메뉴 건너뛰기




Volumn 8, Issue 2, 2010, Pages 266-277

Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; FIBRONECTIN; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PACLITAXEL; TRANSCRIPTION FACTOR; VIMENTIN;

EID: 77249135186     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-09-0221     Document Type: Article
Times cited : (66)

References (62)
  • 1
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-52.
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 2
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 3
    • 0034607702 scopus 로고    scopus 로고
    • Requirement of JNK for stressinduced activation of the cytochrome c-mediated death pathway
    • Tournier C, Hess P, Yang DD, et al. Requirement of JNK for stressinduced activation of the cytochrome c-mediated death pathway. Science 2000;288:870-4.
    • (2000) Science , vol.288 , pp. 870-874
    • Tournier, C.1    Hess, P.2    Yang, D.D.3
  • 4
    • 54249119561 scopus 로고    scopus 로고
    • JNK signaling in apoptosis
    • Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene 2008;27:6245-51.
    • (2008) Oncogene , vol.27 , pp. 6245-6251
    • Dhanasekaran, D.N.1    Reddy, E.P.2
  • 5
    • 0029998491 scopus 로고    scopus 로고
    • Cellular transformation and malignancy induced by ras require c-jun
    • Johnson R, Spiegelman B, Hanahan D, Wisdom R. Cellular transformation and malignancy induced by ras require c-jun. Mol Cell Biol 1996;16:4504-11.
    • (1996) Mol Cell Biol , vol.16 , pp. 4504-4511
    • Johnson, R.1    Spiegelman, B.2    Hanahan, D.3    Wisdom, R.4
  • 6
    • 0034682264 scopus 로고    scopus 로고
    • Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
    • Behrens A, Jochum W, Sibilia M, Wagner EF. Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 2000;19:2657-63.
    • (2000) Oncogene , vol.19 , pp. 2657-2663
    • Behrens, A.1    Jochum, W.2    Sibilia, M.3    Wagner, E.F.4
  • 7
    • 0030927326 scopus 로고    scopus 로고
    • Activation of the JNK pathway is essential for transformation by the Met oncogene
    • Rodrigues GA, Park M, Schlessinger J. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J 1997;16:2634-45.
    • (1997) EMBO J , vol.16 , pp. 2634-2645
    • Rodrigues, G.A.1    Park, M.2    Schlessinger, J.3
  • 8
    • 0030826412 scopus 로고    scopus 로고
    • A cytoplasmic inhibitor of the JNK signal transduction pathway
    • Dickens M, Rogers JS, Cavanagh J, et al. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 1997;277:693-6.
    • (1997) Science , vol.277 , pp. 693-696
    • Dickens, M.1    Rogers, J.S.2    Cavanagh, J.3
  • 9
    • 0346497823 scopus 로고    scopus 로고
    • NF-κB RelA opposes epidermal proliferation driven by TNFR1 and JNK
    • Zhang JY, Green CL, Tao S, Khavari PA. NF-κB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev 2004;18: 17-22.
    • (2004) Genes Dev , vol.18 , pp. 17-22
    • Zhang, J.Y.1    Green, C.L.2    Tao, S.3    Khavari, P.A.4
  • 10
    • 6044240634 scopus 로고    scopus 로고
    • Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    • Nakshatri H, Rice SE, Bhat-Nakshatri P. Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. Oncogene 2004;23:7330-44.
    • (2004) Oncogene , vol.23 , pp. 7330-7344
    • Nakshatri, H.1    Rice, S.E.2    Bhat-Nakshatri, P.3
  • 11
    • 0842308312 scopus 로고    scopus 로고
    • All-trans retinoic acid potentiates Taxotereinduced cell death mediated by Jun N-terminal kinase in breast cancer cells
    • Wang Q, Wieder R. All-trans retinoic acid potentiates Taxotereinduced cell death mediated by Jun N-terminal kinase in breast cancer cells. Oncogene 2004;23:426-33.
    • (2004) Oncogene , vol.23 , pp. 426-433
    • Wang, Q.1    Wieder, R.2
  • 12
    • 0842329801 scopus 로고    scopus 로고
    • 2-M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells
    • 2-M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. Oncogene 2004;23:596-604.
    • (2004) Oncogene , vol.23 , pp. 596-604
    • Mingo-Sion, A.M.1    Marietta, P.M.2    Koller, E.3    Wolf, D.M.4    Van Den Berg, C.L.5
  • 13
    • 0033118607 scopus 로고    scopus 로고
    • The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    • Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999; 22:667-76.
    • (1999) Neuron , vol.22 , pp. 667-676
    • Kuan, C.Y.1    Yang, D.D.2    Samanta Roy, D.R.3    Davis, R.J.4    Rakic, P.5    Flavell, R.A.6
  • 14
    • 0034194714 scopus 로고    scopus 로고
    • Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
    • Almeida EA, Ilic D, Han Q, et al. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol 2000;149:741-54.
    • (2000) J Cell Biol , vol.149 , pp. 741-754
    • Almeida, E.A.1    Ilic, D.2    Han, Q.3
  • 15
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • Yu C, Minemoto Y, Zhang J, et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004;13:329-40.
    • (2004) Mol Cell , vol.13 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3
  • 16
    • 0038433303 scopus 로고    scopus 로고
    • JunD mediates survival signaling by the JNK signal transduction pathway
    • Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ. JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell 2003;11:1479-89.
    • (2003) Mol Cell , vol.11 , pp. 1479-1489
    • Lamb, J.A.1    Ventura, J.J.2    Hess, P.3    Flavell, R.A.4    Davis, R.J.5
  • 17
    • 18544372157 scopus 로고    scopus 로고
    • Elevated JNK activation contributes to the pathogenesis of human brain tumors
    • Antonyak MA, Kenyon LC, Godwin AK, et al. Elevated JNK activation contributes to the pathogenesis of human brain tumors. Oncogene 2002;21:5038-46.
    • (2002) Oncogene , vol.21 , pp. 5038-5046
    • Antonyak, M.A.1    Kenyon, L.C.2    Godwin, A.K.3
  • 18
    • 0037237136 scopus 로고    scopus 로고
    • C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma
    • Yang YM, Bost F, Charbono W, et al. C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma. Clin Cancer Res 2003;9:391-401.
    • (2003) Clin Cancer Res , vol.9 , pp. 391-401
    • Yang, Y.M.1    Bost, F.2    Charbono, W.3
  • 19
    • 0037385030 scopus 로고    scopus 로고
    • Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas
    • Papachristou DJ, Batistatou A, Sykiotis GP, Varakis I, Papavassiliou AG. Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. Bone 2003;32:364-71.
    • (2003) Bone , vol.32 , pp. 364-371
    • Papachristou, D.J.1    Batistatou, A.2    Sykiotis, G.P.3    Varakis, I.4    Papavassiliou, A.G.5
  • 20
    • 33646383098 scopus 로고    scopus 로고
    • Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival
    • Yeh YT, Hou MF, Chung YF, et al. Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival. Int J Cancer 2006;118:2678-84.
    • (2006) Int J Cancer , vol.118 , pp. 2678-2684
    • Yeh, Y.T.1    Hou, M.F.2    Chung, Y.F.3
  • 21
    • 33748609676 scopus 로고    scopus 로고
    • The mitogenactivated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma
    • Davidson B, Konstantinovsky S, Kleinberg L, et al. The mitogenactivated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma. Gynecol Oncol 2006;102:453-61.
    • (2006) Gynecol Oncol , vol.102 , pp. 453-461
    • Davidson, B.1    Konstantinovsky, S.2    Kleinberg, L.3
  • 22
    • 33845383714 scopus 로고    scopus 로고
    • Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
    • Dearth RK, Cui X, Kim HJ, et al. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol 2006;26:9302-14.
    • (2006) Mol Cell Biol , vol.26 , pp. 9302-9314
    • Dearth, R.K.1    Cui, X.2    Kim, H.J.3
  • 23
    • 0037119423 scopus 로고    scopus 로고
    • Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype
    • Rennefahrt UE, Illert B, Kerkhoff E, Troppmair J, Rapp UR. Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype. J Biol Chem 2002;277:29510-8.
    • (2002) J Biol Chem , vol.277 , pp. 29510-29518
    • Rennefahrt, U.E.1    Illert, B.2    Kerkhoff, E.3    Troppmair, J.4    Rapp, U.R.5
  • 24
    • 33744927684 scopus 로고    scopus 로고
    • Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH2-Terminal kinase/activator protein-1 signaling to regulate cell migration
    • Cui X, Kim HJ, Kuiatse I, Kim H, Brown PH, Lee AV. Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH2-Terminal kinase/activator protein-1 signaling to regulate cell migration. Cancer Res 2006;66:5304-13.
    • (2006) Cancer Res , vol.66 , pp. 5304-5313
    • Cui, X.1    Kim, H.J.2    Kuiatse, I.3    Kim, H.4    Brown, P.H.5    Lee, A.V.6
  • 26
    • 34147193818 scopus 로고    scopus 로고
    • Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and snail
    • Kim HJ, Litzenburger BC, Cui X, et al. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and snail. Mol Cell Biol 2007;27:3165-75.
    • (2007) Mol Cell Biol , vol.27 , pp. 3165-3175
    • Kim, H.J.1    Litzenburger, B.C.2    Cui, X.3
  • 27
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 28
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson CJ, Miller FR. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992;52:1399-405.
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 29
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117:927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 30
    • 0030802419 scopus 로고    scopus 로고
    • A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis
    • Olive M, Krylov D, Echlin DR, Gardner K, Taparowsky E, Vinson C. A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis. J Biol Chem 1997;272: 18586-94.
    • (1997) J Biol Chem , vol.272 , pp. 18586-18594
    • Olive, M.1    Krylov, D.2    Echlin, D.R.3    Gardner, K.4    Taparowsky, E.5    Vinson, C.6
  • 31
  • 32
    • 0028793798 scopus 로고
    • Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation
    • Cavigelli M, Dolfi F, Claret FX, Karin M. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J 1995; 14:5957-64.
    • (1995) EMBO J , vol.14 , pp. 5957-5964
    • Cavigelli, M.1    Dolfi, F.2    Claret, F.X.3    Karin, M.4
  • 33
    • 7644237126 scopus 로고    scopus 로고
    • Involvement of insulin receptor substrate 2 in mammary tumor metastasis
    • Nagle JA, Ma Z, Byrne MA, White MF, Shaw LM. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol 2004;24:9726-35.
    • (2004) Mol Cell Biol , vol.24 , pp. 9726-9735
    • Nagle, J.A.1    Ma, Z.2    Byrne, M.A.3    White, M.F.4    Shaw, L.M.5
  • 34
    • 0035504405 scopus 로고    scopus 로고
    • Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines
    • Jackson JG, Zhang X, Yoneda T, Yee D. Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines. Oncogene 2001;20:7318-25.
    • (2001) Oncogene , vol.20 , pp. 7318-7325
    • Jackson, J.G.1    Zhang, X.2    Yoneda, T.3    Yee, D.4
  • 35
    • 0031616132 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
    • White MF. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog Horm Res 1998;53:119-38.
    • (1998) Recent Prog Horm Res , vol.53 , pp. 119-138
    • White, M.F.1
  • 36
    • 0034164455 scopus 로고    scopus 로고
    • The c-Jun N-terminal kinase pathway and apoptotic signaling [review]
    • Chen YR, Tan TH. The c-Jun N-terminal kinase pathway and apoptotic signaling [review]. Int J Oncol 2000;16:651-62.
    • (2000) Int J Oncol , vol.16 , pp. 651-662
    • Chen, Y.R.1    Tan, T.H.2
  • 37
    • 0033578905 scopus 로고    scopus 로고
    • Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells
    • Brown MR, Miller FJ, Jr., Li WG, et al. Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. Circ Res 1999;85:524-33.
    • (1999) Circ Res , vol.85 , pp. 524-533
    • Brown, M.R.1    Miller Jr., F.J.2    Li, W.G.3
  • 38
    • 0041343263 scopus 로고    scopus 로고
    • Induction of apoptosis in fetal pulmonary arterial smooth muscle cells by a combined superoxide dismutase/ catalase mimetic
    • Wedgwood S, Black SM. Induction of apoptosis in fetal pulmonary arterial smooth muscle cells by a combined superoxide dismutase/ catalase mimetic. Am J Physiol Lung Cell Mol Physiol 2003;285: L305-12.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285
    • Wedgwood, S.1    Black, S.M.2
  • 39
    • 0034614098 scopus 로고    scopus 로고
    • Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo
    • Schiff R, Reddy P, Ahotupa M, et al. Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo. J Natl Cancer Inst 2000;92:1926-34.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1926-1934
    • Schiff, R.1    Reddy, P.2    Ahotupa, M.3
  • 40
    • 0033049975 scopus 로고    scopus 로고
    • Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance
    • Johnston SR, Lu B, Scott GK, et al. Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance. Clin Cancer Res 1999;5: 251-6.
    • (1999) Clin Cancer Res , vol.5 , pp. 251-256
    • Johnston, S.R.1    Lu, B.2    Scott, G.K.3
  • 41
    • 0042734434 scopus 로고    scopus 로고
    • The true face of JNK activation in apoptosis
    • Lin A, Dibling B. The true face of JNK activation in apoptosis. Aging Cell 2002;1:112-6.
    • (2002) Aging Cell , vol.1 , pp. 112-116
    • Lin, A.1    Dibling, B.2
  • 42
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, et al. Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001;61:4222-8.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3
  • 43
    • 33748776858 scopus 로고    scopus 로고
    • JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
    • Santibanez JF. JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett 2006;580:5385-91.
    • (2006) FEBS Lett , vol.580 , pp. 5385-5391
    • Santibanez, J.F.1
  • 44
    • 43149111275 scopus 로고    scopus 로고
    • Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1
    • Alcorn JF, Guala AS, van der Velden J, et al. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1. J Cell Sci 2008;121:1036-45.
    • (2008) J Cell Sci , vol.121 , pp. 1036-1045
    • Alcorn, J.F.1    Guala, A.S.2    van der Velden, J.3
  • 45
    • 0036134934 scopus 로고    scopus 로고
    • Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently
    • Young MR, Nair R, Bucheimer N, et al. Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently. Mol Cell Biol 2002;22:587-98.
    • (2002) Mol Cell Biol , vol.22 , pp. 587-598
    • Young, M.R.1    Nair, R.2    Bucheimer, N.3
  • 46
    • 0029738257 scopus 로고    scopus 로고
    • Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation
    • Peverali FA, Isaksson A, Papavassiliou AG, et al. Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. EMBO J 1996;15:3943-50.
    • (1996) EMBO J , vol.15 , pp. 3943-3950
    • Peverali, F.A.1    Isaksson, A.2    Papavassiliou, A.G.3
  • 47
    • 0024276523 scopus 로고
    • The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
    • Angel P, Hattori K, Smeal T, Karin M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 1988;55: 875-85.
    • (1988) Cell , vol.55 , pp. 875-885
    • Angel, P.1    Hattori, K.2    Smeal, T.3    Karin, M.4
  • 49
    • 0034602395 scopus 로고    scopus 로고
    • Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells
    • Tamura K, Chen YE, Lopez-Ilasaca M, et al. Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells. J Biol Chem 2000;275:34619-27.
    • (2000) J Biol Chem , vol.275 , pp. 34619-34627
    • Tamura, K.1    Chen, Y.E.2    Lopez-Ilasaca, M.3
  • 50
    • 0035872409 scopus 로고    scopus 로고
    • Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice
    • Chen N, Nomura M, She QB, et al. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res 2001;61:3908-12.
    • (2001) Cancer Res , vol.61 , pp. 3908-3912
    • Chen, N.1    Nomura, M.2    She, Q.B.3
  • 51
    • 34047198390 scopus 로고    scopus 로고
    • Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2
    • Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle 2007;6:705-13.
    • (2007) Cell Cycle , vol.6 , pp. 705-713
    • Dearth, R.K.1    Cui, X.2    Kim, H.J.3    Hadsell, D.L.4    Lee, A.V.5
  • 52
    • 34047234959 scopus 로고    scopus 로고
    • Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis
    • Gibson SL, Ma Z, Shaw LM. Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis. Cell Cycle 2007;6:631-7.
    • (2007) Cell Cycle , vol.6 , pp. 631-637
    • Gibson, S.L.1    Ma, Z.2    Shaw, L.M.3
  • 53
    • 0040973209 scopus 로고    scopus 로고
    • Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells
    • Bruning JC, Winnay J, Cheatham B, Kahn CR. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol 1997;17:1513-21.
    • (1997) Mol Cell Biol , vol.17 , pp. 1513-1521
    • Bruning, J.C.1    Winnay, J.2    Cheatham, B.3    Kahn, C.R.4
  • 54
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • Tamemoto H, Kadowaki T, Tobe K, et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 1994;372:182-6.
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1    Kadowaki, T.2    Tobe, K.3
  • 55
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • Araki E, Lipes MA, Patti ME, et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994;372:186-90.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3
  • 56
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-4.
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1    Gutierrez, J.S.2    Towery, H.3
  • 57
    • 21444460644 scopus 로고    scopus 로고
    • Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes
    • Huang C, Thirone AC, Huang X, Klip A. Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. J Biol Chem 2005;280:19426-35.
    • (2005) J Biol Chem , vol.280 , pp. 19426-19435
    • Huang, C.1    Thirone, A.C.2    Huang, X.3    Klip, A.4
  • 58
  • 59
    • 0029753773 scopus 로고    scopus 로고
    • The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. Duration of JNK activation may determine cell death and proliferation
    • Chen YR, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 1996;271:31929-36.
    • (1996) J Biol Chem , vol.271 , pp. 31929-31936
    • Chen, Y.R.1    Wang, X.2    Templeton, D.3    Davis, R.J.4    Tan, T.H.5
  • 60
    • 0028061674 scopus 로고
    • Signal transduction by tumor necrosis factor mediated by JNK protein kinases
    • Sluss HK, Barrett T, Derijard B, Davis RJ. Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 1994;14:8376-84.
    • (1994) Mol Cell Biol , vol.14 , pp. 8376-8384
    • Sluss, H.K.1    Barrett, T.2    Derijard, B.3    Davis, R.J.4
  • 61
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 2007;19:142-9.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 62
    • 21244472975 scopus 로고    scopus 로고
    • IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-90.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.