Excitation-contraction coupling gain in ventricular myocytes: Insights from a parsimonious model

Journal of Physiology

Volumn 587, Issue 6, 2009, Pages 1293-1299

  Sobie, Eric A ^a   Ramay, Hena R ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL L TYPE; CALCIUM ION;

ARTICLE; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; EXPERIMENTAL STUDY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART VENTRICLE CONDUCTION; INTERMETHOD COMPARISON; MATHEMATICAL MODEL; PARSIMONY ANALYSIS; PRIORITY JOURNAL; PROBABILITY; VOLTAGE CLAMP; BETA ADRENERGIC STIMULATION; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; HEART MUSCLE CELL; MATHEMATICAL COMPUTING; VOLTAGE CLAMP TECHNIQUE;

ALGORITHMS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; COMPUTER SIMULATION; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MUSCLE CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES;

EID: 62749121668     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.163915     Document Type: Article

References (26)

1. 2+ current amplitude and open channel probability. Circ Res 101, 590-597.
2. Bers DM (2002). Cardiac excitation-contraction coupling. Nature 415, 198-205.
3. Bers DM & Stiffel VM (1993). Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for E-C coupling. Am J Physiol Cell Physiol 264, C1587-C1593.
4. Cannell MB, Cheng H & Lederer WJ (1995). The control of calcium release in heart muscle. Science 268, 1045-1049.
5. Cannell MB & Soeller C (1999). Mechanisms underlying calcium sparks in cardiac muscle. J Gen Physiol 113, 373-376.
6. Cheng H, Lederer WJ & Cannell MB (1993). Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle. Science 262, 740-744.
7. 2+ release events in rat ventricular myocytes. J Physiol 516, 117-128.
8. Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA & Lederer WJ (1997). Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276, 800-806.
9. 2+] i transient. J Mol Cell Cardiol 34, 941-950.
10. Guia A, Stern MD, Lakatta EG & Josephson IR (2001). Ion concentration-dependence of rat cardiac unitary L-type calcium channel conductance. Biophys J 80, 2742-2750.
11. 2+ channels. Circ Res 92, 532-538.
12. Litwin SE, Li J & Bridge JH (1998). Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: Studies in adult rabbit ventricular myocytes. Biophys J 75, 359-371.
13. 2+ sparks in myocytes from infarcted hearts. Circ Res 87, 1040-1047.
14. Lopez-Lopez JR, Shacklock PS, Balke CW & Wier WG (1995). Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science 268, 1042-1045.
15. Pandit SV, Clark RB, Giles WR & Demir SS (2001). A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes. Biophys J 81, 3029-3051.
16. Polakova E, Zahradnikova JA, Pavelkova J, Zahradnik I & Zahradnikova A (2008). Local calcium release activation by DHPR calcium channel openings in rat cardiac myocytes. J Physiol 586, 3839-3854.
17. 2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ Res 78, 166-171.
18. Shannon TR, Ginsburg KS & Bers DM (2000). Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophys J 78, 334-343.
19. 2+ release in ventricular myocytes. Biophys J 94, L54-L56.
20. 2+ sparks: An investigative mathematical model of calcium-induced calcium release. Biophys J 83, 59-78.
21. Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW & Cheng H (2006). Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A 103, 4305-4310.
22. 2+ release during excitation-contraction coupling in cardiac myocytes. Circ Res 88, 794-801.
23. Stern MD, Song LS, Cheng H, Sham JS, Yang HT, Boheler KR & Rios E (1999). Local control models of cardiac excitation-contraction coupling. A possible role for allosteric interactions between ryanodine receptors. J Gen Physiol 113, 469-489.
24. 2+ channels and ryanodine receptors in heart cells. Nature 410, 592-596.
25. Wier WG (2007). Gain and cardiac E-C coupling: Revisited and revised. Circ Res 101, 533-535.
26. Wier WG, Egan TM, Lopez-Lopez JR & Balke CW (1994). Local control of excitation-contraction coupling in rat heart cells. J Physiol 474, 463-471.