Robustness of burst firing in dissociated Purkinje neurons with acute or long-term reductions in sodium conductance

Journal of Neuroscience

Volumn 25, Issue 14, 2005, Pages 3509-3520

  Swensen, Andrew M ^a,b   Bean, Bruce P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Action potential clamp; Ca2+ channel; Complex spike; Na+ channel; Resurgent sodium current; T type channel

Indexed keywords

TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; DISSOCIATION; FEEDBACK SYSTEM; HYPERPOLARIZATION; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PURKINJE CELL; SODIUM CONDUCTANCE; SODIUM CURRENT; SPIKE; VOLTAGE CLAMP; WAVEFORM; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELL COUNT; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC CONDUCTIVITY; ELECTRIC STIMULATION; ION CHANNEL GATING; KINETICS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PURKINJE CELLS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 17044407383     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3929-04.2005     Document Type: Article

References (40)

1. 2+ channel antagonist mibefradil (Ro 40-5967). Mol Pharmacol 48:540-549.
2. Burdakov D, Ashcroft FM (2002) Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-type potassium channels. J Neurosci 22:6380-6387.
3. Callaway JC, Ross WN (1997) Spatial distribution of synaptically activated sodium concentration changes in cerebellar Purkinje neurons. J Neurophysiol 77:145-152.
4. 2+ spikes in Purkinje cells from rat cerebellar slice cultures. J Physiol (Lond) 540:57-72.
5. + channel expression and function in rat Purkinje neurons. J Neurosci 22:4456-4467.
6. Cohen CJ, Bean BP, Tsien RW (1984) Maximal upstroke velocity as an index of available conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers. Circ Res 54:636-651.
7. Desai NS, Rutherford LC, Turrigiano GG (1999) Plasticity in the intrinsic excitability of cortical pyramidal neurons. Nat Neurosci 2:515-520.
8. v 1.6-null mice. J Neurophysiol 92:726-733.
9. Eccles JC, Llinás R, Sasaki K (1966) The excitatory synaptic action of climbing fibres on the purkinje cells of the cerebellum. J Physiol (Lond) 182:268-296.
10. Goldman MS, Golowasch J, Marder E, Abbott LF (2001) Global structure, robustness, and modulation of neuronal models. J Neurosci 21:5229-5238.
11. Golowasch J, Abbott LF, Marder E (1999) Activity-dependent regulation of potassium currents in an identified neuron of the stomatogastric ganglion of the crab Cancer borealis. J Neurosci 19:RC33(1-5).
12. Golowasch J, Goldman MS, Abbott LF, Marder E (2002) Failure of averaging in the construction of a conductance-based neuron model. J Neurophysiol 87:1129-1131.
13. Hille B (2001) Selective permeability: independence. In: Ion channels of excitable membranes, Ed 3. Sunderland, MA: Sinauer.
14. Kay AR, Sugimori M, Llinás R (1998) Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells. J Neurophysiol 80:1167-1179.
15. Khaliq ZM, Gouwens NW, Raman IM (2003) The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. J Neurosci 23:4899-4912.
16. Kohrman DC, Harris JB, Meisler MH (1996) Mutation detection in the med and medj alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron. J Biol Chem 271:17576-17581.
17. Liu Z, Golowasch J, Marder E, Abbott LF (1998) A model neuron with activity-dependent conductances regulated by multiple calcium sensors. J Neurosci 18:2309-2320.
18. MacLean JN, Zhang Y, Johnson BR, Harris-Warrick RM (2003) Activity-independent homeostasis in rhythmically active neurons. Neuron 37:109-120.
19. Madeja M (2000) Do neurons have a reserve of sodium channels for the generation of action potentials? A study on acutely isolated CA1 neurons from the guinea-pig hippocampus. Eur J Neurosci 12:1-7.
20. Magee JC (1998) Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J Neurosci 18:7613-7624.
21. Martina M, Yao GL, Bean BP (2003) Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J Neurosci 23:5698-5707.
22. McDonough SI, Bean BP (1998) Mibefradil inhibition of T-type calcium channels in cerebellar Purkinje neurons. Mol Pharmacol 54:1080-1087.
23. McKay BE, Turner RW (2004) Kv3 K+ channels enable burst output in rat cerebellar Purkinje cells. Eur J Neurosci 20:729-739.
24. Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, Adams ME (1992a) P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature 355:827-829.
25. Mintz IM, Adams ME, Bean BP (1992b) P-type calcium channels in rat central and peripheral neurons. Neuron 9:85-95.
26. Neher E (1992) Correction for liquid junction potentials in patch clamp experiments. Methods Enzymol 207:123-131.
27. Pouille F, Cavelier P, Desplantez T, Beekenkamp H, Craig PJ, Beattie RE, Volsen SG, Bossu JL (2000) Dendro-somatic distribution of calcium-mediated electrogenesis in purkinje cells from rat cerebellar slice cultures. J Physiol (Lond) 527:265-282.
28. Raman IM, Bean BP (1997) Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci 17:4517-4526.
29. Raman IM, Bean BP (1999) Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci 19:1663-1674.
30. Raman IM, Bean BP (2001) Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J 80:729-737.
31. Raman IM, Sprunger LK, Meisler MH, Bean BP (1997) Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19:881-891.
32. Rudy B, McBain CJ (2001) Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing. Trends Neurosci 24:517-526.
33. + currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals. J Neurosci 20:114-122.
34. Sprunger LK, Escayg A, Tallaksen-Greene S, Albin RL, Meisler MH (1999) Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3. Hum Mol Genet 8:471-479.
35. Swensen AM, Bean BP (2003) Ionic mechanisms of burst firing in dissociated Purkinje neurons. J Neurosci 23:9650-9663.
36. Taddese A, Bean BP (2002) Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33:587-600.
37. Ca, currents by internally applied gluconate in rat hippocampal pyramidal neurones. Pflügers Arch 433:343-350.
38. Womack MD, Khodakhah K (2002) Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar purkinje neurons. J Neurosci 22:10603-10612.
39. Womack MD, Chevez C, Khodakhah K (2004) Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons. J Neurosci 24:8818-8822.
40. Yokoyama CT, Westenbroek RE, Hell JW, Soong TW, Snutch TP, Catterall WA (1995) Biochemical properties and subcellular distribution of the neuronal class E calcium channel α1 subunit. J Neurosci 15:6419-6432.