메뉴 건너뛰기




Volumn 18, Issue 4, 2008, Pages 749-754

Absence of epidermal growth factor receptor mutations in cervical cancer

Author keywords

Cervical cancer; EGFR; Mutation analysis; Tyrosine kinase inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 47649119001     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2007.01111.x     Document Type: Article
Times cited : (42)

References (48)
  • 1
    • 0034184994 scopus 로고    scopus 로고
    • International trends in incidence of cervical cancer: II. Squamous-cell carcinoma
    • Vizcaino A, Moreno V, Bosch F et al. International trends in incidence of cervical cancer: II. Squamous-cell carcinoma. Int J Cancer 2000 86 : 429 35.
    • (2000) Int J Cancer , vol.86 , pp. 429-35
    • Vizcaino, A.1    Moreno, V.2    Bosch, F.3
  • 3
    • 3042628862 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival
    • Jemal A, Clegg L, Ward E et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer 2004 101 : 3 27.
    • (2004) Cancer , vol.101 , pp. 3-27
    • Jemal, A.1    Clegg, L.2    Ward, E.3
  • 4
    • 32944470177 scopus 로고    scopus 로고
    • Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix
    • CD002225.
    • Green J, Kirwan J, Tierney J et al. Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix. Cochrane Database Syst Rev 2005 : CD002225.
    • (2005) Cochrane Database Syst Rev
    • Green, J.1    Kirwan, J.2    Tierney, J.3
  • 5
    • 0037667420 scopus 로고    scopus 로고
    • Targeting HER1/EGFR: A molecular approach to cancer therapy
    • Arteaga C. Targeting HER1/EGFR: a molecular approach to cancer therapy. Semin Oncol 2003 30 (Suppl. 7 3 14.
    • (2003) Semin Oncol , vol.30 , Issue.7 , pp. 3-14
    • Arteaga, C.1
  • 6
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005 23 : 2445 59.
    • (2005) J Clin Oncol , vol.23 , pp. 2445-59
    • Baselga, J.1    Arteaga, C.L.2
  • 7
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004 350 : 2129 39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-39
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 8
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004 304 : 1497 500.
    • (2004) Science , vol.304 , pp. 1497-500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 9
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004 101 : 13306 11.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-11
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 10
    • 17844390172 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions
    • Pao W, Miller VA. Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions. J Clin Oncol 2005 23 : 2556 68.
    • (2005) J Clin Oncol , vol.23 , pp. 2556-68
    • Pao, W.1    Miller, V.A.2
  • 11
    • 27944444486 scopus 로고    scopus 로고
    • Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells
    • Janmaat ML, Rodriguez JA, Gallegos-Ruiz M, Kruyt FA, Giaccone G. Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells. Int J Cancer 2006 118 : 209 14.
    • (2006) Int J Cancer , vol.118 , pp. 209-14
    • Janmaat, M.L.1    Rodriguez, J.A.2    Gallegos-Ruiz, M.3    Kruyt, F.A.4    Giaccone, G.5
  • 12
    • 5644293135 scopus 로고    scopus 로고
    • Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
    • Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson BE, Janne PA. Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res 2004 64 : 7241 4.
    • (2004) Cancer Res , vol.64 , pp. 7241-4
    • Tracy, S.1    Mukohara, T.2    Hansen, M.3    Meyerson, M.4    Johnson, B.E.5    Janne, P.A.6
  • 13
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell D, Haber D, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004 305 : 1163 7.
    • (2004) Science , vol.305 , pp. 1163-7
    • Sordella, R.1    Bell, D.2    Haber, D.3    Settleman, J.4
  • 14
    • 0033042754 scopus 로고    scopus 로고
    • Oncogene alterations in carcinomas of the uterine cervix: Overexpression of the epidermal growth factor receptor is associated with poor prognosis
    • Kersemaekers AM, Fleuren GJ, Kenter GG et al. Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis. Clin Cancer Res 1999 5 : 577 86.
    • (1999) Clin Cancer Res , vol.5 , pp. 577-86
    • Kersemaekers, A.M.1    Fleuren, G.J.2    Kenter, G.G.3
  • 15
    • 12144290754 scopus 로고    scopus 로고
    • Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: A potential predictor of poor survival
    • Kim GE, Kim YB, Cho NH et al. Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. Clin Cancer Res 2004 10 : 1366 74.
    • (2004) Clin Cancer Res , vol.10 , pp. 1366-74
    • Kim, G.E.1    Kim, Y.B.2    Cho, N.H.3
  • 16
    • 1842477822 scopus 로고    scopus 로고
    • Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: Prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis
    • Lee C, Lee R, Hammond E et al. Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis. Gynecol Oncol 2004 93 : 209 14.
    • (2004) Gynecol Oncol , vol.93 , pp. 209-14
    • Lee, C.1    Lee, R.2    Hammond, E.3
  • 17
    • 0038386695 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy
    • Gaffney DK, Haslam D, Tsodikov A et al. Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys 2003 56 : 922 8.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 922-8
    • Gaffney, D.K.1    Haslam, D.2    Tsodikov, A.3
  • 19
    • 0029954643 scopus 로고    scopus 로고
    • Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study
    • Kristensen GB, Holm R, Abeler VM, Trope CG. Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. Cancer 1996 78 : 433 40.
    • (1996) Cancer , vol.78 , pp. 433-40
    • Kristensen, G.B.1    Holm, R.2    Abeler, V.M.3    Trope, C.G.4
  • 20
    • 27144469023 scopus 로고    scopus 로고
    • Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix
    • Lee CM, Shrieve DC, Zempolich KA et al. Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix. Gynecol Oncol 2005 99 : 415 21.
    • (2005) Gynecol Oncol , vol.99 , pp. 415-21
    • Lee, C.M.1    Shrieve, D.C.2    Zempolich, K.A.3
  • 21
    • 0026557152 scopus 로고
    • Immunohistochemical demonstration of elevated expression of epidermal growth factor receptor in the neoplastic changes of cervical squamous epithelium
    • Maruo T, Yamasaki M, Ladines-Llave CA, Mochizuki M. Immunohistochemical demonstration of elevated expression of epidermal growth factor receptor in the neoplastic changes of cervical squamous epithelium. Cancer 1992 69 : 1182 7.
    • (1992) Cancer , vol.69 , pp. 1182-7
    • Maruo, T.1    Yamasaki, M.2    Ladines-Llave, C.A.3    Mochizuki, M.4
  • 22
    • 0024599422 scopus 로고
    • Clinical implications of the epidermal growth factor receptor in the squamous cell carcinoma of the uterine cervix
    • Pfeiffer D, Stellwag B, Pfeiffer A, Borlinghaus P, Meier W, Scheidel P. Clinical implications of the epidermal growth factor receptor in the squamous cell carcinoma of the uterine cervix. Gynecol Oncol 1989 33 : 146 50.
    • (1989) Gynecol Oncol , vol.33 , pp. 146-50
    • Pfeiffer, D.1    Stellwag, B.2    Pfeiffer, A.3    Borlinghaus, P.4    Meier, W.5    Scheidel, P.6
  • 24
    • 1242281346 scopus 로고    scopus 로고
    • Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: Its relationship to clinical outcome
    • Narayan G, Arias-Pulido H, Koul S et al. Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol Cancer 2003 2 : 24.
    • (2003) Mol Cancer , vol.2 , pp. 24
    • Narayan, G.1    Arias-Pulido, H.2    Koul, S.3
  • 25
    • 2942534707 scopus 로고    scopus 로고
    • Mapping common deleted regions on 5p15 in cervical carcinoma and their occurrence in precancerous lesions
    • Arias-Pulido H, Narayan G, Vargas H, Mansukhani M, Murty V. Mapping common deleted regions on 5p15 in cervical carcinoma and their occurrence in precancerous lesions. Mol Cancer 2002 1 : 3.
    • (2002) Mol Cancer , vol.1 , pp. 3
    • Arias-Pulido, H.1    Narayan, G.2    Vargas, H.3    Mansukhani, M.4    Murty, V.5
  • 26
    • 12844259590 scopus 로고    scopus 로고
    • High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines
    • Coe B, Henderson L, Garnis C et al. High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines. Genes Chromosomes Cancer 2005 42 : 308 13.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 308-13
    • Coe, B.1    Henderson, L.2    Garnis, C.3
  • 27
    • 33646596267 scopus 로고    scopus 로고
    • Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
    • Arias-Pulido H, Peyton CL, Joste NE, Vargas H, Wheeler CM. Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J Clin Microbiol 2006 44 : 1755 62.
    • (2006) J Clin Microbiol , vol.44 , pp. 1755-62
    • Arias-Pulido, H.1    Peyton, C.L.2    Joste, N.E.3    Vargas, H.4    Wheeler, C.M.5
  • 28
    • 0034541210 scopus 로고    scopus 로고
    • Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer
    • Pulido HA, Fakruddin MJ, Chatterjee A et al. Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer. Cancer Res 2000 60 : 6677 82.
    • (2000) Cancer Res , vol.60 , pp. 6677-82
    • Pulido, H.A.1    Fakruddin, M.J.2    Chatterjee, A.3
  • 29
    • 19944427851 scopus 로고    scopus 로고
    • Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
    • Amann J, Kalyankrishna S, Massion PP et al. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res 2005 65 : 226 35.
    • (2005) Cancer Res , vol.65 , pp. 226-35
    • Amann, J.1    Kalyankrishna, S.2    Massion, P.P.3
  • 30
    • 3142579208 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 6 in HPV-16 positive cervical carcinomas carrying the DRB1*1501-DQB1*0602 haplotype
    • Arias-Pulido H, Joste N, Wheeler C. Loss of heterozygosity on chromosome 6 in HPV-16 positive cervical carcinomas carrying the DRB1*1501- DQB1*0602 haplotype. Genes Chromosomes Cancer 2004 40 : 277 84.
    • (2004) Genes Chromosomes Cancer , vol.40 , pp. 277-84
    • Arias-Pulido, H.1    Joste, N.2    Wheeler, C.3
  • 31
    • 20044364933 scopus 로고    scopus 로고
    • EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
    • Marchetti A, Martella C, Felicioni L et al. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 2005 23 : 857 65.
    • (2005) J Clin Oncol , vol.23 , pp. 857-65
    • Marchetti, A.1    Martella, C.2    Felicioni, L.3
  • 32
    • 23844544647 scopus 로고    scopus 로고
    • Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
    • Qiulu P, Pao W, Ladanyi M. Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn 2005 7 : 396 403.
    • (2005) J Mol Diagn , vol.7 , pp. 396-403
    • Qiulu, P.1    Pao, W.2    Ladanyi, M.3
  • 33
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 2006 33 : 369 85.
    • (2006) Semin Oncol , vol.33 , pp. 369-85
    • Mendelsohn, J.1    Baselga, J.2
  • 35
    • 0038461104 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs
    • Ciardiello F, Tortora G. Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer 2003 39 : 1348 54.
    • (2003) Eur J Cancer , vol.39 , pp. 1348-54
    • Ciardiello, F.1    Tortora, G.2
  • 36
    • 0036221471 scopus 로고    scopus 로고
    • The causal relation between human papillomavirus and cervical cancer
    • Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002 55 : 244 65.
    • (2002) J Clin Pathol , vol.55 , pp. 244-65
    • Bosch, F.X.1    Lorincz, A.2    Munoz, N.3    Meijer, C.J.4    Shah, K.V.5
  • 37
    • 0027216860 scopus 로고
    • The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes
    • Straight SW, Hinkle PM, Jewers RJ, McCance DJ. The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes. J Virol 1993 67 : 4521 32.
    • (1993) J Virol , vol.67 , pp. 4521-32
    • Straight, S.W.1    Hinkle, P.M.2    Jewers, R.J.3    McCance, D.J.4
  • 38
    • 17844396023 scopus 로고    scopus 로고
    • HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes
    • Zhang B, Srirangam A, Potter DA, Roman A. HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes. Oncogene 2005 24 : 2585 8.
    • (2005) Oncogene , vol.24 , pp. 2585-8
    • Zhang, B.1    Srirangam, A.2    Potter, D.A.3    Roman, A.4
  • 39
    • 0035328577 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes
    • Akerman GS, Tolleson WH, Brown KL et al. Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes. Cancer Res 2001 61 : 3837 43.
    • (2001) Cancer Res , vol.61 , pp. 3837-43
    • Akerman, G.S.1    Tolleson, W.H.2    Brown, K.L.3
  • 40
    • 0032505713 scopus 로고    scopus 로고
    • Transcriptional regulation of the EGF receptor promoter by HPV16 and retinoic acid in human ectocervical epithelial cells
    • Sizemore N, Choo CK, Eckert RL, Rorke EA. Transcriptional regulation of the EGF receptor promoter by HPV16 and retinoic acid in human ectocervical epithelial cells. Exp Cell Res 1998 244 : 349 56.
    • (1998) Exp Cell Res , vol.244 , pp. 349-56
    • Sizemore, N.1    Choo, C.K.2    Eckert, R.L.3    Rorke, E.A.4
  • 41
    • 0030817148 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor and human papillomavirus E6/E7 proteins in cervical carcinoma cells
    • Hu G, Liu W, Mendelsohn J et al. Expression of epidermal growth factor receptor and human papillomavirus E6/E7 proteins in cervical carcinoma cells. J Natl Cancer Inst 1997 89 : 1271 6.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1271-6
    • Hu, G.1    Liu, W.2    Mendelsohn, J.3
  • 42
    • 1242319406 scopus 로고    scopus 로고
    • Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins
    • Duensing S, Munger K. Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins. Int J Cancer 2004 109 : 157 62.
    • (2004) Int J Cancer , vol.109 , pp. 157-62
    • Duensing, S.1    Munger, K.2
  • 43
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005 97 : 339 46.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-46
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 44
    • 11144333540 scopus 로고    scopus 로고
    • Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer
    • Lee JW, Soung YH, Kim SY et al. Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer. Int J Cancer 2005 113 : 510 1.
    • (2005) Int J Cancer , vol.113 , pp. 510-1
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 47
    • 33947412800 scopus 로고    scopus 로고
    • Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor
    • Steiner P, Joynes C, Bassi R et al. Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor. Clin Cancer Res 2007 13 : 1540 51.
    • (2007) Clin Cancer Res , vol.13 , pp. 1540-51
    • Steiner, P.1    Joynes, C.2    Bassi, R.3
  • 48
    • 0141869054 scopus 로고    scopus 로고
    • Selection of HER-2/neu-positive tumor cells in early stage cervical cancer: Implications for Herceptin-mediated therapy
    • Bellone S, Palmieri M, Gokden M et al. Selection of HER-2/neu-positive tumor cells in early stage cervical cancer: implications for Herceptin-mediated therapy. Gynecol Oncol 2003 91 : 231 40.
    • (2003) Gynecol Oncol , vol.91 , pp. 231-40
    • Bellone, S.1    Palmieri, M.2    Gokden, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.