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Volumn 17, Issue 2, 2012, Pages 203-218

Emerging drugs for cervical cancer

Author keywords

Advanced cervical cancer; Chemoradiation; Chemotherapy; E6 E7 oncogenes; Histone deacetylase inhibitors; HPV; Locally advanced cervical cancer; Monoclonal antibodies; Novel cytotoxics; Proteasome inhibitors; Radiosensitizers; Tyrosine kinase inhibitors

Indexed keywords

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; BELOTECAN; BENDAMUSTINE; BEVACIZUMAB; BRYOSTATIN 1; CABAZITAXEL; CEDIRANIB; CETUXIMAB; CISPLATIN; EVEROLIMUS; EXATECAN; GEFITINIB; GEMCITABINE; HYDRALAZINE; IMATINIB; IXABEPILONE; MAPATUMUMAB; NAVELBINE; OLAPARIB; PACLITAXEL; PANITUMUMAB; PAZOPANIB; PRALATREXATE; SORAFENIB; SUNITINIB; TIRAPAZAMINE; TOPOTECAN; UNINDEXED DRUG; VALPROIC ACID; VELIPARIB;

EID: 84861646049     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2012.683409     Document Type: Review
Times cited : (14)

References (128)
  • 3
    • 77949287219 scopus 로고    scopus 로고
    • Pharmacoterapy options for locally advanced and advanced cervical cancer
    • Duenas-Gonzalez A, Cetina L, Coronel J, Martinez-Banos D. Pharmacoterapy options for locally advanced and advanced cervical cancer. Drugs 2010;70:403-32
    • (2010) Drugs , vol.70 , pp. 403-432
    • Duenas-Gonzalez, A.1    Cetina, L.2    Coronel, J.3    Martinez-Banos, D.4
  • 4
    • 84855557781 scopus 로고    scopus 로고
    • Preventing cancer with vaccines: Progress in the global control of cancer
    • Kane MA. Preventing cancer with vaccines: progress in the global control of cancer. Cancer Prev Res (Phila) 2012;5:24-9
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 24-29
    • Kane, M.A.1
  • 5
    • 0033740178 scopus 로고    scopus 로고
    • Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
    • Goodwin EC, DiMaio D. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc Natl Acad Sci USA 2000;97:12513-18
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12513-12518
    • Goodwin, E.C.1    Dimaio, D.2
  • 7
    • 56549090405 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy and conservative surgery for stage IB1 cervical cancer
    • Maneo A, Chiari S, Bonazzi C, et al. Neoadjuvant chemotherapy and conservative surgery for stage IB1 cervical cancer. Gynecol Oncol 2008;111:438-43
    • (2008) Gynecol Oncol , vol.111 , pp. 438-443
    • Maneo, A.1    Chiari, S.2    Bonazzi, C.3
  • 8
    • 77950877038 scopus 로고    scopus 로고
    • Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: Individual patient data meta-analysis
    • Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC)
    • Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC). Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis. Cochrane Database Syst Rev 2010(1):CD008285
    • (2010) Cochrane Database Syst Rev , Issue.1
  • 9
    • 0033560677 scopus 로고    scopus 로고
    • Improved treatment for cervical cancer - Concurrent chemotherapy and radiotherapy
    • DOI 10.1056/NEJM199904153401509
    • Thomas GM. Improved treatment for cervical cancer: concurrent chemotherapy and radiotherapy. N Engl J Med 1999;340:1198-200 (Pubitemid 29177880)
    • (1999) New England Journal of Medicine , vol.340 , Issue.15 , pp. 1198-1200
    • Thomas, G.M.1
  • 10
    • 84861647284 scopus 로고    scopus 로고
    • Impact of NCI clinical announcement upon use of chemoradiation for women with cervical cancer [abstract]
    • Trimble EL, Gius D, Harlan LC. Impact of NCI clinical announcement upon use of chemoradiation for women with cervical cancer [abstract]. J Clin Oncol 2007;25:5537
    • (2007) J Clin Oncol , vol.25 , pp. 5537
    • Trimble, E.L.1    Gius, D.2    Harlan, L.C.3
  • 11
    • 79955582400 scopus 로고    scopus 로고
    • Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix
    • Duenas-Gonzalez A, Zarba JJ, Patel F, et al. Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J Clin Oncol 2011;29:1678-85
    • (2011) J Clin Oncol , vol.29 , pp. 1678-1685
    • Duenas-Gonzalez, A.1    Zarba, J.J.2    Patel, F.3
  • 12
    • 70350433286 scopus 로고    scopus 로고
    • Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: A Gynecologic Oncology Group study
    • Monk BJ, Sill MW, McMeekin DS, et al. Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. J Clin Oncol 2009;27:4649-55
    • (2009) J Clin Oncol , vol.27 , pp. 4649-4655
    • Monk, B.J.1    Sill, M.W.2    McMeekin, D.S.3
  • 13
    • 78149359590 scopus 로고    scopus 로고
    • Health-related quality of life outcomes associated with four cisplatin-based doublet chemotherapy regimens for stage IVB recurrent or persistent cervical cancer: A Gynecologic Oncology Group study
    • Cella D, Huang HQ, Monk BJ, et al. Health-related quality of life outcomes associated with four cisplatin-based doublet chemotherapy regimens for stage IVB recurrent or persistent cervical cancer: a Gynecologic Oncology Group study. Gynecol Oncol 2010;119:531-7
    • (2010) Gynecol Oncol , vol.119 , pp. 531-537
    • Cella, D.1    Huang, H.Q.2    Monk, B.J.3
  • 14
    • 0002591286 scopus 로고    scopus 로고
    • Carcinoma of the cervix uteri: FIGO annual report on the results of treatment in gynaecological cancer
    • Benedet J, Odicino F, Maisonneuve P, et al. Carcinoma of the cervix uteri: FIGO annual report on the results of treatment in gynaecological cancer. J Epidemiol Biost 3:5-34
    • J Epidemiol Biost , vol.3 , pp. 5-34
    • Benedet, J.1    Odicino, F.2    Maisonneuve, P.3
  • 17
    • 80054914456 scopus 로고    scopus 로고
    • Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis
    • Forouzanfar MH, Foreman KJ, Delossantos AM, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 2011;378(9801):1461-84
    • (2011) Lancet , vol.378 , Issue.9801 , pp. 1461-1484
    • Forouzanfar, M.H.1    Foreman, K.J.2    Delossantos, A.M.3
  • 19
    • 77953332977 scopus 로고    scopus 로고
    • Bethesda, MD, USA: National Cancer Institute
    • Ries LAG, Harkins D, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2003. Bethesda, MD, USA: National Cancer Institute; 2006. Available from: http://seer.cancer.gov/csr/1975-2003/results-merged/sect-05- cervi-uteri.pdf
    • (2006) SEER Cancer Statistics Review 1975-2003
    • Lag, R.1    Harkins, D.2    Krapcho, M.3
  • 20
    • 84861639470 scopus 로고    scopus 로고
    • Available from: http://www.datamonitor.com/store/Product/epidemiology- cervical-cancer-the-small-decrease-in- cervical-cancer-cases-over-the-next- decade-in-the-seven-major-markets- is-driven-by-decreasing-incidence- rates?productid=HC00202-001
  • 21
    • 0342646896 scopus 로고    scopus 로고
    • Epidemiology of cervical cancer
    • Mohar A, Frias-Mendivil M. Epidemiology of cervical cancer. Cancer Invest 2000;18:584-90 (Pubitemid 30485675)
    • (2000) Cancer Investigation , vol.18 , Issue.6 , pp. 584-590
    • Mohar, A.1    Frias-Mendivil, M.2
  • 22
    • 84861639472 scopus 로고    scopus 로고
    • Market Research: Cervical Cancer Market Is Forecast to Show Slow Growth
    • Market Research: Cervical Cancer Market Is Forecast to Show Slow Growth. Available from: http://www.sys-con.com/node/2124321
  • 24
    • 84861639473 scopus 로고    scopus 로고
    • Available from: http://www.sanger.ac.uk/perl/genetics/CGP/core-line- viewer?action=byhist&ss=NS&sn=cervix&s=3
  • 26
    • 80155191242 scopus 로고    scopus 로고
    • Oncogene addition as a foundational rationales for targeted anti-cancer therapy: Promises and perils
    • Torti D, Trusolino L. Oncogene addition as a foundational rationales for targeted anti-cancer therapy: promises and perils. EMBO Mol Med 2011;3:623-36
    • (2011) EMBO Mol Med , vol.3 , pp. 623-636
    • Torti, D.1    Trusolino, L.2
  • 27
    • 0036849734 scopus 로고    scopus 로고
    • Human papillomavirus immortalization and transformation functions
    • DOI 10.1016/S0168-1702(02)00190-9, PII S0168170202001909
    • Munger K, Howley PM. Human papillomavirus immortalization and transformation functions. Virus Res 2002;89:213-28 (Pubitemid 35351540)
    • (2002) Virus Research , vol.89 , Issue.2 , pp. 213-228
    • Munger, K.1    Howley, P.M.2
  • 28
    • 0026639028 scopus 로고
    • Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products
    • Munger K, Scheffner M, Huibregtse JM, et al. Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. Cancer Surv 1992;12:197-217
    • (1992) Cancer Surv , vol.12 , pp. 197-217
    • Munger, K.1    Scheffner, M.2    Huibregtse, J.M.3
  • 29
    • 38149075312 scopus 로고    scopus 로고
    • Papillomavirus E6 and E7 proteins and their cellular targets
    • DOI 10.2741/2739
    • Wise-Draper TM, Wells SI. Papillomavirus E6 and E7 proteins and their cellular targets. Front Biosci 2008;13:1003-17 (Pubitemid 351594744)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.3 , pp. 1003-1017
    • Wise-Draper, T.M.1    Wells, S.I.2
  • 30
    • 34548152357 scopus 로고    scopus 로고
    • Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: Roles of E6 and E7 proteins
    • DOI 10.1111/j.1349-7006.2007.00546.x
    • Narisawa-Saito M, Kiyono T. Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci 2007;98:1505-11 (Pubitemid 47308443)
    • (2007) Cancer Science , vol.98 , Issue.10 , pp. 1505-1511
    • Narisawa-Saito, M.1    Kiyono, T.2
  • 31
    • 38649111038 scopus 로고    scopus 로고
    • Interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
    • Sima N, Wang W, Kong D, et al. Interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53. Apoptosis 2008;13:273-81
    • (2008) Apoptosis , vol.13 , pp. 273-281
    • Sima, N.1    Wang, W.2    Kong, D.3
  • 32
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 2002;21:6041-8
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 33
    • 34447629237 scopus 로고    scopus 로고
    • Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells
    • DOI 10.1016/j.ygyno.2007.04.039, PII S0090825807002624
    • Sima N, Wang S, Wang W, et al. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol 2007;106:299-304 (Pubitemid 47087935)
    • (2007) Gynecologic Oncology , vol.106 , Issue.2 , pp. 299-304
    • Sima, N.1    Wang, S.2    Wang, W.3    Kong, D.4    Xu, Q.5    Tian, X.6    Luo, A.7    Zhou, J.8    Xu, G.9    Meng, L.10    Lu, Y.11    Ma, D.12
  • 34
    • 60849088248 scopus 로고    scopus 로고
    • Inhibition of cervical cancer cell growth by human papillomavirus virus-like particles packaged with human papillomavirus oncoprotein short hairpin RNAs
    • Bousarghin L, Touze A, Gaud G, et al. Inhibition of cervical cancer cell growth by human papillomavirus virus-like particles packaged with human papillomavirus oncoprotein short hairpin RNAs. Mol Cancer Ther 2009;8:357-65
    • (2009) Mol Cancer Ther , vol.8 , pp. 357-365
    • Bousarghin, L.1    Touze, A.2    Gaud, G.3
  • 35
    • 33749873618 scopus 로고    scopus 로고
    • Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes
    • DOI 10.1038/sj.cgt.7700971, PII 7700971
    • Gu W, Putral L, Hengst K, et al. Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes. Cancer Gene Ther 2006;13:1023-32 (Pubitemid 44564738)
    • (2006) Cancer Gene Therapy , vol.13 , Issue.11 , pp. 1023-1032
    • Gu, W.1    Putral, L.2    Hengst, K.3    Minto, K.4    Saunders, N.A.5    Leggatt, G.6    McMillan, N.A.J.7
  • 37
    • 0035134457 scopus 로고    scopus 로고
    • Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells
    • DOI 10.1006/gyno.2000.6053
    • Moon MS, Lee CJ, Um SJ, et al. Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells. Gynecol Oncol 2001;80:168-75 (Pubitemid 32158454)
    • (2001) Gynecologic Oncology , vol.80 , Issue.2 , pp. 168-175
    • Moon, M.S.1    Lee, C.J.2    Um, S.J.3    Park, J.S.4    Yang, J.M.5    Hwang, E.S.6
  • 39
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002;7(S4):2-8 (Pubitemid 34977157)
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 40
    • 80053148870 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as biomarker for cervical cancer
    • Soonthornthum T, Arias-Pulido H, Joste N, et al. Epidermal growth factor receptor as biomarker for cervical cancer. Ann Oncol 2011;22:2166-78
    • (2011) Ann Oncol , vol.22 , pp. 2166-2178
    • Soonthornthum, T.1    Arias-Pulido, H.2    Joste, N.3
  • 42
    • 0026593192 scopus 로고
    • Human papillomavirus type 16 E5 gene stimulates the transforming activity of the epidermal growth factor receptos
    • Pim D, Collins M, Banks L. Human papillomavirus type 16 E5 gene stimulates the transforming activity of the epidermal growth factor receptos. Oncogene 1992;7:27-32
    • (1992) Oncogene , vol.7 , pp. 27-32
    • Pim, D.1    Collins, M.2    Banks, L.3
  • 43
    • 0035328577 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes
    • Akerman GS, Tolleson WH, Brown KL, et al. Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes. Cancer Res 2001;61:3837-43 (Pubitemid 32695001)
    • (2001) Cancer Research , vol.61 , Issue.9 , pp. 3837-3843
    • Akerman, G.S.1    Tolleson, W.H.2    Brown, K.L.3    Zyzak, L.L.4    Mourateva, E.5    Engin, T.S.W.6    Basaraba, A.7    Coker, A.L.8    Creek, K.E.9    Pirisi, L.10
  • 44
    • 0032505713 scopus 로고    scopus 로고
    • Transcriptional regulation of the EGF receptor promoter by HPV16 and retinoic acid in human ectocervical epithelial cells
    • DOI 10.1006/excr.1998.4179
    • Sizemore N, Choo CK, Eckert RL, Rorke EA. Transcriptional regulation of the GF receptor promoter by HPV16 and retinoic acid in human ectocervical epithelial cells. Exp Cell Res 1998;244:349-56 (Pubitemid 28480883)
    • (1998) Experimental Cell Research , vol.244 , Issue.1 , pp. 349-356
    • Sizemore, N.1    Choo, C.K.2    Eckert, R.L.3    Rorke, E.A.4
  • 46
    • 37449004176 scopus 로고    scopus 로고
    • A phase II trial to evaluate gefitinib as second-or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer
    • Goncalves A, Fabbro M, Lhomme C, et al. A phase II trial to evaluate gefitinib as second-or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer. Gynecol Oncol 2008;108:42-6
    • (2008) Gynecol Oncol , vol.108 , pp. 42-46
    • Goncalves, A.1    Fabbro, M.2    Lhomme, C.3
  • 47
    • 69449086850 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study
    • Schilder RJ, Sill MW, Lee YC, et al. A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Int J Gynecol Cancer 2009;19:929-33
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 929-933
    • Schilder, R.J.1    Sill, M.W.2    Lee, Y.C.3
  • 48
    • 77955874058 scopus 로고    scopus 로고
    • Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer
    • Monk BJ, Mas Lopez L, Zarba JJ, et al. Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer. J Clin Oncol 2010;28:3562-9
    • (2010) J Clin Oncol , vol.28 , pp. 3562-3569
    • Monk, B.J.1    Mas Lopez, L.2    Zarba, J.J.3
  • 49
    • 58149151263 scopus 로고    scopus 로고
    • Phase i trial of erlotinib combined with cisplatin and radiotherapy for patients with locally advanced cervical squamous cell cancer
    • Nogueira-Rodrigues A, do Carmo CC, Viegas C, et al. Phase I trial of erlotinib combined with cisplatin and radiotherapy for patients with locally advanced cervical squamous cell cancer. Clin Cancer Res 2008;14:6324-9
    • (2008) Clin Cancer Res , vol.14 , pp. 6324-6329
    • Nogueira-Rodrigues, A.1    Do Carmo, C.C.2    Viegas, C.3
  • 50
    • 77954767460 scopus 로고    scopus 로고
    • Erlotinib (E) combined with cisplatin (C) and radiotherapy (RT) for patients with locally advanced squamous cell cervical cancer: A phase II trial [abstract]
    • Ferreira CG, Erlich F, Carmo CC, et al. Erlotinib (E) combined with cisplatin (C) and radiotherapy (RT) for patients with locally advanced squamous cell cervical cancer: a phase II trial [abstract]. J Clin Oncol 2008;26:5511
    • (2008) J Clin Oncol , vol.26 , pp. 5511
    • Ferreira, C.G.1    Erlich, F.2    Carmo, C.C.3
  • 52
    • 67651093726 scopus 로고    scopus 로고
    • Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma
    • Longatto-Filho A, Pinheiro C, Martinho O, et al. Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. BMC Cancer 2009;9:212
    • (2009) BMC Cancer , vol.9 , pp. 212
    • Longatto-Filho, A.1    Pinheiro, C.2    Martinho, O.3
  • 53
    • 80051551247 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: A gynecologic oncology group study
    • Santin AD, Sill MW, McMeekin DS, et al. Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a gynecologic oncology group study. Gynecol Oncol 2011;122:495-500
    • (2011) Gynecol Oncol , vol.122 , pp. 495-500
    • Santin, A.D.1    Sill, M.W.2    McMeekin, D.S.3
  • 54
    • 78751582338 scopus 로고    scopus 로고
    • Cetuximab monotherapy in advanced cervical cancer: A retrospective study with five patients
    • Hertlein L, Lenhard M, Kirschenhofer A, et al. Cetuximab monotherapy in advanced cervical cancer: a retrospective study with five patients. Arch Gynecol Obstet 2011;283:109-13
    • (2011) Arch Gynecol Obstet , vol.283 , pp. 109-113
    • Hertlein, L.1    Lenhard, M.2    Kirschenhofer, A.3
  • 55
    • 62749156047 scopus 로고    scopus 로고
    • Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial
    • Kurtz E, Hardy-Bessard AC, Deslandres M, et al. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: a phase II GINECO trial. Gynecol Oncol 2009;113:16-20
    • (2009) Gynecol Oncol , vol.113 , pp. 16-20
    • Kurtz, E.1    Hardy-Bessard, A.C.2    Deslandres, M.3
  • 56
    • 79955481029 scopus 로고    scopus 로고
    • Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: A Gynecologic Oncology Group study
    • Farley J, Sill MW, Birrer M, et al. Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study. Gynecol Oncol 2011;121:303-8
    • (2011) Gynecol Oncol , vol.121 , pp. 303-308
    • Farley, J.1    Sill, M.W.2    Birrer, M.3
  • 57
    • 34248386122 scopus 로고    scopus 로고
    • Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma
    • DOI 10.1016/j.ygyno.2007.01.045, PII S009082580700100X
    • Kang S, Kim HS, Seo SS, et al. Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma. Gynecol Oncol 2007;105:662-6 (Pubitemid 46734191)
    • (2007) Gynecologic Oncology , vol.105 , Issue.3 , pp. 662-666
    • Kang, S.1    Kim, H.-S.2    Seo, S.S.3    Park, S.-Y.4    Sidransky, D.5    Dong, S.M.6
  • 59
    • 0025339154 scopus 로고
    • Growth-regulating functions of human papillomavirus early gene products in cervical cancer cells acting dominant over enhanced epidermal growth factor receptor expression
    • von Knebel Doeberitz M, Gissmann L, zur-Haussen H. Growth-regulating functions of human papillomavirus early gene products in cervical cancer cells acting dominant over enhanced epidermal growth factor receptor expression. Cancer Res 1990;50:3730-6 (Pubitemid 20194123)
    • (1990) Cancer Research , vol.50 , Issue.12 , pp. 3730-3736
    • Von Knebel Doeberitz, M.1    Gissmann, L.2    Zur Hausen, H.3
  • 60
    • 0029155712 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia
    • Guidi AJ, Abu-Jawdeh G, Berse B, et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst 1995;87:1237-45
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1237-1245
    • Guidi, A.J.1    Abu-Jawdeh, G.2    Berse, B.3
  • 61
    • 0347360384 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in the progression of cervical neoplasia and its relation to angiogenesis and p53 status
    • Lee JS, Kim HS, Park JT, et al. Expression of vascular endothelial growth factor in the progression of cervical neoplasia and its relation to angiogenesis and p53 status. Anal Quant Cytol Histol 2003;25:303-11 (Pubitemid 38044607)
    • (2003) Analytical and Quantitative Cytology and Histology , vol.25 , Issue.6 , pp. 303-311
    • Lee, J.S.1    Kim, H.S.2    Park, J.T.3    Lee, M.C.4    Park, C.S.5
  • 62
    • 0033790637 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and prognosis of cervical carcinoma
    • Cheng WF, Chen CA, Lee CN, et al. Vascular endothelial growth factor and prognosis of cervical carcinoma. Obstet Gynecol 2000;96:721-6
    • (2000) Obstet Gynecol , vol.96 , pp. 721-726
    • Cheng, W.F.1    Chen, C.A.2    Lee, C.N.3
  • 63
    • 0034009738 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in progression of cervical cancer: Correlation with thymidine phosphorylase expression, angiogenesis, tumor cell proliferation, and apoptosis
    • Fujiwaki R, Hata K, Iida K, et al. Vascular endothelial growth factor expression in progression of cervical cancer: correlation with thymidine phosphorylase expression, angiogenesis, tumor cell proliferation, and apoptosis. Anticancer Res 2000;20:1317-22 (Pubitemid 30240721)
    • (2000) Anticancer Research , vol.20 , Issue.2 B , pp. 1317-1322
    • Fujiwaki, R.1    Hata, K.2    Iida, K.3    Maede, Y.4    Miyazaki, K.5
  • 64
    • 34548681867 scopus 로고    scopus 로고
    • Human papillomavirus causes an angiogenic switch in keratinocytes which is sufficient to alter endothelial cell behavior
    • DOI 10.1016/j.virol.2007.05.030, PII S0042682207003868
    • Chen W, Li F, Mead L, et al. Human papillomavirus causes an angiogenic switch in keratinocytes which is sufficient to alter endothelial cell behavior. Virology 2007;367:168-74 (Pubitemid 47418936)
    • (2007) Virology , vol.367 , Issue.1 , pp. 168-174
    • Chen, W.1    Li, F.2    Mead, L.3    White, H.4    Walker, J.5    Ingram, D.A.6    Roman, A.7
  • 65
    • 0034699338 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis: The HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner
    • Lopez-Ocejo O, Viloria-Petit A, Bequet-Romero M, et al. Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner. Oncogene 2000;19:4611-20
    • (2000) Oncogene , vol.19 , pp. 4611-4620
    • Lopez-Ocejo, O.1    Viloria-Petit, A.2    Bequet-Romero, M.3
  • 67
    • 77954124424 scopus 로고    scopus 로고
    • Chemotherapy with low-dose bevacizumab and carboplatin in the treatment of a patient with recurrent cervical cancer
    • Tan SJ, Juan JH, Fu PT, et al. Chemotherapy with low-dose bevacizumab and carboplatin in the treatment of a patient with recurrent cervical cancer. Eur J Gynaecol Oncol 2010;31:350-3
    • (2010) Eur J Gynaecol Oncol , vol.31 , pp. 350-353
    • Tan, S.J.1    Juan, J.H.2    Fu, P.T.3
  • 68
    • 61549141361 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in the treatment of persistent or recurrent squamous cell carcinoma of the cervix: A Gynecology Oncology Group study
    • Monk BJ, Sill MW, Burger RA, et al. Phase II trial of bevacizumab in the treatment of persistent or recurrent squamous cell carcinoma of the cervix: a Gynecology Oncology Group study. J Clin Oncol 2009;27:1069-74
    • (2009) J Clin Oncol , vol.27 , pp. 1069-1074
    • Monk, B.J.1    Sill, M.W.2    Burger, R.A.3
  • 69
    • 33847405376 scopus 로고    scopus 로고
    • Pazopanib: A novel multitargeted tyrosine kinase inhibitor
    • DOI 10.1007/s11912-007-0007-2
    • Sonpavde G, Hutson TE. Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep 2007;9:115-19 (Pubitemid 46332383)
    • (2007) Current Oncology Reports , vol.9 , Issue.2 , pp. 115-119
    • Sonpavde, G.1    Hutson, T.E.2
  • 70
    • 84555197179 scopus 로고    scopus 로고
    • Survival data from a phase II, open-label study of pazopanib or lapatinib monotherapy in patients with advanced and recurrent cervical cancer
    • Monk BJ, Pandite LN. Survival data from a phase II, open-label study of pazopanib or lapatinib monotherapy in patients with advanced and recurrent cervical cancer. J Clin Oncol 2011;29:4845
    • (2011) J Clin Oncol , vol.29 , pp. 4845
    • Monk, B.J.1    Pandite, L.N.2
  • 73
    • 84855466019 scopus 로고    scopus 로고
    • A phase 3 trial of bevacizumab in ovarian cancer
    • Perren TJ, Swart AM, Pfisterer J, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011;365:2484-96
    • (2011) N Engl J Med , vol.365 , pp. 2484-2496
    • Perren, T.J.1    Swart, A.M.2    Pfisterer, J.3
  • 74
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of bevacizumab in the primary treatment of ovarian cancer
    • Burger RA, Brady MF, Bookman MA, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011;365:2473-83
    • (2011) N Engl J Med , vol.365 , pp. 2473-2483
    • Burger, R.A.1    Brady, M.F.2    Bookman, M.A.3
  • 75
    • 33750203160 scopus 로고    scopus 로고
    • Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer
    • Taja-Chayeb L, Chavez-Blanco A, Martinez-Tlahuel J, et al. Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer. Cancer Cell Int 2006;6:22
    • (2006) Cancer Cell Int , vol.6 , pp. 22
    • Taja-Chayeb, L.1    Chavez-Blanco, A.2    Martinez-Tlahuel, J.3
  • 76
    • 54949144410 scopus 로고    scopus 로고
    • MTOR inhibitors in the treatment of cancer
    • Fasolo A, Sessa C. mTOR inhibitors in the treatment of cancer. Expert Opin Investig Drugs 2008;17:1717-34
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1717-1734
    • Fasolo, A.1    Sessa, C.2
  • 77
    • 78049463500 scopus 로고    scopus 로고
    • High expression of mTOR is associated with radiation resistance in cervical cancer
    • Kim MK, Kim TJ, Sung CO, et al. High expression of mTOR is associated with radiation resistance in cervical cancer. J Gynecol Oncol 2010;21:181-5
    • (2010) J Gynecol Oncol , vol.21 , pp. 181-185
    • Kim, M.K.1    Kim, T.J.2    Sung, C.O.3
  • 78
    • 77951938324 scopus 로고    scopus 로고
    • A phase i study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies
    • Temkin SM, Yamada SD, Fleming GF. A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol Oncol 2010;117:473-6
    • (2010) Gynecol Oncol , vol.117 , pp. 473-476
    • Temkin, S.M.1    Yamada, S.D.2    Fleming, G.F.3
  • 79
    • 80355135233 scopus 로고    scopus 로고
    • PARP inhibitors in breast cancer: BRCA and beyond
    • Rios J, Puhalla S. PARP inhibitors in breast cancer: BRCA and beyond. Oncology 2011;25:1014-25
    • (2011) Oncology , vol.25 , pp. 1014-1025
    • Rios, J.1    Puhalla, S.2
  • 80
    • 77957944911 scopus 로고    scopus 로고
    • Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers
    • Powell C, Mikropoulos C, Kaye SB, et al. Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. Cancer Treat Rev 2010;36:566-75
    • (2010) Cancer Treat Rev , vol.36 , pp. 566-575
    • Powell, C.1    Mikropoulos, C.2    Kaye, S.B.3
  • 81
    • 58049156959 scopus 로고    scopus 로고
    • Induction of apoptosis by the inhibitors of poly (ADP-ribose)polymerase in HeLa cells
    • Ghosh U, Bhattacharyya NP. Induction of apoptosis by the inhibitors of poly (ADP-ribose)polymerase in HeLa cells. Mol Cell Biochem 2009;320:15-23
    • (2009) Mol Cell Biochem , vol.320 , pp. 15-23
    • Ghosh, U.1    Bhattacharyya, N.P.2
  • 82
    • 34547549214 scopus 로고    scopus 로고
    • Epigenetic therapy in cancer: Molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors
    • Schneider-Stock R, Ocker M. Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors. IDrugs 2007;10:557-61 (Pubitemid 47186508)
    • (2007) IDrugs , vol.10 , Issue.8 , pp. 557-561
    • Scneider-Stock, R.1    Ocker, M.2
  • 83
    • 27744492604 scopus 로고    scopus 로고
    • Epigenetics of cervical cancer. An overview and therapeutic perspectives
    • Duenas-Gonzalez A, Lizano M, Candelaria M, et al. Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer 2005;4:38
    • (2005) Mol Cancer , vol.4 , pp. 38
    • Duenas-Gonzalez, A.1    Lizano, M.2    Candelaria, M.3
  • 84
    • 0026018911 scopus 로고
    • 5-aza 2¢ deoxycytidine in advanced or recurrent cancer of the uterine cervix
    • Vermorken JB, Tumolo S, Roozendaal KJ, et al. 5-aza 2¢ deoxycytidine in advanced or recurrent cancer of the uterine cervix. Eur J Cancer 1991;27:5216-17
    • (1991) Eur J Cancer , vol.27 , pp. 5216-5217
    • Vermorken, J.B.1    Tumolo, S.2    Roozendaal, K.J.3
  • 86
    • 51649091668 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas
    • Gore L, Rothenberg ML, O'Bryant CL, et al. A phase I and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas. Clin Cancer Res 2008;14:4517-25
    • (2008) Clin Cancer Res , vol.14 , pp. 4517-4525
    • Gore, L.1    Rothenberg, M.L.2    O'Bryant, C.L.3
  • 88
    • 80052216583 scopus 로고    scopus 로고
    • Pharmacokinetics of hydralazine, an antihypertensive and DNA-demethylating agent, using controlled-release formulations designed for use in dosing schedules based on the acetylator phenotype
    • Gonzalez-Fierro A, Vasquez-Bahena D, Taja-Chayeb L, et al. Pharmacokinetics of hydralazine, an antihypertensive and DNA-demethylating agent, using controlled-release formulations designed for use in dosing schedules based on the acetylator phenotype. Int J Clin Pharmacol Ther 2011;49:519-24
    • (2011) Int J Clin Pharmacol Ther , vol.49 , pp. 519-524
    • Gonzalez-Fierro, A.1    Vasquez-Bahena, D.2    Taja-Chayeb, L.3
  • 89
    • 33645071947 scopus 로고    scopus 로고
    • Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
    • Chavez-Blanco A, Perez-Plasencia C, Perez-Cardenas E, et al. Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines. Cancer Cell Int 2006;6:2
    • (2006) Cancer Cell Int , vol.6 , pp. 2
    • Chavez-Blanco, A.1    Perez-Plasencia, C.2    Perez-Cardenas, E.3
  • 90
    • 78651363567 scopus 로고    scopus 로고
    • Transcriptional changes induced by epigenetic therapy with hydralazine and magnesium valproate in cervical carcinoma
    • De la Cruz-Hernandez E, Perez-Plasencia C, Pérez-Cárdenas E, et al. Transcriptional changes induced by epigenetic therapy with hydralazine and magnesium valproate in cervical carcinoma. Oncol Rep 2011;25:399-407
    • (2011) Oncol Rep , vol.25 , pp. 399-407
    • De La Cruz-Hernandez, E.1    Perez-Plasencia, C.2    Pérez-Cárdenas, E.3
  • 91
    • 33846862931 scopus 로고    scopus 로고
    • Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid
    • Mora-Garcia M de L, Duenas-Gonzalez A, Hernandez-Montes J, et al. Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid. J Transl Med 2006;4:55
    • (2006) J Transl Med , vol.4 , pp. 55
    • De Mora-Garcia, M.L.1    Duenas-Gonzalez, A.2    Hernandez-Montes, J.3
  • 93
    • 77956123071 scopus 로고    scopus 로고
    • Epigenetic therapy and cisplatin chemoradiation in FIGO stage IIIB cervical cancer
    • Candelaria M, Cetina L, Perez-Cardenas E, et al. Epigenetic therapy and cisplatin chemoradiation in FIGO stage IIIB cervical cancer. Eur J Gynaecol Oncol 2010;31:386-91
    • (2010) Eur J Gynaecol Oncol , vol.31 , pp. 386-391
    • Candelaria, M.1    Cetina, L.2    Perez-Cardenas, E.3
  • 94
    • 61749098365 scopus 로고    scopus 로고
    • Radiosensitizing potential of epigenetic anticancer drugs
    • De Schutter H, Nuyts S. Radiosensitizing potential of epigenetic anticancer drugs. Anticancer Agents Med Chem 2009;9:99-108
    • (2009) Anticancer Agents Med Chem , vol.9 , pp. 99-108
    • De Schutter, H.1    Nuyts, S.2
  • 95
    • 84655175030 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer
    • Coronel J, Cetina L, Pacheco I, et al. A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results. Med Oncol 2011;28(S1):540-6
    • (2011) Preliminary Results. Med Oncol , vol.28 , Issue.S1 , pp. 540-546
    • Coronel, J.1    Cetina, L.2    Pacheco, I.3
  • 96
    • 1542269125 scopus 로고    scopus 로고
    • The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors
    • Schoffski P. The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors. Anticancer Drugs 2004;15:85-106 (Pubitemid 38316741)
    • (2004) Anti-Cancer Drugs , vol.15 , Issue.2 , pp. 85-106
    • Schoffski, P.1
  • 97
    • 79957800354 scopus 로고    scopus 로고
    • Phase II study of S-1, an oral fluoropyrimidine, in patients with advanced or recurrent cervical cancer
    • Katsumata N, Hirai Y, Kamiura S, et al. Phase II study of S-1, an oral fluoropyrimidine, in patients with advanced or recurrent cervical cancer. Ann Oncol 2011;22:1353-7
    • (2011) Ann Oncol , vol.22 , pp. 1353-1357
    • Katsumata, N.1    Hirai, Y.2    Kamiura, S.3
  • 98
    • 45549107234 scopus 로고    scopus 로고
    • Novel cytotoxic agents: Epothilones
    • Goodin S. Novel cytotoxic agents: epothilones. Am J Health Syst Pharm 2008;65(10 Suppl 3):S10-15
    • (2008) Am J Health Syst Pharm , vol.65 , Issue.10 SUPPL. 3
    • Goodin, S.1
  • 99
    • 0038500736 scopus 로고    scopus 로고
    • Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog
    • DOI 10.1016/S0090-8258(03)00146-X
    • Agrawal M, Edgerly M, Fojo T, Kotz H. Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog. Gynecol Oncol 2003;90:96-9 (Pubitemid 37338082)
    • (2003) Gynecologic Oncology , vol.90 , Issue.1 , pp. 96-99
    • Agrawal, M.1    Edgerly, M.2    Fojo, T.3    Kotz, H.4
  • 100
    • 0036304427 scopus 로고    scopus 로고
    • Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins
    • Garcia-Carbonero R, Supko JG. Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins. Clin Cancer Res 2002;8:641-61 (Pubitemid 34742090)
    • (2002) Clinical Cancer Research , vol.8 , Issue.3 , pp. 641-661
    • Garcia-Carbonero, R.1    Supko, J.G.2
  • 101
    • 73849111678 scopus 로고    scopus 로고
    • Chemosensitivity of uterine cervical cancer demonstrated by the histoculture drug response assay
    • Lee SW, Kim YM, Kim MB, et al. Chemosensitivity of uterine cervical cancer demonstrated by the histoculture drug response assay. Tohoku J Exp Med 2009;219:277-82
    • (2009) Tohoku J Exp Med , vol.219 , pp. 277-282
    • Lee, S.W.1    Kim, Y.M.2    Kim, M.B.3
  • 102
    • 79955857726 scopus 로고    scopus 로고
    • Phase II study of belotecan (CKD 602) as a single agent in patients with recurrent or progressive carcinoma of uterine cervix
    • Hwang JH, Lim MC, Seo SS, et al. Phase II study of belotecan (CKD 602) as a single agent in patients with recurrent or progressive carcinoma of uterine cervix. Jpn J Clin Oncol 2001;41:624-9
    • (2001) Jpn J Clin Oncol , vol.41 , pp. 624-629
    • Hwang, J.H.1    Lim, M.C.2    Seo, S.S.3
  • 103
    • 0029150444 scopus 로고
    • A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo
    • Mitsui I, Kumazawa E, Hirota Y, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res 1995;86:776-82
    • (1995) Jpn J Cancer Res , vol.86 , pp. 776-782
    • Mitsui, I.1    Kumazawa, E.2    Hirota, Y.3
  • 104
    • 67649380881 scopus 로고    scopus 로고
    • Tirapazamine: A novel agent targeting hypoxic tumor cells
    • Reddy SB, Williamson SK. Tirapazamine: a novel agent targeting hypoxic tumor cells. Expert Opin Investig Drugs 2009;18:77-87
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 77-87
    • Reddy, S.B.1    Williamson, S.K.2
  • 105
    • 0034306888 scopus 로고    scopus 로고
    • A phase I/II evaluation of tirapazamine administered intravenously concurrent with cisplatin and radiotherapy in women with locally advanced cervical cancer
    • Craighead PS, Pearcey R, Stuart G. A phase I/II evaluation of tirapazamine administered intravenously concurrent with cisplatin and radiotherapy in women with locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 2000;48:791-5
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 791-795
    • Craighead, P.S.1    Pearcey, R.2    Stuart, G.3
  • 106
    • 0033975268 scopus 로고    scopus 로고
    • Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity
    • DOI 10.1016/S0006-2952(99)00419-0, PII S0006295299004190
    • Finch RA, Liu M, Grill SP, et al. Triapine (3-aminopyridine-2- carboxaldehyde-thiosemicarbazone): a potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. Biochem Pharmacol 2000;59:983-91 (Pubitemid 30110814)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.8 , pp. 983-991
    • Finch, R.A.1    Liu, M.-C.2    Grill, S.P.3    Rose, W.C.4    Loomis, R.5    Vasquez, K.M.6    Cheng, Y.-C.7    Sartorelli, A.C.8
  • 107
    • 77958091728 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
    • Kunos CA, Radivoyevitch T, Pink J, et al. Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers. Radiat Res 2010;174:574-81
    • (2010) Radiat Res , vol.174 , pp. 574-581
    • Kunos, C.A.1    Radivoyevitch, T.2    Pink, J.3
  • 108
    • 76749092292 scopus 로고    scopus 로고
    • Phase i trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer
    • Kunos CA, Waggoner S, von Gruenigen V, et al. Phase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer. Clin Cancer Res 2010;16:1298-306
    • (2010) Clin Cancer Res , vol.16 , pp. 1298-1306
    • Kunos, C.A.1    Waggoner, S.2    Von Gruenigen, V.3
  • 109
    • 34447122735 scopus 로고    scopus 로고
    • Therapeutic application of small interfering RNA directed against bcr-abl transcripts to a patient with imatinib-resistant chronic myeloid leukaemia
    • DOI 10.1007/s10238-007-0125-z
    • Koldehoff M, Steckel NK, Beelen DW, Elmaagacli AH. Therapeutic application of small interfering RNA directed against bcr-abl transcripts to a patient with imatinib-resistant chronic myeloid leukaemia. Clin Exp Med 2007;7:47-55 (Pubitemid 47036743)
    • (2007) Clinical and Experimental Medicine , vol.7 , Issue.2 , pp. 47-55
    • Koldehoff, M.1    Steckel, N.K.2    Beelen, D.W.3    Elmaagacli, A.H.4
  • 110
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis ME, Zuckerman JE, Choi CH, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010;464(7291):1067-70
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.3
  • 111
    • 77951067833 scopus 로고    scopus 로고
    • Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation
    • Zhao CY, Szekely L, Bao W, Selivanova G. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res 2010;70:3372-81
    • (2010) Cancer Res , vol.70 , pp. 3372-3381
    • Zhao, C.Y.1    Szekely, L.2    Bao, W.3    Selivanova, G.4
  • 112
    • 80755168352 scopus 로고    scopus 로고
    • Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells
    • Mungala R, Kausar H, Munjal C, Gupta RC. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis 2011;32:1697-705
    • (2011) Carcinogenesis , vol.32 , pp. 1697-1705
    • Mungala, R.1    Kausar, H.2    Munjal, C.3    Gupta, R.C.4
  • 113
    • 34447520141 scopus 로고    scopus 로고
    • A plant lignan, 3′-o-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells
    • DOI 10.1002/mc.20305
    • Allen KL, Tschantz DR, Awad KS, et al. A plant lignan, 3¢-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells. Mol Carcinog 2007;46:564-75 (Pubitemid 47068075)
    • (2007) Molecular Carcinogenesis , vol.46 , Issue.7 , pp. 564-575
    • Allen, K.L.1    Tschantz, D.R.2    Awad, K.S.3    Lynch, W.P.4    DeLucia, A.L.5
  • 114
    • 0033803148 scopus 로고    scopus 로고
    • Inactivation of the human papillomavirus-16 E6 oncoprotein by organic disulfides
    • Beerheide W, Sim MM, Tan YJ, et al. Inactivation of the human papillomavirus-16 E6 oncoprotein by organic disulfides. Bioorg Med Chem 2000;8:2549-60
    • (2000) Bioorg Med Chem , vol.8 , pp. 2549-2560
    • Beerheide, W.1    Sim, M.M.2    Tan, Y.J.3
  • 115
    • 33747881135 scopus 로고    scopus 로고
    • Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
    • DOI 10.1016/j.antiviral.2006.03.014, PII S0166354206000891
    • Baleja JD, Cherry JJ, Liu Z, et al. Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins. Antiviral Res 2006;72:49-59 (Pubitemid 44291470)
    • (2006) Antiviral Research , vol.72 , Issue.1 , pp. 49-59
    • Baleja, J.D.1    Cherry, J.J.2    Liu, Z.3    Gao, H.4    Nicklaus, M.C.5    Voigt, J.H.6    Chen, J.J.7    Androphy, E.J.8
  • 116
    • 0033818726 scopus 로고    scopus 로고
    • Development of screening systems for drugs against human papillomavirus-associated cervical cancer: Based on E6-E6AP binding
    • Cho Y, Cho C, Joung O, et al. Development of screening systems for drugs against human papillomavirus-associated cervical cancer: based on E6-E6AP binding. Antiviral Res 2000;47:199-206
    • (2000) Antiviral Res , vol.47 , pp. 199-206
    • Cho, Y.1    Cho, C.2    Joung, O.3
  • 118
    • 15244363807 scopus 로고    scopus 로고
    • Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivity
    • DOI 10.1016/j.oraloncology.2004.11.003
    • Sirianni N, Wang J, Ferris RL. Antiviral activity of cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivity. Oral Oncol 2005;41:423-8 (Pubitemid 40387872)
    • (2005) Oral Oncology , vol.41 , Issue.4 , pp. 423-428
    • Sirianni, N.1    Wang, J.2    Ferris, R.L.3
  • 119
    • 77956936289 scopus 로고    scopus 로고
    • Effects of cidofovir on human papillomavirus-positive cervical cancer cells xenografts in nude mice
    • Yang Y, Zhao X, Chen W, et al. Effects of cidofovir on human papillomavirus-positive cervical cancer cells xenografts in nude mice. Oncol Res 2010;18:519-27
    • (2010) Oncol Res , vol.18 , pp. 519-527
    • Yang, Y.1    Zhao, X.2    Chen, W.3
  • 121
    • 69249213419 scopus 로고    scopus 로고
    • Topical treatment of CIN 2+ by cidofovir: Results of a phase II, double-blind, prospective, placebo-controlled study
    • Van Pachterbeke C, Becella D, Rozenber S, et al. Topical treatment of CIN 2+ by cidofovir: results of a phase II, double-blind, prospective, placebo-controlled study. Gynecol Oncol 2009;115:69-74
    • (2009) Gynecol Oncol , vol.115 , pp. 69-74
    • Van Pachterbeke, C.1    Becella, D.2    Rozenber, S.3
  • 123
    • 33847772150 scopus 로고    scopus 로고
    • The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study
    • de la Cruz-Hernandez E, Perez-Cardenas E, Contreras-Paredes A, et al. The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study. Virol J 2007;4:18
    • (2007) Virol J , vol.4 , pp. 18
    • De La Cruz-Hernandez, E.1    Perez-Cardenas, E.2    Contreras-Paredes, A.3
  • 124
    • 0037043118 scopus 로고    scopus 로고
    • Down-regulation of human papillomavirus E6/E7 oncogene by arsenic trioxide in cervical carcinoma cells
    • Um SJ, Lee SY, Kim EJ, et al. Down-regulation of human papillomavirus E6/E7 oncogene by arsenic trioxide in cervical carcinoma cells. Cancer Lett 2002;181:11-22
    • (2002) Cancer Lett , vol.181 , pp. 11-22
    • Um, S.J.1    Lee, S.Y.2    Kim, E.J.3
  • 125
    • 84862796395 scopus 로고    scopus 로고
    • Arsenic trioxide induces cervical cancer apoptosis, but specifically targets human papillomavirus-infected cell populations
    • [Epub ahead of print]
    • Wen X, Li D, Zhang Y, et al. Arsenic trioxide induces cervical cancer apoptosis, but specifically targets human papillomavirus-infected cell populations. Anticancer Drugs 2012; [Epub ahead of print]
    • (2012) Anticancer Drugs
    • Wen, X.1    Li, D.2    Zhang, Y.3
  • 126
    • 76349085626 scopus 로고    scopus 로고
    • Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1) in patients with refractory colorectal cancer
    • Trarbach T, Moehler M, Heinemann V, et al. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1) in patients with refractory colorectal cancer. Br J Cancer 2010;102:506-12
    • (2010) Br J Cancer , vol.102 , pp. 506-512
    • Trarbach, T.1    Moehler, M.2    Heinemann, V.3
  • 127
    • 78650942871 scopus 로고    scopus 로고
    • Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells
    • Ariza ME, Ramakrishnan R, Singh NP, et al. Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells. J Biol Chem 2011;286:24-34
    • (2011) J Biol Chem , vol.286 , pp. 24-34
    • Ariza, M.E.1    Ramakrishnan, R.2    Singh, N.P.3
  • 128
    • 79952659833 scopus 로고    scopus 로고
    • Interleukin 12 in cancer treatment
    • Bubenik J. Interleukin 12 in cancer treatment. Folia Biol (Praha) 2011;57:1-2
    • (2011) Folia Biol (Praha) , vol.57 , pp. 1-2
    • Bubenik, J.1


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