Arrhythmia formation in subclinical ("silent") long QT syndrome requires multiple insults: Quantitative mechanistic study using the KCNQ1 mutation Q357R as example

Heart Rhythm

Volumn 9, Issue 2, 2012, Pages 275-282

  O'Hara, Thomas ^a   Rudy, Yoram ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Adrenergic stimulation; Action potential; Computational models; Electrophysiology; Isoproterenol; Long QT syndrome; Repolarization reserve; Silent mutation

Indexed keywords

ISOPRENALINE; POTASSIUM CHANNEL KCNQ1;

ACCURACY; ARTICLE; BETA ADRENERGIC STIMULATION; ELECTROCARDIOGRAM; EPICARDIUM; GENE; GENE MUTATION; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; KCNQ1 GENE; LONG QT SYNDROME; MATHEMATICAL MODEL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; WILD TYPE;

ACTION POTENTIALS; ADULT; ARRHYTHMIAS, CARDIAC; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; FEMALE; HEART VENTRICLES; HUMANS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MARKOV CHAINS; MODELS, CARDIOVASCULAR; MUTATION, MISSENSE; PHENOTYPE; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 84856162498     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.09.066     Document Type: Article

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