, 14:927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6    Rubin, L.L.7
  • 36
    • 0030854775 scopus 로고    scopus 로고
    • Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death
    • Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J. Biol. Chem. 1997, 272:18842-18848.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18842-18848
    • Imaizumi, K.1    Tsuda, M.2    Imai, Y.3    Wanaka, A.4    Takagi, T.5    Tohyama, M.6
  • 38
    • 0033583218 scopus 로고    scopus 로고
    • The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein
    • Imaizumi K., Morihara T., Mori Y., Katayama T., Tsuda M., Furuyama T., Wanaka A., Takeda M., Tohyama M. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. J. Biol. Chem. 1999, 274:7975-7981.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7975-7981
    • Imaizumi, K.1    Morihara, T.2    Mori, Y.3    Katayama, T.4    Tsuda, M.5    Furuyama, T.6    Wanaka, A.7    Takeda, M.8    Tohyama, M.9
  • 39
    • 66249098555 scopus 로고    scopus 로고
    • The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons
    • Towers E., Gilley J., Randall R., Hughes R., Kristiansen M., Ham J. The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons. Nucleic Acids Res. 2009, 37:3044-3060.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 3044-3060
    • Towers, E.1    Gilley, J.2    Randall, R.3    Hughes, R.4    Kristiansen, M.5    Ham, J.6
  • 40
    • 24944474714 scopus 로고    scopus 로고
    • Bim is a direct target of a neuronal E2F-dependent apoptotic pathway
    • Biswas S.C., Liu D.X., Greene L.A. Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J. Neurosci. 2005, 25:8349-8358.
    • (2005) J. Neurosci. , vol.25 , pp. 8349-8358
    • Biswas, S.C.1    Liu, D.X.2    Greene, L.A.3
  • 42
    • 0023133256 scopus 로고
    • Gene transfer and molecular cloning of the rat nerve growth factor receptor
    • Radeke M.J., Misko T.P., Hsu C., Herzenberg L.A., Shooter E.M. Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 1987, 325:593-597.
    • (1987) Nature , vol.325 , pp. 593-597
    • Radeke, M.J.1    Misko, T.P.2    Hsu, C.3    Herzenberg, L.A.4    Shooter, E.M.5
  • 43
    • 0025774207 scopus 로고
    • High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
    • Hempstead B.L., Martin-Zanca D., Kaplan D.R., Parada L.F., Chao M.V. High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 1991, 350:678-683.
    • (1991) Nature , vol.350 , pp. 678-683
    • Hempstead, B.L.1    Martin-Zanca, D.2    Kaplan, D.R.3    Parada, L.F.4    Chao, M.V.5
  • 44
    • 0028150734 scopus 로고
    • Structure-function relationships in the neurotrophin family
    • Ibanez C.F. Structure-function relationships in the neurotrophin family. J. Neurobiol. 1994, 25:1349-1361.
    • (1994) J. Neurobiol. , vol.25 , pp. 1349-1361
    • Ibanez, C.F.1
  • 45
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee R., Kermani P., Teng K.K., Hempstead B.L. Regulation of cell survival by secreted proneurotrophins. Science 2001, 294:1945-1948.
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 47
    • 0027942459 scopus 로고
    • The p75 neurotrophin receptor
    • Chao M.V. The p75 neurotrophin receptor. J. Neurobiol. 1994, 25:1373-1385.
    • (1994) J. Neurobiol. , vol.25 , pp. 1373-1385
    • Chao, M.V.1
  • 49
    • 0028270620 scopus 로고
    • The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development
    • Barrett G.L., Bartlett P.F. The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:6501-6505.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 6501-6505
    • Barrett, G.L.1    Bartlett, P.F.2
  • 50
    • 0038659005 scopus 로고    scopus 로고
    • Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR)
    • Rabizadeh S., Bredesen D.E. Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). Cytokine Growth Factor Rev. 2003, 14:225-239.
    • (2003) Cytokine Growth Factor Rev. , vol.14 , pp. 225-239
    • Rabizadeh, S.1    Bredesen, D.E.2
  • 51
    • 77950517630 scopus 로고    scopus 로고
    • Dependence receptors: a new paradigm in cell signaling and cancer therapy
    • Goldschneider D., Mehlen P. Dependence receptors: a new paradigm in cell signaling and cancer therapy. Oncogene 2010, 29:1865-1882.
    • (2010) Oncogene , vol.29 , pp. 1865-1882
    • Goldschneider, D.1    Mehlen, P.2
  • 56
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: a question of life or death
    • Mehlen P., Puisieux A. Metastasis: a question of life or death. Nat. Rev. Cancer 2006, 6:449-458.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 57
  • 58
    • 0029787071 scopus 로고    scopus 로고
    • Induction of cell death by endogenous nerve growth factor through its p75 receptor
    • Frade J.M., Rodriguez-Tebar A., Barde Y.A. Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 1996, 383:166-168.
    • (1996) Nature , vol.383 , pp. 166-168
    • Frade, J.M.1    Rodriguez-Tebar, A.2    Barde, Y.A.3
  • 59
    • 0029805770 scopus 로고    scopus 로고
    • Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
    • Casaccia-Bonnefil P., Carter B.D., Dobrowsky R.T., Chao M.V. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 1996, 383:716-719.
    • (1996) Nature , vol.383 , pp. 716-719
    • Casaccia-Bonnefil, P.1    Carter, B.D.2    Dobrowsky, R.T.3    Chao, M.V.4
  • 61
    • 0034279150 scopus 로고    scopus 로고
    • Neurotrophins induce death of hippocampal neurons via the p75 receptor
    • Friedman W.J. Neurotrophins induce death of hippocampal neurons via the p75 receptor. J. Neurosci. 2000, 20:6340-6346.
    • (2000) J. Neurosci. , vol.20 , pp. 6340-6346
    • Friedman, W.J.1
  • 62
    • 13144259635 scopus 로고    scopus 로고
    • TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
    • Davey F., Davies A.M. TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons. Curr. Biol. 1998, 8:915-918.
    • (1998) Curr. Biol. , vol.8 , pp. 915-918
    • Davey, F.1    Davies, A.M.2
  • 64
    • 23044488902 scopus 로고    scopus 로고
    • The yin and yang of neurotrophin action
    • Lu B., Pang P.T., Woo N.H. The yin and yang of neurotrophin action. Nat. Rev. Neurosci. 2005, 6:603-614.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 603-614
    • Lu, B.1    Pang, P.T.2    Woo, N.H.3
  • 66
    • 77952644392 scopus 로고    scopus 로고
    • Proneurotrophins, seizures, and neuronal apoptosis
    • Friedman W.J. Proneurotrophins, seizures, and neuronal apoptosis. Neuroscientist 2010, 16:244-252.
    • (2010) Neuroscientist , vol.16 , pp. 244-252
    • Friedman, W.J.1
  • 67
    • 78449258688 scopus 로고    scopus 로고
    • ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons
    • Song W., Volosin M., Cragnolini A.B., Hempstead B.L., Friedman W.J. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. J. Neurosci. 2010, 30:15608-15615.
    • (2010) J. Neurosci. , vol.30 , pp. 15608-15615
    • Song, W.1    Volosin, M.2    Cragnolini, A.B.3    Hempstead, B.L.4    Friedman, W.J.5
  • 68
    • 77949729496 scopus 로고    scopus 로고
    • Understanding proneurotrophin actions: Recent advances and challenges
    • Teng K.K., Felice S., Kim T., Hempstead B.L. Understanding proneurotrophin actions: Recent advances and challenges. Dev. Neurobiol. 2010, 70:350-359.
    • (2010) Dev. Neurobiol. , vol.70 , pp. 350-359
    • Teng, K.K.1    Felice, S.2    Kim, T.3    Hempstead, B.L.4
  • 69
    • 27844442187 scopus 로고    scopus 로고
    • TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    • Geetha T., Kenchappa R.S., Wooten M.W., Carter B.D. TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 2005, 24:3859-3868.
    • (2005) EMBO J. , vol.24 , pp. 3859-3868
    • Geetha, T.1    Kenchappa, R.S.2    Wooten, M.W.3    Carter, B.D.4
  • 70
    • 33646052860 scopus 로고    scopus 로고
    • Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons
    • Kenchappa R.S., Zampieri N., Chao M.V., Barker P.A., Teng H.K., Hempstead B.L., Carter B.D. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron 2006, 50:219-232.
    • (2006) Neuron , vol.50 , pp. 219-232
    • Kenchappa, R.S.1    Zampieri, N.2    Chao, M.V.3    Barker, P.A.4    Teng, H.K.5    Hempstead, B.L.6    Carter, B.D.7
  • 71
    • 2242447082 scopus 로고    scopus 로고
    • NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway
    • Salehi A.H., Xanthoudakis S., Barker P.A. NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. J. Biol. Chem. 2002, 277:48043-48050.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48043-48050
    • Salehi, A.H.1    Xanthoudakis, S.2    Barker, P.A.3
  • 77
    • 78649950296 scopus 로고    scopus 로고
    • A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis
    • Boucher J., Macotela Y., Bezy O., Mori M.A., Kriauciunas K., Kahn C.R. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Sci. Signal. 2010, 3:ra87.
    • (2010) Sci. Signal. , vol.3
    • Boucher, J.1    Macotela, Y.2    Bezy, O.3    Mori, M.A.4    Kriauciunas, K.5    Kahn, C.R.6
  • 78
    • 78649962088 scopus 로고    scopus 로고
    • Dependence receptors: the trophic theory revisited
    • Mehlen P. Dependence receptors: the trophic theory revisited. Sci. Signal. 2010, 3:e47.
    • (2010) Sci. Signal. , vol.3
    • Mehlen, P.1
  • 79
    • 0035964486 scopus 로고    scopus 로고
    • Trk receptor tyrosine kinases: a bridge between cancer and neural development
    • Nakagawara A. Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett. 2001, 169:107-114.
    • (2001) Cancer Lett. , vol.169 , pp. 107-114
    • Nakagawara, A.1


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