A novel computational model of the human ventricular action potential and Ca transient

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 1, 2010, Pages 112-121

  Grandi, Eleonora ^a   Pasqualini, Francesco S ^b   Bers, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Computer model; Human ventricular myocyte; K current block; Reverse rate dependence

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ION CHANNEL;

ACTION POTENTIAL; ARTICLE; CALCIUM TRANSPORT; ENDOCARDIUM; EPICARDIUM; EXCITATION CONTRACTION COUPLING; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; ION TRANSPORT; MATHEMATICAL MODEL; POTASSIUM CURRENT; PRIORITY JOURNAL; STEADY STATE;

ACTION POTENTIALS; ANIMALS; CALCIUM; COMPUTER SIMULATION; HEART VENTRICLES; HUMANS; MYOCYTES, CARDIAC; POTASSIUM; RABBITS; SODIUM;

ORYCTOLAGUS CUNICULUS;

EID: 73049094376     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.09.019     Document Type: Article

References (51)

1. i overloaded cardiac myocytes: A Simulation Study. Biophys J 78 5 (2000) 2392
2. Shannon T.R., Wang F., Puglisi J., Weber C., and Bers D.M. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J 87 5 (2004) 3351
3. Bondarenko V.E., Szigeti G.P., Bett G.C.L., Kim S.-J., and Rasmusson R.L. Computer model of action potential of mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 287 3 (2004) H1378-H1403
4. Hund T.J., and Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 110 20 (2004) 3168-3174
5. Grandi E., Puglisi J.L., Wagner S., Maier L.S., Severi S., and Bers D.M. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J 93 11 (2007) 3835
6. Clancy C.E., Zhu Z.I., and Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am J Physiol Heart Circ Physiol 292 1 (2007) H66-75
7. Priebe L., and Beuckelmann D.J. Simulation study of cellular electric properties in heart failure. Circ Res 82 11 (1998) 1206-1223
8. ten Tusscher K.H.W.J., and Panfilov A.V. Alternans and spiral breakup in a human ventricular tissue model. Am J Physiol Heart Circ Physiol 291 3 (2006) H1088-100
9. ten Tusscher K.H.W.J., and Panfilov A.V. Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions. Phys Med Biol 51 23 (2006) 6141
10. ten Tusscher K.H.W.J., Noble D., Noble P.J., and Panfilov A.V. A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 286 4 (2004) H1573-H1589
11. Iyer V., Mazhari R., and Winslow R.L.A. Computational model of the human left-ventricular epicardial myocyte. Biophys J 87 3 (2004) 1507-1525
12. Bernus O., Wilders R., Zemlin C.W., Verschelde H., and Panfilov A.V. A computationally efficient electrophysiological model of human ventricular cells. Am J Physiol Heart Circ Physiol 282 6 (2002) H2296-308
13. Weber C.R., Piacentino III V., Houser S.R., and Bers D.M. Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation 108 18 (2003) 2224-2229
14. Virág L., Iost N., Opincariu M., Szolnoky J., Szécsi J., Bogats G., et al. The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 49 4 (2001) 790-797
15. Zhou Z., Gong Q., Ye B., Fan Z., Makielski J.C., Robertson G.A., et al. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J 74 1 (1998) 230-241
16. 2+. Evidence for two distinct voltage sensors. J Gen Physiol 113 4 (1999) 565-580
17. Jost N., Varró A., Szüts V., Kovács P.P., Seprényi G., Biliczki P., et al. Molecular basis of repolarization reserve differences between dogs and man. Circulation 118 8 (2008) Suppl-2, S342 (abstract)
18. Iost N., Virág L., Opincariu M., Szécsi J., Varró A., and Papp J.G. Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 40 3 (1998) 508-515
19. Magyar J., Iost N., Körtvély Á., Bányász T., Virág L., Szigligeti P., et al. Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes. Pflügers Archiv European Journal of Physiology 441 1 (2000) 144
20. Näbauer M., Beuckelmann D.J., Uberfuhr P., and Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93 1 (1996) 168-177
21. Wettwer E., Amos J., Posival H., and Ravens U. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75 3 (1994) 473-482
22. Varró A., Virág L., Acsai K., Jost N., Lengyel C., and Papp J.G. Role of the slowly inactivating transient outward potassium current in cardiac repolarization. Heart Rhythm 3 5 (2006) May Suppl., S302 (abstract)
23. Shampine L.F., and Reichelt M.W. The MATLAB ODE suite. SIAM J Sci Comput 18 (1997) 1-22
24. Morgan J.M., Cunningham D., and Rowland E. Electrical restitution in the endocardium of the intact human right ventricle. Br Heart J 67 1 (1992) 42-46
25. Drouin E., Lande G., and Charpentier F. Amiodarone reduces transmural heterogeneity of repolarization in the human heart. J Am Coll Cardiol 32 4 (1998) 1063-1067
26. Li G.-R., Feng J., Yue L., and Carrier M. Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle. Am J Physiol Heart Circ Physiol 275 2 (1998) H369-377
27. Piacentino III V., Weber C.R., Chen X., Weisser-Thomas J., Margulies K.B., Bers D.M., et al. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res 92 6 (2003) 651-658
28. Ca contributes to rate-dependent changes of action potentials in human ventricular myocytes. Am J Physiol Heart Circ Physiol 276 1 (1999) H98-106
29. Pereon Y., Demolombe S., Baro I., Drouin E., Charpentier F., and Escande D. Differential expression of KvLQT1 isoforms across the human ventricular wall. Am J Physiol Heart Circ Physiol 278 6 (2000) H1908-15
30. 2+] during the cardiac action potential. Circ Res 90 2 (2002) 182-189
31. Pieske B., Kretschmann B., Meyer M., Holubarsch C., Weirich J., Posival H., et al. Alterations in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy. Circulation 92 5 (1995) 1169-1178
32. Li G.-R., Lau C.-P., Leung T.-K., and Nattel S. Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 1 4 (2004) 460
33. Schmidt U., Hajjar R.J., Helm P.A., Kim C.S., Doye A.A., and Gwathmey J.K. Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol 30 10 (1998) 1929
34. i and contractility in nonfailing and failing human myocardium. Circulation 106 4 (2002) 447-453
35. Ks in human ventricular muscle. Circulation 112 10 (2005) 1392-1399
36. Ks in dog ventricular muscle and Purkinje fibre repolarization. J Physiol 523 Pt 1 (2000) 67-81
37. Ks participation in cardiac repolarization and repolarization reserve. Circulation 112 10 (2005) 1384-1391
38. Rocchetti M., Besana A., Gurrola G.B., Possani L.D., and Zaza A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol 534 Pt 3 (2001) 721-732
39. 2+ exchange: evidence for differential expression in normal and failing hearts. Circ Res 97 3 (2005) 207-209
40. Laurita K.R., Wible B., Wan X., and Koo M.H. Transmural heterogeneity of calcium handling in canine. Circ Res 92 6 (2003) 668-675
41. Prestle J., Dieterich S., Preuss M., Bieligk U., and Hasenfuss G. Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heart. Cardiovasc Res 43 2 (1999) 323-331
42. i in canine ventricle. 2005; 89(3):1700.
43. Weisser-Thomas J., Piacentino III V., Gaughan J.P., Margulies K., and Houser S.R. Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovasc Res 57 4 (2003) 974-985
44. + pump inhibition: evaluation of electrophysiological mechanisms. J Pharmacol Exp Ther 305 2 (2003) 765-771
45. Hordof A.J., Spotnitz A., Mary-Rabine L., Edie R.N., and Rosen M.R. The cellular electrophysiologic effects of digitalis on human atrial fibers. Circulation 57 2 (1978) 223-229
46. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 38 2 (1998) 441-450
47. + current in human ventricular myocytes. Circ Res 78 4 (1996) 689-696
48. + current by dofetilide. Circ Res 72 1 (1993) 75-83
49. Ks) and the repolarization reserve. Ann Noninvasive Electrocardiol 12 1 (2007) 64-78
50. Virág L., Acsai K., Hála O., Zaza A., Bitay M., Bogáts G., et al. Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency. Br J Pharmacol 156 7 (2009) 1076-1084
51. Zaza A. Control of the cardiac action potential: the role of repolarization dynamics. J Mol Cell Cardiol 48 (2010) 106-111